The need to move away from fecal transplant towards targeted, refined microbiome therapy
(2018)
Journal Article
Russell, L., Monaghan, T., & Kao, D. (2018). The need to move away from fecal transplant towards targeted, refined microbiome therapy. Journal of Thoracic Disease, 10(10),
All Outputs (8)
Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway (2018)
Journal Article
Monaghan, T. M., Mullish, B. H., Patterson, J., Wong, G. K., Marchesi, J. R., Xu, H., …Kao, D. (2018). Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes, https://doi.org/10.1080/19490976.2018.1506667The mechanisms of efficacy for fecal microbiota# transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions representing one possible explanation. F... Read More about Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid-farnesoid X receptor-fibroblast growth factor pathway.
A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection (2018)
Journal Article
Negm, O. H., Hamed, M. R., & Monaghan, T. M. (in press). A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection. Journal of Visualized Experiments, 136, Article e57399. https://doi.org/10.3791/57399We provide a detailed overview of a novel high-throughput protein microarray assay for the determination of anti-C. difficile antibody levels in human sera and in separate preparations of polyclonal IVIg. The protocol describes the methodological ste... Read More about A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection.
Novel lactoferrin-loaded alginate microbeads display anti-Clostridium difficile defence properties (2018)
Journal Article
Monaghan, T. M., Braim, S., Spiewak, K., Brindell, M., & Alexander, C. (2018). Novel lactoferrin-loaded alginate microbeads display anti-Clostridium difficile defence properties. Gut, 67(Supp 1), Article A194-A195. https://doi.org/10.1136/gutjnl-2018-BSGAbstracts.387
Serum trace metal concentrations in Clostridium difficile infection and their relationship to disease severity (2018)
Journal Article
Monaghan, T. M., Jilani, T., Frankowski, M., Spiewak, K., & Brindell, M. (2018). Serum trace metal concentrations in Clostridium difficile infection and their relationship to disease severity. Gut, 67(Supp 1), Article A195-A196. https://doi.org/10.1136/gutjnl-2018-BSGAbstracts.389
High prevalence of Clostridium difficile Ribotype 078 in IBD outpatients (2018)
Journal Article
Monaghan, T. M., Sloan, T. J., Freeman, J., Pickering, D., Eyre, D., Lingaya, M., …Wilcox, M. H. (2018). High prevalence of Clostridium difficile Ribotype 078 in IBD outpatients. Gut, 67(Supp 1), Article A195. https://doi.org/10.1136/gutjnl-2018-BSGAbstracts.388
Novel oral targeted therapies in inflammatory bowel disease (2018)
Journal Article
White, J. R., Philips, F., Monaghan, T. M., Fateen, W., Samuel, S., Ghosh, S., & Moran, G. W. (2018). Novel oral targeted therapies in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 47(12), 1610-1622. https://doi.org/10.1111/apt.14669Background: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of me... Read More about Novel oral targeted therapies in inflammatory bowel disease.
Orbital inflammatory complications of Crohn’s disease: a rare case series (2018)
Journal Article
Monaghan, T. M., Albanese, G., Kaye, P., Thomas, J. D., Abercrombie, L., & Moran, G. W. (in press). Orbital inflammatory complications of Crohn’s disease: a rare case series. Clinical Medicine Insights: Gastroenterology, 11, https://doi.org/10.1177/1179552218757512Orbital inflammatory disease is a rare ophthalmic manifestation of Crohn’s disease. Inflammation is characteristically non-specific, involving one or multiple structures of the orbit. Mechanisms of disease and optimal methods of treatment are poorly... Read More about Orbital inflammatory complications of Crohn’s disease: a rare case series.