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Impact of dietetic intervention on skin autofluorescence and nutritional status in persons receiving dialysis: a proof of principle study (2020)
Journal Article
Hörner, D. V., Willingham, F. C., Selby, N. M., & Taal, M. W. (2020). Impact of dietetic intervention on skin autofluorescence and nutritional status in persons receiving dialysis: a proof of principle study. Journal of Renal Nutrition, https://doi.org/10.1053/j.jrn.2019.12.006

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from oxidative stress and food consumption. We have previously reported that markers of malnutrition are more important determinants of increased skin autofluorescence (S... Read More about Impact of dietetic intervention on skin autofluorescence and nutritional status in persons receiving dialysis: a proof of principle study.

The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles (2020)
Journal Article
Messa, G. A. M., Piasecki, M., Hurst, J., Hill, C., Tallis, J., & Degens, H. (2020). The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles. Journal of Experimental Biology, https://doi.org/10.1242/jeb.217117

Prolonged high-fat diets (HFD) can cause intramyocellular lipids (IMCL) accumulation that may negatively affect muscle function. We investigated the duration of a HFD required to instigate these changes, and whether effects are muscle-specific and ag... Read More about The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles.

A multi-centre study using comprehensive geriatric assessment to determine differences between older women with operable breast cancer undergoing surgery or non-operative treatment (2020)
Presentation / Conference
Parks, R., Howard, P., Zahit, R., Kayani, A., Lakshmanan, R., Tang, S., …Cheung, K. (2020, January). A multi-centre study using comprehensive geriatric assessment to determine differences between older women with operable breast cancer undergoing surgery or non-operative treatment. Paper presented at 2nd UK Interdisciplinary Breast Cancer Symposium, Birmingham, UK

Aims/Objectives: Shared decision making on the choice of treatment for older women with breast cancer involves many factors. Comprehensive geriatric assessment (CGA) is recognised to have a role in older patients with cancer, but how this should be u... Read More about A multi-centre study using comprehensive geriatric assessment to determine differences between older women with operable breast cancer undergoing surgery or non-operative treatment.

Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid (2020)
Journal Article
Woodhouse, L. J., Mistri, A. K., Bath, P. M., Law, Z. K., England, T. J., Mistri, A. K., …TICH-2 investigators, . (2020). Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid. European Stroke Journal, https://doi.org/10.1177/2396987320901391

Introduction Seizures are common after intracerebral haemorrhage. Tranexamic acid increases the risk of seizures in non-intracerebral haemorrhage population but its effect on post-intracerebral haemorrhage seizures is unknown. We explored the risk f... Read More about Incidence and predictors of early seizures in intracerebral haemorrhage and the effect of tranexamic acid.

Network analysis of human muscle adaptation to aging and contraction (2020)
Journal Article
Etheridge, T., Willis, C., Atherton, P., Ames, R., Szewczyk, N., Deane, C., …Lund, J. (2020). Network analysis of human muscle adaptation to aging and contraction. Aging, 12(1), 740-755. https://doi.org/10.18632/aging.102653

Resistance exercise (RE) remains a primary approach for minimising aging muscle decline. Understanding muscle adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies. Herein, we em... Read More about Network analysis of human muscle adaptation to aging and contraction.

Methodology and the professional doctorate – the muddy waters of knowledge creation, transfer and workplace capital (2020)
Journal Article
Smith, S. (2020). Methodology and the professional doctorate – the muddy waters of knowledge creation, transfer and workplace capital. Professional Development in Education, 1-8. https://doi.org/10.1080/19415257.2020.1711800

The professional doctorate creates opportunities for shared research and novel findings to inform and shape the workplace and cultivate professional capital. In this paper I discuss my own journey in undertaking an Educational doctorate. I critique h... Read More about Methodology and the professional doctorate – the muddy waters of knowledge creation, transfer and workplace capital.

MeMa: Designing the Memory Machine (2019)
Conference Proceeding
Price, D., Jacobs, R., Darzentas, D., Perez Vallejos, E., Chadborn, N., Martindale, S., & Urquhart, L. (2019). MeMa: Designing the Memory Machine. In Companion Publication of the 2019 on Designing Interactive Systems Conference 2019 Companion, 271--276. doi:10.1145/3301019.3323882

The Memory Machine is an ambitious project that aims to develop a device to capture people's memories to create a blend of personal and factual data that builds identities, and contextualizes personal recollections. The Memory Machine has been guided... Read More about MeMa: Designing the Memory Machine.

Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study (2019)
Journal Article
Mamza, J., Anyanwagu, U., Alkharaiji, M., & Idris, I. (2020). Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study. Journal of Drug Assessment, 9(1), https://doi.org/10.1080/21556660.2019.1704415

Background There is limited data on the real world evidence of Humalog 200 units/ml KwikPen (U-200) insulin. We assessed the use of U-200 insulin in UK routine clinical practice to provide information on clinical characteristics, treatment satisfacti... Read More about Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study.

Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT) (2019)
Journal Article
Robertson, J. F., Coleman, R. E., Cheung, K., Evans, A., Holcombe, C., Skene, A., …Gee, J. M. (2019). Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT). Clinical Cancer Research, https://doi.org/10.1158/1078-0432.ccr-19-3053

Purpose: The STAKT study examined short-term exposure (4.5 days) to oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to significantly modulate key biomarker... Read More about Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT).

Coffee Consumption and Kidney Function: A Mendelian Randomization Study (2019)
Journal Article
Kennedy, O. J., Pirastu, N., Poole, R., Fallowfield, J. A., Hayes, P. C., Grzeszkowiak, E. J., …Roderick, P. J. (2019). Coffee Consumption and Kidney Function: A Mendelian Randomization Study. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2019.08.025

Rationale & Objective Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex mixture of chemicals, and consumption has been associated with mo... Read More about Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Treatment of acute stroke: the hazard of negative (not neutral) trials: a review (2019)
Journal Article
Bath, P. M., Appleton, J. P., & England, T. (2019). Treatment of acute stroke: the hazard of negative (not neutral) trials: a review. JAMA Neurology, 77(1), 114-124. https://doi.org/10.1001/jamaneurol.2019.4107

Importance While there are a limited number of beneficial treatments for acute stroke (eg, stroke units, reperfusion, aspirin, hemicraniectomy), there are more negative (as opposed to neutral) interventions spanning multiple different mechanisms of... Read More about Treatment of acute stroke: the hazard of negative (not neutral) trials: a review.

Personalising care in the older woman with primary breast cancer (2019)
Journal Article
Parks, R. M., & Cheung, K. L. (2019). Personalising care in the older woman with primary breast cancer. Annals of the Academy of Medicine, Singapore, 48(11), 370-375

The incidence of breast cancer increases with age. Despite this, most research in the field is targeted at younger patients. Age-specific guidelines are not widely referred to and guidelines which allude to the older woman as an individual are based... Read More about Personalising care in the older woman with primary breast cancer.

Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article
Sander, K. N., Kim, D., Ortori, C. A., Warren, A. Y., Anyanwagu, U. C., Hay, D. P., …Barrett, D. A. (2019). Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome. Metabolomics, 15, 1-10. https://doi.org/10.1007/s11306-019-1600-8

Introduction Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies. Objectives As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.