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All Outputs (224)

Barriers and facilitators of provision of telemedicine in Nigeria: A systematic review (2025)
Journal Article
Kenneth Cole, O., Muhammed Abubakar, M., Isah, A., Hayatu Sule, S., & Onyinye Ukoha-Kalu, B. (2025). Barriers and facilitators of provision of telemedicine in Nigeria: A systematic review. PLOS Digital Health, 4(7), Article e0000934. https://doi.org/10.1371/journal.pdig.0000934

Healthcare access remains a challenge in developing countries and could be a drawback to the attainment of Objective 3 of the Sustainable Development Goals. Digital interventions such as telemedicine have been identified as an effective tool to impro... Read More about Barriers and facilitators of provision of telemedicine in Nigeria: A systematic review.

A realist review of acute pain management in children and young people attended by ambulance (2025)
Journal Article
Whitley, G., Nicholls, G., Baliousis, M., Bujor, T., Eaton, G., Hodgson, J., Leighton, P., Lord, B., Ortega, M., Redsell, S., Siriwarden, N., & Sumera, K. (2025). A realist review of acute pain management in children and young people attended by ambulance. Paramedicine, https://doi.org/10.1177/27536386251356690

Acute pain management in children and young people (CYP) attended by ambulance services is a significant challenge due to the complex nature of pain, the variation of approach needed across the age range, and the unpredictability of the environment.... Read More about A realist review of acute pain management in children and young people attended by ambulance.

Regional profiling reveals a distinct glioblastoma infiltrative margin proteome (2025)
Journal Article
Kocon, A., Smith, S. J., Morentin, B., Callado, L. F., Carter, W., & Rahman, R. (2025). Regional profiling reveals a distinct glioblastoma infiltrative margin proteome. Scientific Reports, 15, Article 24021. https://doi.org/10.1038/s41598-025-09228-z

Isocitrate dehydrogenase wild-type glioblastoma, a malignant brain tumour of glial origin, confers a poor prognosis with a median survival of 12 to 16 months from diagnosis. Glioblastomas are aggressive tumours that rapidly proliferate and diffusely... Read More about Regional profiling reveals a distinct glioblastoma infiltrative margin proteome.

Impact of physician assistants on quality of care: rapid review (2025)
Journal Article
Cooper, N., Agius, S., Freeman, K., Church, H., Yoosoof, F., Frain, A., Frain, J., McConnell, R., Wilson, E., & Leonardi-Bee, J. (2025). Impact of physician assistants on quality of care: rapid review. BMJ, 390, Article e086358. https://doi.org/10.1136/bmj-2025-086358

Objective To determine the impact of physician assistants, compared with physicians, on quality of care in the context of an ongoing UK policy review.

Design Rapid systematic review.

Search strategy Keyword search of three databases; search and... Read More about Impact of physician assistants on quality of care: rapid review.

A Medical Student Curriculum on Functional Medical Disorders (2025)
Journal Article
Butt, M., Scotto, D., Gilmartin, C., Dhali, A., Gonem, S., Singhal, S., Monaghan, T., Frain, J., & Corsetti, M. (2025). A Medical Student Curriculum on Functional Medical Disorders. Clinical Teacher, 22(4), Article e70117. https://doi.org/10.1111/tct.70117

Background

Functional medical disorders (FMDs) refer to persistent physical symptoms that result in impairment or disability, which cannot be diagnosed using routine medical testing. Negative perceptions towards FMDs exist among a variety of heal... Read More about A Medical Student Curriculum on Functional Medical Disorders.

Factors associated with antibiotic utilisation among household heads living in the staff quarters of the University of Nigeria (2025)
Journal Article
Amoke, C. M., Isah, A., Ugochukwu, E. J., Agbo, C. E., Olanrewaju, O. F., Collins Amoke, J., Mmesomachi, M. S., Offor, O. O., Chibueze, O. S., Idabor, C. C., Onyehalu, J. C., Ma’aji, H. U., Amauche Pearl, N., & Ukoha-Kalu, B. O. (2025). Factors associated with antibiotic utilisation among household heads living in the staff quarters of the University of Nigeria. Discover Public Health, 22(1), Article 271. https://doi.org/10.1186/s12982-025-00671-x

The World Health Organization (WHO) and global health authorities have highlighted the misuse of antibiotics as a critical public health issue, prompting increased examination of antibiotic use practices. This study assessed factors influencing antib... Read More about Factors associated with antibiotic utilisation among household heads living in the staff quarters of the University of Nigeria.

