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Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial (2021)
Journal Article
Mingrone, G., Baar, A. C. V., Devière, J., Hopkins, D., Moura, E. G. D., Cercato, C., …Bergman, J. J. (2022). Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial. Gut, 71(2), 254-264. https://doi.org/10.1136/gutjnl-2020-323608

Objective: Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, a double-blind, superiority RCT, investigates safety and efficacy of DMR using the single catheter Revita system (Revita DMR [catheter an... Read More about Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial.

Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19 (2021)
Journal Article
Yan, H., Vijay, A., Jiang, F., Zheng, N., Hu, Y., Ye, H., …Aithal, G. P. (2021). Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19. Endocrinology, Diabetes and Metabolism, 4(2), Article e00215. https://doi.org/10.1002/edm2.215

Background: COVID-19 has a broad clinical specturm. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods: Clinical and la... Read More about Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19.

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome (2021)
Journal Article
Menni, C., Louca, P., Berry, S. E., Vijay, A., Astbury, S., Leeming, E. R., …Valdes, A. M. (2021). High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome. BMC Medicine, 19, 1-10. https://doi.org/10.1186/s12916-021-01913-w

Background: Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19. Methods: Here, we assessed th... Read More about High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome.

The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK (2021)
Journal Article
Adiamah, A., Thompson, A., Lewis-Lloyd, C., Dickson, E., Blackburn, L., Moody, N., …Brooks, A. (2021). The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK. European Journal of Trauma and Emergency Surgery, 47, 637–645. https://doi.org/10.1007/s00068-020-01593-w

Background The global pandemic caused by SARS-CoV-2 has impacted population health and care delivery worldwide. As information emerges regarding the impact of “lockdown measures” and changes to clinical practice worldwide; there is no comparative in... Read More about The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK.

Metabolic Imaging in Non-Alcoholic Fatty Liver Disease: Applications of Magnetic Resonance Spectroscopy (2021)
Journal Article
Thiagarajan, P., Bawden, S. J., & Aithal, G. P. (2021). Metabolic Imaging in Non-Alcoholic Fatty Liver Disease: Applications of Magnetic Resonance Spectroscopy. Journal of Clinical Medicine, 10(4), Article 632. https://doi.org/10.3390/jcm10040632

Non-alcoholic fatty liver disease (NAFLD) is poised to dominate the landscape of clinical hepatology in the 21st century. Its complex, interdependent aetiologies, non-linear disease progression and uncertain natural history have presented great chall... Read More about Metabolic Imaging in Non-Alcoholic Fatty Liver Disease: Applications of Magnetic Resonance Spectroscopy.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment (2021)
Journal Article
Corsetti, M., Brown, S., Chiarioni, G., Dimidi, E., Dudding, T., Emmanuel, A., …Scott, S. M. (2021). Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment. Neurogastroenterology and Motility, 33(7), Article e14070. https://doi.org/10.1111/nmo.14070

Background: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment.

SARS-CoV-2 vaccination for patients with inflammatory bowel disease: a British Society of Gastroenterology Inflammatory Bowel Disease section and IBD Clinical Research Group position statement (2021)
Journal Article
Alexander, J. L., Moran, G., Gaya, D. R., Raine, T., Hart, A., Kennedy, N. A., …Powell, N. (2021). SARS-CoV-2 vaccination for patients with inflammatory bowel disease: a British Society of Gastroenterology Inflammatory Bowel Disease section and IBD Clinical Research Group position statement. Lancet Gastroenterology and Hepatology, 6(3), 218-224. https://doi.org/10.1016/S2468-1253%2821%2900024-8

SARS-CoV2 has caused a global health crisis and mass vaccination programmes provide the best opportunity for controlling transmission and protecting populations. Despite the impressive clinical trial results of the BNT162b2 (Pfizer/BioNTech), ChAdOx1... Read More about SARS-CoV-2 vaccination for patients with inflammatory bowel disease: a British Society of Gastroenterology Inflammatory Bowel Disease section and IBD Clinical Research Group position statement.

Evaluating the sensitivity and specificity of promising circulating biomarkers to diagnose liver injury in humans (2021)
Journal Article
Llewellyn, H. P., Vaidya, V. S., Wang, Z., Peng, Q., Hyde, C., Potter, D., …Ramaiah, S. K. (2021). Evaluating the sensitivity and specificity of promising circulating biomarkers to diagnose liver injury in humans. Toxicological Sciences, 181(1), 23-34. https://doi.org/10.1093/toxsci/kfab003

Early diagnosis of drug-induced liver injury (DILI) continues to be a major hurdle during drug development and post marketing. The objective of this study was to evaluate the diagnostic performance of promising biomarkers of liver injury - glutamate... Read More about Evaluating the sensitivity and specificity of promising circulating biomarkers to diagnose liver injury in humans.

Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis (2021)
Journal Article
Subhani, M., Knight, H., Ryder, S., & Morling, J. R. (2021). Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis. Alcohol and Alcoholism, 56(2), 185–200. https://doi.org/10.1093/alcalc/agaa143

Background: Alcohol dependence affects over 240 million people worldwide and attributed to 3 million deaths annually. Early identification and intervention are key to prevent harm. We aim to systematically review literature on the effectiveness of ad... Read More about Does advice based on biomarkers of liver injury or non-invasive tests of liver fibrosis impact high-risk drinking behaviour: A systematic review with meta-analysis.

Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home (2021)
Journal Article
Tsien, C., Tan, H., Sharma, S., Palaniyappan, N., Wijayasiri, P., Leung, K., …Aravinthan, A. D. (2021). Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home. Clinical Medicine, 21(1), e32-e38. https://doi.org/10.7861/clinmed.2020-0609

Introduction: Increasing rates of liver transplantation and improved outcomes have led to greater numbers of transplant recipients followed up in non-transplant centres. Our aim was to document long-term clinical outcomes of liver transplant recipien... Read More about Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home.

“A little (PPI) MAGIC can take you a long way” : involving children and young people in research from inception of a novel medical device to multi-centre clinical trial Roald Dahl, James and the Giant Peach (1961) (2021)
Journal Article
Abrehart, N., Frost, K., YPAG, Y. P. A. G., Harris, R., Wragg, A., Stewart, D., …Marciani, L. (2021). “A little (PPI) MAGIC can take you a long way” : involving children and young people in research from inception of a novel medical device to multi-centre clinical trial Roald Dahl, James and the Giant Peach (1961). Research Involvement and Engagement, 7, Article 2. https://doi.org/10.1186/s40900-020-00243-0

Background: There is often a great urgency to be inclusive when conducting research and to focus efforts with groups and communities that can be referred to as marginalised. This is especially the case in research concerning medical devices aimed a... Read More about “A little (PPI) MAGIC can take you a long way” : involving children and young people in research from inception of a novel medical device to multi-centre clinical trial Roald Dahl, James and the Giant Peach (1961).

Patient-centric goal-oriented perioperative care (2021)
Journal Article
Roberts, G. P., Levy, N., & Lobo, D. N. (2021). Patient-centric goal-oriented perioperative care. British Journal of Anaesthesia, 126(3), 559-564. https://doi.org/10.1016/j.bja.2020.12.004

Anaesthetists and surgeons largely focus on quantifiable postoperative outcome measures as a means for improving the quality of patient care. However, whilst traditional measures, such as postoperative morbidity and mortality, are useful and relative... Read More about Patient-centric goal-oriented perioperative care.

Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection (2020)
Journal Article
Huus, K. E., Frankowski, M., Pučić-Baković, M., Vučković, F., Lauc, G., Mullish, B. H., …Finlay, B. B. (2021). Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection. Gut Microbes, 13(1), 1-12. https://doi.org/10.1080/19490976.2020.1862027

Secretory immunoglobulin A (IgA) interacts with intestinal microbiota and promotes mucosal homeostasis. IgA-bacteria interactions are altered during inflammatory diseases, but how these interactions are shaped by bacterial, host, and environmental fa... Read More about Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection.

New models of adipogenic differentiation highlight a cell-autonomous response to temperature (2020)
Journal Article
Velickovic, K., Lugo Leija, H., McGinlay, S., Symonds, M., & Sottile, V. (2020). New models of adipogenic differentiation highlight a cell-autonomous response to temperature. Biocell, 44(4), 501-512. https://doi.org/10.32604/biocell.2020.012942

Temperature is a key regulator of brown adipose tissue (BAT) function, acting through central sensory inputs to influence metabolism and energy storage. Although animal models have produced a wealth of information on the pathways, effectors and respo... Read More about New models of adipogenic differentiation highlight a cell-autonomous response to temperature.

MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability (2020)
Journal Article
Scott, R. A., Williams, H. G., Hoad, C. L., Alyami, A., Ortori, C. A., Grove, J. I., …Gowland, P. A. (2021). MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability. Journal of Magnetic Resonance Imaging, 53(5), 1422-1431. https://doi.org/10.1002/jmri.27463

Background: Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the efficacy of... Read More about MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability.

High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications (2020)
Journal Article
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021). High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications. Neurogastroenterology and Motility, 33(5), Article e14040. https://doi.org/10.1111/nmo.14040

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications.