Research Repository

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A systematic review of Patient Reported Outcome Measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy (2019)
Journal Article
Daliya, P., Gemmill, E. H., Lobo, D. N., & Parsons, S. L. (2019). A systematic review of Patient Reported Outcome Measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy. Hepatobiliary Surgery and Nutrition, doi:10.21037/hbsn.2019.03.16

Background Patient Reported Outcome Measures (PROMs) provide a valuable means of measuring outcomes subjectively from a patient's perspective, facilitating the assessment of service quality across healthcare providers, and assisting patients and clin... Read More

Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery (2019)
Journal Article
Rollins, K., Mathias, N., & Lobo, D. (in press). Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery. BJS Open,

Background: Intraoperative goal-directed fluid therapy (GDFT) is recommended for intraoperative fluid management for elective colorectal surgery in most perioperative guidelines. However, the evidence in elective colorectal surgery alone is not welle... Read More

Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort (2019)
Journal Article
Chalmers, J., Ban, L., Leena, K., Edwards, K., Grove, J., Aithal, G., & Shenoy, K. (2019). Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort. BMJ Open, 9, doi:10.1136/bmjopen-2018-027244

Purpose The Trivandrum NAFLD cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population. Participants Between 201... Read More

In search of stool donors: a multicentre study of prior knowledge, perceptions, motivators and deterrents among potential donors for fecal microbiota transplantation (2019)
Journal Article
McSweeney, B., Allegretti, J. R., Fischer, M., Xu, H., Goodman, K. J., Monaghan, T., …Kao, D. (in press). In search of stool donors: a multicentre study of prior knowledge, perceptions, motivators and deterrents among potential donors for fecal microbiota transplantation. Gut Microbes,

Introduction: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection. Stool donors are essential, but difficult to recruit and retain. We identified factors influencing willingness to donate... Read More

Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers (2019)
Journal Article
Zhao, D., Corsetti, M., Moeini-Jazani, M., Weltens, N., Tuk, M., Tack, J., …Van Oudenhove, L. (2019). Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers. Neurogastroenterology and Motility, doi:10.1111/nmo.13600

Background: Past research has demonstrated that moderate urge to urinate improves inhibitory control, specifically among participants with higher behavioral inhibition sensitivity (BIS). The effect was absent when the urge exceeded intolerable level.... Read More

Enhancing our understanding of small bowel function using modern imaging techniques (2019)
Journal Article
Hoad, C., & Spiller, R. (in press). Enhancing our understanding of small bowel function using modern imaging techniques. Neurogastroenterology and Motility,

Small intestinal function is critical to digestive health and patients believe an abnormal reaction to food is responsible for many of their symptoms. Despite this, our ability to assess disturbed function in clinical practice has been limited, parti... Read More

The impact of pre-existing and post-transplant diabetes mellitus on outcomes following liver transplantation (2019)
Journal Article
Aravinthan, A. D., Fateen, W., Doyle, A. C., Venkatachalapathy, S. V., Issachar, A., Galvin, Z., …Bhat, M. (2019). The impact of pre-existing and post-transplant diabetes mellitus on outcomes following liver transplantation. Transplantation, doi:10.1097/TP.0000000000002757

Background: Diabetes mellitus (DM) is said to adversely affect transplant outcomes. The aim of this study was to investigate the impact of pre-existing and post-transplant DM on liver transplant (LT) recipients. Method: A single centre retrospective... Read More

Duration and magnitude of postoperative risk of venous thromboembolism after cholecystectomy: a population based cohort study (2019)
Journal Article
Henry, M., Abdul-Sultan, A., Walker, A., West, J., & Humes, D. (2019). Duration and magnitude of postoperative risk of venous thromboembolism after cholecystectomy: a population based cohort study. Digestive Surgery, doi:10.1159/000496435

Background: This study aimed to identify burden and risk of VTE associated with cholecystectomy in England. Methods: An historical cohort study of cholecystectomy patients from 2001-2011 was undertaken using linked primary (Clinical Practice... Read More

Lactoferrin-loaded Alginate Microparticles to Target Clostridioides difficile infection (2019)
Journal Article
Braim, S., Śpiewakb, K., Brindell, M., Heeg, D., Alexandera, C., & Monaghan, T. (2019). Lactoferrin-loaded Alginate Microparticles to Target Clostridioides difficile infection. Journal of Pharmaceutical Sciences, doi:10.1016/j.xphs.2019.02.025

Some forms of bovine lactoferrin (bLf) are effective in delaying Clostridioides difficile growth and preventing toxin production. However, therapeutic use of bLf may be limited by protein stability issues. The objective of this study was to prepare a... Read More

Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders? (2019)
Journal Article
Corsetti, M., Pannemans, J., & Whorwell, P. (2019). Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research, 8, doi:10.12688/f1000research.15974.1

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term bas... Read More

Spatio-Temporal Motility MRI analysis of the stomach and colon (2019)
Journal Article
Menys, A., Hoad, C., Spiller, R., Scott, M., Atkinson, D., Marciani, L., & Taylor, S. (2019). Spatio-Temporal Motility MRI analysis of the stomach and colon. Neurogastroenterology and Motility, 31(5), doi:10.1111/nmo.13557

Background: MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do no not offer insights into the nature of contractile action. This study introduces a systematic method of making spatiotemporal m... Read More

Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28 (2019)
Journal Article
Levy, N., Lobo, D. N., Fawcett, W. J., Ljungqvist, O., & Scott, M. J. (2019). Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28. British Journal of Anaesthesia, doi:10.1016/j.bja.2019.01.028

We read with interest the special and insightful article by Soffin and colleagues1 on the prescription opioid crisis. They carefully examine many of the drivers for subsequent opioid dependence after surgery and provide suggestions on how practice ca... Read More

The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer: a systematic review and meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer: a systematic review and meta-analysis. Annals of Surgery, doi:10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Summary background data: Although studies have shown that perioperative IMN... Read More

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (2019)
Journal Article
Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., …Wain, L. V. (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics, doi:10.1038/s41588-018-0321-7

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar... Read More

Evolution of treatment targets in Crohn’s Disease (2019)
Journal Article
White, J., Moran, G., & Jairath, V. (2019). Evolution of treatment targets in Crohn’s Disease. Best Practice and Research: Clinical Gastroenterology, doi:10.1016/j.bpg.2019.02.001

Crohn’s disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient’s qualit... Read More

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective (2019)
Journal Article
Allison, S. P., & Lobo, D. N. (2019). The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective. Clinical Nutrition, doi:10.1016/j.clnu.2019.01.027

Many theories have been advanced concerning the cause of Charlotte Bronte’s death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tubercul... Read More

Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease (2019)
Journal Article
Shivaji, U. N., Sharratt, C. L., Thomas, T., Smith, S. C., Iacucci, M., Moran, G. W., …Bhala, N. (2019). Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 49(6), 664-680. doi:10.1111/apt.15097

Background: Biological therapy is currently widely used to treat inflammatory bowel disease (IBD). Infliximab, adalimumab and golimumab are currently licensed anti-TNF therapies. Biosimilar anti-TNF monoclonal antibodies are increasingly used. Anti-T... Read More