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Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women (2015)
Journal Article
Kluzek, S., Bay-Jensen, A., Judge, A., Karsdal, M. A., Shorthose, M., Spector, T., …Arden, N. K. (2015). Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women. Biomarkers, 20(8), 557-564. https://doi.org/10.3109/1354750x.2015.1105498

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged... Read More about Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.

Impact of gout on the risk of atrial fibrillation (2015)
Journal Article
Kuo, C., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2016). Impact of gout on the risk of atrial fibrillation. Rheumatology, 55(4), 721-728. https://doi.org/10.1093/rheumatology/kev418

OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF.... Read More about Impact of gout on the risk of atrial fibrillation.

Comorbidities in patients with gout prior to and following diagnosis: case-control study (2015)
Journal Article
Kuo, C., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2016). Comorbidities in patients with gout prior to and following diagnosis: case-control study. Annals of the Rheumatic Diseases, 75(1), https://doi.org/10.1136/annrheumdis-2014-206410

OBJECTIVES: To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis. METHODS: There were 39 111 patients with incident gout and 39 111 matched controls identified fro... Read More about Comorbidities in patients with gout prior to and following diagnosis: case-control study.

Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23?years follow-up of a population-based cohort of middle-aged women (2015)
Journal Article
Kluzek, S., Sanchez-Santos, M. T., Leyland, K. M., Judge, A., Spector, T. D., Hart, D., …Arden, N. K. (2016). Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women. Annals of the Rheumatic Diseases, 75(10), 1749-1756. https://doi.org/10.1136/annrheumdis-2015-208056

To assess whether joint pain or radiographic osteoarthritis (ROA) of the knee and hand is associated with all-cause and disease-specific mortality in middle-aged women. Methods: Four subgroups from the prospective community-based Chingford Cohort... Read More about Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23?years follow-up of a population-based cohort of middle-aged women.

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis (2015)
Journal Article
Prieto-Potin, I., Largo, R., Roman-Blas, J. A., Herrero-Beaumont, G., & Walsh, D. A. (2015). Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis. BMC Musculoskeletal Disorders, 16, Article 226. https://doi.org/10.1186/s12891-015-0664-5

Background: Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description in rheumatoid synovium. However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains b... Read More about Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis.

Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease (2015)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Russell, P., Chakrabarti, I., Fullilove, S., …Davis, T. (2016). Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease. Journal of Hand Surgery (European Volume), 41(6), https://doi.org/10.1177/1753193415601350

This study investigated aspects of the validity and reliability of the 30-item Disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and its relationship with the shorter 11-item QuickDASH in patients with Dupuytren’s dis... Read More about Validity of the disabilities of the Arm, Shoulder and Hand patient-reported outcome measure (DASH) and the Quickdash when used in Dupuytren’s disease.

Behavioural physical activity interventions in participants with lower-limb osteoarthritis: a systematic review with meta-analysis (2015)
Journal Article
Williamson, W., Kluzek, S., Roberts, N., Richards, J., Arden, N., Leeson, P., …Foster, C. (2015). Behavioural physical activity interventions in participants with lower-limb osteoarthritis: a systematic review with meta-analysis. BMJ Open, 5(8), Article e007642. https://doi.org/10.1136/bmjopen-2015-007642

Objective: To assess effectiveness of osteoarthritis interventions to promote long-term physical activity behaviour change. Design: A systematic review and meta-analysis. Protocol registration PROSPERO CRD4201300444 5 (http://www.crd.york.ac.uk/pr... Read More about Behavioural physical activity interventions in participants with lower-limb osteoarthritis: a systematic review with meta-analysis.

Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families (2015)
Journal Article
Kuo, C., Grainge, M. J., Valdes, A. M., See, L., Luo, S., Yu, K., …Doherty, M. (2015). Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. JAMA Internal Medicine, 175(9), 1518-1526. https://doi.org/10.1001/jamainternmed.2015.3528

IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contri... Read More about Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families.

