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All Outputs (31)

Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice? (2022)
Journal Article
Ojha, S., Abramson, J., & Dorling, J. (2022). Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?. BMJ Paediatrics Open, 6(1), Article e001460. https://doi.org/10.1136/bmjpo-2022-001460

Mechanical ventilation is an uncomfortable and potentially painful intervention. Opioids, such as morphine and fentanyl, are used for analgesia and sedation but there is uncertainty whether they reduce pain in mechanically ventilated infants. Moreove... Read More about Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?.

Management of pregnancy complications in women of advanced maternal age (2022)
Journal Article
Garcia, M., Walker, K. F., & Thornton, J. G. (2022). Management of pregnancy complications in women of advanced maternal age. Obstetrics, Gynaecology and Reproductive Medicine, 32(6), 101-104. https://doi.org/10.1016/j.ogrm.2022.04.001

The average age of women at childbirth in high resource obstetric settings has been increasing steadily for approximately 30 years. Women aged 35 years or over have an increased risk of gestational hypertensive disease, gestational diabetes, placenta... Read More about Management of pregnancy complications in women of advanced maternal age.

The Effect of Tobacco Control Mass Media Campaigns on Smoking-Related Behavior Among People With Mental Illness: A Systematic Literature Review (2022)
Journal Article
Perman-Howe, P. R., McNeill, A., Brose, L. S., Tildy, B. E., Langley, T. E., & Robson, D. (2022). The Effect of Tobacco Control Mass Media Campaigns on Smoking-Related Behavior Among People With Mental Illness: A Systematic Literature Review. Nicotine & Tobacco Research, 24(11), 1695-1704. https://doi.org/10.1093/ntr/ntac079

Introduction Tobacco control mass media campaigns (MMCs) can be effective generally, but little is known about their effects among people with mental illness. The objectives of this study were to systematically review: (1) Whether tobacco control MMC... Read More about The Effect of Tobacco Control Mass Media Campaigns on Smoking-Related Behavior Among People With Mental Illness: A Systematic Literature Review.

Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation (2022)
Journal Article
Gupta, A., McKeever, T. M., Hutchinson, J. P., & Bolton, C. E. (2022). Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation. International Journal of Chronic Obstructive Pulmonary Disease, 2022(17), 535-544. https://doi.org/10.2147/copd.s345751

Purpose: People with COPD are at a higher risk of cognitive dysfunction than the general population. However, the additional impact of dementia amongst such patients is not well understood, particularly in those admitted with a COPD exacerbation. We... Read More about Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation.

Understanding the current nutritional management for people with amyotrophic lateral sclerosis - A mapping review (2022)
Journal Article
Essat, M., Coates, E., Clowes, M., Beever, D., Hackney, G., White, S., …McDermott, C. (2022). Understanding the current nutritional management for people with amyotrophic lateral sclerosis - A mapping review. Clinical Nutrition ESPEN, 49, 328-340. https://doi.org/10.1016/j.clnesp.2022.03.026

Background & aims
Poor nutritional outcomes are observed in people with Amyotrophic Lateral Sclerosis (pwALS) including weight loss and poor dietary intake. Surveys of healthcare professionals have highlighted the lack of evidence and knowledge rega... Read More about Understanding the current nutritional management for people with amyotrophic lateral sclerosis - A mapping review.

Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis (2022)
Preprint / Working Paper
Middleton, S., Chalitsios, C., McKeever, T. M., Jenkins, A. R., & Bolton, C. E. Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis

Background Acute COVID-19 clinical symptoms have been clearly documented, but long-term functional and symptomatic recovery from COVID -19 is less well described.

Methods A systematic review and meta-analysis were conducted to describe patient-rep... Read More about Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis.

Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial (2022)
Journal Article
Hancox, J., Ayling, K., Bedford, L., Vedhara, K., Robertson, J. F. R., Young, B., …Kendrick., D. (2023). Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial. Journal of Public Health, 45(2), e275–e284. https://doi.org/10.1093/pubmed/fdac032

Background: The Early CDT®-Lung antibody blood test plus serial CT-scans for test-positives reduces late-stage lung cancer presentation. This study assessed psychological outcomes of this approach.

Methods: Randomised controlled trial (n=12,208) c... Read More about Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomised controlled trial.

Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study (2022)
Journal Article
Buendia, O., Shankar, S., Mahon, H., Toal, C., Menzies, L., Ravichandran, P., …Evans, W. (2022). Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study. Orphanet Journal of Rare Diseases, 17, Article 54. https://doi.org/10.1186/s13023-022-02216-w

Introduction: This study implemented MendelScan, a primary care rare disease case-finding tool, into a UK National Health Service population. Rare disease diagnosis is challenging due to disease complexity and low physician awareness. The 2021 UK Rar... Read More about Is it possible to implement a rare disease case-finding tool in primary care? A UK-based pilot study.

Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis (2022)
Journal Article
Webb, K., Zain, N. M. M., Stewart, I., Fogarty, A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., Lilley, A. K., Knox, A., Williams, P., Cámara, M., Bruce, K., & Barr, H. L. (2022). Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis. Journal of Medical Microbiology, 71(2), Article 001481. https://doi.org/10.1099/jmm.0.001481

Although anaerobic bacteria exist in abundance in cystic fibrosis (CF) airways, their role in disease progression is poorly understood. We hypothesized that the presence and relative abundance of the most prevalent, live, anaerobic bacteria in sputum... Read More about Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis.

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study (2022)
Journal Article
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C. F., Sarmanova, A., …Zhang, W. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, 30(5), 702-713. https://doi.org/10.1016/j.joca.2021.12.013

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study.