All Outputs (577)

Near Fibre Electromyography (2020)
Working Paper
Piasecki, M., C Estruch, O. G., & Stashuk, D. W. Near Fibre Electromyography

Near fibre electromyography (NFEMG) is the use of specifically high-pass filtered motor unit potential (MUPs) (i.e. near fibre MUPs (NFMs)) extracted from needle-detected EMG signals for the examination of changes in motor unit (MU) morphology and el... Read More about Near Fibre Electromyography.

Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach: Lessons Learnt from Six Projects Conducted in the UK and The Netherlands (2020)
Journal Article
Devi, R., Martin, G., Banerjee, J., Butler, L., Pattison, T., Cruickshank, L., …Gordon, A. L. (2020). Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach: Lessons Learnt from Six Projects Conducted in the UK and The Netherlands. International Journal of Environmental Research and Public Health, 17(20), Article 7601. https://doi.org/10.3390/ijerph17207601

The Breakthrough Series Quality Improvement Collaborative (QIC) initiative is a well-developed and widely used approach, but most of what we know about it has come from healthcare settings. In this article, those leading QICs to improve care in care... Read More about Improving the Quality of Care in Care Homes Using the Quality Improvement Collaborative Approach: Lessons Learnt from Six Projects Conducted in the UK and The Netherlands.

Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age (2020)
Journal Article
Sayda, M. H., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2020). Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age. Nutrients, 12(10), https://doi.org/10.3390/nu12103029

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates. However, p... Read More about Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age.

Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer (2020)
Journal Article
Morgan, J. L., Holmes, G., Ward, S., Martin, C., Burton, M., Walters, S. J., …Parmeshwar, R. (2021). Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer. EJSO - European Journal of Surgical Oncology, 47(2), 261-268. https://doi.org/10.1016/j.ejso.2020.09.029

© 2020 The Authors Background: In the UK there is variation in the treatment of older women with breast cancer, with up to 40% receiving primary endocrine therapy (PET), which is associated with inferior survival. Case mix and patient choice may expl... Read More about Observational cohort study to determine the degree and causes of variation in the rate of surgery or primary endocrine therapy in older women with operable breast cancer.

Symptom-burden in people living with frailty and chronic kidney disease (2020)
Journal Article
Nixon, A. C., Wilkinson, T. J., Young, H. M. L., Taal, M. W., Pendleton, N., Mitra, S., …Smith, A. C. (2020). Symptom-burden in people living with frailty and chronic kidney disease. BMC Nephrology, 21, Article 411. https://doi.org/10.1186/s12882-020-02063-6

Background: Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This... Read More about Symptom-burden in people living with frailty and chronic kidney disease.

The care of older cancer patients in the United Kingdom (2020)
Journal Article
Gomes, F., Lewis, A., Morris, R., Parks, R., Kalsi, T., Babic-Illamn, G., …Simcock, R. (2020). The care of older cancer patients in the United Kingdom. ecancermedicalscience, 14, Article 1101. https://doi.org/10.3332/ECANCER.2020.1101

The ageing population poses new challenges globally. Cancer care for older patients is one of these challenges, and it has a significant impact on societies. In the United Kingdom (UK), as the number of older cancer patients increases, the management... Read More about The care of older cancer patients in the United Kingdom.

Seeking Answers for Care Homes during the COVID-19 pandemic (COVID SEARCH) (2020)
Journal Article
Spilsbury, K., Devi, R., Griffiths, A., Akrill, C., Astle, A., Goodman, C., …Thompson, C. (2021). Seeking Answers for Care Homes during the COVID-19 pandemic (COVID SEARCH). Age and Ageing, 50(2), 335–340. https://doi.org/10.1093/ageing/afaa201

The care and support of older people residing in long-term care facilities during the COVID-19 pandemic has created new and unanticipated uncertainties for staff. In this short report, we present our analyses of the uncertainties of care home manager... Read More about Seeking Answers for Care Homes during the COVID-19 pandemic (COVID SEARCH).

The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial (2020)
Journal Article
Greenwood, S. A., Koufaki, P., Macdonald, J., Bhandari, S., Burton, J., Dasgupta, I., …Mercer, T. H. (2021). The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial. Clinical Kidney Journal, 14(5), 1345–1355. https://doi.org/10.1093/ckj/sfaa107

Background Exercise interventions designed to improve physical function and reduce sedentary behaviour in haemodialysis (HD) patients might improve exercise capacity, reduce fatigue and lead to improved quality of life (QOL). The PrEscription of int... Read More about The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial.

Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease (2020)
Journal Article
Viramontes-Hörner, D., & Taal, M. W. (2020). Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease. Current Opinion in Nephrology and Hypertension, 29(6), 547-554. https://doi.org/10.1097/MNH.0000000000000651

Purpose of review: Malnutrition is a frequent complication and risk factor for adverse outcomes in the dialysis population that is often underrecognized and neglected. This article reviews published literature on the associations between malnutrition... Read More about Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease.

Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial (2020)
Journal Article
Kang Law, Z., Dineen, R., England, T. J., Cala, L., Mistri, A. K., Appleton, J. P., …TICH-2 investigators. (2021). Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial. Translational Stroke Research, 12, 275-283. https://doi.org/10.1007/s12975-020-00845-6

Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexa... Read More about Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial.

Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes (2020)
Journal Article
Chadborn, N. H., Devi, R., Hinsliff-Smith, K., Banerjee, J., & Gordon, A. L. (2021). Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes. European Geriatric Medicine, 12, 17-26. https://doi.org/10.1007/s41999-020-00389-w

Purpose We conducted a scoping review of quality improvement in care homes. We aimed to identify participating occupational groups and methods for evaluation. Secondly, we aimed to describe resident-level interventions and which outcomes were measur... Read More about Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes.

Development of a Malaysian Undergraduate Geriatric Medicine Curriculum (2020)
Journal Article
Sallehuddin, H., Tan, M. P., Blundell, A., Gordon, A. L., & Masud, T. (2020). Development of a Malaysian Undergraduate Geriatric Medicine Curriculum. Aging Medicine and Healthcare, 11(3), 82-88. https://doi.org/10.33879/AMH.113.2020.05015

Objective: Malaysia is only beginning to age in 2020, but is expected to do this at an unprecedented rate in the next two decades. We aim to develop a national curriculum for undergraduate geriatric medicine in Malaysia to ensure future doctors are a... Read More about Development of a Malaysian Undergraduate Geriatric Medicine Curriculum.

Clinical relevance of biomarkers in oestrogen receptor positive breast cancer (2020)
Book Chapter
Parks, R. M., & Cheung, K. L. (2020). Clinical relevance of biomarkers in oestrogen receptor positive breast cancer. In G. G. Chen, M. C. Tong, & C. van Hasselt (Eds.), Estrogen receptors: structure, functions and clinical aspects (53-91). Nova Science Publishers

© 2020 Nova Science Publishers, Inc. Some biomarkers have been examined extensively in the context of breast cancer, including the oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). They are now routinely measured and used c... Read More about Clinical relevance of biomarkers in oestrogen receptor positive breast cancer.

Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study (2020)
Journal Article
Izza, M. A. D., Lunt, E., Gordon, A. L., Gladman, J. R. F., Armstrong, S., & Logan, P. A. (2020). Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study. European Geriatric Medicine, 11, 1043-1050. https://doi.org/10.1007/s41999-020-00376-1

Purpose: Falls and polypharmacy are both common in care home residents. Deprescribing of medications in residents with increased falls risk is encouraged. Psychotropic medications are known to increase falls risk in older adults. These drugs are ofte... Read More about Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study.

Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016 (2020)
Journal Article
Hounkpatin, H. O., Harris, S., Fraser, S. D., Day, J., Mindell, J. S., Taal, M. W., …Roderick, P. J. (2020). Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016. BMJ Open, 10(8), Article e038423. https://doi.org/10.1136/bmjopen-2020-038423

Objectives: To identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic, behavioural and clinical factors. Design: Pooled cross-sectional analysis. Setting: Health... Read More about Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016.

The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ (2020)
Journal Article
Miligy, I. M., Toss, M. S., Shiino, S., Oni, G., Syed, B. M., Khout, H., …Rakha, E. A. (2020). The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ. British Journal of Cancer, 123(10), 1513-1520. https://doi.org/10.1038/s41416-020-1023-3

Background: Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of out... Read More about The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ.

Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study (2020)
Journal Article
Fraser, S. D., Barker, J., Roderick, P. J., Yuen, H. M., Shardlow, A., Morris, J. E., …Taal, M. W. (2020). Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study. BMJ Open, 10, Article e040286. https://doi.org/10.1136/bmjopen-2020-040286

Objectives: To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care. Design: Cross-sectional analysis at 5-y... Read More about Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study.

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States (2020)
Journal Article
Stokes, T., Timmons, J. A., Crossland, H., Tripp, T. R., Murphy, K., McGlory, C., …Phillips, S. M. (2020). Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States. Cell Reports, 32(5), Article 107980. https://doi.org/10.1016/j.celrep.2020.107980

Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators. A within-person diffe... Read More about Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States.

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle (2020)
Journal Article
Abdulla, H., Phillips, B. E., Wilkinson, D. J., Limb, M., Jandova, T., Bass, J. J., …Atherton, P. J. (2020). Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle. Aging Cell, 19(9), Article e13202. https://doi.org/10.1111/acel.13202

© 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd Background: Despite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-stat... Read More about Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome (2020)
Journal Article
Parks, R. M., Albanghali, M., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2020). Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome. Cancers, 12(8), https://doi.org/10.3390/cancers12082067

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The majority of biological profiling studies use surgical excision (SE) samples, excluding patients receiving nonsurgical and neoadjuvant therapy. We propose using core needle biopsy (CNB) for... Read More about Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome.