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Visual histological assessment of morphological features reflects the underlying molecular profile in invasive breast cancer: a morpho‐molecular study (2020)
Journal Article
Rakha, E. A., Alsaleem, M., Elsharawy, K. A., Toss, M. S., Raafat, S., Mihai, R., …Mongan, N. P. (2020). Visual histological assessment of morphological features reflects the underlying molecular profile in invasive breast cancer: a morpho‐molecular study. Histopathology, https://doi.org/10.1111/his.14199

Background: Tumour genotype and phenotype are related and can predict outcome. In this study, we hypothesised that the visual assessment of breast cancer morphological features can provide valuable insight into underlying molecular profiles. Metho... Read More about Visual histological assessment of morphological features reflects the underlying molecular profile in invasive breast cancer: a morpho‐molecular study.

Feasibility of integrated high‐wavenumber Raman imaging and fingerprint Raman spectroscopy for fast margin assessment in breast cancer surgery (2020)
Journal Article
Liao, Z., Lizio, M. G., Corden, C., Khout, H., Rakha, E., & Notingher, I. (2020). Feasibility of integrated high‐wavenumber Raman imaging and fingerprint Raman spectroscopy for fast margin assessment in breast cancer surgery. Journal of Raman Spectroscopy, https://doi.org/10.1002/jrs.5937

Intraoperative assessment of surgical margins remains one of the main challenges in cancer surgery. Raman spectroscopy can detect cancer cells with high accuracy, but it is time‐consuming. In this paper, we investigated a selective‐sampling Raman spe... Read More about Feasibility of integrated high‐wavenumber Raman imaging and fingerprint Raman spectroscopy for fast margin assessment in breast cancer surgery.

Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement (2020)
Journal Article
Vankemmelbeke, M., McIntosh, R. S., Chua, J. X., Kirk, T., Daniels, I., Patsalidou, M., …Durrant, L. G. (2020). Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement. Cancer Research, https://doi.org/10.1158/0008-5472.CAN-19-3599

Murine IgG3 glycan-targeting mAb often induces direct cell killing in the absence of immune effector cells or complement via a proinflammatory mechanism resembling oncotic necrosis. This cancer cell killing is due to non-covalent association between... Read More about Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement.

The prognostic significance of BMI-1 expression in invasive breast cancer is dependent on its molecular subtypes (2020)
Journal Article
Althobiti, M., Aleskandarany, M. A., Joseph¹, C., Muftah, A. A., Toss, M. S., Green, A., & Rakha, E. (2020). The prognostic significance of BMI-1 expression in invasive breast cancer is dependent on its molecular subtypes. Breast Cancer Research and Treatment, 182, 581–589. https://doi.org/10.1007/s10549-020-05719-x

Purpose: BMI-1, which is a major component of the polycomb group complex 1 is an essential epigenetic repressor of multiple regulatory genes and has been identified as a cancer stem cell (CSC) marker in several cancers. However, its role in breast c... Read More about The prognostic significance of BMI-1 expression in invasive breast cancer is dependent on its molecular subtypes.

Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study (2020)
Journal Article
Milojkovic, D., Cross, N. C., Ali, S., Byrne, J., Campbell, G., Dignan, F. L., …Mead, A. J. (2020). Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study. British Journal of Haematology, https://doi.org/10.1111/bjh.16733

Management of chronic myeloid leukaemia (CML) has recently undergone dramatic changes, prompting the European LeukemiaNet (ELN) to issue recommendations in 2013; however, it remains unclear whether real-world CML management is consistent with these g... Read More about Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study.

Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas (2020)
Journal Article
Martin, S., Yao, A., Storr, S. J., Al-Hadyan, K., Rahman, R., Smith, S., …Paine, S. (2020). Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas. Molecular Neurobiology, 57(7), 2889–2901. https://doi.org/10.1007/s12035-020-01928-z

The thioredoxin (Trx) system is an important enzyme family that regulates cellular redox homeostasis. Protein expression of Trx system family members has been assessed in various cancers and linked to various clinicopathological variables, disease pr... Read More about Thioredoxin system protein expression is associated with poor clinical outcome in adult and paediatric gliomas and medulloblastomas.

PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer (2020)
Journal Article
Alfarsi, L. H., El Ansari, R., Craze, M. L., Masisi, B. K., Ellis, I. O., Rakha, E. A., & Green, A. R. (2020). PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer. BMC Cancer, 20(1), https://doi.org/10.1186/s12885-020-06939-6

Background PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate that PPFIA1 is an important pro... Read More about PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer.

A novel prognostic two-gene signature for triple negative breast cancer (2020)
Journal Article
Alsaleem, M. A., Ball, G., Toss, M. S., Raafat, S., Aleskandarany, M., Joseph, C., …Rakha, E. (2020). A novel prognostic two-gene signature for triple negative breast cancer. Modern Pathology, https://doi.org/10.1038/s41379-020-0563-7

The absence of a robust risk stratification tool for triple negative breast cancer (TNBC) underlies imprecise and non-selective treatment of these patients with cytotoxic chemotherapy. This study aimed to interrogate transcriptomes of TNBC resected s... Read More about A novel prognostic two-gene signature for triple negative breast cancer.

The Use of Biomaterials in Internal Radiation Therapy (2020)
Journal Article
Milborne, B., Arafat, A., Layfield, R., Thompson, A., & Ahmed, I. (2020). The Use of Biomaterials in Internal Radiation Therapy. 00 Journal not listed, 2(2), https://doi.org/10.21926/rpm.2002012

Radiotherapy has become one of the most prominent and effective modalities for cancer treatment and care. Ionising radiation, delivered either from external or internal sources, can be targeted to cancerous cells causing damage to DNA that can induce... Read More about The Use of Biomaterials in Internal Radiation Therapy.

The prognostic significance of ALDH1A1 expression in early invasive breast cancer (2020)
Journal Article
Althobiti, M., Ansari, R. E., Aleskandarany, M., Joseph, C., Toss, M. S., Green, A. R., & Rakha, E. A. (2020). The prognostic significance of ALDH1A1 expression in early invasive breast cancer. Histopathology, https://doi.org/10.1111/his.14129

Aims: Aldehyde dehydrogenase family 1 member A1 (ALDH1A1)is reportedly a key ALDH isozyme linked to the cancer stem cells (CSC) of many solid tumours, where it is involved in self-renewal, differentiation and self-protection. In this study, the progn... Read More about The prognostic significance of ALDH1A1 expression in early invasive breast cancer.

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer (2020)
Journal Article
Monteiro, P. F., Gulfam, M., Monteiro, C. J., Travanut, A., Abelha, T. F., Pearce, A. K., …Alexander, C. (2020). Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer. Journal of Controlled Release, 323, 549-564. https://doi.org/10.1016/j.jconrel.2020.04.049

© 2020 Elsevier B.V. Triple negative or basal-like breast cancer (TNBC) is characterised by aggressive progression, lack of standard therapies and poorer overall survival rates for patients. The bad prognosis, high rate of relapse and resistance agai... Read More about Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer.

The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer (2020)
Journal Article
Fallon, M., Dolan, R. D., Daly, L. E., Simmons, C. P., Wilcock, A., Usborne, C., …Maddocks, M. (2020). The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer. Cancers, 12(5), https://doi.org/10.3390/cancers12051187

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the prese... Read More about The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer.

Non‐invasive measurement of retinal permeability in a diabetic rat model (2020)
Journal Article
Whatmore, J. L., Allen, C. L., Malhi, N. K., Whatmore, J. D., Bates, D. O., & Arkill, K. P. (2020). Non‐invasive measurement of retinal permeability in a diabetic rat model. Microcirculation, https://doi.org/10.1111/micc.12623

Objective: The gold standard for measuring blood-retinal barrier permeability is the Evans blue assay. However, this technique has limitations in vivo, including non-specific tissue binding and toxicity. This study describes a non-toxic, high through... Read More about Non‐invasive measurement of retinal permeability in a diabetic rat model.

Myxovirus Resistance 1 (MX1) is an Independent Predictor of Poor Outcome in Invasive Breast Cancer (2020)
Journal Article
Aljohani, A. I., Joseph, C., Kurozumi, S., Mohammed, O. J., Miligy, I. M., Green, A. R., & Rakha, E. (2020). Myxovirus Resistance 1 (MX1) is an Independent Predictor of Poor Outcome in Invasive Breast Cancer. Breast Cancer Research and Treatment, 181(3), 541–551. https://doi.org/10.1007/s10549-020-05646-x

Background: Breast cancer (BC) is a disease with variable morphology, clinical behaviour and response to therapy. Identifying factors associated with the progression of early stage BC can help understand the risk of metastasis and guide treatment dec... Read More about Myxovirus Resistance 1 (MX1) is an Independent Predictor of Poor Outcome in Invasive Breast Cancer.

Molecular Complexity of Lymphovascular Invasion: The Role of Cell Migration in Breast Cancer as a Prototype (2020)
Journal Article
Kariri, Y. A., Aleskandarany, M. A., Joseph, C., Toss, M. S., Kurozumi, S., Mohammed, O. J., …Rakha, E. A. (in press). Molecular Complexity of Lymphovascular Invasion: The Role of Cell Migration in Breast Cancer as a Prototype. Pathobiology,

Lymphovascular invasion (LVI) is associated with poor outcome in breast cancer (BC); however, its underlying mechanisms remain ill-defined. LVI in BC develops through complex molecular pathways involving not only the interplay with the surrounding mi... Read More about Molecular Complexity of Lymphovascular Invasion: The Role of Cell Migration in Breast Cancer as a Prototype.

Mathematical model to determine the effect of a sub-glycocalyx space (2020)
Journal Article
Dyson, R. J., Dalwadi, M. P., Dalwadi, M. P., King, J. R., Dyson, R. J., & Arkill, K. P. (2020). Mathematical model to determine the effect of a sub-glycocalyx space. Physical Review Fluids, 5(4), https://doi.org/10.1103/physrevfluids.5.043103

We consider the drainage of blood plasma across the capillary wall, focusing on the flow through the endothelial glycocalyx layer that coats the luminal surface of vascular endothelial cells. We investigate how the presence of a sub-glycocalyx space... Read More about Mathematical model to determine the effect of a sub-glycocalyx space.

SPAG5: an emerging oncogene (2020)
Journal Article
He, J., Green, A. R., Li, Y., Chan, S. Y. T., & Liu, D. (2020). SPAG5: an emerging oncogene. Trends in Cancer, 6(7), 543-547. https://doi.org/10.1016/j.trecan.2020.03.006

SPAG5 is a mitotic spindle protein. Recent studies have found that it is overexpressed in many human cancers and functions as an oncogene. We summarize the current underlying mechanisms for its oncogenic roles in regulating cellular behaviors of canc... Read More about SPAG5: an emerging oncogene.

Regional differences in human biliary tissues and corresponding in vitro derived organoids (2020)
Journal Article
Rimland, C. A., Tilson, S. G., Morell, C. M., Tomaz, R. A., Lu, W., Adams, S. E., …Vallier, L. (2020). Regional differences in human biliary tissues and corresponding in vitro derived organoids. Hepatology, https://doi.org/10.1002/hep.31252

Background Organoids provide a powerful system to study epithelia in vitro . Recently, this approach was applied successfully to the biliary tree, a series of ductular tissues responsible for the drainage of bile and pancreatic secretions. More prec... Read More about Regional differences in human biliary tissues and corresponding in vitro derived organoids.


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