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The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature? (2017)
Journal Article
Corsetti, M., & Fox, M. (2017). The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?. F1000Research, 6, Article 1778. https://doi.org/10.12688/f1000research.12089.1

© 2017 Corsetti M and Fox M. Functional dyspepsia is a prevalent functional gastrointestinal disorder that can significantly erode the quality of life of sufferers and places a major cost burden on healthcare services. In this article, we review the... Read More about The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?.

Development of a telehealth monitoring service after colorectal surgery: a feasibility study (2017)
Journal Article
Bragg, D. D., Edis, H., Clark, S., Parsons, S. L., Perumpalath, B., Lobo, D. N., & Maxwell-Armstrong, C. A. (in press). Development of a telehealth monitoring service after colorectal surgery: a feasibility study. World Journal of Gastroenterology, 9(9), https://doi.org/10.4240/wjgs.v9.i9.193

AIM: To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery, within an enhanced recovery protocol.
METHODS: Florence (FLO) is a National Health Service te... Read More about Development of a telehealth monitoring service after colorectal surgery: a feasibility study.

Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging (2017)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Leija, A. L., Velickovic, K., Marques, L., …Clark, M. (2017). Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging

The mechanical properties of cells play an important role in cell function and behavior. This paper presents recent developments that have enabled the use of laser-generated phonons (ultrasound) with sub-optical wavelengths to look inside living cell... Read More about Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging.

Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans (2017)
Journal Article
Law, J., Morris, D. E., Izzi Engbeaya, C., Salem, V., Coello, C., Robinson, L. J., …Symonds, M. E. (2018). Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans. Journal of Nuclear Medicine, 59(3), https://doi.org/10.2967/jnumed.117.190546

Background
Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilises glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BA... Read More about Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans.

Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study (2017)
Journal Article
Taye, B., Enquselassie, F., Tsegaye, A., Amberbir, A., Medhin, G., Fogarty, A. W., …Davey, G. (in press). Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study. Clinical and Experimental Allergy, 47(10), https://doi.org/10.1111/cea.12995

Background: Epidemiological evidence from developed countries indicates that Helicobacter pylori infection correlates with a reduced risk of atopy and allergic disorders, however limited data are available from low-income countries.

Objective: We... Read More about Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study.

MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans (2017)
Journal Article
Khalaf, A., Hoad, C., Menys, A., Nowak, A., Taylor, S. A., Paparo, S., …Moran, G. W. (2018). MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans. Neurogastroenterology and Motility, 30(1), Article e13182. https://doi.org/10.1111/nmo.13182

Background: Feeding triggers inter-related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan-intestinal, non-invasive assessment of motility... Read More about MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans.

The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers (2017)
Journal Article
Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G. P., Ilyas, M., Satthaporn, S., & Eremin, O. (2017). The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers. Journal of Immunology Research, 2017, Article 1049023. https://doi.org/10.1155/2017/1049023

The tumour microenvironment consists of malignant cells, stroma, and immune cells. The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied. The contribution... Read More about The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers.

Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures (2017)
Journal Article
Kumar, D., Workman, V., O'Brien, M. C., McLaren, J. S., White, L. J., Ragunath, K., …Rose, F. R. (2017). Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures. Advanced Functional Materials, 27(38), Article 1702424. https://doi.org/10.1002/adfm.201702424

Endoscopic treatment of Barrett’s oesophagus often leads to further damage of healthy tissue causing fibrotic tissue formation termed as strictures. This study shows that synthetic, self-assembling peptide hydrogels (PeptiGelDesign) support the activ... Read More about Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures.

Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts (2017)
Journal Article
Tack, J., Corsetti, M., Camilleri, M., Quigley, A., Simren, M., Suzuki, H., …Van Oudenhove, L. (in press). Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts. Gut, https://doi.org/10.1136/gutjnl-2016-312230

The functional gastrointestinal disorders (FGIDs), are extremely common conditions associated with a considerable personal, social and health economic burden. Managing FGIDs in clinical practice is challenging because of the uncertainty of symptom-ba... Read More about Plausibility criteria for putative pathophysiological mechanisms in functional gastrointestinal disorders: a consensus of experts.

Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers (2017)
Journal Article
Deloose, E., Corsetti, M., Van Oudenhove, L., Depoortere, I., & Tack, J. (2017). Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers. Neurogastroenterology and Motility, 30(1), Article e13171. https://doi.org/10.1111/nmo.13171

Intragastric administration of the bitter tastant denatonium benzoate inhibits the increase of motilin plasma levels and antral contractility. While these findings suggest that gastrointestinal bitter taste receptors could be new targets to modulate... Read More about Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in health female volunteers.

Tissue cell stress response to obesity and its interaction with late gestational diet (2017)
Journal Article
Saroha, V., Dellschaft, N. S., Keisler, D. H., Gardner, D. S., Budge, H., Sebert, S. P., & Symonds, M. E. (2018). Tissue cell stress response to obesity and its interaction with late gestational diet. Reproduction, Fertility and Development, 30, https://doi.org/10.1071/RD16494

Intra-uterine growth restriction in late pregnancy can contribute to adverse long term metabolic health in the offspring. We utilised an animal (sheep) model of maternal dietary manipulation in late pregnancy, combined with exposure of the offspring... Read More about Tissue cell stress response to obesity and its interaction with late gestational diet.

