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All Outputs (27)

Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability (2022)
Journal Article
Batchelor, J. M., Gran, S., Leighton, P., Howells, L., Montgomery, A. A., Tan, W., …Thomas, K. S. (2022). Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability. British Journal of Dermatology, 187(4), 548-556. https://doi.org/10.1111/bjd.21671

Background: Validated outcome measures are needed for vitiligo trials. Objectives: To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS). Methods: We used images of vitiligo before and... Read More about Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study) (2021)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., Abdul-Wahab, A., …Thomas, K. S. (2022). Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study). British Journal of Dermatology, 186(2), 341-351. https://doi.org/10.1111/bjd.20689

Background In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared to adults. Objectives To test the diagnostic accuracy of previously agreed consensus criteria and develop... Read More about Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study).

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis (2021)
Journal Article
Hasanaj, A., Zaki, F., Harman, K. E., Grindlay, D., & Gran, S. (2022). Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis. British Journal of Dermatology, 186(2), 359-361. https://doi.org/10.1111/bjd.20759

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality. 1,2 As people with BP and PV often have comorbidity and require treatment that ha... Read More about Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article
Persson, M. S., Harman, K. E., Thomas, K. S., Chalmers, J. R., Vinogradova, Y., Langan, S. M., …Gran, S. (2021). Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study. British Journal of General Practice, 71(713), e904-e911. https://doi.org/10.3399/BJGP.2020.0870

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

The global incidence of bullous pemphigoid: a systematic review and meta-analysis (2021)
Journal Article
Persson, M. S., Begum, N., Grainge, M. J., Harman, K. E., Grindlay, D., & Gran, S. (2022). The global incidence of bullous pemphigoid: a systematic review and meta-analysis. British Journal of Dermatology, 186(3), 414-425. https://doi.org/10.1111/bjd.20743

Background: Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. Objectives: The study... Read More about The global incidence of bullous pemphigoid: a systematic review and meta-analysis.

Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study (2021)
Journal Article
Kirby, L., Gran, S., Orekoya, F., Owen, C., & Simpson, R. (2021). Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study. British Journal of Dermatology, 185(5), 1063-1065. https://doi.org/10.1111/bjd.20583

Increasing evidence suggests the pathogenesis of male genital lichen sclerosus (LS) is driven by chronic, occluded exposure of susceptible epithelium to the irritant effect of urine (1, 2). It is not clear how this can be extrapolated to females, how... Read More about Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study.

Do patient characteristics matter when calculating sample size for eczema clinical trials? (2021)
Journal Article
Howells, L., Gran, S., Chalmers, J. R., Stuart, B., Santer, M., Bradshaw, L., …Thomas, K. S. (2021). Do patient characteristics matter when calculating sample size for eczema clinical trials?. Skin Health and Disease, 1(3), Article e42. https://doi.org/10.1002/ski2.42

Background: The Patient-Oriented Eczema Measure (POEM) is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To ensure that the statistical significance of clinical trial results is meani... Read More about Do patient characteristics matter when calculating sample size for eczema clinical trials?.

Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis (2021)
Journal Article
Cunliffe, A., Gran, S., Ali, U., Grindlay, D., Lax, S., Williams, H., & Burden-Teh, E. (2021). Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis. Skin Health and Disease, 1(2), Article e29. https://doi.org/10.1002/ski2.29

Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta?analysis.

Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records (2021)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2021). Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records. Osteoarthritis and Cartilage, 3(2), Article 100165. https://doi.org/10.1016/j.ocarto.2021.100165

Objective To examine the association between the current use of analgesics and the risk of falls in people with knee osteoarthritis (KOA). Methods A retrospective cohort study using data from the UK Clinical Practice Research Datalink, with... Read More about Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records.

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis (2021)
Journal Article
Kirby, L., Gran, S., Kreuser-Genis, I., Owen, C., & Simpson, R. (2021). Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis. Skin Health and Disease, 1(1), Article e13. https://doi.org/10.1002/ski2.13

Background Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epith... Read More about Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta?analysis.

