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All Outputs (11)

Nominal group technique to establish the core components of home-based rehabilitation for survivors of stroke with severe disability (2021)
Journal Article
Fisher, R. J., Riley-Bennett, F., Russell, L., Lee, C., Sturt, R., Walker, M., & Sackley, C. (2021). Nominal group technique to establish the core components of home-based rehabilitation for survivors of stroke with severe disability. BMJ Open, 11(12), Article e052593. https://doi.org/10.1136/bmjopen-2021-052593

In the UK, over 20% of patients leaving hospital after a stroke will be severely disabled. Despite this, limited clinical guidance is available to teams tasked with providing support for this complex population at home. Additionally, many areas acros... Read More about Nominal group technique to establish the core components of home-based rehabilitation for survivors of stroke with severe disability.

Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial (2019)
Journal Article
Ford, G. A., Bhakta, B. B., Cozens, A., Hartley, S., Holloway, I., Meads, D., …Farrin, A. J. (2019). Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial. Lancet, 18, 530–538

Background Dopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving m... Read More about Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial.

Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial (2019)
Journal Article
Ford, G. A., Bhakta, B. B., Cozens, A., Hartley, S., Holloway, I., Meads, D., …Farrin, A. J. (2019). Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial. Lancet Neurology, 18(6), 530-538. https://doi.org/10.1016/s1474-4422%2819%2930147-4

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Dopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials... Read More about Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial.

Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease: a large pragmatic randomised controlled trial (PD REHAB) (2016)
Journal Article
Clarke, C. E., Patel, S., Ives, N., Rick, C. E., Woolley, R., Wheatley, K., …Sackley, C. M. (2016). Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease: a large pragmatic randomised controlled trial (PD REHAB). Health Technology Assessment, 20(63), https://doi.org/10.3310/hta20630

Background Cochrane reviews of physiotherapy (PT) and occupational therapy (OT) for Parkinson’s disease found insufficient evidence of effectiveness, but previous trials were methodologically flawed with small sample size and short-term follow-up.... Read More about Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease: a large pragmatic randomised controlled trial (PD REHAB).

An Occupational Therapy intervention for residents with stroke-related disabilities in UK Care Homes (OTCH): cluster randomised controlled trial with economic evaluation (2016)
Journal Article
Sackley, C. M., Walker, M. F., Burton, C. R., Watkins, C. L., Mant, J., Roalfe, A. K., …Peryer, G. (2016). An Occupational Therapy intervention for residents with stroke-related disabilities in UK Care Homes (OTCH): cluster randomised controlled trial with economic evaluation. Health Technology Assessment, 20(15), 1-138. https://doi.org/10.3310/hta20150

Background: Care home residents with stroke-related disabilities have significant activity limitations. Phase II trial results suggested a potential benefit of occupational therapy (OT) in maintaining residents’ capacity to engage in functional activ... Read More about An Occupational Therapy intervention for residents with stroke-related disabilities in UK Care Homes (OTCH): cluster randomised controlled trial with economic evaluation.

Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial (2016)
Journal Article
Clarke, C. E., Patel, S., Ives, N., Dowling, F., Rick, C. E., Woolley, R., …Sackley, C. M. (in press). Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial. JAMA Neurology, 73(3), https://doi.org/10.1001/jamaneurol.2015.4452

IMPORTANCE It is unclear whether physiotherapy and occupational therapy are clinically effective and cost-effective in Parkinson disease (PD). OBJECTIVE To perform a large pragmatic randomized clinical trial to evaluate the clinical effectiveness of... Read More about Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial.

An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial (2015)
Journal Article
Sackley, C. M., Walker, M. F., Burton, C. R., Watkins, C. L., Mant, J., Roalfe, A. K., …Peryer, G. (2015). An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial. BMJ, 350(feb05), 1-11. https://doi.org/10.1136/bmj.h468

Objective: To evaluate the clinical efficacy of an established programme of occupational therapy in maintaining functional activity and reducing further health risks from inactivity in care home residents living with stroke sequelae. Design: Pragmat... Read More about An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial.

Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial (2015)
Journal Article
das Nair, R., Lincoln, N., Ftizsimmons, D., Brain, N., Montgomery, A., Bradshaw, L., …Pink, A. (2015). Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial. Trials, 16(6), https://doi.org/10.1186/1745-6215-16-6

Background Impairments of memory are commonly reported by people with traumatic brain injuries (TBI). Such deficits are persistent, debilitating, and can severely impact quality of life. Currently, many do not routinely receive follow-up appointment... Read More about Rehabilitation of memory following brain injury (ReMemBrIn): study protocol for a randomised controlled trial.

The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke (2014)
Journal Article
Bhakta, B., Hartley, S., Holloway, I., Couzens, A., Ford, G., Meads, D., …Farrin, A. (2014). The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke. Trials, 15(316), https://doi.org/10.1186/1745-6215-15-316

Background: Stroke has a huge impact, leaving more than a third of affected people with lasting disability and rehabilitation remains a cornerstone treatment in the National Health Service (NHS). Recovery of mobility and arm function post-stroke occu... Read More about The DARS (Dopamine Augmented Rehabilitation in Stroke) trial: protocol for a randomised controlled trial of Co-careldopa treatment in addition to routine NHS occupational and physical therapy after stroke.