All Outputs (40)

Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells (2019)
Journal Article
Ahmed, M., Jinks, N., Babaei-Jadidi, R., Kashfi, H., Castellanos-Uribe, M., May, S. T., …Nateri, A. S. (2019). Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells. Cancers, 12(1), Article 106. https://doi.org/10.3390/cancers12010106

Tumour-promoting inflammation is involved in colorectal cancer (CRC) development and therapeutic resistance. However, the antibiotics and antibacterial drugs and signalling that regulate the potency of anticancer treatment upon forced differentiation... Read More about Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells.

In Situ Monitoring of Heterogeneous Catalytic Hydrogenation via 129Xe NMR Spectroscopy and Proton MRI (2019)
Journal Article
Burueva, D. B., Pokochueva, E. V., Wang, X., Filkins, M., Svyatova, A., Rigby, S. P., …Koptyug, I. V. (2020). In Situ Monitoring of Heterogeneous Catalytic Hydrogenation via 129Xe NMR Spectroscopy and Proton MRI. ACS Catalysis, 10(2), 1417-1422. https://doi.org/10.1021/acscatal.9b05000

Loss of ELK1 has differential effects on age-dependent organ fibrosis (2019)
Journal Article
Cairns, J. T., Habgood, A., Edwards-Pritchard, R. C., Joseph, C., John, A. E., Wilkinson, C., …Tatler, A. L. (2020). Loss of ELK1 has differential effects on age-dependent organ fibrosis. International Journal of Biochemistry and Cell Biology, 120, Article 105668. https://doi.org/10.1016/j.biocel.2019.105668

© 2019 The Author(s) ETS domain-containing protein-1 (ELK1) is a transcription factor important in regulating αvβ6 integrin expression. αvβ6 integrins activate the profibrotic cytokine Transforming Growth Factor β1 (TGFβ1) and are increased in the al... Read More about Loss of ELK1 has differential effects on age-dependent organ fibrosis.

Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression (2019)
Journal Article
Cairns, J. T., Habgood, A., Edwards-Pritchard, R. C., Wilkinson, C., Stewart, I. D., Leslie, J., …Tatler, A. L. (2020). Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression. International Journal of Biochemistry and Cell Biology, 120, Article 105668. https://doi.org/10.1016/j.biocel.2019.105668

ETS domain-containing protein-1 (ELK1) is a transcription factor important in regulating ?v?6 integrin expression. ?v?6 integrins activate the profibrotic cytokine Transforming Growth Factor ?1 (TGF?1) and are increased in the alveolar epithelium in... Read More about Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression.

Highlights 2019: fresh focus on health (2019)
Journal Article
Palmer, J., Bolton, C. E., Shrestha, P., Adhikari, P., & Karmacharya, B. (2019). Highlights 2019: fresh focus on health. Lancet, 394(10216), 2219-2236. https://doi.org/10.1016/s0140-6736%2819%2933060-0

Contribution towards Fresh focus on health: Highlights 2019 photography competition open for submissions. Palmer J. Lancet. 2019 Jun 8;393(10188):2284-2285. doi: 10.1016/S0140-6736(19)31258-9. Epub 2019 Jun 6 https://www.ncbi.nlm.nih.gov/pubm... Read More about Highlights 2019: fresh focus on health.

Clinical quantification of the integrin ?v?6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study) (2019)
Journal Article
Lukey, P. T., Coello, C., Gunn, R., Parker, C., Wilson, F. J., Saleem, A., …Marshall, R. P. (2020). Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study). European Journal of Nuclear Medicine, 47(4), 967-979. https://doi.org/10.1007/s00259-019-04586-z

Is the English Cancer Patient Experience Survey representative? A comparative analysis with the National Lung Cancer Audit (2019)
Journal Article
Nartey, Y., Stewart, I., Khakwani, A., Beattie, V., Wilcock, A., Woolhouse, I., …Tata, L. J. (2020). Is the English Cancer Patient Experience Survey representative? A comparative analysis with the National Lung Cancer Audit. Lung Cancer, 140, 27-34. https://doi.org/10.1016/j.lungcan.2019.11.023

© 2019 Elsevier B.V. Objectives: Healthcare systems increasingly recognise the importance of service users’ perspectives for improving care organisation and delivery. The English Cancer Patient Experience Survey (CPES) is carried out annually, howeve... Read More about Is the English Cancer Patient Experience Survey representative? A comparative analysis with the National Lung Cancer Audit.

Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study (2019)
Journal Article
Young, B., Cranwell, J., Fogarty, A. W., Skelly, R., Sturrock, N., Norwood, M., …Thurley, P. (2019). Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study. BMC Health Services Research, 19, https://doi.org/10.1186/s12913-019-4712-y

Background: In the context of increasing availability of computed tomography (CT) scans, judicious use of ionising radiation is a priority to minimise the risk of future health problems. Hence, education of clinicians on the risks and benefits of CT... Read More about Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study.

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis (2019)
Journal Article
Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S., Dressen, A., Paynton, M. L., …Wain, L. V. (2020). Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 201(5), 564-574. https://doi.org/10.1164/rccm.201905-1017oc

RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of... Read More about Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.