A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA (2017)
Journal Article
Alandiyjany, M. N., Croxall, N. J., Grove, J. I., & Delahay, R. M. (2017). A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA. PLoS ONE, 12(7), Article e0182144. https://doi.org/10.1371/journal.pone.0182144

Two distinct type IV secretion systems (T4SSs) can be identified in certain Helicobacter pylori strains, encoded on mobile genetic elements termed tfs3 and tfs4. Although their function remains unknown, both have been implicated in clinical outcomes... Read More about A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA.

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection (2017)
Journal Article
Monaghan, T. M., Negm, O. H., MacKenzie, B., Hamed, M. R., Shone, C. C., Humphreys, D., …Wilcox, M. H. (2017). High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection. Clinical and Experimental Gastroenterology, 10, https://doi.org/10.2147/CEG.S133939

Objectives: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C.... Read More about High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection.

Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study (2017)
Journal Article
Aravinthan, A. D., Barbas, A. S., Doyle, A. C., Tazari, M., Sapisochin, G., Cattral, M. S., Ghanekar, A., McGilvray, I. D., Selzner, M., Greig, P. D., Bhat, M., Selzner, N., Grant, D. R., Lilly, L. B., & Renner, E. L. (in press). Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study. Transplant International, https://doi.org/10.1111/tri.13008

Whether and when recovery beyond the need for transplant may occur in patients listed for decompensation remains unclear. This study aimed to investigate the characteristics of patients delisted following recompensation. Seventy-seven patients who we... Read More about Characteristics of liver transplant candidates delisted following recompensation and predictors of such delisting in alcohol-related liver disease: a case-control study.

Economic evaluation of a community-based diagnostic pathway to stratify adults for non-alcoholic fatty liver disease: a Markov model informed by a feasibility study (2017)
Journal Article
Tanajewski, L., Harris, R., Harman, D. J., Aithal, G. P., Card, T. R., Gkountouras, G., …Elliott, R. (in press). Economic evaluation of a community-based diagnostic pathway to stratify adults for non-alcoholic fatty liver disease: a Markov model informed by a feasibility study. BMJ Open, 7(6), https://doi.org/10.1136/bmjopen-2016-015659

Objectives: To assess the long-term cost-effectiveness of a risk stratification pathway, compared with standard care, for detecting non-alcoholic fatty liver disease (NAFLD) in primary care.

Setting: Primary care general practices in England.

P... Read More about Economic evaluation of a community-based diagnostic pathway to stratify adults for non-alcoholic fatty liver disease: a Markov model informed by a feasibility study.

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans (2017)
Journal Article
Murray, K., Hoad, C. L., Mudie, D. M., Wright, J., Heissam, K., Abrehart, N., …Marciani, L. (2017). Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans. Molecular Pharmaceutics, 14(8), 2629-2638. https://doi.org/10.1021/acs.molpharmaceut.7b00095

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a... Read More about Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans.

Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies (2017)
Journal Article
Mitchell, W. K., Thomas, P. F., Zaitoun, A. M., Brooks, A. J., & Lobo, D. N. (in press). Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies. World Journal of Gastroenterology, 23(23), https://doi.org/10.3748/wjg.v23.i23.4252

AIM

To investigate the range of pathologies treated by pancreas preserving distal duodenectomy (PPDD) and present the outcome of follow-up.

METHODS

Neoplastic lesions of the duodenum are treated conventionally by pancreaticoduodenectomy. Les... Read More about Pancreas preserving distal duodenectomy: a versatile operation for a range of infra-papillary pathologies.

Beyond obesity - thermogenic adipocytes and cardiometabolic health (2017)
Journal Article
Aldiss, P., Dellschaft, N. S., Sacks, H., Budge, H., & Symonds, M. E. (in press). Beyond obesity - thermogenic adipocytes and cardiometabolic health. Hormone Molecular Biology and Clinical Investigation, 31(2), https://doi.org/10.1515/hmbci-2017-0007

The global prevalence of obesity and related cardiometabolic disease continues to increase through the 21st century. Whilst multi-factorial, obesity is ultimately caused by chronic caloric excess. However, despite numerous interventions focussing on... Read More about Beyond obesity - thermogenic adipocytes and cardiometabolic health.

Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence (2017)
Journal Article
Kruis, W., Kardalinos, V., Eisenbach, T., Lukas, M., Vich, T., Bunganic, I., …Spiller, R. (2017). Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence. Alimentary Pharmacology and Therapeutics, 46(3), 282-291. https://doi.org/10.1111/apt.14152

Background

Previous studies have reached conflicting conclusions regarding the efficacy of mesalazine in the prevention of recurrent diverticulitis.

Aim

To investigate the efficacy and safety of mesalazine granules in the prevention of recur... Read More about Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence.