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A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3 (2009)
Journal Article
Foster, T. L., Tedbury, P. R., Pearson, A. R., & Harris, M. (2010). A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3. BBA - Proteins and Proteomics, 1804(1), 212-222. doi:10.1016/j.bbapap.2009.10.006

Hepatitis C virus encodes an autoprotease, NS2-3, which is required for processing of the viral polyprotein between the non-structural NS2 and NS3 proteins. This protease activity is vital for the replication and assembly of the virus and therefore r... Read More

Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro (2009)
Journal Article
StGelais, C., Foster, T. L., Verow, M., Atkins, E., Fishwick, C. W. G., Rowlands, D., …Griffin, S. (2009). Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro. Journal of Virology, 83(16), 7970-7981. doi:10.1128/jvi.00521-09

Hepatitis C virus (HCV) chronically infects 170 million individuals, causing severe liver disease. Although antiviral chemotherapy exists, the current regimen is ineffective in 50% of cases due to high levels of innate virus resistance. New, virus-sp... Read More