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England (2021)
Journal Article
Persson, M., Harman, K., Thomas, K., Chalmers, J., Vinogradova, Y., Langan, S., …Gran, S. (2021). Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England. BMC Medical Research Methodology, 21(1), Article 22. https://doi.org/10.1186/s12874-021-01212-1

Background Trials of novel agents are required to improve the care of patients with rare diseases, but trial feasibility may be uncertain due to concerns over insufficient patient numbers. We aimed to determine the size of the pool of potential part... Read More about Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.

A 10?year Review of Surgical Management of Dermatofibrosarcoma Protuberans (2020)
Journal Article
Durack, A., Gran, S., Gardiner, M., Jain, A., Craythorne, E., Proby, C., …Matin, R. (2021). A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans. British Journal of Dermatology, 184(4), 731-739. https://doi.org/10.1111/bjd.19346

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Standard treatment in the United Kingdom (UK) is either surgical wide local excision (WLE) or Mohs micrographic surgery (MMS). It is unclear which approach has the lower recurr... Read More about A 10?year Review of Surgical Management of Dermatofibrosarcoma Protuberans.

Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP) (2019)
Journal Article
Howells, L. M., Chalmers, J. R., Gran, S., Ahmed, A., Apfelbacher, C., Burton, T., …Thomas, K. S. (2020). Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP). British Journal of Dermatology, 183(3), 524-536. https://doi.org/10.1111/bjd.18780

Background: Eczema control has been identified as an important outcome by key stakeholders in eczema research (including patients, carers, healthcare professionals and researchers) but no validated instruments for the domain have been identified. Obj... Read More about Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP).

Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics (2019)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., & Thomas, K. S. (2019). Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics. BMJ Open, 9(8), e028689. https://doi.org/10.1136/bmjopen-2018-028689

Introduction Diagnosing psoriasis in children can be challenging. Early and accurate diagnosis is important to ensure patients receive psoriasis specific treatment and monitoring. It is recognised that the physical, psychological, quality of life, fi... Read More about Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics.

Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016 (2019)
Journal Article
van Lee, C. B., Kan, W. C., Gran, S., Mooyaart, A., Mureau, M. A., Williams, H., …Hollestein, L. M. (2019). Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016. Acta Dermato-Venereologica, 99(12), 1160-1165. https://doi.org/10.2340/00015555-3287

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (less than 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890... Read More about Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016.

Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts (2019)
Journal Article
Andersen, Y. M., Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., …Thyssen, J. P. (2019). Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care, 42(6), 1095-1103. https://doi.org/10.2337/dc18-2158

Background Topical corticosteroids (CS) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. While topical CS package inserts describe hyperglycaemia and glycosuria as adverse drug reactions, it is unclear whether... Read More about Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts.

Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema (2019)
Journal Article
Howells, L., Thomas, K. S., Sears, A. V., Nasr, I., Wollenberg, A., Schuttelaar, M. L., …Chalmers, J. R. (2019). Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema. Journal of the European Academy of Dermatology and Venereology, 33(6), 1124-1132. https://doi.org/10.1111/jdv.15475

Background: Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients’ health and wellbeing. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that “long-term control of eczema”... Read More about Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema.

Long-term topical corticosteroid use and risk of skin cancer: a systematic review (2018)
Journal Article
Ratib, S., Burden-Teh, E., Leonardi-Bee, J., Harwood, C., & Bath-Hextall, F. (in press). Long-term topical corticosteroid use and risk of skin cancer: a systematic review. JBI Database of Systematic Reviews and Implementation Reports, 16(6), https://doi.org/10.11124/jbisrir-2017-003393

Objective: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS). Introduction: Topical corticosteroids are one of... Read More about Long-term topical corticosteroid use and risk of skin cancer: a systematic review.

Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis (2018)
Journal Article
Ban, L., Labbouz, S., Grindlay, D. J., Batchelor, J. M., & Ratib, S. (2018). Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis. British Journal of Dermatology, 179(4), 971-972. https://doi.org/10.1111/bjd.16703

Vitiligo is a chronic disorder causing skin depigmentation with around 1% global prevalence, affecting people of all ages, skin types and genders.1 Due to the absence of melanin in lesional skin there is a theoretical concern that there might be a hi... Read More about Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis.