Research Repository

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Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis (2019)
Journal Article
Rowbotham, N. J., Smith, S. J., Elliott, Z. C., Leighton, P. A., Rayner, O. C., Morley, R., & Smyth, A. R. (2019). Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis. Research Involvement and Engagement, 5(1), doi:10.1186/s40900-019-0159-x

Background The James Lind Alliance (JLA) method is well recognised for setting research priorities. The JLA approach involves a combination of surveys and workshop interactions between patients, carers and health care professionals to identify and... Read More

The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases (2019)
Journal Article
Pander, B., Harris, G., Scott, D. J., Winzer, K., Köpke, M., Simpson, S. D., …Henstra, A. M. (2019). The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases. Applied Microbiology and Biotechnology, doi:10.1007/s00253-019-10015-w

Carbonic anhydrase catalyses the interconversion of carbon dioxide and water to bicarbonate and protons. It was unknown if the industrial relevant acetogen Clostridium autoethanogenum possesses these enzymes. We identified two putative carbonic anhyd... Read More

Polymer microparticles with defined surface chemistry and topography mediate the formation of stem cell aggregates and cardiomyocyte function (2019)
Journal Article
Alvarez-Paino, M., Amer, M. H., Nasir, A., Cuzzucoli Crucitti, V., Needham, D., Denning, C., …Alexander, C. (2019). Polymer microparticles with defined surface chemistry and topography mediate the formation of stem cell aggregates and cardiomyocyte function. ACS Applied Materials and Interfaces, doi:10.1021/acsami.9b04769

Surface-functionalized microparticles are relevant to fields spanning engineering and biomedicine, with uses ranging from cell culture to advanced cell delivery. Varying topographies of biomaterial surfaces are also being investigated as mediators of... Read More

Patients' perspectives on care pathways and informed shared decision making in the transition between psychiatric hospitalization and the community (2019)
Journal Article
Sather, E. W., Iversen, V. C., Svindseth, M. F., Crawford, P., & Vasset, F. (2019). Patients' perspectives on care pathways and informed shared decision making in the transition between psychiatric hospitalization and the community. Journal of Evaluation in Clinical Practice, doi:10.1111/jep.13206

Rationale, aims, and objectives Patients with mental health problems experience numerous transitions into and out of hospital. This study explores former patients' views of pathways in transition between district psychiatric hospital centres (DPCs)... Read More

Try to see it my way: exploring the co-design of visual presentations of well-being through a workshop process (2019)
Journal Article
Craven, M. P., Goodwin, R., Rawsthorne, M., Butler, D., Waddingham, P., Brown, S., & Jamieson, M. (2019). Try to see it my way: exploring the co-design of visual presentations of well-being through a workshop process. Perspectives in Public Health, 139(3), 153-161. doi:10.1177/1757913919835231

Aims: A 10-month project funded by the NewMind network sought to develop the specification of a visualisation toolbox that could be applied on digital platforms (web- or app- based) to support adults with lived experience of mental health difficultie... Read More

Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Takwoingi, Y., Dinnes, J., Chuchu, N., Bayliss, S. E., Davenport, C., …Williams, H. C. (2018). Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), doi:10.1002/14651858.CD013186

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high‐risk skin cancers which have the potentia... Read More

Physical activity levels and barriers to exercise in people living with a stoma (2018)
Journal Article
Lowe, B., Alsaleh, E., & Blake, H. (in press). Physical activity levels and barriers to exercise in people living with a stoma. Nursing Standard,

Background: Physical activity is important for physical and mental health although people with a stoma commonly experience a reduction in physical activity following their stoma formation. Aim: To assess whether adults with a stoma achieve the recom... Read More

Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours? (2018)
Journal Article
Clark, M. E., Young, B., Bedford, L. E., Robertson, J. F., das Nair, R., Vedhara, K., …Kendrick, D. (2018). Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours?. Journal of Public Health, doi:10.1093/pubmed/fdy158. ISSN 1741-3842

Background Lung cancer screening can reduce lung cancer mortality by 20%. Screen-detected abnormalities may provide teachable moments for smoking cessation. This study assesses impact of pulmonary nodule detection on smoking behaviours within the fi... Read More

Attenuated post-movement beta rebound associated with schizotypal features in healthy people (2018)
Journal Article
Hunt, B. A., Liddle, E. B., Gascoyne, L. E., Magazzini, L., Routley, B. C., Singh, K. D., …Liddle, P. F. (2018). Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin, doi:10.1093/schbul/sby117

Introduction: Schizophrenia and Schizotypal Personality Disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the two conditions. However, schizotypy is a heterogeneous facet of per... Read More

An end-to-end deep learning histochemical scoring system for breast cancer TMA (2018)
Journal Article
Liu, J., Xu, B., Zheng, C., Gong, Y., Garibaldi, J., Soria, D., …Qiu, G. (2019). An end-to-end deep learning histochemical scoring system for breast cancer TMA. IEEE Transactions on Medical Imaging, 38(2), 617-628. doi:10.1109/TMI.2018.2868333

One of the methods for stratifying different molecular classes of breast cancer is the Nottingham prognostic index plus, which uses breast cancer relevant biomarkers to stain tumor tissues prepared on tissue microarray (TMA). To determine the molecul... Read More

Cognitive stimulation therapy for dementia (2018)
Journal Article
Rai, H., Yates, L., & Orrell, M. (2018). Cognitive stimulation therapy for dementia. Clinics in Geriatric Medicine, 34(4), 653-665. doi:10.1016/j.cger.2018.06.010

Use of mirtazapine in patients with chronic breathlessness: a case series (2018)
Journal Article
Lovell, N., Bajwah, S., Maddocks, M., Wilcock, A., & Higginson, I. J. (2018). Use of mirtazapine in patients with chronic breathlessness: a case series. Palliative Medicine, doi:10.1177/0269216318787450. ISSN 1477-030X

Background: Breathlessness remains a common and distressing symptom in people with advanced disease with few effective treatment options. Repurposing of existing medicines has been effective in other areas of palliative care, for example, antidepres... Read More

Identifying key components for a psychological intervention for people with vitiligo: a quantitative and qualitative study in the United Kingdom using web-based questionnaires of people with vitiligo and healthcare professionals (2018)
Journal Article
Ahmed, A., Steed, L., Burden-Teh, E., Shah, R., Sanyal, S., Tour, S., …Bewley, A. (2018). Identifying key components for a psychological intervention for people with vitiligo: a quantitative and qualitative study in the United Kingdom using web-based questionnaires of people with vitiligo and healthcare professionals. Journal of the European Academy of Dermatology and Venereology, doi:10.1111/jdv.15168. ISSN 0926-9959

Background: Psychological interventions are recommended as part of routine management of vitiligo. However, the development and effectiveness of such interventions have been rarely addressed. This study aimed to identify key components for a psycholo... Read More

Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets (2018)
Journal Article
Vinogradova, Y., Coupland, C., Hill, T., & Hippisley-Cox, J. (2018). Risk of bleeding with direct oral anticoagulants versus warfarin: cohort studies using primary care datasets. British Journal of General Practice, 68(suppl 1), doi:10.3399/bjgp18X696629

Background: There is limited evidence on the safety of direct oral anticoagulants (DOACs) in real world settings. Aim: To investigate risks of bleeding and all-cause mortality in DOACs compared to warfarin. Method: Prospective cohorts of incide... Read More

Panoptic overview of triple-negative breast cancer in Nigeria: current challenges and promising global initiatives (2018)
Journal Article
Wright, N., Rida, P., Rakha, E., Agboola, A., & Aneja, R. (2018). Panoptic overview of triple-negative breast cancer in Nigeria: current challenges and promising global initiatives. Journal of Global Oncology, (1-20). doi:10.1200/jgo.17.00116. ISSN 2378-9506

Purpose Triple-negative breast cancer (TNBC) is the most deadly form of breast cancer (BC) today. TNBC treatment is fraught with challenges because of the extensive interpatient heterogeneity in clinical behavior and scarcity of stratifying biomar... Read More

Managing health, safety and well-being: ethics, responsibility and sustainability (2018)
Book
Jain, A., Leka, S., & Zwetsloot, G. I. (2018). Managing health, safety and well-being: ethics, responsibility and sustainability. Springer Nature. doi:10.1007/978-94-024-1261-1

To achieve sustainable progress in workplace and societal functioning and development, it is essential to align perspectives for the management of health, safety and well-being. Employers are responsible for providing every individual with a working... Read More

Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: the impact of the experimental design (2018)
Journal Article
De Santis, S., Bastiani, M., Droby, A., Kolber, P., Zipp, F., Pracht, E., …Roebroeck, A. (2018). Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: the impact of the experimental design. Neuroscience, doi:10.1016/j.neuroscience.2018.03.048. ISSN 0306-4522

The recent introduction of advanced magnetic resonance (MR) imaging techniques to characterize focal and global degeneration in multiple sclerosis (MS), like the Composite Hindered and Restricted Model of Diffusion, or CHARMED, diffusional kurtosis i... Read More

Responding to domestic violence and abuse: considerations for health visitors (2018)
Journal Article
McGarry, J., & Ali, P. (2018). Responding to domestic violence and abuse: considerations for health visitors. Journal of Health Visiting, 6(2), 95-98. doi:10.12968/johv.2018.6.2.95

Domestic violence and abuse (DVA) exerts a significant impact on the lives, health and wellbeing of all of those who experience it and this includes children. Health professionals in a variety of settings are well placed to identify potential DVA cas... Read More