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Wallerian degeneration is executed by an NMN-SARM1-dependent late Ca(2+) influx but only modestly influenced by mitochondria (2015)
Journal Article
Loreto, A., Di Stefano, M., Gering, M., & Conforti, L. (2015). Wallerian degeneration is executed by an NMN-SARM1-dependent late Ca(2+) influx but only modestly influenced by mitochondria. Cell Reports, 13(11), 2539-2552. doi:10.1016/j.celrep.2015.11.032

Axon injury leads to rapid depletion of NAD-biosynthetic enzyme NMNAT2 and high levels of its substrate, NMN. We proposed a key role for NMN in Wallerian degeneration but downstream events and their relationship to other mediators remain unclear. Her... Read More about Wallerian degeneration is executed by an NMN-SARM1-dependent late Ca(2+) influx but only modestly influenced by mitochondria.

Horizontal gene flow from Eubacteria to Archaebacteria and what it means for our understanding of eukaryogenesis (2015)
Journal Article
Akanni, W. A., Siu-Ting, K., Creevey, C. J., McInerney, J. O., Wilkinson, M., Foster, P. G., & Pisani, D. (2015). Horizontal gene flow from Eubacteria to Archaebacteria and what it means for our understanding of eukaryogenesis. Philosophical Transactions B: Biological Sciences, 370(1678), Article 20140337. https://doi.org/10.1098/rstb.2014.0337

© 2015 The Author(s) Published by the Royal Society. All rights reserved. The origin of the eukaryotic cell is considered one of the major evolutionary transitions in the history of life. Current evidence strongly supports a scenario of eukaryotic or... Read More about Horizontal gene flow from Eubacteria to Archaebacteria and what it means for our understanding of eukaryogenesis.

Electrochemical Measurements of the Kinetics of Inhibition of Two FeFe Hydrogenases by O2 Demonstrate That the Reaction Is Partly Reversible (2015)
Journal Article
Orain, C., Saujet, L., Gauquelin, C., Soucaille, P., Meynial-Salles, I., Baffert, C., …Léger, C. (2015). Electrochemical Measurements of the Kinetics of Inhibition of Two FeFe Hydrogenases by O2 Demonstrate That the Reaction Is Partly Reversible. Journal of the American Chemical Society, 137(39), 12580-12587. https://doi.org/10.1021/jacs.5b06934

© 2015 American Chemical Society. The mechanism of reaction of FeFe hydrogenases with oxygen has been debated. It is complex, apparently very dependent on the details of the protein structure, and difficult to study using conventional kinetic techniq... Read More about Electrochemical Measurements of the Kinetics of Inhibition of Two FeFe Hydrogenases by O2 Demonstrate That the Reaction Is Partly Reversible.