Research Repository

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Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data (2019)
Presentation / Conference
Stocks, J., Persson, M., van Middelkoop, M., Bierma-Zeinstra, S., Runhaar, J., Sawitzke, A., …Zhang, W. (2019, May). Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data. Presented at 2019 World Congress on Osteoarthritis

Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae (2019)
Presentation / Conference
McWilliams, D., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019, April). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae. Poster presented at Rheumatology 2019

Background RA flares are common and disabling. They are described in terms of worsening pain, swelling, or other symptoms. We aimed to determine characteristics, antecedants and sequelae of painful and inflammatory flare subtypes during the first 11... Read More

Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts (2019)
Journal Article
Andersen, Y. M., Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., …Thyssen, J. P. (in press). Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care,

Background Topical corticosteroids (CS) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. While topical CS package inserts describe hyperglycaemia and glycosuria as adverse drug reactions, it is unclear whether... Read More

Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: systematic review and network meta-analysis (2019)
Journal Article
Goh, S., Persson, M. S., Stocks, J., Hou, Y., Welton, N. J., Lin, J., …Zhang, W. (2019). Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: systematic review and network meta-analysis. Sports Medicine, doi:10.1007/s40279-019-01082-0

Background: Guidelines recommend exercise as a core treatment for osteoarthritis (OA). However, it is unclear which type of exercise is most effective, leading to inconsistency between different recommendations. Objectives: To investigate the rel... Read More

Trajectories of pain predict disabilities affecting daily living in arthritis (2019)
Journal Article
James, R. J., Walsh, D. A., & Ferguson, E. (in press). Trajectories of pain predict disabilities affecting daily living in arthritis. British Journal of Health Psychology,

Purpose: To examine the interplay between pain and disability in arthritis when adjusting for patient heterogeneity in pain progression. There is consistent evidence to suggest that people experience osteoarthritis heterogeneously, with subgroups of... Read More

Microorganisms attached to the lumens and balloons of indwelling urinary catheters and correlation with symptoms, antibiotic use, and catheter specimen of urine results (2019)
Journal Article
Belfield, K., Kalith, S., Aimar, K., Parkinson, R., & Bayston, R. (2019). Microorganisms attached to the lumens and balloons of indwelling urinary catheters and correlation with symptoms, antibiotic use, and catheter specimen of urine results. Journal of Medical Microbiology, doi:10.1099/jmm.0.000946

Purpose: To quantify and identify microorganisms attached to the lumens and balloons of removed urethral urinary catheters and relate this to patient-specific information. Methodology: Indwelling urethral urinary catheters were collected from pati... Read More

Living with vulval lichen sclerosus: a systematic review (2019)
Journal Article
Rees, S., Kirby, L., & Simpson, R. (2019). Living with vulval lichen sclerosus: a systematic review. British Journal of Dermatology, doi:10.1111/bjd.17790

Lichen sclerosus (LS) is an under‐researched disorder, particularly from the perspective of individuals who have the condition. A recent James Lind Alliance Priority Setting Partnership identified uncertainties in many aspects of the condition, inclu... Read More

Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II) (2019)
Journal Article
Chinchilla, S. P., Doherty, M., & Abhishek, A. (2019). Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II). Rheumatology,

Objectives: To examine the predictive validity of the Gout Activity Score (GAS), its’ correlation with the Gout Impact Scale (GIS), and their sensitivity to change. Methods: Data from a clinical trial in which participants with ≥1 gout flare in th... Read More

Open versus arthroscopic repair of 1B ulnar-sided triangular fibrocartilage complex (TFCC) tears: a systemetic review (2019)
Journal Article
Robba, V., Fowler, A., Karantana, A., Grindlay, D., & Lindau, T. (2019). Open versus arthroscopic repair of 1B ulnar-sided triangular fibrocartilage complex (TFCC) tears: a systemetic review. Hand, doi:10.1177/1558944718815244

Background: Peripheral 1B tears of the triangular fibrocartilage complex (TFCC) can result in distal radioulnar joint (DRUJ) instability. In the context of associated DRUJ instability, combined evidence supports successful outcomes for peripheral tea... Read More

Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts (2019)
Journal Article
McWilliams, D. F., Dawson, O., Young, A., Kiely, P., Ferguson, E., & Walsh, D. A. (2019). Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: results from three UK cohorts. Journal of Pain, doi:10.1016/j.jpain.2019.01.001

Rheumatoid arthritis (RA) is an example of human chronic inflammatory pain. Modern treatments suppress inflammation, yet pain remains a major problem for many people with RA. We hypothesised that discrete RA subgroups might display favourable or unfa... Read More

Defining displacement thresholds for surgical intervention for distal radius fractures – a Delphi study (2019)
Journal Article
Johnson, N., Leighton, P., Pailthorpe, C., Dias, J., & Distal Radius Fracture Delphi Study Group, . (2019). Defining displacement thresholds for surgical intervention for distal radius fractures – a Delphi study. PLoS ONE, 14(1), 1-12. doi:10.1371/journal.pone.0210462

Distal radius fractures are very common yet controversy exists regarding which require treatment and is reflected by significant variation in surgical intervention rate. Evidence regarding which fractures would benefit from intervention is varied and... Read More

Interventions for treating wrist fractures in children (Review) (2018)
Journal Article
H.G. Handoll, H., Elliott, J., Iheozor‐Ejiofor, Z., Hunter, J., & Karantana, A. (2018). Interventions for treating wrist fractures in children (Review). Cochrane Database of Systematic Reviews, 12, 1-239. doi:10.1002/14651858.CD012470.pub2

Temporal relationships between systemic lupus erythematosus and comorbidities (2018)
Journal Article
Kuo, C., Chou, I., Rees, F., Grainge, M. J., Lanyon, P., Davenport, G., …Doherty, M. (2018). Temporal relationships between systemic lupus erythematosus and comorbidities. Rheumatology, doi:10.1093/rheumatology/key335

Objective To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality. Methods We identified 1605 incident cases of SLE and 6284 matched controls from the UK primary care. The risks of comorbidities... Read More

Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable (2018)
Journal Article
Schmitt, J., Lange, T., Kottner, J., Prinsen, C. A. C., Weberschock, T., Hahnel, E., …Cochrane Skin Core Outcome Set Initiative (CS-COUSIN), . (2018). Cochrane reviews and dermatological trials outcome concordance: why Core Outcome Sets could make trial results more usable. Journal of Investigative Dermatology, doi:10.1016/j.jid.2018.11.019

Evidence-based healthcare requires that relevant outcomes for patients are included in clinical trials which investigating treatment effects allowing subsequent systematic reviews to summarize all relevant evidence to guide clinical practice. Current... Read More

Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation? (2018)
Journal Article
Rutter, C., Silverwood, R. J., Williams, H. C., Elwood, P., Asher, I., Garcia-Marcos, L., …ISAAC Phase Three Group, . (2018). Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?. Journal of Investigative Dermatology, doi:10.1016/j.jid.2018.08.035

Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors. ISAAC Phase Thre... Read More

Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Takwoingi, Y., Dinnes, J., Chuchu, N., Bayliss, S. E., Davenport, C., …Williams, H. C. (2018). Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), doi:10.1002/14651858.CD013186

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high‐risk skin cancers which have the potentia... Read More

A trans-atlantic perspective on stagnation in clinical translation of antimicrobial strategies for the control of biomaterial-implant associated infection (2018)
Journal Article
Busscher, H. J., Alt, V., Van Der Mei, H. C., Fagette, P. H., Zimmerli, W., Moriarty, T. F., …Grainger, D. W. (2018). A trans-atlantic perspective on stagnation in clinical translation of antimicrobial strategies for the control of biomaterial-implant associated infection. ACS Biomaterials Science and Engineering, doi:10.1021/acsbiomaterials.8b01071

Current regulatory requirements impede clinical translation and market introduction of many new antimicrobial combination implants and devices, causing unnecessary patient suffering, doctor frustration, and costs to healthcare payers. Regulatory requ... Read More