Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Bath, Philip M.W.; Christensen, L M; Woodhouse, Lisa J.; Bentsen, L; Appleton, Jason P.; Krarup Hansen, C; Beridze, M.; Thomsen, T T; Christensen, Hanne; Kruuse, C; Dineen, Robert A.; Jensen, H H; Duley, Lelia; Hansen, S S; England, Timothy J.; Petrovic, V; Flaherty, Katie; Beridze, N; Havard, Diane; Kakabadze, N; Heptinstall, Stan; Kherkheulidze, T; James, Marilyn; Kakabadze, D; Krishnan, Kailash; Toidze, I; Markus, H.S.; Lobjanidze, N; Montgomery, Alan A.; Akiashvili, N; Pocock, Stuart J.; ATevdoradze; Randall, Marc; Khizanishvili, N; Ranta, A.; Tsanava, T; Robinson, Thompson G.; Taylor, R; Scutt, Polly; Iniesta, I; Venables, Graham S.; Kok, J; Sprigg, Nikola; Duignan, J; Funnell, M; Cariga, P; Rodriguez, M; Watson, I J; Tennant, S; Macleod, M; Furnace, J; Gow, H; Irvine, J; Joyson, A; Nelson, S; Taylor, V; Smith, M; Bellfield, R; Hairsine, B; Davies, R; Dodd, A; Corrigan, J; Doherty, M; Ahmed, A; Denniss, C; Johnson-Holland, S; Kay, K A; Icart Palau, R; Auld, G; Daboo, P; Erande, R; Grimwood, G; Hove, D; Howaniec, L; Redjep, O; Rangasamay, R; Butt, G; Sandler, D; Reddan, J; Stafford, S; McIlmoyle, J; Maguire, S; Murphy, P; Chambers, J; Guthrie, L; Osborn, M; Steele, A; Burn, M; Benford, A; Misra, A; Hilton, D; O'Brien, E; Amis, E; Finlay, S; Mitchell, J; Geraghty, O; Harvey, K; Hazel, B; Mashate, S; Wilding, P; Sajid, M; Ball, M; Gascoyne, R; Sivakumar, R; Wright, A; Chatterjee, K; Booth, S; Eccleson, H; Kelly, C; Leason, S; Perkins, C; Bruce, D; Brown, E; Clayton, S; Garside, M; Rogers, G; Lawrence, E; Mahmood, S; Watchurst, C; Chadha, D; Glover, L; Holford, L; Smith, K; Walstow, D; Williams, R; O'Shea, L; Goodsell, J; Athulathmudali, C; Barbon, E; Namushi, R; Jacob, P; Johnson, L; Morse, D; McGhee, C; Speirs, O; Atkinson, S; Peacocke, A; Langhorne, P; Graham, R; Wright, F; McAlpine, C; Ravindrane, A; Bajoriene, M; Matter, L; Windebank, S; Giallombardo, E; Dellafera, D; Eglinton, C; Wilson, J; Broughton, D; Chapman, K; Dixon, L; Zaidi, M; Ayes, K; Kessell, J; Manawadu, D; Adegbaju, O; Aeron-Thomas, J; Anderson, K; Brigden, A; Cattermole, E; Good, J; Hassan, S; Khoromana, E; Lee-Carbon, L; Marks, K; Mckenzie, E; Sikondari, N; Cooper, M; Whysall, K; Wynter, I; Bamford, J; Hassan, A; Wanklyn, P; Kambafwile, M; Makawa, L; Waugh, D; Veraque, E; Soliman, M G G; Arif, S; Brown, R; Butler, S; Hewitt, C; Hindle, J; Pusalkar, A; Beadle, H; Chan, K; Siddiqui, M; Dangri, P; Buddha, S; Asokanathan, A; Mistri, A; Eveson, D; Musarrat, K; Manning, L; Anand, S; Christian, P; Khan, S; Patel, C; Sein, M; Banns, J; Gibson, E; Gordon, T; Gruenbeck, Y; Wong, S; Datta, P; Bateman, G; Jackson, L; Needle, A; Duodu, Y; Oliver, R; Padilla-Harris, C; Barber, M; Esson, D; Brodie, F; McInnes, C; Fotherby, K; Butler, D; Morgan, D; Preece, K; Willberry, A; Dent, M; Hammonds, F; Hunt, J; Vernon, C; O'Kane, D; Faola, F; Lai, P; O'Callaghan, J; Smith, C; Price, C; Lakey, R; Riddell, V; Smith, A; Storey, G; Munshi, S; Buck, A; Clarke, J; Gilzeane, N; Godfrey, M; Keshvara, R; Richardson, C; Roffe, J; Ryan, L; Shelton, F; Sunman, W; Tittle, A; Tomlinson, J; Whittamore, K; Wilkes, G; Owusu-Agyei, P; Temple, N; Mangion, D; Hardwick, A; Netherton, K; MohdNor, A; Hyams, B; Norman, S; Persad, N; Ragab, S; Dickson, C; Dube, J; Jinks, E; Knops, K; Wadams, B; Ali, K; Gaylard, J; Spurling, G; Sztriha, L; Ajao, T; Alao, M; KChan, F; Webster, P; HowardT