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All Outputs (39)

Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA (2021)
Journal Article
Wang, Y., Meng, X., Wang, A., Xie, X., Pan, Y., Johnston, S. C., …CHANCE-2 Investigators. (2021). Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA. New England Journal of Medicine, 385(27), 2520-2530. https://doi.org/10.1056/NEJMoa2111749

BACKGROUND Comparisons between ticagrelor and clopidogrel for the secondary prevention of stroke in CYP2C19 loss-of-function carriers have not been extensively performed. METHODS We conducted a randomized, double-blind, placebo-controlled trial at 20... Read More about Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA.

Physical Activity Interventions After Hip or Knee Joint Replacement: a Systematic Review (2020)
Journal Article
Ishaku, T., Min, S. M., & Hall, M. (2020). Physical Activity Interventions After Hip or Knee Joint Replacement: a Systematic Review. Current Physical Medicine and Rehabilitation Reports, 8(3), 299-311. https://doi.org/10.1007/s40141-020-00275-3

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: This study is aimed at describing and evaluating physical activity interventions in individuals that have undergone hip or knee joint replacement due to osteoar... Read More about Physical Activity Interventions After Hip or Knee Joint Replacement: a Systematic Review.

Prospective analysis of health-related quality of life after surgery for spinal metastases (2020)
Journal Article
Quraishi, N. A., Pasku, D., Koch, J. E. J., Arealis, G., Boszczyk, B. M., & Edwards, K. L. (2020). Prospective analysis of health-related quality of life after surgery for spinal metastases. European Spine Journal, https://doi.org/10.1007/s00586-020-06396-6

Purpose Most spinal metastases are detected late and thus the impact of treatment on the health related quality of life (HRQOL) is an important consideration. This study investigated the HRQOL following surgery for spinal metastases. Methods Prospect... Read More about Prospective analysis of health-related quality of life after surgery for spinal metastases.

Natural course of adult-onset vitelliform lesions in eyes with and without comorbid subretinal drusenoid deposits (2020)
Journal Article
Yeung, A. M., Wilde, C., Awad, M., Giannouladis, K., Lakshmanan, A., Dua, H., & Amoaku, W. M. (2020). Natural course of adult-onset vitelliform lesions in eyes with and without comorbid subretinal drusenoid deposits. International Ophthalmology, 40, 1501–1508. https://doi.org/10.1007/s10792-020-01319-2

Purpose Adult vitelliform lesions (AVL) are associated with age related macular degeneration (AMD) and subretinal drusenoid deposits (SRDD). We evaluated the natural course of AVL, assessing the influence of SRDD on disease progression, visual fun... Read More about Natural course of adult-onset vitelliform lesions in eyes with and without comorbid subretinal drusenoid deposits.

Access to and interventions to improve maternity care services for immigrant women: a narrative synthesis systematic review (2020)
Journal Article
Higginbottom, G. M., Evans, C., Morgan, M., Bharj, K. K., Eldridge, J., Hussain, B., & Salt, K. (2020). Access to and interventions to improve maternity care services for immigrant women: a narrative synthesis systematic review. Health Services and Delivery Research, 8(14), 1-122. https://doi.org/10.3310/hsdr08140

Limited evidence suggests experiences of immigrant women accessing and using UK maternity services were mixed but largely poor, and there were few rigorously evaluated interventions focused on improving care.

Clinical Scene Segmentation with Tiny Datasets (2019)
Conference Proceeding
Smith, T. J., Sharkey, D., Crowe, J., & Valstar, M. (2019). Clinical Scene Segmentation with Tiny Datasets. In 2019 IEEE/CVF International Conference on Computer Vision Workshop (ICCVW) (1637-1645). https://doi.org/10.1109/ICCVW.2019.00203

Many clinical procedures could benefit from automatic scene segmentation and subsequent action recognition. Using Convolutional Neural Networks to semantically segment meaningful parts of an image or video is still an unsolved problem. This becomes e... Read More about Clinical Scene Segmentation with Tiny Datasets.

Specialist healthcare services for UK care home residents: a latent class analysis (2019)
Journal Article
Hargreaves, C., Tucker, S., Hughes, J., Hays, R., & Challis, D. (2019). Specialist healthcare services for UK care home residents: a latent class analysis. Primary Health Care Research and Development, 20, Article e132. https://doi.org/10.1017/s1463423619000586

Aim: To identify discrete approaches to specialist healthcare support for older care home residents in the UK and to estimate their prevalence. Background: Internationally, a range of new initiatives are emerging to meet the multiple and complex heal... Read More about Specialist healthcare services for UK care home residents: a latent class analysis.

Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis (2019)
Journal Article
Rowbotham, N. J., Smith, S. J., Elliott, Z. C., Leighton, P. A., Rayner, O. C., Morley, R., & Smyth, A. R. (2019). Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis. Research Involvement and Engagement, 5(1), Article 24. https://doi.org/10.1186/s40900-019-0159-x

Background The James Lind Alliance (JLA) method is well recognised for setting research priorities. The JLA approach involves a combination of surveys and workshop interactions between patients, carers and health care professionals to identify and... Read More about Adapting the James Lind Alliance priority setting process to better support patient participation: an example from cystic fibrosis.

