Research Repository

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Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Takwoingi, Y., Dinnes, J., Chuchu, N., Bayliss, S. E., Davenport, C., …Williams, H. C. (2018). Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), doi:10.1002/14651858.CD013186

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high‐risk skin cancers which have the potentia... Read More

Physical activity levels and barriers to exercise in people living with a stoma (2018)
Journal Article
Lowe, B., Alsaleh, E., & Blake, H. (in press). Physical activity levels and barriers to exercise in people living with a stoma. Nursing Standard,

Background: Physical activity is important for physical and mental health although people with a stoma commonly experience a reduction in physical activity following their stoma formation. Aim: To assess whether adults with a stoma achieve the recom... Read More

Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours? (2018)
Journal Article
Clark, M. E., Young, B., Bedford, L. E., Robertson, J. F., das Nair, R., Vedhara, K., …Kendrick, D. (2018). Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours?. Journal of Public Health, doi:10.1093/pubmed/fdy158. ISSN 1741-3842

Background Lung cancer screening can reduce lung cancer mortality by 20%. Screen-detected abnormalities may provide teachable moments for smoking cessation. This study assesses impact of pulmonary nodule detection on smoking behaviours within the fi... Read More

Attenuated post-movement beta rebound associated with schizotypal features in healthy people (2018)
Journal Article
Hunt, B. A., Liddle, E. B., Gascoyne, L. E., Magazzini, L., Routley, B. C., Singh, K. D., …Liddle, P. F. (2018). Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin, doi:10.1093/schbul/sby117

Introduction: Schizophrenia and Schizotypal Personality Disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the two conditions. However, schizotypy is a heterogeneous facet of per... Read More

An end-to-end deep learning histochemical scoring system for breast cancer TMA (2018)
Journal Article
Liu, J., Xu, B., Zheng, C., Gong, Y., Garibaldi, J., Soria, D., …Qiu, G. (2019). An end-to-end deep learning histochemical scoring system for breast cancer TMA. IEEE Transactions on Medical Imaging, 38(2), 617-628. doi:10.1109/TMI.2018.2868333

One of the methods for stratifying different molecular classes of breast cancer is the Nottingham prognostic index plus, which uses breast cancer relevant biomarkers to stain tumor tissues prepared on tissue microarray (TMA). To determine the molecul... Read More

Cognitive stimulation therapy for dementia (2018)
Journal Article
Rai, H., Yates, L., & Orrell, M. (2018). Cognitive stimulation therapy for dementia. Clinics in Geriatric Medicine, 34(4), 653-665. doi:10.1016/j.cger.2018.06.010

Use of mirtazapine in patients with chronic breathlessness: a case series (2018)
Journal Article
Lovell, N., Bajwah, S., Maddocks, M., Wilcock, A., & Higginson, I. J. (2018). Use of mirtazapine in patients with chronic breathlessness: a case series. Palliative Medicine, doi:10.1177/0269216318787450. ISSN 1477-030X

Background: Breathlessness remains a common and distressing symptom in people with advanced disease with few effective treatment options. Repurposing of existing medicines has been effective in other areas of palliative care, for example, antidepres... Read More

Identifying key components for a psychological intervention for people with vitiligo: a quantitative and qualitative study in the United Kingdom using web-based questionnaires of people with vitiligo and healthcare professionals (2018)
Journal Article
Ahmed, A., Steed, L., Burden-Teh, E., Shah, R., Sanyal, S., Tour, S., …Bewley, A. (2018). Identifying key components for a psychological intervention for people with vitiligo: a quantitative and qualitative study in the United Kingdom using web-based questionnaires of people with vitiligo and healthcare professionals. Journal of the European Academy of Dermatology and Venereology, doi:10.1111/jdv.15168. ISSN 0926-9959

Background: Psychological interventions are recommended as part of routine management of vitiligo. However, the development and effectiveness of such interventions have been rarely addressed. This study aimed to identify key components for a psycholo... Read More

Panoptic overview of triple-negative breast cancer in Nigeria: current challenges and promising global initiatives (2018)
Journal Article
Wright, N., Rida, P., Rakha, E., Agboola, A., & Aneja, R. (2018). Panoptic overview of triple-negative breast cancer in Nigeria: current challenges and promising global initiatives. Journal of Global Oncology, (1-20). doi:10.1200/jgo.17.00116. ISSN 2378-9506

Purpose Triple-negative breast cancer (TNBC) is the most deadly form of breast cancer (BC) today. TNBC treatment is fraught with challenges because of the extensive interpatient heterogeneity in clinical behavior and scarcity of stratifying biomar... Read More

