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Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial (2023)
Journal Article
Gunn, D., Topan, R., Barnard, L., Fried, R., Holloway, I., Brindle, R., …Spiller, R. (2023). Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial. Alimentary Pharmacology and Therapeutics, 57(11), 1258-1271. https://doi.org/10.1111/apt.17426

Summary: Background: Ondansetron may be beneficial in irritable bowel syndrome with diarrhoea (IBS‐D). Aim: To conduct a 12‐week parallel group, randomised, double‐blind, placebo‐controlled trial of ondansetron 4 mg o.d. (titrated up to 8 mg t.d.s.)... Read More about Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial.

A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men (2023)
Journal Article
Aliyu, A. I., Nixon, A., Hoad, C., Marciani, L., Corsetti, M., Aithal, G. P., …Taylor, M. A. (2023). A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men. British Journal of Nutrition, 130(8), 1316-1328. https://doi.org/10.1017/S0007114523000302

AbstractInclusion in nasogastric tube feeds (NGTF) of acid-sensitive, seaweed-derived alginate, expected to form a reversible gel in the stomach, may create a more normal intragastric state and modified gastrointestinal responses. This may ameliorate... Read More about A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men.

Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP) (2022)
Journal Article
Barbara, G., Cremon, C., Bellini, M., Corsetti, M., Di Nardo, G., Falangone, F., …Marasco, G. (2022). Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP). Digestive and Liver Disease, https://doi.org/10.1016/j.dld.2022.11.015

The irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction. IBS is still associated with areas of uncertainties, especially regarding the optimal diagnostic work-up and the more appropriate management. Experts from 7 Italian So... Read More about Italian guidelines for the management of irritable bowel syndrome: Joint Consensus from the Italian Societies of: Gastroenterology and Endoscopy (SIGE), Neurogastroenterology and Motility (SINGEM), Hospital Gastroenterologists and Endoscopists (AIGO), Digestive Endoscopy (SIED), General Medicine (SIMG), Gastroenterology, Hepatology and Pediatric Nutrition (SIGENP) and Pediatrics (SIP).

Functional Abdominal Cramping Pain: Expert Practical Guidance (2022)
Journal Article
Müller-Lissner, S., Andresen, V., Corsetti, M., Bustos Fernández, L., Forestier, S., Pace, F., & Valdovinos, M. A. (2022). Functional Abdominal Cramping Pain: Expert Practical Guidance. Journal of Clinical Gastroenterology, 56(10), 844-852. https://doi.org/10.1097/MCG.0000000000001764

Functional abdominal cramping pain (FACP) is a common complaint, which may present either on its own or in association with a functional gastrointestinal disorder. It is likely caused by a variety of, probably partly unknown, etiologies. Effective ma... Read More about Functional Abdominal Cramping Pain: Expert Practical Guidance.

Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients (2022)
Journal Article
Hay, P. D., Corsetti, M., Tucker, E., Fox, M. R., & Perkins, A. (2022). Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients. Neurogastroenterology and Motility, https://doi.org/10.1111/nmo.14454

Background: Scintigraphy is used for overall assessment of gastric emptying. Adherence to an international consensus protocol is recommended to ensure quality; however, this has not been widely adopted because preparation of the “egg-beater” meal is... Read More about Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients.

Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice (2022)
Journal Article
Corsetti, M., Forestier, S., & Jiménez, M. (2023). Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice. Neurogastroenterology and Motility, 35(4), Article e14451. https://doi.org/10.1111/nmo.14451

Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of... Read More about Hyoscine butylbromide mode of action on bowel motility: From pharmacology to clinical practice.

British Society of Gastroenterology guidelines on the management of functional dyspepsia (2022)
Journal Article
Black, C. J., Paine, P. A., Agrawal, A., Aziz, I., Eugenicos, M. P., Houghton, L. A., …Ford, A. C. (2022). British Society of Gastroenterology guidelines on the management of functional dyspepsia. Gut, 71(9), 1697-1723. https://doi.org/10.1136/gutjnl-2022-327737

Functional dyspepsia (FD) is a common disorder of gut-brain interaction, affecting approximately 7% of individuals in the community, with most patients managed in primary care. The last British Society of Gastroenterology (BSG) guideline for the mana... Read More about British Society of Gastroenterology guidelines on the management of functional dyspepsia.

Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility (2022)
Journal Article
Savarino, E., Zingone, F., Barberio, B., Marasco, G., Akyuz, F., Akpinar, H., …Barbara, G. (2022). Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility. United European Gastroenterology Journal, 10(6), 556-584. https://doi.org/10.1002/ueg2.12259

Irritable bowel syndrome with diarrhoea (IBS-D) and functional diarrhoea (FDr) are the two major functional bowel disorders characterized by diarrhoea. In spite of their high prevalence, IBS-D and FDr are associated with major uncertainties, especial... Read More about Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility.

Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective (2022)
Journal Article
Hungin, A. P. S., Scarpignato, C., Keefer, L., Corsetti, M., Anastasiou, F., Muris, J. W., …Kahrilas, P. J. (2022). Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective. Alimentary Pharmacology and Therapeutics, 55(12), 1492-1500. https://doi.org/10.1111/apt.16930

Background: Despite widespread adoption of potent acid suppression treatment with proton pump inhibitors (PPI) for reflux-like symptoms, persistent symptoms are commonly reported in primary care and community studies. Aims: This multidisciplinary rev... Read More about Review article: rethinking the “ladder” approach to reflux-like symptom management in the era of PPI “resistance”: a multidisciplinary perspective.

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research (2022)
Journal Article
Senekowitsch, S., Schick, P., Abrahamsson, B., Augustijns, P., Gießmann, T., Lennernäs, H., …Koziolek, M. (2022). Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14(4), Article 801. https://doi.org/10.3390/pharmaceutics14040801

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Un... Read More about Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research.

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia (2021)
Journal Article
Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., Enck, P., …ESNM FD consensus group. (2021). United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia. United European Gastroenterology Journal, 10(3), 307-331. https://doi.org/10.1002/ueg2.12061

Background Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on Functional Dyspepsia.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021)
Journal Article
Vasant, D. H., Paine, P. A., Black, C. J., Houghton, L. A., Everitt, H. A., Corsetti, M., …Ford, A. C. (2021). British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut, 70(7), 1214-1240. https://doi.org/10.1136/gutjnl-2021-324598

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication of the last British Society of Gastroenterology guideline in 2007, substantial advances... Read More about British Society of Gastroenterology guidelines on the management of irritable bowel syndrome.

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis (2021)
Journal Article
Schol, J., Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., …Corsetti, M. (2021). United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis. United European Gastroenterology Journal, 9(3), 287-306. https://doi.org/10.1002/ueg2.12060

Background: Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The condition is challenging in clinical practice by the lack of guidance concerning... Read More about United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.

The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis (2021)
Journal Article
Bosman, M., Elsenbruch, S., Corsetti, M., Tack, J., Simrén, M., Winkens, B., …Keszthelyi, D. (2021). The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology, 6(6), 459-473. https://doi.org/10.1016/S2468-1253%2821%2900023-6

Background Clinical trials in irritable bowel syndrome are associated with high placebo response rates. We aimed to identify the magnitude of the placebo response and the contributing factors to this occurrence. Methods We did a systematic revie... Read More about The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis.

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review (2021)
Journal Article
Vinarov, Z., Abdallah, M., Agundez, J. A., Allegaert, K., Basit, A. W., Braeckmans, M., …Augustijns, P. (2021). Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review. European Journal of Pharmaceutical Sciences, 162, Article 105812. https://doi.org/10.1016/j.ejps.2021.105812

The absorption of oral drugs is frequently plagued by significant variability with potentially serious therapeutic consequences. The source of variability can be traced back to interindividual variability in physiology, differences in special populat... Read More about Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review.

Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation (2021)
Journal Article
Corsetti, M., Landes, S., & Lange, R. (2021). Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation. Neurogastroenterology and Motility, 33(10), Article e14123. https://doi.org/10.1111/nmo.14123

Background: Bisacodyl is a member of the diphenylmethane family and is considered to be a stimulant laxative. It has a dual prokinetic and secretory action and needs to be converted into the active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (... Read More about Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation.

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment (2021)
Journal Article
Corsetti, M., Brown, S., Chiarioni, G., Dimidi, E., Dudding, T., Emmanuel, A., …Scott, S. M. (2021). Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment. Neurogastroenterology and Motility, 33(7), Article e14070. https://doi.org/10.1111/nmo.14070

Background: Chronic constipation is a prevalent disorder that affects quality of life of patients and consumes resources in healthcare systems worldwide. In clinical practice, it is still considered a challenge as clinicians frequently are unsure as... Read More about Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment.

High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications (2020)
Journal Article
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021). High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications. Neurogastroenterology and Motility, 33(5), Article e14040. https://doi.org/10.1111/nmo.14040

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High‐resolution manometry reveals different effect of polyethylene glycol, bisacodyl, and prucalopride on colonic motility in healthy subjects: An acute, open label, randomized, crossover, reader‐blinded study with potential clinical implications.

High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications (2020)
Journal Article
Corsetti, M., Thys, A., Harris, A., Pagliaro, G., Deloose, E., Demedts, I., & Tack, J. (2021). High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications. Neurogastroenterology and Motility, 33(5), Article e14040. https://doi.org/10.1111/nmo.14040

PEG, bisacodyl and prucalopride have been reported to be more effective than placebo in treating patients with constipation but about 50% of the patients still do not respond to these medications. Only bisacodyl and pucalopride are expected to direct... Read More about High-resolution manometry reveals different effect of polyethylene glycol, bisacodyl and prucalopride on colonic motility in healthy subjects: an acute, open label, randomised, crossover, reader blinded study with potential clinical implications.