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Investigation of colonic motility (2019)
Book Chapter
CORSETTI, M., & GUNN, D. (in press). Investigation of colonic motility. In S. Rao, Y. Lee, & U. Ghosal (Eds.), Clinical and Basic Neurogastroenterology and MotilityElsevier

Investigation of anorectal motility (2019)
Book Chapter
WILKINSON-SMITH, V., Basilisco, G., & CORSETTI, M. (in press). Investigation of anorectal motility. In S. Rao, Y. Lee, & U. Ghoshal (Eds.), Clinical and Basic Neurogastroenterology and MotilityElsevier

Outcomes following an index emergency admission with cholecystitis: a national cohort study (2019)
Journal Article
Mytton, J., Daliya, P., Singh, P., Parsons, S., Lobo, D., Lilford, R., & Vohra, R. (in press). Outcomes following an index emergency admission with cholecystitis: a national cohort study. Annals of Surgery,

This study has shown that over 50% of the 99,139 admitted with acute cholecystitis in England did not undergo cholecystectomy following index admission. Mortality was higher in the non-operated group, which was mostly due to non-gallbladder pathologi... Read More

Glycaemic, Gastrointestinal , Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans (2019)
Journal Article
Alyami, J., Whitehouse, E., Yakubov, G. E., Pritchard, S. E., Hoad, C. L., Blackshaw, E., …Marciani, L. (2019). Glycaemic, Gastrointestinal , Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans. British Journal of Nutrition, doi:10.1017/S0007114519001880

Whole grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known... Read More

Perioperative probiotics or synbiotics in adults undergoing elective abdominal surgery: A systematic review and meta-analysis of randomized controlled trials (2019)
Journal Article
Chowdhury, A., Adiamah, A., Kushairi, A., Varadhan, K. K., Krznaric, Z., Kulkarni, A. D., …Lobo, D. (in press). Perioperative probiotics or synbiotics in adults undergoing elective abdominal surgery: A systematic review and meta-analysis of randomized controlled trials. Annals of Surgery,

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications foll... Read More

How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery) (2019)
Journal Article
Pauwels, A., Boecxstaens, V., Andrews, C., Attwood, S. E., Berrisford, R., Bisschops, R., …Tack, J. F. (2019). How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery). Gut, doi:10.1136/gutjnl-2019-318260

Objective: Anti-reflux surgery can be proposed in patients with gastro-esophageal reflux disease, especially when proton pump inhibitor use leads to incomplete symptom improvement. However, to date, international consensus guidelines on the clinical... Read More

Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron (2019)
Journal Article
Gunn, D., Garsed, K., Lam, C., Singh, G., Lingaya, M., Wahl, V., …Spiller, R. (2019). Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron. Alimentary Pharmacology and Therapeutics, 50(5), 538-546. doi:10.1111/apt.15420

Background Irritable bowel syndrome with diarrhoea (IBS‐D) is a common condition, greatly reducing the quality of life with few effective treatment options available. Aims To report the beneficial response shown in our trial with the 5‐hydroyxtr... Read More

Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis (2019)
Journal Article
Sebastian, S., Myers, S., Argyriou, K., Martin, G., Los, L., Fiske, J., …Raine, T. (in press). Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis. Alimentary Pharmacology and Therapeutics,

Background: Accelerated induction regimens of infliximab have been proposed to improve response rates in patients with steroid refractory acute severe colitis. Aims: We aimed to determine differences in outcome for acute severe ulcerative colit... Read More

Systematic review: Physical activity and fatigue in adults with Inflammatory Bowel Disease (IBD) (2019)
Journal Article
Radford, S. J., Janiszewski, H., & Moran, G. W. (in press). Systematic review: Physical activity and fatigue in adults with Inflammatory Bowel Disease (IBD). Gastrointestinal Nursing,

Background: Fatigue is frequently reported in inflammatory bowel disease (IBD). IBD has been shown to have an impact on, and be impacted by, physical activity levels in IBD patients, Yet, to date, there have been no systematic reviews considering the... Read More

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques (2019)
Journal Article
Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P., …Tack, J. (2019). First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nature Reviews Gastroenterology and Hepatology, doi:10.1038/s41575-019-0167-1

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminol... Read More

Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery (2019)
Journal Article
Rollins, K., Mathias, N., & Lobo, D. (2019). Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery. BJS Open, doi:10.1002/bjs5.50188

Background: Intraoperative goal-directed fluid therapy (GDFT) is recommended for intraoperative fluid management for elective colorectal surgery in most perioperative guidelines. However, the evidence in elective colorectal surgery alone is not welle... Read More

Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study (2019)
Journal Article
West, J., Otete, H., Sultan, A. A., & Crooks, C. J. (2019). Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study. Epidemiology, 30(4), e23-e24. doi:10.1097/EDE.0000000000001006

The diagnosis rates of coeliac disease differ substantially between countries. Intriguingly, there has been recent evidence from Olmstead County, USA and Finland that in the last 5-10 years incidence has plateaued or even declined. In most population... Read More

A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy (2019)
Journal Article
Daliya, P., Gemmill, E. H., Lobo, D. N., & Parsons, S. L. (2019). A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy. Hepatobiliary Surgery and Nutrition, 8(3), doi:10.21037/hbsn.2019.03.16

Background Patient Reported Outcome Measures (PROMs) provide a valuable means of measuring outcomes subjectively from a patient's perspective, facilitating the assessment of service quality across healthcare providers, and assisting patients and clin... Read More

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo (2019)
Journal Article
Velickovic, K., Wayne, D., Lugo Leija, H. A., Bloor, I., Morris, D. E., Law, J., …Sottile, V. (2019). Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Scientific Reports, 9, doi:10.1038/s41598-019-45540-1

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet can modulate UCP1 function but the capacity of individual nut... Read More

Increased fasting small bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging (2019)
Journal Article
Lam, C., Sanders, D., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., …Spiller, R. (2019). Increased fasting small bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal, doi:10.1177/2050640619860372

Background and aims: The regular overnight migrating motor complex (MMC) ensures that the normal fasting small bowel water content (SBWC) is minimised. We have applied our recently validated non-invasive magnetic resonance technique to assess SBWC... Read More

"Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy. (2019)
Journal Article
Hens, B., Corsetti, M., Bermejo, M., Löbenberg, R., González, P. M., Mitra, A., …Aceituno, A. (2019). "Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy. AAPS Journal, 21, 1-16. doi:10.1208/s12248-019-0346-6

The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature pose... Read More