Managing health, safety and well-being: ethics, responsibility and sustainability (2018)
Book
Jain, A., Leka, S., & Zwetsloot, G. I. (2018). Managing health, safety and well-being: ethics, responsibility and sustainability. Springer Nature. doi:10.1007/978-94-024-1261-1

To achieve sustainable progress in workplace and societal functioning and development, it is essential to align perspectives for the management of health, safety and well-being. Employers are responsible for providing every individual with a working... Read More

Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: the impact of the experimental design (2018)
Journal Article
De Santis, S., Bastiani, M., Droby, A., Kolber, P., Zipp, F., Pracht, E., …Roebroeck, A. (2018). Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: the impact of the experimental design. Neuroscience, doi:10.1016/j.neuroscience.2018.03.048. ISSN 0306-4522

The recent introduction of advanced magnetic resonance (MR) imaging techniques to characterize focal and global degeneration in multiple sclerosis (MS), like the Composite Hindered and Restricted Model of Diffusion, or CHARMED, diffusional kurtosis i... Read More

Responding to domestic violence and abuse: considerations for health visitors (2018)
Journal Article
McGarry, J., & Ali, P. (2018). Responding to domestic violence and abuse: considerations for health visitors. Journal of Health Visiting, 6(2), 95-98. doi:10.12968/johv.2018.6.2.95

Domestic violence and abuse (DVA) exerts a significant impact on the lives, health and wellbeing of all of those who experience it and this includes children. Health professionals in a variety of settings are well placed to identify potential DVA cas... Read More

The Developing Human Connectome Project: a minimal processing pipeline for neonatal cortical surface reconstruction (2018)
Journal Article
Makropoulos, A., Robinson, E. C., Schuh, A., Wright, R., Fitzgibbon, S., Bozek, J., …Rueckert, D. (2018). The Developing Human Connectome Project: a minimal processing pipeline for neonatal cortical surface reconstruction. NeuroImage, 173, (88-112). doi:10.1101/125526

The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development. Following est... Read More

The challenges of training, support and assessment of healthcare support workers: a qualitative study of experiences in three English acute hospitals (2017)
Journal Article
Sarre, S., Maben, J., Aldus, C., Schneider, J., Wharrad, H., Nicholson, C., & Arthur, A. (2018). The challenges of training, support and assessment of healthcare support workers: a qualitative study of experiences in three English acute hospitals. International Journal of Nursing Studies, 79, 145-153. doi:10.1016/j.ijnurstu.2017.11.010

Background Ever-growing demands on care systems have increased reliance on healthcare support workers. In the UK, their training has been variable, but organisation-wide failures in care have prompted questions about how this crucial section of the... Read More

Peripartum hysterectomy: an economic analysis of direct healthcare costs using routinely collected data (2017)
Journal Article
Achana, F., Fleming, K., Tata, L., Sultan, A. A., & Petrou, S. (2018). Peripartum hysterectomy: an economic analysis of direct healthcare costs using routinely collected data. BJOG: An International Journal of Obstetrics and Gynaecology, 125(7), 874-883. doi:10.1111/1471-0528.14950

Objective To estimate resource use and costs associated with peripartum hysterectomy for the English National Health Service. Design/Setting Analysis of linked Clinical Practice Research Datalink and Hospital Episodes Statistics (CPRD‐HES) data.... Read More

Towards a comprehensive framework for movement and distortion correction of diffusion MR images: within volume movement (2017)
Journal Article
Andersson, J. L., Graham, M. S., Drobnjak, I., Zhang, H., Filippini, N., & Bastiani, M. (2017). Towards a comprehensive framework for movement and distortion correction of diffusion MR images: within volume movement. NeuroImage, 152, (450-466). doi:10.1016/j.neuroimage.2017.02.085. ISSN 1053-8119

Most motion correction methods work by aligning a set of volumes together, or to a volume that represents a reference location. These are based on an implicit assumption that the subject remains motionless during the several seconds it takes to acqui... Read More

CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation (2017)
Journal Article
Siddiqui, Y. H., Kershaw, R. M., Humphreys, E. H., Marcolino de Assis Junior, E., Chaudhri, S., Jayaraman, P., & Gaston, K. (2017). CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation. Oncogenesis, 6, doi:10.1038/oncsis.2016.82. ISSN 2157-9024

PRH/HHEX (Proline Rich Homeodomain protein/Haematopoietically-Expressed Homeobox protein) is a transcription factor that controls cell proliferation, cell differentiation and cell migration. Our previous work has shown that in haematopoietic cells Pr... Read More