Research Repository

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Lactoferrin-loaded Alginate Microparticles to Target Clostridioides difficile infection (2019)
Journal Article
Braim, S., Śpiewakb, K., Brindell, M., Heeg, D., Alexandera, C., & Monaghan, T. (2019). Lactoferrin-loaded Alginate Microparticles to Target Clostridioides difficile infection. Journal of Pharmaceutical Sciences, doi:10.1016/j.xphs.2019.02.025

Some forms of bovine lactoferrin (bLf) are effective in delaying Clostridioides difficile growth and preventing toxin production. However, therapeutic use of bLf may be limited by protein stability issues. The objective of this study was to prepare a... Read More

Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders? (2019)
Journal Article
Corsetti, M., Pannemans, J., & Whorwell, P. (2019). Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research, 8, doi:10.12688/f1000research.15974.1

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term bas... Read More

Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28 (2019)
Journal Article
Levy, N., Lobo, D. N., Fawcett, W. J., Ljungqvist, O., & Scott, M. J. (2019). Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28. British Journal of Anaesthesia, doi:10.1016/j.bja.2019.01.028

We read with interest the special and insightful article by Soffin and colleagues1 on the prescription opioid crisis. They carefully examine many of the drivers for subsequent opioid dependence after surgery and provide suggestions on how practice ca... Read More

The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer: a systematic review and meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer: a systematic review and meta-analysis. Annals of Surgery, doi:10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Summary background data: Although studies have shown that perioperative IMN... Read More

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (2019)
Journal Article
Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., …Wain, L. V. (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics, doi:10.1038/s41588-018-0321-7

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar... Read More

Evolution of treatment targets in Crohn’s Disease (2019)
Journal Article
White, J., Moran, G., & Jairath, V. (2019). Evolution of treatment targets in Crohn’s Disease. Best Practice and Research: Clinical Gastroenterology, doi:10.1016/j.bpg.2019.02.001

Crohn’s disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient’s qualit... Read More

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective (2019)
Journal Article
Allison, S. P., & Lobo, D. N. (2019). The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective. Clinical Nutrition, doi:10.1016/j.clnu.2019.01.027

Many theories have been advanced concerning the cause of Charlotte Bronte’s death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tubercul... Read More

Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease (2019)
Journal Article
Shivaji, U. N., Sharratt, C. L., Thomas, T., Smith, S. C., Iacucci, M., Moran, G. W., …Bhala, N. (2019). Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 49(6), 664-680. doi:10.1111/apt.15097

Background: Biological therapy is currently widely used to treat inflammatory bowel disease (IBD). Infliximab, adalimumab and golimumab are currently licensed anti-TNF therapies. Biosimilar anti-TNF monoclonal antibodies are increasingly used. Anti-T... Read More

Incidence and etiology of drug-induced liver injury in mainland China (2019)
Journal Article
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., …Chen, C. (2019). Incidence and etiology of drug-induced liver injury in mainland China. Gastroenterology, doi:10.1053/j.gastro.2019.02.002

Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China. Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from... Read More

Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers (2019)
Journal Article
Wilkinson-Smith, V., Dellschaft, N., Ansell, J., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2019). Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers. Alimentary Pharmacology and Therapeutics, 49(6), 759-768. doi:10.1111/apt.15127

Background: Chronic constipation affects approximately 17% of the population worldwide and remains an important unmet need since patients are often dissatisfied with treatment. Kiwifruit may offer an alternative to traditional laxatives and have been... Read More

A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer (2019)
Journal Article
Chapman, C., Bunce, J., Oliver, S., Ng, O., Tangri, A., Rogers, R., …Banerjea, A. (2019). A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer. BJS Open, doi:10.1002/bjs5.50131

Introduction: New national guidance on urgent referral for investigation for Colorectal Cancer (CRC) included faecal occult blood testing in 2015. We evaluated faecal immunochemical testing (FIT) and anaemia as risk stratification tools in symptomati... Read More

Drug-induced injury due to flucloxacillin: relevance of multiple HLA alleles (2019)
Journal Article
Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., …Daly, A. K. (2019). Drug-induced injury due to flucloxacillin: relevance of multiple HLA alleles. CPT: Pharmacometrics and Systems Pharmacology, doi:10.1002/cpt.1375

Some patients prescribed flucloxacillin (~0.01%) develop drug-induced liver injury (DILI). HLAB*57:01 is an established genetic risk factor for flucloxacillin DILI. To consolidate this finding, identify additional genetic factors and assess relevance... Read More

The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig (2019)
Journal Article
Hammond, J. S., Godtliebsen, F., Steigen, S., Guha, I. N., Wyatt, J., Revhaug, A., …Mortensen, K. E. (2019). The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clinical Science, 133(1), 153-166. doi:10.1042/CS20180858

Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis and when PVP is reduced, rates of liver dysfunction decrease. The aim of this s... Read More

Identification of a PTPN22 missense variant as a general genetic risk factor for drug-induced liver injury (2019)
Journal Article
Cirulli, E. T., Nicoletti, P., Abramson, K., Andrade, R. J., Bjornsson, E. S., Chalasani, N., …Watkins, P. B. (in press). Identification of a PTPN22 missense variant as a general genetic risk factor for drug-induced liver injury. Gastroenterology,

Background & Aims: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility. Methods: We performed a genome-wide association study of... Read More

Timeline and location of recurrence following successful ablation in Barrett’s oesophagus: an international multicentre study (2019)
Journal Article
Sami, S. S., Ravindran, A., Kahn, A., Snyder, D., Santiago, J., Ortiz-Fernandez-Sordo, J., …Iyer, P. G. (2019). Timeline and location of recurrence following successful ablation in Barrett’s oesophagus: an international multicentre study. Gut, doi:10.1136/gutjnl-2018-317513

Objectives: Surveillance intervals protocols after complete remission of intestinal metaplasia (CRIM) post radiofrequency ablation (RFA) in Barrett’s esophagus (BE) are currently empiric and not based on substantial evidence. We aimed to assess the t... Read More

An interactive web-based educational tool improves detection and delineation of Barrett’s esophagus related neoplasia (2019)
Journal Article
Bergman, J., de Groof, A., Pech, O., Ragunath, K., Armstrong, D., Mostafavi, N., …Sharma, P. (2019). An interactive web-based educational tool improves detection and delineation of Barrett’s esophagus related neoplasia. Gastroenterology, doi:10.1053/j.gastro.2018.12.021

Background & Aims: Endoscopic detection of early Barrett’s esophagus-related neoplasia (BORN) is a challenge. We aimed to develop a web-based teaching tool for improving detection and delineation of BORN. Methods: We made high-definition digital... Read More

Narrow band imaging and serology in the assessment of premalignant gastric pathology (2019)
Journal Article
White, J. R., Sami, S. S., Reddiar, D., Mannath, J., Ortiz Fernández-Sordo, J., Beg, S., …Ragunath, K. (2019). Narrow band imaging and serology in the assessment of premalignant gastric pathology. Scandinavian Journal of Gastroenterology, 53(12), 1611-1618. doi:10.1080/00365521.2018.1542455

Background: Patient outcomes in gastric adenocarcinoma are poor due to late diagnosis. Detecting and treating at the premalignant stage has the potential to improve this. Helicobacter pylori is also a strong risk factor for this disease. Aims: Pri... Read More

Upper GI biopsies for adenocarcinoma: how many biopsies should endoscopists take? (2018)
Journal Article
Kaye, P., Lindsay, D., Madhusudan, S., Vohra, R., Catton, J., Platt, C., & Ragunath, K. (2018). Upper GI biopsies for adenocarcinoma: how many biopsies should endoscopists take?. Histopathology, doi:10.1111/his.13816

Aims: There is evidence that 4 or 5 gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to a... Read More

SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis (2018)
Journal Article
Athwal, V. S., Pritchett, J., Martin, K., Llewellyn, J., Scott, J., Harvey, E., …Piper Hanley, K. (2018). SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis. Scientific Reports, 8, doi:10.1038/s41598-018-36037-4

Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators of ECM deposition may lead to urgently needed diagnostic and therapetic strategies for the d... Read More