All Outputs (375)

An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis (2023)
Journal Article
Dumitrescu, L., Papathanasiou, A., Coclitu, C., Garjani, A., Evangelou, N., Constantinescu, C. S., …Tanasescu, R. (2023). An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis. Expert Opinion on Pharmacotherapy, 24(4), 495-509. https://doi.org/10.1080/14656566.2023.2178898

Multiple sclerosis (MS) is an immune-mediated disorder of the CNS manifested by recurrent attacks of neurological symptoms (related to focal inflammation) and gradual disability accrual (related to progressive neurodegeneration and neuroinflammation)... Read More about An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis.

Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families (2023)
Journal Article
Neves, R., Perez, B. D. D., Tindall, T., Fernandez, N. S., Panek, R., Wilne, S., …Glazebrook, C. (2023). Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families. Health Expectations, 26(3), 1358-1367. https://doi.org/10.1111/hex.13756

Background/Objectives: Ataxia–telangiectasia (A-T) is a complex inherited disease associated with an increased risk of malignancy. Surveillance guidelines have demonstrated significant health benefits in other cancer predisposition syndromes. However... Read More about Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families.

Incidence and predictors of poor functional outcome despite complete recanalisation following endovascular thrombectomy for acute ischaemic stroke (2023)
Journal Article
Dhillon, P. S., Butt, W., Marei, O., Podlasek, A., McConachie, N., Lenthall, R., …England, T. J. (2023). Incidence and predictors of poor functional outcome despite complete recanalisation following endovascular thrombectomy for acute ischaemic stroke. Journal of Stroke and Cerebrovascular Diseases, 32(5), Article 107083. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107083

Background: Numerous ischaemic stroke patients experience poor functional outcome despite successful recanalisation following endovascular thrombectomy (EVT). We aimed to identify the incidence and predictors of futile complete recanalisation (FCR) i... Read More about Incidence and predictors of poor functional outcome despite complete recanalisation following endovascular thrombectomy for acute ischaemic stroke.

What’s up with everyone?’: The effectiveness of a digital media mental health literacy campaign for young people (2023)
Journal Article
Curran, T., Ito-Jaeger, S., Perez Vallejos, E., & Crawford, P. (2023). What’s up with everyone?’: The effectiveness of a digital media mental health literacy campaign for young people. Journal of Mental Health, 32(3), 612-618. https://doi.org/10.1080/09638237.2023.2182412

Background: In 2021, the Arts and Humanities Research Council commissioned a mass-media mental health campaign called “What’s up With Everyone?” Here, innovative co-created messages were professionally storied and animated by an internationally recog... Read More about What’s up with everyone?’: The effectiveness of a digital media mental health literacy campaign for young people.

T1 based oxygen-enhanced MRI in tumours; a scoping review of current research (2023)
Journal Article
McCabe, A., Martin, S., Shah, J., Morgan, P. S., & Panek, R. (2023). T1 based oxygen-enhanced MRI in tumours; a scoping review of current research. British Journal of Radiology, 96(1146), Article 20220624. https://doi.org/10.1259/bjr.20220624

OBJECTIVE: Oxygen-enhanced MRI (OE-MRI) or tissue oxygen-level dependent (TOLD) MRI is an imaging technique under investigation for its ability to quantify and map oxygen distributions within tumours. The aim of this study was to identify and charact... Read More about T1 based oxygen-enhanced MRI in tumours; a scoping review of current research.

Experiences and understanding of apathy in people with neurocognitive disorders and their carers: a qualitative interview study (2023)
Journal Article
Burgon, C., Goldberg, S., van der Wardt, V., & Harwood, R. H. (2023). Experiences and understanding of apathy in people with neurocognitive disorders and their carers: a qualitative interview study. Age and Ageing, 52(3), Article afad031. https://doi.org/10.1093/ageing/afad031

Background
apathy, defined as reduced goal-directed activity, interests and emotion, is highly prevalent in neurocognitive disorders (NCDs). Apathy has important consequences for the individuals who experience it and their carers, yet the lived expe... Read More about Experiences and understanding of apathy in people with neurocognitive disorders and their carers: a qualitative interview study.

Exploring listening-related fatigue in children with and without hearing loss using self-report and parent-proxy measures (2023)
Journal Article
Adams, B., Thornton, S. K., Naylor, G., Spriggs, R. V., Wiggins, I. M., & Kitterick, P. T. (2023). Exploring listening-related fatigue in children with and without hearing loss using self-report and parent-proxy measures. Frontiers in Pediatrics, 11, Article 1127578. https://doi.org/10.3389/fped.2023.1127578

Children with hearing loss appear to experience greater fatigue than children with normal hearing (CNH). Listening-related fatigue is often associated with an increase in effortful listening or difficulty in listening situations. This has been observ... Read More about Exploring listening-related fatigue in children with and without hearing loss using self-report and parent-proxy measures.

From Social Network to Peer Support Network: Opportunities to Explore Mechanisms of Online Peer Support for Mental Health (2023)
Journal Article
Rayland, A., & Andrews, J. (2023). From Social Network to Peer Support Network: Opportunities to Explore Mechanisms of Online Peer Support for Mental Health. JMIR Mental Health, 10, Article e41855. https://doi.org/10.2196/41855

An increasing number of psychological interventions are shifting to online modes of delivery. One such intervention is peer-to-peer support, which in this context may provide internet users living with mental health disorders an opportunity to connec... Read More about From Social Network to Peer Support Network: Opportunities to Explore Mechanisms of Online Peer Support for Mental Health.

Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial (2023)
Journal Article
Rodgers, J., Goodwin, J., Nielsen, E., Bhattarai, N., Heslop, P., Kharatikoopaei, E., …Cassidy, S. (2023). Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 9, Article 31. https://doi.org/10.1186/s40814-023-01264-8

Background: Suicide prevention is a national priority for the UK government. Autistic people are at greater risk of experiencing self-harm and suicidal thoughts and behaviours than the general population. Safety plans are widely used in suicide preve... Read More about Adapted suicide safety plans to address self-harm, suicidal ideation, and suicide behaviours in autistic adults: protocol for a pilot randomised controlled trial.

Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention (2023)
Preprint / Working Paper
Rennick-Egglestone, S., Newby, C., Robinson, C., Yeo, C., Ng, F., Elliott, R. A., Ali, Y., Llewellyn-Beardsley, J., Pomberth, S., Harrison, J., Gavan, S. P., Cuijpers, P., Priebe, S., Hall, C. L., & Slade, M. Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention

Background:
Digital health interventions have become an established part of mental health service provision internationally. Regulators have positioned the best-practice standard of evidence as an interventional study with a comparator reflective of... Read More about Differences between online trial participants who have used statutory mental health services and who have not: analysis of baseline data from two pragmatic trials of a digital health intervention.

A mixed-methods feasibility case series of a job retention vocational rehabilitation intervention for people with multiple sclerosis (2023)
Journal Article
De Dios Pérez, B., das Nair, R., & Radford, K. (2024). A mixed-methods feasibility case series of a job retention vocational rehabilitation intervention for people with multiple sclerosis. Disability and Rehabilitation, 46(5), 875-886. https://doi.org/10.1080/09638288.2023.2181411

Purpose: To ascertain the feasibility and acceptability of delivering a job retention vocational rehabilitation intervention [MSVR] for people with multiple sclerosis (pwMS) in a community setting. Secondary objectives included determining whether MS... Read More about A mixed-methods feasibility case series of a job retention vocational rehabilitation intervention for people with multiple sclerosis.

Home based remotely supervised tDCS in children with acquired brain injury: a feasibility study protocol (2023)
Presentation / Conference Contribution
Stein, A., Iyer, K., Dux, P., Friehs, M., Riddle, J., Craven, M., …Barlow, K. (2023, February). Home based remotely supervised tDCS in children with acquired brain injury: a feasibility study protocol. Poster presented at 5th International Brain Stimulation Conference, Lisbon, Portugal

Introduction: Traumatic brain injury (TBI) is the most common acquired brain injury (ABI), where 16% of children sustain at least one TBI requiring medical attention, and 25-30% experience chronic problems. Attention and concentration problems are am... Read More about Home based remotely supervised tDCS in children with acquired brain injury: a feasibility study protocol.

Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study (2023)
Journal Article
Jack, R. H., Joseph, R. M., Coupland, C. A., Hall, C. L., & Hollis, C. (2023). Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study. eClinicalMedicine, 57, Article 101857. https://doi.org/10.1016/j.eclinm.2023.101857

Background: Since the onset of the coronavirus (COVID-19) pandemic, clinicians have reported an increase in presentations of sudden and new onset tics particularly affecting teenage girls. This population-based study aimed to describe and compare the... Read More about Impact of the COVID-19 pandemic on incidence of tics in children and young people: a population-based cohort study.

Factors influencing COVID-19 health protective behaviours in Zambian university students with symptoms of low mood (2023)
Journal Article
Ncheka, J. M., Menon, J. A., Davies, E. B., Paul, R., Mwaba, S. O. C., Mudenda, J., …Glazebrook, C. (2023). Factors influencing COVID-19 health protective behaviours in Zambian university students with symptoms of low mood. BMC Public Health, 23(1), Article 336. https://doi.org/10.1186/s12889-023-15073-4

Background
Health protective behaviours are crucial in the prevention of the spread of COVID-19, particularly in university students who typically live and study in large groups. Depression and anxiety are common in students and can impact young peo... Read More about Factors influencing COVID-19 health protective behaviours in Zambian university students with symptoms of low mood.