JDobson, P; Hyatt, L; Sims, D; Cunningham, J; Esisi, B; Cassidy, T; Bokhari, M; McClelland, B; Mokoena, B; Gunathilagan, G; Jones, S; Reader, M; Thomas, G; Tilby, S; Findlay, P; Barrett, F; Leslie, F; Ross, S; Shread, I; Okwera, J; Howe, J; Harrington, F; Courtauld, G; Schofield, C; Donnelly, R; Maddula, M; Scott, J; Beavan, J; Muhidden, K; Memon, I; Clarke, M; Hedstrom, A; Mills, L; Hemsley, A; Bowring, A; Boxall, L; Kingwell, H; Keenan, S; Roughan, C; Manoj, A; Cox, P; Fletcher, G; Lopez, P; Emsley, H; Gregary, B; McLoughlin, A; Raj, S; Roffe, C; Abano, N; Barry, A; Butler, A; Carpio, R; Castro, K; Finney, K; Gomm, S; Hiden, J; Grocott, J; Lyjko, S; Maguire, H; Remegoso, A; Sanyal, R; Stevens, S; Natarajan, I; Chembala, J; Muddegowda, G; Warusevitane, A; Blight, A; Balazikova, O; Lawlor, C; Shaw, L; Button, D; Howcroft, D; Lucas, S; Madigan, B; McCann, S; Dixit, A; Barkat, A; Davis, J; Fawcett, M; Finlay, L; Guy, H; Hays, C; Hogg, V; Horsley, E; Hubbuck, C; Pringle, C; Stevenson, C; Storey, K; Thompson, T; Woodward, S; Banerjee, A; Allcock, C; Merotra, S; Douglass, C; Campbell, E; Jarapa, R; Johnes, M; Keaveney, C; Marsden, T; Naing, Z; Perez, J; Shaw, K; Black, T; Anthony, A; Clarke, C; Paterson, J; Deighton, K; Temlett, E; Blank, C; Doyle, C; Duty, S; Gill, K; Harkness, K; Kamara, C; Richards, E; Elfandi, K; Guyler, P; Harman, P; Khuoge, C; Kunhunny, S; Tysoe, S; Moynihan, B; Adedoyin, T; Chopra, N; Dayal, N; Ghatala, R; Jeyaraj, N; Jones, I; Kennedy, F; Kerin, L; Khanom, N; Lewis, S; Maheswaran, S; Montague, L; Niemierko, M; O'Reilly, J; Trippier, S; Watson, F; Wilkinson, P; Young, E; Dizayee, K; Cochrane, H; O'Connell, J; Mokoena, L; Osborne, E; Nair, A; Greig, J; Jenkins, C; Powell, J; Price, F; Chowdhury, M; Brixey, S; Hunt, L; Rands, N; Rose, G; Stoddart, S; Srinivasan, M; Motherwell, N; Shekhar, R; Fuller, T; Lankester, A; Lingwood, P; Rankin, C; Webb, H; Jupp, B; Bell, J; Hann, G; Longland, B; Ovington, C; Bhaskaran, B; Ayres, G; Bailey, C; Bearne, H; Buxton, J; Fitzell, P; Hilaire, C; Kelly, D; Szabo, S; Tomlin, D; Gamble, E; Charles, B; Kumar, R; Fluskey, T; Mellor, Z; Peters, J; Sutton, V; Kenton, A; Martin, I; Nyabadza, S; Ghosh, S; Henry, M; Kumar, B; Bruce, D; Ambulo, C; Crawford, S; Nozedar, T; Platton, M; Cvoro, V; Couser, M; McCormick, K; Wilkinson, D; Javaid, K; Hurdowar, S; Attygalle, T; Sundayi, S; Orugun, O; Crowther, H; Jolly, R; Poultney, U; Azim, A; Krasinska-Chavez, M; White, J; Sengupta, N; Margalef, J; Metiu, M G; Meenakshisundaram, S; Dealing, S; Hargroves, D; Beranova, E; Cowie, L; Rudenko, H; Thomson, A; Verrion, A; Rashed, K; Board, S; Buckley, C; Hayward, D; Jenkins, K; Keeling, E; Rowland-Axe, R; Vickers, C; Wood, D; Lehman, A; Erande, R; Patel, M; Russell, H; Rehman, H; Forrest, D; Farren, P