A data analysis of the Chilean housing stock and the development of modelling archetypes (2019)
Journal Article
Molina, C., Kent, M., Hall, I., & Jones, B. (2020). A data analysis of the Chilean housing stock and the development of modelling archetypes. Energy and Buildings, 206, Article 109568. https://doi.org/10.1016/j.enbuild.2019.109568

Chile is a South American country experiencing greater social and economic development than the majority of its neighbours and whose economy is transitioning from developing to developed status. It is committed to reduce its greenhouse gas (GHG) emis... Read More about A data analysis of the Chilean housing stock and the development of modelling archetypes.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., …Cámara, M. (2019). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology, 68(12), 1823-1828. https://doi.org/10.1099/jmm.0.001099

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

Hypertension in adults: summary of updated NICE guidance (2019)
Journal Article
Boffa, R. J., Constanti, M., Floyd, C. N., Wierzbicki, A. S., & Glover, M. (2019). Hypertension in adults: summary of updated NICE guidance. BMJ, 367, 1-6. https://doi.org/10.1136/bmj.l5310

Hypertension is a leading global cause of morbidity and mortality. More than 25% of the adult UK population has hypertension, and in about 30% blood pressure remains uncontrolled.1 In August, the National Institute for Health and Care Excellence (NIC... Read More about Hypertension in adults: summary of updated NICE guidance.

Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study (2019)
Journal Article
Lewis, S., Young, B., Thurley, P., Shaw, D., Cranwell, J., Skelly, R., …Fogarty, A. W. (2019). Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study. Future Healthcare Journal, 6(3), 204-208. https://doi.org/10.7861/fhj.2019-0001

Background: Behavioural insights or ‘nudge’ theory suggests that non-directional interventions may be used to modify human behaviour. We have tested the hypothesis that the provision of the cost of common blood tests with their results may modify sub... Read More about Does cost feedback modify demand for common blood tests in secondary care? A prospective controlled intervention study.

European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia (2019)
Journal Article
Duijts, L., van Meel, E. R., Moschino, L., Baraldi, E., Barnhoorn, M., Bramer, W. M., …Pijnenburg, M. W. (2020). European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia. European Respiratory Journal, 55(1), Article 1900788. https://doi.org/10.1183/13993003.00788-2019

This document provides recommendations for monitoring and treatment of children in whom bronchopulmonary dysplasia (BPD) has been established and were discharged from the hospital, or who were older than 36 weeks of postmenstrual age. The guideline w... Read More about European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia.

Is targeted lung cancer screening an opportune time to address cardiovascular risk? (2019)
Journal Article
Fisk, M., & Bolton, C. E. (2019). Is targeted lung cancer screening an opportune time to address cardiovascular risk?. Thorax, 74(12), 1107-1108. https://doi.org/10.1136/thoraxjnl-2019-213790

Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea-are we any closer? Authors' reply (2019)
Journal Article
Gunn, D., Garsed, K., Lam, C., Singh, G., Lingaya, M., Wahl, V., …Spiller, R. (2019). Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea-are we any closer? Authors' reply. Alimentary Pharmacology and Therapeutics, 50(7), 826-827. https://doi.org/10.1111/apt.15465

Setting the standard: The acceptability of kitchen ventilation for the English housing stock (2019)
Journal Article
O'Leary, C., Jones, B., Dimitroulopoulou, S., & Hall, I. P. (2019). Setting the standard: The acceptability of kitchen ventilation for the English housing stock. Building and Environment, 166, https://doi.org/10.1016/j.buildenv.2019.106417

Exposure to particulate matter with diameter ?2.5??m (PM2.5) is associated with an elevated risk of adverse health effects and cooking is a primary source of PM2.5 in non-smoking households. Therefore, it is important to investigate PM2.5 concentrati... Read More about Setting the standard: The acceptability of kitchen ventilation for the English housing stock.

Changes in Asthma Mortality in England and Wales since 2001 (2019)
Journal Article
Shaw, D. E., Gaynor, C. M., & Fogarty, A. (2019). Changes in Asthma Mortality in England and Wales since 2001. Thorax, 74(12), 1174-1175. https://doi.org/10.1136/thoraxjnl-2019-213350

The number of deaths from asthma in England and Wales has not changed significantly over the last decade. This lack of improvement has received attention from both national asthma guidelines and the media. We examined asthma death data from the Offic... Read More about Changes in Asthma Mortality in England and Wales since 2001.

Exposure to lippolysaccharide (LPS) reduces contractile response of small airways from GSTCD+ mice (2019)
Journal Article
Liu, B., Henry, A. P., Azimi, S., Miller, S., Lee, F. K., Lee, J. C., …Hall, I. P. (2019). Exposure to lippolysaccharide (LPS) reduces contractile response of small airways from GSTCD+ mice. PLoS ONE, 14(9), Article e0221899. https://doi.org/10.1371/journal.pone.0221899

Introduction: Genome-Wide Association Studies suggest glutathione S transferase C terminal domain (GSTCD) may play a role in development of Chronic Obstructive Pulmonary Disease. We aimed to define the potential role of GSTCD in airway inflammation a... Read More about Exposure to lippolysaccharide (LPS) reduces contractile response of small airways from GSTCD+ mice.

Defining a role for lung function associated gene GSTCD in cell homeostasis (2019)
Journal Article
Henry, A. P., Probert, K., Stewart, C. E., Thakker, D., Bhaker, S., Azimi, S., …Sayers, I. (2019). Defining a role for lung function associated gene GSTCD in cell homeostasis. Respiratory Research, 20(1), Article 172. https://doi.org/10.1186/s12931-019-1146-3

Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a candidate causal gene in this locus, how... Read More about Defining a role for lung function associated gene GSTCD in cell homeostasis.