Treatment Strategies for Triple-Negative Primary Breast Cancer in Older Women: A Systematic Review (2025)
Journal Article
Ahmed, B., Al-Khames Aga, Q., Cheung, K.-L., de Boniface, J., Gnant, M., Cardoso, M.-J., Rakha, E., Elumalai, T., Harbeck, N., Kaidar-Person, O., & Amit, A. (2025). Treatment Strategies for Triple-Negative Primary Breast Cancer in Older Women: A Systematic Review. JNCI Cancer Spectrum, 9(3), Article pkaf049. https://doi.org/10.1093/jncics/pkaf049

Purpose

Although the relative proportion of triple-negative breast cancer (TNBC) decreases with age, its prevalence is rising with an ageing population. This study examines real-world treatment practices, whether age in older women with TNBC (owTN... Read More about Treatment Strategies for Triple-Negative Primary Breast Cancer in Older Women: A Systematic Review.

Twelve tips for using phenomenology as a qualitative research approach in health professions education (2025)
Journal Article
Tavakol, M., & Sandars, J. (2025). Twelve tips for using phenomenology as a qualitative research approach in health professions education. Medical Teacher, https://doi.org/10.1080/0142159X.2025.2478871

Phenomenology is a qualitative research approach that seeks to understand the individual meanings of lived experience. This 12 Tips article highlights the importance of understanding the philosophical foundations that inform the choice of phenomenolo... Read More about Twelve tips for using phenomenology as a qualitative research approach in health professions education.

Really good stuff just got even better (2025)
Journal Article
Anderson, M. B., Church, H., & Eva, K. W. (2025). Really good stuff just got even better. Medical Education, 59(5), 452. https://doi.org/10.1111/medu.15635

Medical Education's Editors announce that Really Good Stuff will now be published monthly, with rolling peer review. Read this to discover how to join our RGS Reviewer Panel.

Addressing Ethnicity in the Design and Evaluation of an Educational Intervention on Interindividual Variation in Pharmacokinetics (2025)
Journal Article
Koenig, J. A., Olafuyi, O., & Patel, R. (2025). Addressing Ethnicity in the Design and Evaluation of an Educational Intervention on Interindividual Variation in Pharmacokinetics. Pharmacology Research and Perspectives, 13(1), Article e70073. https://doi.org/10.1002/prp2.70073

Interindividual variation in pharmacokinetics can occur due to diet, environmental or lifestyle factors, underlying pathology, and gene variants, typically single nucleotide polymorphisms (SNPs). Genetic mechanisms have received the most attention in... Read More about Addressing Ethnicity in the Design and Evaluation of an Educational Intervention on Interindividual Variation in Pharmacokinetics.

Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: a retrospective analysis of the EUSOMA database (2025)
Journal Article
Catanuto, G., Gentile, D., Martorana, F., Tomatis, M., Ponti, A., Marotti, L., Aristei, C., Cardoso, M. J., Cheung, K. L., Curigliano, G., De Vries, J., Karakatsanis, A., Santini, D., Sardanelli, F., Van Dam, P., Rubio, I. T., & EUSOMA Working Group. (2025). Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: a retrospective analysis of the EUSOMA database. EJSO - European Journal of Surgical Oncology, 51(6), Article 109643. https://doi.org/10.1016/j.ejso.2025.109643

Aims: We investigated factors related to the type of surgery, i.e. mastectomy versus breast conserving surgery (BCS), in breast cancer (BC) patients with complete pathologic response in the breast (ypT0) after neoadjuvant therapy (NAT). Methods: A re... Read More about Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: a retrospective analysis of the EUSOMA database.

The impact of an educational intervention on undergraduate students’ knowledge, acceptability, and willingness to pay for dapivirine vaginal ring in Nigeria's first indigenous university: a single-arm, non-randomized study (2025)
Journal Article
Isah, A., Ezenri, G., Obi, O., Okibe, N. A., Ma’aji, H. U., Ugochukwu, E. J., Eze, C. C., Amoke, C. M., Ezeodimegwu, A., Idabor, C. C., Abubakar, M. M., Iloabuchi, F., Ugwu, I. J., Asogwa, C. M., Ukwe, C. V., & Ukoha-kalu, B. O. (2025). The impact of an educational intervention on undergraduate students’ knowledge, acceptability, and willingness to pay for dapivirine vaginal ring in Nigeria's first indigenous university: a single-arm, non-randomized study. Discover Social Science and Health, 5(1), Article 8. https://doi.org/10.1007/s44155-025-00153-0

Background: This study aimed to assess the impact of an educational intervention on knowledge, acceptability, and willingness to pay (WTP) for dapivirine vaginal ring (DPV-VR) by undergraduate female students at the University of Nigeria (UNN). Metho... Read More about The impact of an educational intervention on undergraduate students’ knowledge, acceptability, and willingness to pay for dapivirine vaginal ring in Nigeria's first indigenous university: a single-arm, non-randomized study.

