All Outputs (11)

Human gnathostomiasis: a neglected food-borne zoonosis (2020)
Journal Article
Liu, G., Sun, M., Elsheikha, H. M., Fu, Y., Sugiyama, H., Ando, K., …Yao, C. (2020). Human gnathostomiasis: a neglected food-borne zoonosis. Parasites and Vectors, 13, Article 616. https://doi.org/10.1186/s13071-020-04494-4

Background: Human gnathostomiasis is a food-borne zoonosis. Its etiological agents are the third-stage larvae of Gnathostoma spp. Human gnathostomiasis is often reported in developing countries, but it is also an emerging disease in developed countri... Read More about Human gnathostomiasis: a neglected food-borne zoonosis.

First record of besnoitiosis caused by Besnoitia bennetti in donkeys from the UK (2020)
Journal Article
Elsheikha, H. M., Schares, G., Paraschou, G., Sullivan, R., & Fox, R. (2020). First record of besnoitiosis caused by Besnoitia bennetti in donkeys from the UK. Parasites and Vectors, 13, https://doi.org/10.1186/s13071-020-04145-8

Background: The involvement of Besnoitia bennetti in skin pathologies was investigated in a series of 20 donkeys from the Donkey Sanctuary in England, in the 2013-2019 period. Methods: The initial histopathological finding of Besnoitia cysts in skin... Read More about First record of besnoitiosis caused by Besnoitia bennetti in donkeys from the UK.

The multitasking Fasciola gigantica Cathepsin B interferes with various functions of goat peripheral blood mononuclear cells in vitro (2019)
Journal Article
Chen, D., Tian, A., Hou, J., Li, J., Tian, X., Yuan, X., …Zhu, X. (2019). The multitasking Fasciola gigantica Cathepsin B interferes with various functions of goat peripheral blood mononuclear cells in vitro. Frontiers in Immunology, 10, Article 1707. https://doi.org/10.3389/fimmu.2019.01707

Cathepsin B, a lysosomal cysteine protease, is thought to be involved in the pathogenesis of Fasciola gigantica infection, but its exact role remains unclear. In the present study, a recombinant F. gigantica cathepsin B (rFgCatB) protein was expresse... Read More about The multitasking Fasciola gigantica Cathepsin B interferes with various functions of goat peripheral blood mononuclear cells in vitro.

Global serum proteomic changes in water buffaloes infected with Fasciola gigantica (2019)
Journal Article
Zhang, F., Hu, R., Elsheikha, H. M., Sheng, Z., Zhang, W., Zheng, W., …He, J. (2019). Global serum proteomic changes in water buffaloes infected with Fasciola gigantica. Parasites and Vectors, 12(1), Article 281. https://doi.org/10.1186/s13071-019-3533-5

Background: The liver fluke Fasciola gigantica modulates several signaling pathways in infected buffaloes to facilitate its survival and establishment of persistent infection. In response to the parasite invasion, buffaloes activate innate and adapti... Read More about Global serum proteomic changes in water buffaloes infected with Fasciola gigantica.

Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii (2018)
Journal Article
Wang, M., Zhang, F., Elsheikha, H. M., Zhang, N., He, J., Luo, J., & Zhu, X. (2018). Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii. Parasites and Vectors, 11(1), Article 592. https://doi.org/10.1186/s13071-018-3179-8

Background: Although sexual reproduction of the parasite Toxoplasma gondii exclusively occurs in the cat intestine, knowledge about the alteration of gene expression in the intestine of cats infected with T. gondii is still limited. Here, we investig... Read More about Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii.

Survey-based pilot study into the chosen therapy and prophylaxis used by UK primary care veterinary surgeons against canine angiostrongylosis (2018)
Journal Article
Shuttleworth, A., Dunning, M., Wright, I., & Elsheikha, H. M. (2018). Survey-based pilot study into the chosen therapy and prophylaxis used by UK primary care veterinary surgeons against canine angiostrongylosis. Veterinary parasitology (Amsterdam), 14, 144-149. doi:10.1016/j.vprsr.2018.10.010

Canine Angiostrongylosis (CA), a gastropod-borne parasitic infection caused by the metastrongyloid nematode Angiostrongylus vasorum, is an important cause of significant morbidity to domestic dogs across the UK as well as in other European countries.... Read More about Survey-based pilot study into the chosen therapy and prophylaxis used by UK primary care veterinary surgeons against canine angiostrongylosis.

Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using ?-XRF imaging and inductively coupled plasma mass spectrometry (2018)
Journal Article
Al-sandaqchi, A. T., Brignell, C., Collingwood, J. F., Geraki, K., Mirkes, E. M., Kong, K., …Elsheikha, H. M. (2018). Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using μ-XRF imaging and inductively coupled plasma mass spectrometry. Metallomics, 1401-1414. https://doi.org/10.1039/C8MT00136G

In this study, we measured the levels of elements in human brain microvascular endothelial cells (ECs) infected with T. gondii. ECs were infected with tachyzoites of the RH strain, and at 6, 24, and 48 hours post infection (hpi), the intracellular co... Read More about Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using ?-XRF imaging and inductively coupled plasma mass spectrometry.

Prevalence of antibodies against Toxoplasma gondii in pets and their owners in Shandong province, Eastern China (2018)
Journal Article
Cong, W., Elsheikha, H. M., Zhou, N., Peng, P., Qin, S., Meng, Q., & Qian, A. (2018). Prevalence of antibodies against Toxoplasma gondii in pets and their owners in Shandong province, Eastern China. BMC Infectious Diseases, 18(1), Article 430. https://doi.org/10.1186/s12879-018-3307-2

Background: Pet ownership in China has been steadily increasing over recent years. However, the risk of pet-associated zoonotic infection with the protozoan parasite Toxoplasma gondii remains poorly defined. Methods: In a cross-sectional survey, we... Read More about Prevalence of antibodies against Toxoplasma gondii in pets and their owners in Shandong province, Eastern China.

Functional characterization of dense granule proteins in Toxoplasma gondii RH strain using CRISPR-Cas9 system (2018)
Journal Article
Bai, M., Wang, J., Elsheikha, H. M., Liang, Q., Chen, K., Nie, L., & Zhu, X. (2018). Functional characterization of dense granule proteins in Toxoplasma gondii RH strain using CRISPR-Cas9 system. Frontiers in Cellular and Infection Microbiology, 8, 1-9. https://doi.org/10.3389/fcimb.2018.00300

Infection with the apicomplexan protozoan parasite Toxoplasma gondii is an ongoing public health problem. The parasite's ability to invade and replicate within the host cell is dependent on many effectors, such as dense granule proteins (GRAs) releas... Read More about Functional characterization of dense granule proteins in Toxoplasma gondii RH strain using CRISPR-Cas9 system.

Immunization with plasmid DNA expressing Heat Shock Protein 40 confers prophylactic protection against chronic Toxoplasma gondii infection in Kunming mice (2018)
Journal Article
Li, Z., Lu, J., Zhang, N., Elsheikha, H. M., Hou, J., Guo, H., & Zhu, X. (2018). Immunization with plasmid DNA expressing Heat Shock Protein 40 confers prophylactic protection against chronic Toxoplasma gondii infection in Kunming mice. Parasite, 25, Article 37. https://doi.org/10.1051/parasite/2018040

Toxoplasma gondii causes one of the most common protozoal diseases of humans and animals worldwide. With the aim of designing an effective vaccine against T. gondii infection, we examined the immunogenicity of a DNA vaccine expressing heat shock prot... Read More about Immunization with plasmid DNA expressing Heat Shock Protein 40 confers prophylactic protection against chronic Toxoplasma gondii infection in Kunming mice.

Hepatic metabolomics investigation in acute and chronic murine toxoplasmosis (2018)
Journal Article
Chen, X., Elsheikha, H. M., Hu, R., Hu, G., Guo, S., Zhou, C., & Zhu, X. (2018). Hepatic metabolomics investigation in acute and chronic murine toxoplasmosis. Frontiers in Cellular and Infection Microbiology, 8, doi:10.3389/fcimb.2018.00189

Toxoplasma gondii poses a great threat to human health, with no approved vaccine available for the treatment of T. gondii infection. T. gondii infections are not limited to the brain, and may also affect other organs especially the liver. Identificat... Read More about Hepatic metabolomics investigation in acute and chronic murine toxoplasmosis.