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Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function (2013)
Journal Article
Bentham, M. J., Foster, T. L., McCormick, C., & Griffin, S. (2013). Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function. Journal of General Virology, 94, 2236-2248. https://doi.org/10.1099/vir.0.054338-0

Hepatitis C virus (HCV) p7 protein is critical for the efficient production of infectious virions in culture. p7 undergoes genotype-specific protein–protein interactions as well as displaying channel-forming activity, making it unclear whether the ph... Read More about Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function.

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release (2013)
Journal Article
Foster, T. L., Thompson, G. S., Kalverda, A. P., Kankanala, J., Bentham, M., Wetherill, L. F., …Griffin, S. (2014). Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release. Hepatology, 59(2), 408-422. https://doi.org/10.1002/hep.26685

Current interferon‐based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct‐acting antivirals (DAA) with the first protease‐targeted drugs licensed in 2012. Many compounds are in the pipeline... Read More about Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.