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Randomised controlled trial of topical corticosteroid and home?based narrowband UVB for active and limited vitiligo: results of the HI?Light Vitiligo trial (2020)
Journal Article
Thomas, K., Batchelor, J. M., Akram, P., Chalmers, J. R., Haines, R., Meakin, G. D., …Montgomery, A. A. (2021). Randomised controlled trial of topical corticosteroid and home‐based narrowband UVB for active and limited vitiligo: results of the HI‐Light Vitiligo trial. British Journal of Dermatology, 184(5), 828-839. https://doi.org/10.1111/bjd.19592

Background Evidence for the effectiveness of vitiligo treatments is limited. Objectives To determine effectiveness of (a) hand‐held narrowband‐UVB (NB‐UVB) and (b) combination of potent topical corticosteroid (TCS) and NB‐UVB compared to TCS, fo... Read More about Randomised controlled trial of topical corticosteroid and home?based narrowband UVB for active and limited vitiligo: results of the HI?Light Vitiligo trial.

Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology?specific outcome taxonomy (2020)
Journal Article
Lange, T., Kottner, J., Weberschock, T., Hahnel, E., Apfelbacher, C., Brandstetter, S., …Schmitt, J. (2021). Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology‐specific outcome taxonomy. Journal of the European Academy of Dermatology and Venereology, 35(2), 523-535. https://doi.org/10.1111/jdv.16854

Background: Standardized outcome reporting is crucial for trial evidence synthesis and translation of findings into clinical decision making. The OMERACT 2.0 Filter and COMET outcome domain taxonomy propose frameworks for consistent reporting of outc... Read More about Outcome assessment in dermatology clinical trials and cochrane reviews: call for a dermatology?specific outcome taxonomy.

East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol (2020)
Journal Article
Hall, M., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (2020). East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol. BMJ Open, 10(9), https://doi.org/10.1136/bmjopen-2020-037760

© 2020 BMJ Open Introduction Knee pain due to osteoarthritis (OA) is a common cause of disability. The UK National Institute for Health and Care Excellence OA guidelines recommend education, exercise and weight loss advice (if overweight) as core int... Read More about East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol.

Personalised prediction of daily eczema severity scores using a mechanistic machine learning model (2020)
Journal Article
Hurault, G., Domínguez‐Hüttinger, E., Langan, S. M., Williams, H. C., & Tanaka, R. J. (2020). Personalised prediction of daily eczema severity scores using a mechanistic machine learning model. Clinical and Experimental Allergy, 50(11), 1258-1266. https://doi.org/10.1111/cea.13717

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with periods of flares and remission. Designing personalised treatment strategies for AD is challenging, given the apparent unpredictability and large variation in AD symptom... Read More about Personalised prediction of daily eczema severity scores using a mechanistic machine learning model.

The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol (2020)
Journal Article
Hall, M. C., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (2020). The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol. BMJ Open, 10(9), Article e037760

Introduction: Knee pain and osteoarthritis (OA) are a common cause of disability. The UK National Institute of Health and Care Excellence (NICE) OA guidelines recommend education, exercise and weight-loss advice (if overweight) as core interventions... Read More about The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol.

Current management strategies in Osgood Schlatter: A cross-sectional mixed-method study (2020)
Journal Article
Lyng, K. D., Rathleff, M. S., Dean, B. J. F., Kluzek, S., & Holden, S. (2020). Current management strategies in Osgood Schlatter: A cross-sectional mixed-method study. Scandinavian Journal of Medicine and Science in Sports, 30(10), 1985-1991. https://doi.org/10.1111/sms.13751

Background: Osgood Schlatter disease (OSD) is the most common knee condition in adolescent athletes aged 9-16. Without evidence to guide clinical practice, it is unclear how OSD is managed. The aim of this study was to investigate how international h... Read More about Current management strategies in Osgood Schlatter: A cross-sectional mixed-method study.

