Research Repository

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Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study: The SOFtened waTER for eczema prevention trial (SOFTER) (2019)
Journal Article
Jabbar-Lopez, Z., Gurung, N., Greenblatt, D., Briley, A., Chalmers, J., Thomas, K., …Flohr, C. (2019). Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study: The SOFtened waTER for eczema prevention trial (SOFTER). BMJ Open, 9(8), doi:10.1136/bmjopen-2018-027168

Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials (2019)
Journal Article
Mousoulis, C., Thomas, K., Leighton, P., Deshmukh, S., Grindlay, D., & Karantana, A. (2019). Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials. Journal of Hand Surgery (European Volume), doi:10.1177/1753193419865897

The aim of this study was to identify and assess all existing randomized studies on treatment interventions for hand fractures and joint injuries, to inform practice and plan future research. PubMed, Cochrane CENTRAL, MEDLINE and Embase were searche... Read More

Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., …Abhishek, A. (2019). Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, 9(8), doi:10.1136/bmjopen-2019-032050

An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study (2019)
Journal Article
Baystson, R., Ashraf, W., Pelegrin, I., Fowkes, K., Bienemann, A. S., Singleton, W. G., & Scott, I. S. (2019). An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study. Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkz293

Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics (2019)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., & Thomas, K. S. (in press). Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics. BMJ Open,

Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies (2019)
Journal Article
Swain, S., Sarmanova, A., Coupland, C., Doherty, M., & Zhang, W. (2019). Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies. Arthritis Care and Research, doi:10.1002/acr.24008

Objectives Osteoarthritis (OA) is a common chronic condition in older people but its association with other chronic conditions is largely unknown. This study aimed to systematically review the literature on comorbidities in people with OA compared... Read More

Spatial microsimulation of osteoarthritis prevalence at the small area level in England 1 -Constraint selection for a 2-stage microsimulation process (2019)
Journal Article
Ifesemen, O. S., Bestwick-Stevenson, T., & Edwards, K. L. (in press). Spatial microsimulation of osteoarthritis prevalence at the small area level in England 1 -Constraint selection for a 2-stage microsimulation process. International Journal of Microsimulation,

The presence of identical benchmark/constraint variables in both geographic and survey datasets is a principal requirement for static spatial microsimulation models, particularly in the field of medicine and health sciences. This is also a as key lim... Read More

Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis (2019)
Journal Article
Pearson, R. G., Masud, T., Blackshaw, E., Naylor, A., Hinchcliffe, M., Jeffery, K., …Perkins, A. C. (2019). Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis. Pharmaceutics, 11(6), doi:10.3390/pharmaceutics11060265

Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relati... Read More

Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis (2019)
Journal Article
Goh, S., Persson, M. S., Stocks, J., Hou, Y., Lin, J., Hall, M. C., …Zhang, W. (2019). Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine, doi:10.1016/j.rehab.2019.04.006

Background. Exercise is an effective treatment for osteoarthritis. However, the effect may vary from one patient (or study) to another. Objective. To evaluate the efficacy of exercise and its potential determinants for pain, function, performance,... Read More

Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort (2019)
Journal Article
Chalmers, J., Ban, L., Leena, K., Edwards, K., Grove, J., Aithal, G., & Shenoy, K. (2019). Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort. BMJ Open, 9, doi:10.1136/bmjopen-2018-027244

Purpose The Trivandrum NAFLD cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population. Participants Between 201... Read More

Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data (2019)
Presentation / Conference
Stocks, J., Persson, M., van Middelkoop, M., Bierma-Zeinstra, S., Runhaar, J., Sawitzke, A., …Zhang, W. (2019, May). Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data. Presented at 2019 World Congress on Osteoarthritis

Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae (2019)
Presentation / Conference
McWilliams, D., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019, April). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae. Poster presented at Rheumatology 2019

Background RA flares are common and disabling. They are described in terms of worsening pain, swelling, or other symptoms. We aimed to determine characteristics, antecedants and sequelae of painful and inflammatory flare subtypes during the first 11... Read More

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P., Mallen, C. D., Zhang, W., Doherty, M., …Abhishek, A. (2019). Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 78(8), 1122-1126. doi:10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis, and unexplained fever in people w... Read More

Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement? (2019)
Journal Article
Dekker, A., Uzoho, C., & Scammell, B. (2019). Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement?. Wounds, 31(6), 145–150

Background: Neuropathic foot ulcers are common and difficult to treat. Calcium sulphate has been used for antibiotic delivery with success in treating osteomyelitis. Recent case series suggest success in treating osteomyelitis of the foot with a mean... Read More

Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model (2019)
Journal Article
McLaren, J. S., Macri-Pellizzeri, L., Zakir Hossain, K. M., Patel, U., Grant, D. M., Scammell, B. E., …Sottile, V. (2019). Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model. ACS Applied Materials and Interfaces, 11(17), 15436–15446. doi:10.1021/acsami.9b04603

Phosphate-based glasses (PBG) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation and geometry to produce varyin... Read More

Trajectories of pain predict disabilities affecting daily living in arthritis (2019)
Journal Article
James, R. J., Walsh, D. A., & Ferguson, E. (2019). Trajectories of pain predict disabilities affecting daily living in arthritis. British Journal of Health Psychology, 24(3), 465-496. doi:10.1111/bjhp.12364

Purpose: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis heterogeneously, with subgroups of... Read More

Exploring patients' expectations and preferences of glaucoma surgery outcomes to facilitate healthcare delivery and inform future glaucoma research (2019)
Journal Article
Kulkarni, B. B., Leighton, P., & King, A. J. (2019). Exploring patients' expectations and preferences of glaucoma surgery outcomes to facilitate healthcare delivery and inform future glaucoma research. British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2018-313401

Introduction: Glaucoma is a lifelong condition often requiring surgical intervention. To allow us to inform patients’ expectations of surgery effectively, it is important to understand patients’ preferences and concerns regarding outcomes from glauco... Read More