The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases (2019)
Journal Article
Pander, B., Harris, G., Scott, D. J., Winzer, K., Köpke, M., Simpson, S. D., …Henstra, A. M. (2019). The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases. Applied Microbiology and Biotechnology, 103(17), 7275-7286. https://doi.org/10.1007/s00253-019-10015-w

Carbonic anhydrase catalyses the interconversion of carbon dioxide and water to bicarbonate and protons. It was unknown if the industrial relevant acetogen Clostridium autoethanogenum possesses these enzymes. We identified two putative carbonic anhyd... Read More about The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases.

Can we trust what we see online? (2019)
Digital Artefact
Perez Vallejos, E. (in press). Can we trust what we see online?

Websites use algorithms to recommend music, tv and films that you’ll enjoy. But they could also be manipulating us and hiding the truth. Dr Elvira Perez Vallejos from the University of Nottingham is examining how technology can be made more trustwort... Read More about Can we trust what we see online?.

Polymer microparticles with defined surface chemistry and topography mediate the formation of stem cell aggregates and cardiomyocyte function (2019)
Journal Article
Alvarez-Paino, M., Amer, M. H., Nasir, A., Cuzzucoli Crucitti, V., Thorpe, J., Burroughs, L., …Rose, F. (2019). Polymer microparticles with defined surface chemistry and topography mediate the formation of stem cell aggregates and cardiomyocyte function. ACS Applied Materials and Interfaces, 11(38), 34560-34574. https://doi.org/10.1021/acsami.9b04769

Surface-functionalized microparticles are relevant to fields spanning engineering and biomedicine, with uses ranging from cell culture to advanced cell delivery. Varying topographies of biomaterial surfaces are also being investigated as mediators of... Read More about Polymer microparticles with defined surface chemistry and topography mediate the formation of stem cell aggregates and cardiomyocyte function.

Patients' perspectives on care pathways and informed shared decision making in the transition between psychiatric hospitalization and the community (2019)
Journal Article
Sather, E. W., Iversen, V. C., Svindseth, M. F., Crawford, P., & Vasset, F. (2019). Patients' perspectives on care pathways and informed shared decision making in the transition between psychiatric hospitalization and the community. Journal of Evaluation in Clinical Practice, 25(6), 1131-1141. https://doi.org/10.1111/jep.13206

Rationale, aims, and objectives Patients with mental health problems experience numerous transitions into and out of hospital. This study explores former patients' views of pathways in transition between district psychiatric hospital centres (DPCs)... Read More about Patients' perspectives on care pathways and informed shared decision making in the transition between psychiatric hospitalization and the community.

Try to see it my way: exploring the co-design of visual presentations of well-being through a workshop process (2019)
Journal Article
Craven, M. P., Goodwin, R., Rawsthorne, M., Butler, D., Waddingham, P., Brown, S., & Jamieson, M. (2019). Try to see it my way: exploring the co-design of visual presentations of well-being through a workshop process. Perspectives in Public Health, 139(3), 153-161. https://doi.org/10.1177/1757913919835231

Aims: A 10-month project funded by the NewMind network sought to develop the specification of a visualisation toolbox that could be applied on digital platforms (web- or app- based) to support adults with lived experience of mental health difficultie... Read More about Try to see it my way: exploring the co-design of visual presentations of well-being through a workshop process.

Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults (2018)
Journal Article
Ferrante di Ruffano, L., Takwoingi, Y., Dinnes, J., Chuchu, N., Bayliss, S. E., Davenport, C., …Williams, H. C. (2018). Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults. Cochrane Database of Systematic Reviews, 2018(12), Article CD013186. https://doi.org/10.1002/14651858.CD013186

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high‐risk skin cancers which have the potentia... Read More about Computer assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.

Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours? (2018)
Journal Article
Clark, M. E., Young, B., Bedford, L. E., Robertson, J. F., das Nair, R., Vedhara, K., …Kendrick, D. (2019). Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours?. Journal of Public Health, 41(3), 600-608. https://doi.org/10.1093/pubmed/fdy158

Background Lung cancer screening can reduce lung cancer mortality by 20%. Screen-detected abnormalities may provide teachable moments for smoking cessation. This study assesses impact of pulmonary nodule detection on smoking behaviours within the fi... Read More about Lung cancer screening: does pulmonary nodule detection affect a range of smoking behaviours?.

Attenuated post-movement beta rebound associated with schizotypal features in healthy people (2018)
Journal Article
Hunt, B. A., Liddle, E. B., Gascoyne, L. E., Magazzini, L., Routley, B. C., Singh, K. D., …Liddle, P. F. (2019). Attenuated post-movement beta rebound associated with schizotypal features in healthy people. Schizophrenia Bulletin, 45(4), 883-891. https://doi.org/10.1093/schbul/sby117

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. Introduction: Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidenc... Read More about Attenuated post-movement beta rebound associated with schizotypal features in healthy people.

An end-to-end deep learning histochemical scoring system for breast cancer TMA (2018)
Journal Article
Liu, J., Xu, B., Zheng, C., Gong, Y., Garibaldi, J., Soria, D., …Qiu, G. (2019). An end-to-end deep learning histochemical scoring system for breast cancer TMA. IEEE Transactions on Medical Imaging, 38(2), 617-628. https://doi.org/10.1109/TMI.2018.2868333

One of the methods for stratifying different molecular classes of breast cancer is the Nottingham prognostic index plus, which uses breast cancer relevant biomarkers to stain tumor tissues prepared on tissue microarray (TMA). To determine the molecul... Read More about An end-to-end deep learning histochemical scoring system for breast cancer TMA.