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Toward common data elements for international research in long-term care homes: advancing person-centered care (2019)
Journal Article
Corazzini, K. N., Anderson, R. A., Bowers, B. J., Chu, C. H., Edvardsson, D., Fagertun, A., …Lepore, M. J. (2019). Toward common data elements for international research in long-term care homes: advancing person-centered care. Journal of the American Medical Directors Association, doi:10.1016/j.jamda.2019.01.123

To support person-centered, residential long-term care internationally, a consortium of researchers in medicine, nursing, behavioral, and social sciences from 21 geographically and economically diverse countries have launched the WE-THRIVE consortium... Read More

Education of family members to support weaning to solids and nutrition in infants born preterm (Review) Education of family members to support weaning to solids and nutrition in infants born preterm (Review) (2019)
Journal Article
Elfzzani, Z., Kwok, T. C., Ojha, S., & Dorling, J. (2019). Education of family members to support weaning to solids and nutrition in infants born preterm (Review) Education of family members to support weaning to solids and nutrition in infants born preterm (Review). Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD012240.pub2

Background Weaning refers to the period of introduction of solid food to complement breast milk or formula milk. Preterm infants are known to acquire extrauterine growth restriction by the time of discharge from neonatal units. Hence, the postdisc... Read More

Modifying a paediatric rational prescribing tool (POPI) for use in the UK (2019)
Journal Article
Corrick, F., Choonara, I., Conroy, S., & Sammons, H. (2019). Modifying a paediatric rational prescribing tool (POPI) for use in the UK. Healthcare, 7(1), doi:10.3390/healthcare7010033

Rational prescribing tools can be used by individual prescribers, organisations, and researchers to evaluate the quality of prescribing for research and quality improvement purposes. A literature search showed that there is only one tool for evaluati... Read More

Higher education outreach: examining key challenges for academics (2019)
Journal Article
Johnson, M., Danvers, E., Hinton-Smith, T., Atkinson, K., Bowden, G., Foster, J., …Williams, S. (2019). Higher education outreach: examining key challenges for academics. British Journal of Educational Studies, 1-23. doi:10.1080/00071005.2019.1572101

How should academic staff engage in outreach with communities outside of the university? The need of academics to answer this question has intensified in the UK given the changing priorities of academic job roles, shaped by increasing institutional c... Read More

Liver kinase B1—a potential therapeutic target in hormone-sensitive breast cancer in older women (2019)
Journal Article
Syed, B. M., Green, A. R., Morgan, D. A., Ellis, I. O., & Cheung, K. (2019). Liver kinase B1—a potential therapeutic target in hormone-sensitive breast cancer in older women. Cancers, 11(2), 1-17. doi:10.3390/cancers11020149

Background: The role of liver kinase B1 (LKB1), a serine/threonine kinase, has been described in the development of PeutzJagher’s syndrome, where a proportion (~45%) of patients have developed breast cancer in their lifetime. Cell line studies have l... Read More

Liver kinase B1 (LKB1) – a potential therapeutic target in hormone sensitive breast cancer in older women (2019)
Journal Article
Syed, B. M., Green, A. R., Morgan, D. A., Ellis, I. O., & Cheung, K. (2019). Liver kinase B1 (LKB1) – a potential therapeutic target in hormone sensitive breast cancer in older women. Cancers, 11(2), 1-17

Background: The role of liver kinase B1 (LKB1), a serine/threonine kinase, has been described in the development of PeutzJagher’s syndrome, where a proportion (~45%) of patients have developed breast cancer in their lifetime. Cell line studies have l... Read More

Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort (2019)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort. American Journal of Nephrology, 49(2), 146-155. doi:10.1159/000496276

Background: Overt albuminuria (urinary albumin-creatinine ratio (ACR) >300mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether, a reduction in ACR translates into a reduction in mortality and/or car... Read More

Measuring health related quality of life of care home residents: comparison of self-report with staff proxy responses (2019)
Journal Article
Usman, A., Lewis, S., Hinsliff-Smith, K., Long, A., Housley, G., Jordan, J., …Gordon, A. L. (2019). Measuring health related quality of life of care home residents: comparison of self-report with staff proxy responses. Age and Ageing, doi:10.1093/ageing/afy191

Introduction: Care home residents are often unable to complete Health Related Quality of Life questionnaires for themselves because of prevalent cognitive impairment. This study compared care home resident and staff proxy responses for two measures,... Read More

Worms in space for outreach on earth: space life science activities for the classroom (2018)
Journal Article
Gaffney, C. J., Pollard, A. K., Deane, C. S., Cooke, M., Balsamo, M., Hewitt, J., …Phillips, B. E. (2018). Worms in space for outreach on earth: space life science activities for the classroom. Gravitational and space research : publication of the American Society for Gravitational and Space Research, 6(2), 74-82

Long term spaceflight is associated with the loss of skeletal muscle mass and function. The Molecular Muscle Experiment (MME) seeks to identify the causes of muscle decline in space and test potential therapies to attenuate this in the microscopic wo... Read More