Patient Perspectives on Use of Stem Cells to Treat Osteoporosis (2020)
Journal Article
Brown, H. I., Clutton-Brock, T., Walker, D., Sahota, O., Scammell, B. E., & Ahmed, I. (2020). Patient Perspectives on Use of Stem Cells to Treat Osteoporosis. Journal of Regenerative Medicine & Biology Research, 1(1), 1-20

Osteoporosis is a systemic skeletal disease leading to increased risk of fragility fractures. These fractures lead to significant patient morbidity, increased mortality and substantial health and social care costs. The use of stem cells for cell-base... Read More about Patient Perspectives on Use of Stem Cells to Treat Osteoporosis.

Barriers and facilitators to physical activity among ethnic Chinese children in school, home and community settings: a qualitative systematic review (2020)
Journal Article
Wang, H., Swain, S., Luo, J., Blake, H., & Chattopadhyay, K. (2020). Barriers and facilitators to physical activity among ethnic Chinese children in school, home and community settings: a qualitative systematic review. JBI Evidence Synthesis, 18(12), 2445-2511. https://doi.org/10.11124/JBISRIR-D-19-00154

Objective: The review aimed to synthesize the barriers and facilitators from the available studies that dealt with physical activity among ethnic Chinese children and uncover any differences or similarities in these barriers and facilitators. In... Read More about Barriers and facilitators to physical activity among ethnic Chinese children in school, home and community settings: a qualitative systematic review.

Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial (2020)
Journal Article
Dias, J. J., Brealey, S. D., Fairhurst, C., Amirfeyz, R., Bhowal, B., Blewitt, N., …Warwick, D. (2020). Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial. Lancet, 396(10248), 390-401. https://doi.org/10.1016/S0140-6736%2820%2930931-4

Background Scaphoid fractures account for 90% of carpal fractures and occur predominantly in young men. Immediate surgical fixation of this fracture has increased, in spite of insufficient evidence of improved outcomes over non-surgical management.... Read More about Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial.

Outcome domains in lichen sclerosus (2020)
Journal Article
Goodrum, C., Leighton, P., & Simpson, R. (2020). Outcome domains in lichen sclerosus. British Journal of Dermatology, 183(5), 966-968. https://doi.org/10.1111/bjd.19253

Lichen Sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the genitals. It can affect men, women and children. LS affecting female genitalia typically presents with itchy patches that impact on physical and psychosocial?sexua... Read More about Outcome domains in lichen sclerosus.

The presentation, diagnosis and management of non-traumatic wrist pain: an evaluation of current practice in secondary care in the UK NHS (2020)
Journal Article
Dean, B. J., Carr, A., Trickett, R. W., Kluzek, S., Riley, N., Bretherton, C. P., …Cheng, C. (2020). The presentation, diagnosis and management of non-traumatic wrist pain: an evaluation of current practice in secondary care in the UK NHS. Rheumatology Advances in Practice, 4(2), Article rkaa030. https://doi.org/10.1093/rap/rkaa030

Objectives. The study aims were to assess the burden of non-traumatic wrist pain in terms of numbers of referrals to secondary care and to characterize how patients present, are diagnosed and are managed in secondary care in the UK National Health Se... Read More about The presentation, diagnosis and management of non-traumatic wrist pain: an evaluation of current practice in secondary care in the UK NHS.

The presentation, diagnosis and management of non-traumatic wrist pain: an evaluation of current practice in secondary care in the UK NHS (2020)
Journal Article
Dean, B. J., Carr, A., Trickett, R. W., Kluzek, S., Riley, N., Bretherton, C. P., …As-Sultany, M. (2020). The presentation, diagnosis and management of non-traumatic wrist pain: an evaluation of current practice in secondary care in the UK NHS. Rheumatology Advances in Practice, 4(2), Article rkaa030. https://doi.org/10.1093/rap/rkaa030

Abstract Objectives The study aims were to assess the burden of non-traumatic wrist pain in terms of numbers of referrals to secondary care, and to characterise how patients present, are diagnosed and are managed in secondary care in the United Kin... Read More about The presentation, diagnosis and management of non-traumatic wrist pain: an evaluation of current practice in secondary care in the UK NHS.

A 10?year Review of Surgical Management of Dermatofibrosarcoma Protuberans (2020)
Journal Article
Durack, A., Gran, S., Gardiner, M., Jain, A., Craythorne, E., Proby, C., …Matin, R. (2021). A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans. British Journal of Dermatology, 184(4), 731-739. https://doi.org/10.1111/bjd.19346

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Standard treatment in the United Kingdom (UK) is either surgical wide local excision (WLE) or Mohs micrographic surgery (MMS). It is unclear which approach has the lower recurr... Read More about A 10?year Review of Surgical Management of Dermatofibrosarcoma Protuberans.

Critically Appraised Topics (CATs) in Veterinary Medicine: Applying Evidence in Clinical Practice (2020)
Journal Article
Brennan, M. L., Arlt, S. P., Belshaw, Z., Buckley, L., Corah, L., Doit, H., …White, C. (2020). Critically Appraised Topics (CATs) in Veterinary Medicine: Applying Evidence in Clinical Practice. Frontiers in Veterinary Science, 7, Article 314. https://doi.org/10.3389/fvets.2020.00314

Critically appraised topics (CATs) are evidence syntheses that provide veterinary professionals with information to rapidly address clinical questions and support the practice of evidence-based veterinary medicine (EBVM). They also have an important... Read More about Critically Appraised Topics (CATs) in Veterinary Medicine: Applying Evidence in Clinical Practice.

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes (2020)
Journal Article
Menni, C., Zhu, J., Le Roy, C. I., Mompeo, O., Young, K., Rebholz, C. M., …Valdes, A. M. (2020). Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes. Gut Microbes, 11(6), 1632-1642. https://doi.org/10.1080/19490976.2020.1778261

Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity, although the cause is unclear. Metabolites generated by gut microbes also appear to be causative factors in T2D. We therefore searched for serum metabolites predictive of gut... Read More about Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes.

Pain trajectory defines knee osteoarthritis subgroups: a prospective observational study (2020)
Journal Article
Radojčić, M. R., Arden, N. K., Yang, X., Strauss, V. Y., Birrell, F., Cooper, C., …VIDEO Trial Investigators. (2020). Pain trajectory defines knee osteoarthritis subgroups: a prospective observational study. PAIN, 161(12), 2841-2851. https://doi.org/10.1097/j.pain.0000000000001975

Knee osteoarthritis (OA) is a heterogeneous disease, and identification of its subgroups/phenotypes can improve patient treatment and drug development. We aimed to identify homogeneous OA subgroups/phenotypes using pain development over time; to unde... Read More about Pain trajectory defines knee osteoarthritis subgroups: a prospective observational study.

Views and experiences of managing eczema: systematic review and thematic synthesis of qualitative studies (2020)
Journal Article
Teasdale, E., Muller, I., Sivyer, K., Ghio, D., Greenwell, K., Wilczynska, S., …Santer, M. (2021). Views and experiences of managing eczema: systematic review and thematic synthesis of qualitative studies. British Journal of Dermatology, 184(4), 627-637. https://doi.org/10.1111/bjd.19299

Background The number of qualitative studies on eczema has increased rapidly in recent years. Systematically reviewing these can provide greater understandings of people’s perceptions of eczema and eczema treatments. Objectives We sought to... Read More about Views and experiences of managing eczema: systematic review and thematic synthesis of qualitative studies.

Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model (2020)
Journal Article
Gorelick, N. L., Serra, R., Iyer, R., Um, R., Grewal, A., Monroe, A., …Luciano, M. G. (2020). Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model. Neurosurgery, 87(5), 1046-1054. https://doi.org/10.1093/neuros/nyaa203

BACKGROUND Hydrocephalus is managed by surgically implanting flow-diversion technologies such as differential pressure valves and antisiphoning devices; however, such hardware is prone to failure. Extensive research has tested them in flow-control... Read More about Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model.

Development of dual anti-biofilm and anti-bacterial medical devices (2020)
Journal Article
Burroughs, L., Singh, S., Ashraf, W., Martinez-Pomares, L., Bayston, R., & Hook, A. L. (2020). Development of dual anti-biofilm and anti-bacterial medical devices. Biomaterials Science, 8(14), 3926-3934. https://doi.org/10.1039/d0bm00709a

The rising occurrence of antimicrobial resistance demands new strategies for delivering antibiotics to ensure their effective use. In this study, a multi-functional strategy to address medical device associated infections is explored whereby an anti-... Read More about Development of dual anti-biofilm and anti-bacterial medical devices.