Research Repository

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Human vascular cell responses to the circulating bone hormone osteocalcin (2019)
Journal Article
Millar, S. A., Anderson, S. I., & O'sullivan, S. E. (2019). Human vascular cell responses to the circulating bone hormone osteocalcin. Journal of Cellular Physiology, doi:10.1002/jcp.28707

The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothel... Read More

Association between surgeon special interest and mortality after emergency laparotomy (2019)
Journal Article
Boyd‐Carson, H., Doleman, B., Herrod, P. J. J., Anderson, I. D., Williams, J. P., Lund, J. N., …on behalf of the NELA Collaboration, . (2019). Association between surgeon special interest and mortality after emergency laparotomy. British Journal of Surgery, doi:10.1002/bjs.11146

Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are managed by general surgeons with an elective special interest focused o... Read More

International variations in blood pressure control and antihypertensive prescription patterns in chronic kidney disease (2019)
Journal Article
Alencar de Pinho, N., Levin, A., Fukagawa, M., Hoy, W. E., Pecoits-Filho, R., Reichel, H., …Stengel, B. (in press). International variations in blood pressure control and antihypertensive prescription patterns in chronic kidney disease. Kidney International,

Although blood pressure (BP) control is a major goal in chronic kidney disease (CKD), no worldwide overview of either its achievement or antihypertensive prescriptions is currently available. We compared crude prevalence of uncontrolled BP among 17 c... Read More

Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation (2019)
Journal Article
Negm, O. H., Singh, S., Abduljabbar, W., Hamed, M. R., Radford, P., McDermott, E. M., …Tighe, P. J. (2019). Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation. Clinical and Experimental Immunology, doi:10.1111/cei.13306

Tumour necrosis factor receptor‐associated periodic syndrome (TRAPS) is an hereditary autoinflammatory disorder characterised by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, which encod... Read More

The acute transcriptional response to resistance exercise: impact of age and contraction mode (2019)
Journal Article
Deane, C. S., Ames, R. M., Phillips, B. E., Weedon, M. N., Willis, C. R., Boereboom, C., …Etheridge, T. (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging, 11(7), 2111-2126. doi:10.18632/101904

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We... Read More

Sexual dimorphism of brown adipose tissue function (2019)
Journal Article
Robinson, L. J., Law, J., Astle, V., Gutiérrez García, M., Ohja, S., Symonds, M. E., …Budge, H. (2019). Sexual dimorphism of brown adipose tissue function. Journal of Pediatrics, doi:10.1016/j.jpeds.2019.03.003

Studying the Evolving Knowledge of Adverse Drug Reactions in Order to Facilitate the Rational Use of Medicines in Paediatric Patients (2019)
Journal Article
Star, K., & Choonara, I. (2019). Studying the Evolving Knowledge of Adverse Drug Reactions in Order to Facilitate the Rational Use of Medicines in Paediatric Patients. Healthcare, 7(2), doi:10.3390/healthcare7020055

Pharmacovigilance, which is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other possible drug-related problems, generates knowledge to facilitate the rational use of medicines... Read More

Surgical interventions for the treatment of sacrococcygeal pilonidal sinus disease in children: a systematic review and meta-analysis (2019)
Journal Article
Hardy, E. J. O., Herrod, P. J., Doleman, B., Phillips, H. G., Ranat, R., & Lund, J. N. (2019). Surgical interventions for the treatment of sacrococcygeal pilonidal sinus disease in children: a systematic review and meta-analysis. Journal of Pediatric Surgery, doi:10.1016/j.jpedsurg.2019.02.058

Background Pilonidal sinus disease (PNS) is not uncommon in children. Controversy remains over the best treatment and there is limited evidence. This systematic review and meta-analysis aims to establish which techniques have the best outcomes in... Read More

Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease (2019)
Journal Article
Rowe, C., Sitch, A. J., Barratt, J., Brettell, E. A., Cockwell, P., Dalton, R. N., …Lamb, E. J. (2019). Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease. Kidney International, doi:10.1016/j.kint.2019.02.021

When assessing changes in glomerular filtration rate (GFR) it is important to differentiate pathological change from intrinsic biological and analytical variation. GFR is measured using complex reference methods (e.g., iohexol clearance). In clinical... Read More

Toward common data elements for international research in long-term care homes: advancing person-centered care (2019)
Journal Article
Corazzini, K. N., Anderson, R. A., Bowers, B. J., Chu, C. H., Edvardsson, D., Fagertun, A., …Lepore, M. J. (2019). Toward common data elements for international research in long-term care homes: advancing person-centered care. Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2019.01.123

To support person-centered, residential long-term care internationally, a consortium of researchers in medicine, nursing, behavioral, and social sciences from 21 geographically and economically diverse countries have launched the WE-THRIVE consortium... Read More

Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection (2019)
Journal Article
Herrod, P. J., Boyd-Carson, H., Doleman, B., Trotter, J., Schlichtemeier, S., Sathanapally, G., …Lund, J. N. (2019). Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection. Techniques in Coloproctology, 23(2), 129–134. doi:10.1007/s10151-019-1928-0

Purpose: Radiologically-defined sarcopenia has been shown to predict negative outcomes after cancer surgery, however radiological assessment of sarcopenia often requires additional software and standardisation against anthropomorphic data. Measuring... Read More

An Organizational-Level Program of Intervention for AKI: A Pragmatic Stepped Wedge Cluster Randomized Trial (2019)
Journal Article
Selby, N. M., Casula, A., Lamming, L., Stoves, J., Samarasinghe, Y., Lewington, A. J., …Caskey, F. J. (2019). An Organizational-Level Program of Intervention for AKI: A Pragmatic Stepped Wedge Cluster Randomized Trial. Journal of the American Society of Nephrology, 30(3), 505-515. doi:10.1681/asn.2018090886

Background Variable standards of care may contribute to poor outcomes associated with AKI. We evaluated whether a multifaceted intervention (AKI e-alerts, an AKI care bundle, and an education program) would improve delivery of care and patient outc... Read More

Education of family members to support weaning to solids and nutrition in infants born preterm (Review) Education of family members to support weaning to solids and nutrition in infants born preterm (Review) (2019)
Journal Article
Elfzzani, Z., Kwok, T. C., Ojha, S., & Dorling, J. (2019). Education of family members to support weaning to solids and nutrition in infants born preterm (Review) Education of family members to support weaning to solids and nutrition in infants born preterm (Review). Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD012240.pub2

Background Weaning refers to the period of introduction of solid food to complement breast milk or formula milk. Preterm infants are known to acquire extrauterine growth restriction by the time of discharge from neonatal units. Hence, the postdisc... Read More

Modifying a paediatric rational prescribing tool (POPI) for use in the UK (2019)
Journal Article
Corrick, F., Choonara, I., Conroy, S., & Sammons, H. (2019). Modifying a paediatric rational prescribing tool (POPI) for use in the UK. Healthcare, 7(1), doi:10.3390/healthcare7010033

Rational prescribing tools can be used by individual prescribers, organisations, and researchers to evaluate the quality of prescribing for research and quality improvement purposes. A literature search showed that there is only one tool for evaluati... Read More

Higher education outreach: examining key challenges for academics (2019)
Journal Article
Johnson, M., Danvers, E., Hinton-Smith, T., Atkinson, K., Bowden, G., Foster, J., …Williams, S. (2019). Higher education outreach: examining key challenges for academics. British Journal of Educational Studies, 1-23. doi:10.1080/00071005.2019.1572101

How should academic staff engage in outreach with communities outside of the university? The need of academics to answer this question has intensified in the UK given the changing priorities of academic job roles, shaped by increasing institutional c... Read More

Liver kinase B1—a potential therapeutic target in hormone-sensitive breast cancer in older women (2019)
Journal Article
Syed, B. M., Green, A. R., Morgan, D. A., Ellis, I. O., & Cheung, K. (2019). Liver kinase B1—a potential therapeutic target in hormone-sensitive breast cancer in older women. Cancers, 11(2), 1-17. doi:10.3390/cancers11020149

Background: The role of liver kinase B1 (LKB1), a serine/threonine kinase, has been described in the development of PeutzJagher’s syndrome, where a proportion (~45%) of patients have developed breast cancer in their lifetime. Cell line studies have l... Read More

Liver kinase B1 (LKB1) – a potential therapeutic target in hormone sensitive breast cancer in older women (2019)
Journal Article
Syed, B. M., Green, A. R., Morgan, D. A., Ellis, I. O., & Cheung, K. (2019). Liver kinase B1 (LKB1) – a potential therapeutic target in hormone sensitive breast cancer in older women. Cancers, 11(2), 1-17

Background: The role of liver kinase B1 (LKB1), a serine/threonine kinase, has been described in the development of PeutzJagher’s syndrome, where a proportion (~45%) of patients have developed breast cancer in their lifetime. Cell line studies have l... Read More

Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort (2019)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort. American Journal of Nephrology, 49(2), 146-155. doi:10.1159/000496276

Background: Overt albuminuria (urinary albumin-creatinine ratio (ACR) >300mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether, a reduction in ACR translates into a reduction in mortality and/or car... Read More