Is osteoarthritis a metabolic disorder? (2015)
Journal Article
Kluzek, S., Newton, J. L., & Arden, N. K. (2015). Is osteoarthritis a metabolic disorder?. British Medical Bulletin, 115(1), 111-121. https://doi.org/10.1093/bmb/ldv028

Background Obesity is associated with an increased risk of developing osteoarthritis (OA), even in non-weight bearing joints. High levels of adipose tissue-associated inflammation may explain this association. Sources of data and areas of debat... Read More about Is osteoarthritis a metabolic disorder?.

Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study (2015)
Journal Article
Ratib, S., Fleming, K. M., Crooks, C. J., Walker, A. J., & West, J. (2015). Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study. American Journal of Gastroenterology, 110, https://doi.org/10.1038/ajg.2015.191

Introduction Liver cirrhosis is increasing worldwide and associated with high mortality. Precise estimates of cause-specific mortality compared to the general population, by underlying aetiology, are lacking. Such information may demonstrate areas w... Read More about Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study.

Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis (2015)
Journal Article
Kuo, C., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2015). Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis. Rheumatology, 54(12), https://doi.org/10.1093/rheumatology/kev246

Objective: To examine the association between allopurinol use and all-cause mortality for patients with incident gout. Methods: We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exp... Read More about Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score–matched landmark analysis.

Global epidemiology of gout: prevalence, incidence and risk factors (2015)
Journal Article
Kuo, C., Grainge, M. J., Zhang, W., & Doherty, M. (2015). Global epidemiology of gout: prevalence, incidence and risk factors. Nature Reviews Rheumatology, 11(11), 649-662. https://doi.org/10.1038/nrrheum.2015.91

Gout is a crystal-deposition disease that results from chronic elevation of uric acid levels above the saturation point for monosodium urate (MSU) crystal formation. Initial presentation is mainly severely painful episodes of peripheral joint synovit... Read More about Global epidemiology of gout: prevalence, incidence and risk factors.

Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study (2015)
Journal Article
Kuo, C., Grainge, M. J., Valdes, A. M., See, L., Luo, S., Yu, K., …Doherty, M. (2015). Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study. Arthritis and Rheumatology, 67(7), 1904-1912. https://doi.org/10.1002/art.39127

Objective: To investigate familial aggregation of Sjögren's syndrome (SS) and the relative risks (RRs) of other autoimmune disease in relatives of patients with SS. Methods: We identified 23,658,577 beneficiaries enrolled in the Taiwan National Hea... Read More about Familial risk of Sjögren's syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study.

Adipokines as potential prognostic biomarkers in patients with acute knee injury (2015)
Journal Article
Kluzek, S., Arden, N. K., & Newton, J. (2015). Adipokines as potential prognostic biomarkers in patients with acute knee injury. Biomarkers, 20(8), 519-525. https://doi.org/10.3109/1354750x.2014.948914

This review considers adipokines as predictive biomarkers for early onset post-traumatic knee osteoarthritis (KOA). Serum concentrations of leptin and resistin can predict radiographic changes and are elevated in early KOA, with higher leptin concent... Read More about Adipokines as potential prognostic biomarkers in patients with acute knee injury.

Validation of treatment escalation as a definition of atopic eczema flares (2015)
Journal Article
Thomas, K. S., Stuart, B., O’Leary, C., Schmitt, J., Paul, C., Williams, H., & Langan, S. (2015). Validation of treatment escalation as a definition of atopic eczema flares. PLoS ONE, 10(4), 1-13. https://doi.org/10.1371/journal.pone.0124770

Background Atopic eczema (AE) is a chronic disease with flares and remissions. Long-term control of AE flares has been identified as a core outcome domain for AE trials. However, it is unclear how flares should be defined and measured. Objective... Read More about Validation of treatment escalation as a definition of atopic eczema flares.