How people with knee pain understand why their pain changes or remains the same over time: A qualitative study (2023)
Journal Article
Walsh, D. A., Rathbone, J., Akin-Akinyosoye, K., Fernandes, G. S., Valdes, A. M., McWilliams, D. F., …Ferguson, E. (2023). How people with knee pain understand why their pain changes or remains the same over time: A qualitative study. Osteoarthritis and Cartilage Open, 5(2), Article 100345. https://doi.org/10.1016/j.ocarto.2023.100345

Objectives
Guidelines recommend knee osteoarthritis pain management based on biopsychosocial mechanisms. Treatment adherence and effectiveness may be affected if there is a mismatch between patient perspectives and treatment focus. We therefore exam... Read More about How people with knee pain understand why their pain changes or remains the same over time: A qualitative study.

The executive disruption model of tinnitus distress: Model validation in two independent datasets using factor score regression (2023)
Journal Article
Clarke, N. A., Akeroyd, M. A., Henshaw, H., Hall, D. A., Mohamad, W. N. W., & Hoare, D. J. (2023). The executive disruption model of tinnitus distress: Model validation in two independent datasets using factor score regression. Frontiers in Psychology, 14, Article 1006349. https://doi.org/10.3389/fpsyg.2023.1006349

This study presents the executive disruption model (EDM) of tinnitus distress and subsequently validates it statistically using two independent datasets (the Construction Dataset: n = 96 and the Validation Dataset: n = 200). The conceptual EDM was fi... Read More about The executive disruption model of tinnitus distress: Model validation in two independent datasets using factor score regression.

The use of cerebral computed tomographic angiography as an ancillary investigation to support a clinical diagnosis of death using neurological criteria: a consensus guideline (2023)
Journal Article
Thomas, E. O., Manara, A., Dineen, R. A., Mortimer, A., Aziz, O., Dean, P., …Gardiner, D. (2023). The use of cerebral computed tomographic angiography as an ancillary investigation to support a clinical diagnosis of death using neurological criteria: a consensus guideline. Anaesthesia, 78(3), 330-336. https://doi.org/10.1111/anae.15950

This multidisciplinary consensus statement was produced following a recommendation by the Faculty of Intensive Care Medicine to develop a UK guideline for ancillary investigation, when one is required, to support the diagnosis of death using neurolog... Read More about The use of cerebral computed tomographic angiography as an ancillary investigation to support a clinical diagnosis of death using neurological criteria: a consensus guideline.

Antiplatelet Resistance: A Review of Concepts, Mechanisms, and Implications for Management in Acute Ischemic Stroke and Transient Ischemic Attack (2023)
Journal Article
Krishnan, K., Nguyen, T. N., Appleton, J. P., Law, Z. K., Caulfied, M., Cabrera, C. P., …Bath, P. M. (2023). Antiplatelet Resistance: A Review of Concepts, Mechanisms, and Implications for Management in Acute Ischemic Stroke and Transient Ischemic Attack. Stroke: Vascular and Interventional Neurology, 3(3), Article e000576. https://doi.org/10.1161/svin.122.000576

Acute ischemic stroke is a leading cause of death and major disability worldwide. Approximately 50% of ischemic strokes are caused by atherothrombotic occlusion of the cerebral arteries, and antiplatelets are the mainstay of secondary stroke preventa... Read More about Antiplatelet Resistance: A Review of Concepts, Mechanisms, and Implications for Management in Acute Ischemic Stroke and Transient Ischemic Attack.

Inferring the basis of binaural detection with a modified autoencoder (2023)
Journal Article
Smith, S., Sollini, J., & Akeroyd, M. A. (2023). Inferring the basis of binaural detection with a modified autoencoder. Frontiers in Neuroscience, 17, Article 1000079. https://doi.org/10.3389/fnins.2023.1000079

The binaural system utilizes interaural timing cues to improve the detection of auditory signals presented in noise. In humans, the binaural mechanisms underlying this phenomenon cannot be directly measured and hence remain contentious. As an alterna... Read More about Inferring the basis of binaural detection with a modified autoencoder.

Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study (2023)
Journal Article
Tindall, T., Topcu, G., Thomas, S., Bale, C., Evangelou, N., Drummond, A., & das Nair, R. (2023). Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study. Health Expectations, 26(2), 858-868. https://doi.org/10.1111/hex.13711

Background: Diagnosing multiple sclerosis (MS) can be a lengthy process, which can impact psychological wellbeing, condition management, and future engagement with health services. Therefore, providing timely and appropriate emotional support may imp... Read More about Developing a Patient Care Pathway for Emotional Support around the point of Multiple Sclerosis diagnosis: A Stakeholder Engagement Study.