All Outputs (4)

Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated (2023)
Journal Article
Atallah, E., Grove, J., Crooks, C., Burden-Teh, E., Abhishek, A., Moreea, S., …Aithal, G. (2023). Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated. Journal of Hepatology, 78(5), 989-997. https://doi.org/10.1016/j.jhep.2022.12.034

Background & Aims The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-re... Read More about Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated.

Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study (2015)
Journal Article
Ratib, S., Fleming, K. M., Crooks, C. J., Walker, A. J., & West, J. (2015). Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study. American Journal of Gastroenterology, 110, https://doi.org/10.1038/ajg.2015.191

Introduction Liver cirrhosis is increasing worldwide and associated with high mortality. Precise estimates of cause-specific mortality compared to the general population, by underlying aetiology, are lacking. Such information may demonstrate areas w... Read More about Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study.

1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study (2014)
Journal Article
Ratib, S., Fleming, K. M., Crooks, C. J., Aithal, G. P., & West, J. (2014). 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study. Journal of Hepatology, 60(2), https://doi.org/10.1016/j.jhep.2013.09.027

BACKGROUND & AIMS: Large, population-based studies that have included the full spectrum of cirrhosis estimating survival, taking into account time-at-risk are lacking. We aimed to report 1- and 5-year average survival rates for people with cirrhosis... Read More about 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study.

Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer (2014)
Journal Article
Ratib, S., West, J., Crooks, C. J., & Fleming, K. M. (2014). Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer. American Journal of Gastroenterology, 109(2), https://doi.org/10.1038/ajg.2013.405

OBJECTIVES: There is no routine registration of the occurrence of newly diagnosed cases of cirrhosis in the United Kingdom. This study seeks to determine precise estimates and trends of the incidence of cirrhosis in England, and directly compare the... Read More about Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer.