Research Repository

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MeMa: Designing the Memory Machine (2019)
Conference Proceeding
Price, D., Jacobs, R., Darzentas, D., Perez Vallejos, E., Chadborn, N., Martindale, S., & Urquhart, L. (2019). MeMa: Designing the Memory Machine. In Companion Publication of the 2019 on Designing Interactive Systems Conference 2019 Companion, 271--276. doi:10.1145/3301019.3323882

The Memory Machine is an ambitious project that aims to develop a device to capture people's memories to create a blend of personal and factual data that builds identities, and contextualizes personal recollections. The Memory Machine has been guided... Read More

Skin autofluorescence: an emerging biomarker in persons with kidney disease (2019)
Journal Article
Viramontes Horner, D., & Taal, M. W. (in press). Skin autofluorescence: an emerging biomarker in persons with kidney disease. Current Opinion in Nephrology and Hypertension,

Purpose of review: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of “cumulative metabolic stress”. This paper discusses mechanisms of AGE formation and reviews publi... Read More

Early-Stage Breast Cancer in Older Adults (2019)
Book Chapter
Cheung, K., Livi, L., & Brain, E. (2019). Early-Stage Breast Cancer in Older Adults. In M. Extermann (Ed.), Geriatric Oncology, 1-10. Springer. doi:10.1007/978-3-319-44870-1_33-1

Breast cancer is the most common cancer afflicting women worldwide. Its incidence peaks around 70, while mortality increases greatly after 75 years old. Given the competing risks on mortality with multimorbidities, geriatric assessment is a leitmotiv... Read More

Effect of bariatric surgery on cardiovascular events and metabolic outcomes in obese patients with insulin-treated type 2 diabetes: a retrospective cohort study (2019)
Journal Article
Alkharaiji, M., Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Effect of bariatric surgery on cardiovascular events and metabolic outcomes in obese patients with insulin-treated type 2 diabetes: a retrospective cohort study. Obesity Surgery, doi:10.1007/s11695-019-03809-4

Aims: To compare non-fatal cardiovascular (CV) events and metabolic outcomes, among obese patients with insulin-treated type 2 diabetes who underwent bariatric surgery compared to a propensity matched non-bariatric cohort. Methods: A retrospective... Read More

Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients (2019)
Journal Article
Thomas, P. W., Blackwell, J. E. M., Herrod, P. J. J., Peacock, O., Singh, R., Williams, J. P., …Lund, J. N. (2019). Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients. Techniques in Coloproctology, 1-7. doi:10.1007/s10151-019-02056-0

Background Current evidence suggests that pelvic floor reconstruction following extralevator abdominoperineal excision of rectum (ELAPER) may reduce the risk of perineal herniation of intra-abdominal contents. Options for reconstruction include mesh... Read More

A statistical and biological response to an informatics appraisal of healthy aging gene signatures (2019)
Journal Article
Timmons, J. A., Gallagher, I. J., Sood, S., Phillips, B., Crossland, H., Howard, R., …Atherton, P. J. (2019). A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20(1), 1-4. doi:10.1186/s13059-019-1734-z

Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. Read More

The impact of uterine artery embolization on ovarian reserve: a systematic review and meta‐analysis (2019)
Journal Article
El Shamy, T., Amer, S., Mohamed, A., James, C., & Jayaprakasan, K. (2019). The impact of uterine artery embolization on ovarian reserve: a systematic review and meta‐analysis. Acta Obstetricia et Gynecologica Scandinavica, doi:10.1111/aogs.13698

Introduction: In the recent years, uterine artery embolisation (UAE) has been gaining increasing popularity as an effective and minimally invasive treatment for uterine fibroids. However, there has been a growing concern over the risk of unintended e... Read More

International variations in blood pressure control and antihypertensive prescription patterns in chronic kidney disease (2019)
Journal Article
Alencar de Pinho, N., Levin, A., Fukagawa, M., Hoy, W. E., Pecoits-Filho, R., Reichel, H., …Stengel, B. (2019). International variations in blood pressure control and antihypertensive prescription patterns in chronic kidney disease. Kidney International, doi:10.1016/j.kint.2019.04.032

Although blood pressure (BP) control is a major goal in chronic kidney disease (CKD), no worldwide overview of either its achievement or antihypertensive prescriptions is currently available. We compared crude prevalence of uncontrolled BP among 17 c... Read More

Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2 (2019)
Journal Article
Millar, S. A., Anderson, S. I., & O'Sullivan, S. E. (2019). Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2. PeerJ, 7, doi:10.7717/peerj.7139

Bone-derived factors that demonstrate extra-skeletal functions, also termed osteokines, are fast becoming a highly interesting and focused area of cross-disciplinary endocrine research. Osteocalcin (OCN), fibroblast growth factor-23 (FGF23) and lipoc... Read More

The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats (2019)
Journal Article
Khalaf, H. A., Elmorsy, E., Mahmoud, E. M., Aggour, A. M., & Amer, S. A. (2019). The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats. Cell and Tissue Research, doi:10.1007/s00441-019-03067-x

Oxidative stress has been implicated in reproductive toxicity induced by antipsychotics (APs). This study aims to further investigate the role of AP-induced oxidative stress in reproductive dysfunction. Thirty adult female albino rats were divided in... Read More

Unconditional and conditional monetary incentives to increase response to mailed questionnaires: a randomised controlled study within a trial (SWAT) (2019)
Journal Article
Young, B., Bedford, L., das Nair, R., Gallant, S., Littleford, R., Robertson, J. F., …ECLS Study Team, . (2019). Unconditional and conditional monetary incentives to increase response to mailed questionnaires: a randomised controlled study within a trial (SWAT). Journal of Evaluation in Clinical Practice, doi:10.1111/jep.13230

Rationale, aims, and objectives: High response rates to research questionnaires can help to ensure results are more representative of the population studied and provide increased statistical power, on which the study may have been predicated. Improvi... Read More

Differential Stimulation of Post-Exercise Myofibrillar Protein Synthesis in Humans Following Isonitrogenous, Isocaloric Pre-Exercise Feeding (2019)
Journal Article
Davies, R. W., Bass, J. J., Carson, B. P., Norton, C., Kozior, M., Amigo-Benavent, M., …Jakeman, P. M. (2019). Differential Stimulation of Post-Exercise Myofibrillar Protein Synthesis in Humans Following Isonitrogenous, Isocaloric Pre-Exercise Feeding. Nutrients, 11(7), doi:10.3390/nu11071657

The aim of this study was to test the effects of two disparate isonitrogenous, isocaloric pre-exercise feeds on deuterium-oxide (D2O) derived measures of myofibrillar protein synthesis (myoPS) in humans. Methods: In a double-blind parallel group desi... Read More

Determinants of change in Arterial Stiffness over 5 years in Early Chronic Kidney Disease (2019)
Journal Article
Mcintyre, N., Shardlow, A., Fluck, R., Mcintyre, C., & Taal, M. (in press). Determinants of change in Arterial Stiffness over 5 years in Early Chronic Kidney Disease. Nephrology Dialysis Transplantation,

Background Arterial stiffness is an established and potentially modifiable risk factor for cardiovascular disease, associated with chronic kidney disease. There have been few studies to evaluate progression of arterial stiffness over time or factors... Read More

Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review (2019)
Journal Article
Amer, S. A., James, C., Al-Hussaini, T. K., & Mohamed, A. A. (2019). Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review. Journal of Women's Health, doi:10.1089/jwh.2019.7733

Background: The status of ovarian reserve markers during hormonal contraception (HC) remains uncertain with conflicting literature data. The purpose of this study was to assess the impact of HC on circulating anti-Müllerian hormone (AMH) and other ov... Read More

Chronic Kidney Disease: call for an age-adapted definition (2019)
Journal Article
Delanaye, P., Jager, K. J., Bökenkamp, A., Christensson, A., Dubourg, L., Eriksen, B. O., …van den Brand, J. A. (in press). Chronic Kidney Disease: call for an age-adapted definition. Journal of the American Society of Nephrology,

Current criteria for the diagnosis of chronic kidney disease (CKD) in adults include persistent signs of kidney damage; for example, increased urine albumin-to-creatinine ratio or a glomerular filtration rate (GFR) below the threshold of 60 mL/min pe... Read More

Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging (2019)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., McCulloch, T., Prestwich, B. L., Taal, M. W., …Francis, S. T. (2019). Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging. Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfz129

BACKGROUND: Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated... Read More

A systematic review of cannabidiol dosing in clinical populations (2019)
Journal Article
Millar, S. A., Stone, N., Bellman, Z., Yates, A., England, T. .., & O'Sullivan, S. (2019). A systematic review of cannabidiol dosing in clinical populations. British Journal of Clinical Pharmacology, doi:10.1111/bcp.14038

Aims: Cannabidiol is a cannabis-derived medicinal product with potential application in a wide-variety of contexts, however its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied... Read More

Safety of azithromycin in paediatrics: a systematic review protocol (2019)
Journal Article
Xu, P., Zeng, L., Xiong, T., Choonara, I., Qazi, S., & Zhang, L. (2019). Safety of azithromycin in paediatrics: a systematic review protocol. BMJ Paediatrics Open, 3(1), doi:10.1136/bmjpo-2019-000469

Introduction: Azithromycin is widely used in children not only in the treatment of individual children with infectious diseases, but also as mass drug administration (MDA) within a community to eradicate or control specific tropical diseases. MDA has... Read More