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Serine phosphorylation of HIV-1 Vpu and its binding to tetherin regulates interaction with clathrin adaptors (2015)
Journal Article
Kueck, T., Foster, T. L., Weinelt, J., Sumner, J. C., Pickering, S., & Neil, S. J. D. (2015). Serine phosphorylation of HIV-1 Vpu and its binding to tetherin regulates interaction with clathrin adaptors. PLoS Pathogens, 11(8), https://doi.org/10.1371/journal.ppat.1005141

HIV-1 Vpu prevents incorporation of tetherin (BST2/ CD317) into budding virions and targets it for ESCRT-dependent endosomal degradation via a clathrin-dependent process. This requires a variant acidic dileucine-sorting motif (ExxxLV) in Vpu. Structu... Read More about Serine phosphorylation of HIV-1 Vpu and its binding to tetherin regulates interaction with clathrin adaptors.