Effect of non-meat, high protein supplementation on quality of life and clinical outcomes for older people living in care homes: systematic review and meta-analysis (2018)
Journal Article
Donaldson, A., Smith, T. O., Alder, S., Johnstone, A. M., De Roos, B., Aucott, L. S., …Myint, P. K. (2019). Effect of non-meat, high protein supplementation on quality of life and clinical outcomes for older people living in care homes: systematic review and meta-analysis. Nutrition Reviews, 77(2), 116-127. doi:10.1093/nutrit/nuy061

CONTEXT: Care home residents are at risk of malnutrition through reduced overall food intake, ‘anabolic resistance’ in ageing muscle and high prevalence of medical morbidity and functional dependency. There has been limited consensus regarding effect... Read More

A systematic review on the pharmacokinetics of cannabidiol in humans (2018)
Journal Article
Millar, S. A., Stone, N. L., Yates, A. S., & O 'Sullivan, S. E. (2018). A systematic review on the pharmacokinetics of cannabidiol in humans. Frontiers in Pharmacology, 9, 1-13

Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to colla... Read More

Determinants of motivation to quit in smokers screened for the early detection of lung cancer: a qualitative study (2018)
Journal Article
Young, B., Vedhara, K., Kendrick, D., Littleford, R., Robertson, J. F. R., Sullivan, F. M., …in collaboration with the ECLS study team, . (2018). Determinants of motivation to quit in smokers screened for the early detection of lung cancer: a qualitative study. BMC Public Health, 18(1), doi:10.1186/s12889-018-6211-1

Background: The promotion of smoking cessation within lung cancer screening could lead to benefits for smoking-related disease and improve cost-effectiveness of screening. Little is known about how smokers respond to lung cancer screening and how thi... Read More

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans (2018)
Journal Article
Gaffney, C. J., Pollard, A., Barratt, T. F., Constantin-Teodosiu, D., Greenhaff, P. L., & Szewczyk, N. J. (2018). Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans. Aging, 10(11), 3382-3396. doi:10.18632/aging.101654

Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here,... Read More

Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice (2018)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2018). Individual and combined relationship between reduced eGFR and/or increased urinary albumin excretion rate with mortality risk among insulin treated patients with Type 2 diabetes in routine practice. Kidney Diseases, doi:10.1159/000493731

Background: Low estimated glomerular filtration rate (eGFR) and increased urinary albumin-to-creatinine ratio (ACR) are well-recognised prognostic markers of cardiovascular (CV) risk, but their individual and combine relationship with CV disease and... Read More

A quality improvement collaborative aiming for Proactive HEAlthcare of Older People in Care Homes (PEACH): a realist evaluation protocol (2018)
Journal Article
Devi, R., Meyer, J., Banerjee, J., Goodman, C., Gladman, J. R., Dening, T., …Gordon, A. L. (2018). A quality improvement collaborative aiming for Proactive HEAlthcare of Older People in Care Homes (PEACH): a realist evaluation protocol. BMJ Open, 8(11), doi:10.1136/ bmjopen-2018-02328

Introduction: This protocol describes a study of a Quality Improvement Collaborative (QIC) to support implementation and delivery of Comprehensive Geriatric Assessment (CGA) in UK care homes. The QIC will be formed of health and social care professio... Read More

Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease (2018)
Journal Article
Sian, T., Herrod, P., Blackwell, J., Hardy, E., & Lund, J. (2018). Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease. Techniques in Coloproctology, doi:10.1007/s10151-018-1864-4

Background Pilonidal sinus disease (PSD) is a common, chronic inflammatory condition involving hair follicles within the natal cleft. It mainly affects young males and creates a significant health, social and economic burden. Traditional surgery i... Read More

Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs (2018)
Journal Article
Hewitt, J. E., Pollard, A. K., Lesanpezeshki, L., Deane, C. S., Gaffney, C. J., Etheridge, T., …Vanapalli, S. A. (2018). Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs. Disease Models and Mechanisms, 11(12), doi:10.1242/dmm.036137

Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies including Duchenne and Becker muscular dystrophies. Although Caenorhabditis elegans is an established genetic model for studying mechanisms and... Read More

Tier 3 specialist weight management service and pre-bariatric multicomponent weight management programmes for adults with obesity living in the UK: a systemic review (2018)
Journal Article
Alkharaiji, M., Anyanwagu, U., Donnelly, R., & Idris, I. (2019). Tier 3 specialist weight management service and pre-bariatric multicomponent weight management programmes for adults with obesity living in the UK: a systemic review. Endocrinology, Diabetes and Metabolism, 2(1), doi:10.1002/edm2.42

Background: NHS England has recommended a multidisciplinary weight management services (MWMS -Tier 3 services) for patients requiring specialised management of obesity, including bariatric surgery, but clinical and measurable health-related outcomes... Read More

The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis (2018)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2019). The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis. Journal of Renal Nutrition, 29(2), 149-155. doi:10.1053/j.jrn.2018.07.004 hideArticle Info

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from hyperglycemia, oxidative stress and systemic inflammation. AGEs are also formed in food during cooking. On the other hand, malnutrition may contribute to AGE formati... Read More

Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants (2018)
Journal Article
Nasuf, A. W. A., Ojha, S., & Dorling, J. (2018). Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants. Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD011921.pub2

Background Placing a small volume of colostrum directly onto the buccal mucosa of preterm infants during the early neonatal period may provide immunological and growth factors that stimulate the immune system and enhance intestinal growth. These ben... Read More