Research Repository

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Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort (2019)
Journal Article
Chalmers, J., Ban, L., Leena, K., Edwards, K., Grove, J., Aithal, G., & Shenoy, K. (2019). Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort. BMJ Open, 9, doi:10.1136/bmjopen-2018-027244

Purpose The Trivandrum NAFLD cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population. Participants Between 201... Read More

Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data (2019)
Presentation / Conference
Stocks, J., Persson, M., van Middelkoop, M., Bierma-Zeinstra, S., Runhaar, J., Sawitzke, A., …Zhang, W. (2019, May). Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data. Presented at 2019 World Congress on Osteoarthritis

Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae (2019)
Presentation / Conference
McWilliams, D., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019, April). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae. Poster presented at Rheumatology 2019

Background RA flares are common and disabling. They are described in terms of worsening pain, swelling, or other symptoms. We aimed to determine characteristics, antecedants and sequelae of painful and inflammatory flare subtypes during the first 11... Read More

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P., Mallen, C. D., Zhang, W., Doherty, M., …Abhishek, A. (2019). Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis, and unexplained fever in people w... Read More

Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model (2019)
Journal Article
McLaren, J. S., Macri-Pellizzeri, L., Zakir Hossain, K. M., Patel, U., Grant, D. M., Scammell, B. E., …Sottile, V. (2019). Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model. ACS Applied Materials and Interfaces, 11(17), 15436–15446. doi:10.1021/acsami.9b04603

Phosphate-based glasses (PBG) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation and geometry to produce varyin... Read More

Trajectories of pain predict disabilities affecting daily living in arthritis (2019)
Journal Article
James, R. J., Walsh, D. A., & Ferguson, E. (2019). Trajectories of pain predict disabilities affecting daily living in arthritis. British Journal of Health Psychology, doi:10.1111/bjhp.12364

Purpose: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis heterogeneously, with subgroups of... Read More

Uncertainty about cellulitis and unmet patient information needs: a mixed methods study in primary and secondary care (2019)
Journal Article
Teasdale, E., Lalonde, A., Muller, I., Chalmers, J., Smart, P., Hooper, J., …Santer, M. (2019). Uncertainty about cellulitis and unmet patient information needs: a mixed methods study in primary and secondary care. British Journal of General Practice, 69(681), e279-e286. doi:10.3399/bjgp19X701873

Background: Cellulitis is a painful infection of the skin and underlying tissues, commonly affecting the lower leg: approximately a third of people experience recurrence. Patients’ ability to recover from cellulitis or prevent recurrence is likely to... Read More

Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts (2019)
Journal Article
Andersen, Y. M., Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., …Thyssen, J. P. (2019). Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care, doi:10.2337/dc18-2158

Background Topical corticosteroids (CS) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. While topical CS package inserts describe hyperglycaemia and glycosuria as adverse drug reactions, it is unclear whether... Read More

An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks (2019)
Journal Article
Belfield, K., Chen, X., Smith, E. F., Ashraf, W., & Bayston, R. (2019). An antimicrobial impregnated urinary catheter that reduces mineral encrustation and prevents colonisation by multi-drug resistant organisms for up to 12  weeks. Acta Biomaterialia, 90, 157-168. doi:10.1016/j.actbio.2019.03.042

Two major complications of indwelling urinary catheterisation include infection and mineral encrustation of the catheter. Our antimicrobial urinary catheter (AUC) impregnated with rifampicin, triclosan, and sparfloxacin has demonstrated long-term pro... Read More

Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: systematic review and network meta-analysis (2019)
Journal Article
Goh, S., Persson, M. S., Stocks, J., Hou, Y., Welton, N. J., Lin, J., …Zhang, W. (2019). Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: systematic review and network meta-analysis. Sports Medicine, 49(5), 743–761. doi:10.1007/s40279-019-01082-0

Background: Guidelines recommend exercise as a core treatment for osteoarthritis (OA). However, it is unclear which type of exercise is most effective, leading to inconsistency between different recommendations. Objectives: To investigate the rel... Read More

Microorganisms attached to the lumens and balloons of indwelling urinary catheters and correlation with symptoms, antibiotic use, and catheter specimen of urine results (2019)
Journal Article
Belfield, K., Kalith, S., Aimar, K., Parkinson, R., & Bayston, R. (2019). Microorganisms attached to the lumens and balloons of indwelling urinary catheters and correlation with symptoms, antibiotic use, and catheter specimen of urine results. Journal of Medical Microbiology, 68(4), 549-554. doi:10.1099/jmm.0.000946

Purpose: To quantify and identify microorganisms attached to the lumens and balloons of removed urethral urinary catheters and relate this to patient-specific information. Methodology: Indwelling urethral urinary catheters were collected from pati... Read More

Living with vulval lichen sclerosus: a systematic review (2019)
Journal Article
Rees, S., Kirby, L., & Simpson, R. (2019). Living with vulval lichen sclerosus: a systematic review. British Journal of Dermatology, doi:10.1111/bjd.17790

Lichen sclerosus (LS) is an under‐researched disorder, particularly from the perspective of individuals who have the condition. A recent James Lind Alliance Priority Setting Partnership identified uncertainties in many aspects of the condition, inclu... Read More

Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II) (2019)
Journal Article
Chinchilla, S. P., Doherty, M., & Abhishek, A. (2019). Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II). Rheumatology,

Objectives: To examine the predictive validity of the Gout Activity Score (GAS), its’ correlation with the Gout Impact Scale (GIS), and their sensitivity to change. Methods: Data from a clinical trial in which participants with ≥1 gout flare in th... Read More

Open versus arthroscopic repair of 1B ulnar-sided triangular fibrocartilage complex (TFCC) tears: a systemetic review (2019)
Journal Article
Robba, V., Fowler, A., Karantana, A., Grindlay, D., & Lindau, T. (2019). Open versus arthroscopic repair of 1B ulnar-sided triangular fibrocartilage complex (TFCC) tears: a systemetic review. Hand, doi:10.1177/1558944718815244

Background: Peripheral 1B tears of the triangular fibrocartilage complex (TFCC) can result in distal radioulnar joint (DRUJ) instability. In the context of associated DRUJ instability, combined evidence supports successful outcomes for peripheral tea... Read More

Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts (2019)
Journal Article
McWilliams, D. F., Dawson, O., Young, A., Kiely, P., Ferguson, E., & Walsh, D. A. (2019). Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts. Journal of Pain, doi:10.1016/j.jpain.2019.01.001

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesised that discrete RA subgroups might display favourable or unfa... Read More

Defining displacement thresholds for surgical intervention for distal radius fractures – a Delphi study (2019)
Journal Article
Johnson, N., Leighton, P., Pailthorpe, C., Dias, J., & Distal Radius Fracture Delphi Study Group, . (2019). Defining displacement thresholds for surgical intervention for distal radius fractures – a Delphi study. PLoS ONE, 14(1), 1-12. doi:10.1371/journal.pone.0210462

Distal radius fractures are very common yet controversy exists regarding which require treatment and is reflected by significant variation in surgical intervention rate. Evidence regarding which fractures would benefit from intervention is varied and... Read More

Interventions for treating wrist fractures in children (Review) (2018)
Journal Article
H.G. Handoll, H., Elliott, J., Iheozor‐Ejiofor, Z., Hunter, J., & Karantana, A. (2018). Interventions for treating wrist fractures in children (Review). Cochrane Database of Systematic Reviews, 12, 1-239. doi:10.1002/14651858.CD012470.pub2