doi:10.1016/S0140-6736(17)32849-0

All Outputs (6)

Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial (2022)
Journal Article
Bath, P. M., Skinner, C. J. C., Bath, C. S., Woodhouse, L. J., Areti, A., Korovesi, K., …Gordon, A. L. (2022). Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial. European Geriatric Medicine, 13, 1343-1355. https://doi.org/10.1007/s41999-022-00714-5

Purpose Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in ca... Read More about Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial.

The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure (2022)
Journal Article
Gordon, A. L., Rick, C., Juszczak, E., Montgomery, A., Howard, R., Guthrie, B., …Tate, V. (2022). The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure. Age and Ageing, 51(3), Article afac052. https://doi.org/10.1093/ageing/afac052

The COVID-19 pandemic resulted in catastrophic levels of morbidity and mortality for care home residents. Despite this, research platforms for COVID-19 in care homes arrived late in the pandemic compared with other care settings. The Prophylactic The... Read More about The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure.

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article
Bath, P. M., Woodhouse, L. J., Krishnan, K., Appleton, J. P., Anderson, C. S., Berge, E., …Sprigg, N. (2019). Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage. Stroke, 50(11), 3064-3071. https://doi.org/10.1161/STROKEAHA.119.026389

Background and Purpose— Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset. Methods— We undertook a multicentre, paramedic-delivered, ambulance-based, prospective ran... Read More about Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage.

Full Milk Feeds from Day 1 (2019)
Journal Article
Ojha, S., Mitchell, E., Montgomery, A., & Dorling, J. (2019). Full Milk Feeds from Day 1. Neonatology, 116(1), https://doi.org/10.1159/000499676

Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: The TARDIS RCT (2018)
Journal Article
Bath, P. M., Woodhouse, L. J., Appleton, J. P., Beridze, M., Christensen, H., Dineen, R. A., …Sprigg, N. (2018). Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: The TARDIS RCT. Health Technology Assessment, 22(48), 1-75. https://doi.org/10.3310/hta22480

© Queen’s Printer and Controller of HMSO 2018. Background: Two antiplatelet agents are better than one for preventing recurrent stroke after acute ischaemic stroke or transient ischaemic attack (TIA). Therefore, intensive treatment with three agents... Read More about Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: The TARDIS RCT.

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial (2017)
Journal Article
Bath, P. M., Christensen, L. M., Woodhouse, L. J., Bentsen, L., Appleton, J. P., Krarup Hansen, C., …Farren, P. (2018). Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, 391(10123), 850-859. https://doi.org/10.1016/S0140-6736%2817%2932849-0

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplat... Read More about Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.