Updates and Future Directions for the Nottingham Research Programme on Primary Breast Cancer in Older Women (2025)
Journal Article
Parks, R. M., & Cheung, K.-L. (2025). Updates and Future Directions for the Nottingham Research Programme on Primary Breast Cancer in Older Women. Cancers, 17(3), Article 346. https://doi.org/10.3390/cancers17030346

The global population is ageing and the risk of breast cancer increases with age. Therefore, we can expect an increase in the number of cases of breast cancer worldwide in the next 20 years. Currently, there are few age-specific guidelines for the ma... Read More about Updates and Future Directions for the Nottingham Research Programme on Primary Breast Cancer in Older Women.

Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity (2025)
Journal Article
Sherif, M. A., Carter, W. G., & Mellor, I. R. (2025). Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity. Journal of Xenobiotics, 15(1), Article 12. https://doi.org/10.3390/jox15010012

Chlorpyrifos (CPF) is a broad-spectrum organophosphate insecticide. Long-term exposure to low levels of CPF is associated with neurodevelopmental and neurodegenerative disorders. The mechanisms leading to these effects are still not fully understood... Read More about Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity.

Evaluating student understanding of core pharmacokinetic concepts (2025)
Journal Article
Babey, A.-M., Koenig, J., Cunningham, M., Shield, A., Restini, C., Djouma, E., Mraiche, F., Mifsud, J., Kelly, J. P., Nicolazzo, J., Karpa, K. J., Volbrecht, K., Santiago, M. J., Hawes, M., Aljofan, M., Kelly-Laubscher, R., Karunaratne, N., Tucker, S. J., Hinton, T., Liang, W., …White, P. J. (2025). Evaluating student understanding of core pharmacokinetic concepts. European Journal of Pharmacology, 990, Article 177256. https://doi.org/10.1016/j.ejphar.2025.177256

Both educators and graduates have expressed concern about a perceived pharmacology knowledge gap that includes difficulty applying fundamental principles to clinical and research problems. Consequently, we sought to determine the extent to which curr... Read More about Evaluating student understanding of core pharmacokinetic concepts.

Evaluating student understanding of pharmacodynamics core concepts (2025)
Journal Article
Kelly-Laubscher, R., Koenig, J., Cunningham, M., Aljofan, M., Babey, A.-M., Hawes, M., Hinton, T., Karpa, K., Karunaratne, N., Nicolazzo, J., Liang, W., Mraiche, F., Restini, C., Santiago, M., Volbrecht, K., Guilding, C., & White, P. J. (2025). Evaluating student understanding of pharmacodynamics core concepts. European Journal of Pharmacology, 990, Article 177257. https://doi.org/10.1016/j.ejphar.2025.177257

Pharmacodynamics is an essential subdiscipline of pharmacology that underpins safe and effective prescribing and therapeutic decision-making, as well as drug discovery and development. The exponential increase in the number of therapeutic drugs has p... Read More about Evaluating student understanding of pharmacodynamics core concepts.

Impact of hyperkalaemia on renin–angiotensin–aldosterone (RAAS) inhibitor reduction or withdrawal following hospitalisation (2024)
Journal Article
Ellis, H. L., Al-Agil, M., Kelly, P. A., Teo, J., Sharpe, C., & Whyte, M. B. (2025). Impact of hyperkalaemia on renin–angiotensin–aldosterone (RAAS) inhibitor reduction or withdrawal following hospitalisation. Clinical and Experimental Medicine, 25(1), Article 16. https://doi.org/10.1007/s10238-024-01531-9

Background: Inhibitors of the renin–angiotensin–aldosterone system (RAAS), such as ACE inhibitors (ACEi), angiotensin-II receptor blockers and mineralocorticoid receptor antagonists, reduce morbidity and mortality in hypertension, congestive heart fa... Read More about Impact of hyperkalaemia on renin–angiotensin–aldosterone (RAAS) inhibitor reduction or withdrawal following hospitalisation.

Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model (2024)
Journal Article
Francis, J., Baxter, M., Giza, D., Cheung, K.-L., & Parks, R. (2024). Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model. Drugs and Aging, 42(1), 1-7. https://doi.org/10.1007/s40266-024-01167-0

Breast cancer remains the most prevalent cancer worldwide, necessitating advancements in its management. Surgery remains the recommended primary treatment although neoadjuvant or adjuvant treatments, such as chemotherapy, may also be indicated. Howev... Read More about Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model.