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Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori (2020)
Journal Article
Tegtmeyer, N., Neddermann, M., Lind, J., Pachathundikandi, S. K., Sharafutdinov, I., Gutiérrez-Escobar, A. J., …Backert, S. (2020). Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori. Cell Reports, 32(11), 1-15. e1-e9. https://doi.org/10.1016/j.celrep.2020.108159

Helicobacter pylori (Hp) is an important human pathogen associated with gastric inflammation and neoplasia. It is commonly believed that this bacterium avoids major immune recognition by Toll-like receptors (TLRs) because of low intrinsic activity of... Read More about Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori.

Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications (2018)
Journal Article
Kaliyaperumal, K., Grove, J. I., Delahay, R. M., Griffiths, W. J., Duckworth, A., & Aithal, G. P. (2018). Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications. Journal of Hepatology, 69(4), 948-957. https://doi.org/10.1016/j.jhep.2018.05.013

A number of drug-specific and host-related factors contribute to the development of drug-induced liver injury (DILI). Investigations focused on genetic susceptibility to DILI have advanced our understanding of the pathogenesis of this rare, yet poten... Read More about Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications.

Phylogeographic diversity and mosaicism of the Helicobacter pylori tfs integrative and conjugative elements (2018)
Journal Article
Delahay, R. M., Croxall, N. J., & Stephens, A. D. (in press). Phylogeographic diversity and mosaicism of the Helicobacter pylori tfs integrative and conjugative elements. Mobile DNA, 9(5), https://doi.org/10.1186/s13100-018-0109-4

Background: The genome of the gastric pathogen Helicobacter pylori is characterised by considerable variation of both gene sequence and content, much of which is contained within three large genomic islands comprising the cag pathogenicity island (ca... Read More about Phylogeographic diversity and mosaicism of the Helicobacter pylori tfs integrative and conjugative elements.

A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA (2017)
Journal Article
Alandiyjany, M. N., Croxall, N. J., Grove, J. I., & Delahay, R. M. (2017). A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA. PLoS ONE, 12(7), Article e0182144. https://doi.org/10.1371/journal.pone.0182144

Two distinct type IV secretion systems (T4SSs) can be identified in certain Helicobacter pylori strains, encoded on mobile genetic elements termed tfs3 and tfs4. Although their function remains unknown, both have been implicated in clinical outcomes... Read More about A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helicobacter pylori Ser/Thr kinase, CtkA.