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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis (2021)
Journal Article
Aboeldalyl, S., James, C., Seyam, E., Ibrahim, E. M., Shawki, H. E., & Amer, S. (2021). The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 22(5), Article 2734. https://doi.org/10.3390/ijms22052734

Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the in... Read More about The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis.

First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis (2019)
Journal Article
Wang, R., Li, W., Bordewijk, E. M., Legro, R. S., Zhang, H., Wu, X., …the International Ovulation Induction IPDMA Collaboration. (2019). First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update, 25(6), 717-732. https://doi.org/10.1093/humupd/dmz029

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most frequent cause of anovulatory infertility. In women with PCOS, effective ovulation induction serves as an important first-line treatment for anovulatory infertility. Individual participant data... Read More about First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis.

The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis (2019)
Journal Article
El Shamy, T., Amer, S. A., Mohamed, A., James, C., & Jayaprakasan, K. (2020). The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 99(1), 16-23. https://doi.org/10.1111/aogs.13698

Introduction: Uterine artery embolization (UAE) has been gaining increasing popularity as an effective and minimally invasive treatment for uterine fibroids. However, there has been growing concern over the risk of unintended embolization of the uter... Read More about The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis.

The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats (2019)
Journal Article
Khalaf, H. A., Elmorsy, E., Mahmoud, E. M., Aggour, A. M., & Amer, S. A. (2019). The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats. Cell and Tissue Research, 378(2), 371-383. https://doi.org/10.1007/s00441-019-03067-x

Oxidative stress has been implicated in reproductive toxicity induced by antipsychotics (APs). This study aims to further investigate the role of AP-induced oxidative stress in reproductive dysfunction. Thirty adult female albino rats were divided in... Read More about The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats.

Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review (2019)
Journal Article
Amer, S. A., James, C., Al-Hussaini, T. K., & Mohamed, A. A. (2019). Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review. Journal of Women's Health, 29(1), 100-110. https://doi.org/10.1089/jwh.2019.7733

Background: The status of ovarian reserve markers during hormonal contraception (HC) remains uncertain with conflicting literature data. The purpose of this study was to assess the impact of HC on circulating anti-Müllerian hormone (AMH) and other ov... Read More about Assessment of Circulating Anti-Müllerian Hormone in Women Using Hormonal Contraception: A Systematic Review.

The role of oxidative stress in antipsychotics induced ovarian toxicity (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Aggour, A. M., Khan, R., & Amer, S. A. (2017). The role of oxidative stress in antipsychotics induced ovarian toxicity. Toxicology in Vitro, 44, https://doi.org/10.1016/j.tiv.2017.07.008

This study tested the hypothesis that oxidative stress could be an underlying mechanism for APs-induced ovarian cytotoxicity and reproductive dysfunction. Rat ovarian theca interstitial cells (TICs) were isolated and treated with four APs [chlorproma... Read More about The role of oxidative stress in antipsychotics induced ovarian toxicity.

Ovarian reserve after salpingectomy: a systematic review and meta-analysis (2017)
Journal Article
Mohamed, A. A., Yosef, A. H., James, C., Al-Hussaini, T. K., Bedaiwy, M. A., & Amer, S. A. (2017). Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 96(7), 795-803. https://doi.org/10.1111/aogs.13133

Introduction Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may comprom... Read More about Ovarian reserve after salpingectomy: a systematic review and meta-analysis.

The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review (2016)
Journal Article
Mohamed, A. A., Al-Hussaini, T. K., Fathalla, M. M., El Shamy, T. T., Abdelaal, I. I., & Amer, S. A. (2016). The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review. American Journal of Obstetrics and Gynecology, 215(2), https://doi.org/10.1016/j.ajog.2016.03.045

Background Benign nonendometriotic ovarian cysts are very common and often require surgical excision. However, there has been a growing concern over the possible damaging effect of this surgery on ovarian reserve. Objective The aim of this m... Read More about The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review.

Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome (2016)
Journal Article
Cadagan, D., Khan, R., & Amer, S. A. (2016). Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Reproductive Biology -Olsztyn-, 16(1), https://doi.org/10.1016/j.repbio.2015.12.006

This study examined whether a defect of steroid synthesis in ovarian theca cells may lead to the development of PCOS, through contributions to excess androgen secretion. Polycystic ovarian syndrome (PCOS) is one of the leading causes of infertilit... Read More about Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome.

The impact of endometrioma and its surgical treatment on ovarian reserve and reproductive performance (2015)
Book Chapter
Amer, S. A. K. (2015). The impact of endometrioma and its surgical treatment on ovarian reserve and reproductive performance. In M. Metwally, & T. Li (Eds.), Reproductive Surgery in Assisted Conception (43-57). Springer London. https://doi.org/10.1007/978-1-4471-4953-8_5

Endometriomas, which are commonly encountered in women presenting with subfertility, usually represent a dilemma to the Reproductive Specialist. Surgery remains the only effective treatment for endometriomas larger than three cm in diameter. National... Read More about The impact of endometrioma and its surgical treatment on ovarian reserve and reproductive performance.

Laparoscopic ovarian drilling (2015)
Book Chapter
Amer, S. A. K. (2015). Laparoscopic ovarian drilling. In M. Metwally, & T. Li (Eds.), Reproductive Surgery in Assisted Conception (61-71). Springer London. https://doi.org/10.1007/978-1-4471-4953-8_6

Laparoscopic ovarian drilling has been widely accepted as the second line of choice for induction of ovulation in CC-resistant PCOS women in preference to gonadotrophin therapy. In addition to its proven efficacy, LOD offers several advantages over g... Read More about Laparoscopic ovarian drilling.