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ERCC1 is a predictor of anthracycline resistance and taxane sensitivity in early stage or locally advanced breast cancers (2019)
Journal Article
Abdel-Fatah, T. M., Ali, R., Sadiq, M., Moseley, P. M., Mesquita, K. A., Ball, G., …Madhusudan, S. (2019). ERCC1 is a predictor of anthracycline resistance and taxane sensitivity in early stage or locally advanced breast cancers. Cancers, 11(8), doi:10.3390/cancers11081149

Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated 188 DNA repair genes in the METABRIC cohort (n = 1980) to identify genes that influence overall survival (OS). We then evaluated the clinico... Read More

The prognostic significance of Cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ (2019)
Journal Article
Toss, M. S., Miligy, I. M., Gorringe, K. L., Mittal, K., Green, A. R., Aneja, R., …Rakha, E. A. (in press). The prognostic significance of Cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ. Journal of Clinical Pathology,

Aims: Cathepsin V (CTSV/CTSL2) is a lysosomal cystine proteinase and plays a role in extracellular matrix degradation. It is associated with poor prognosis in invasive breast cancer (IBC), but its role in breast ductal carcinoma in situ (DCIS) remain... Read More

Whole-Exome and RNA-Sequencing Analyses of Acinic Cell Carcinomas of the Breast (2019)
Journal Article
Beca, F., Lee, S. S., Pareja, F., da Cruz Paula, A., Selenica, P., Ferrando, L., …Reis‐Filho, J. S. (2019). Whole-Exome and RNA-Sequencing Analyses of Acinic Cell Carcinomas of the Breast. Histopathology, doi:10.1111/his.13962

Aims Acinic cell carcinoma of the breast (ACC) is a rare histologic form of triple‐negative breast cancer (TNBC). Despite its unique histology, targeted sequencing analysis has failed to identify recurrent genetic alterations other than those found... Read More

A Whole Slide Image and Machine Learning Approach to Predict Ductal Carcinoma in Situ (DCIS) Recurrence Risk Short Title: Machine Learning and Image Analysis-Based DCIS Recurrence Prediction (2019)
Journal Article
Klimov, S., Miligy, I. M., Gertych, A., Jiang, Y., Toss, M. S., Rida, P., …Aneja, R. (2019). A Whole Slide Image and Machine Learning Approach to Predict Ductal Carcinoma in Situ (DCIS) Recurrence Risk Short Title: Machine Learning and Image Analysis-Based DCIS Recurrence Prediction. Breast Cancer Research, 21, doi:10.1186/s13058-019-1165-5

Surgical management of ductal carcinoma in situ of the breast: a large retrospective study from a single institution (2019)
Journal Article
Miligy, I. M., Toss, M. S., Khout, H., Hc, B., Ellis, I. O., Green, A. R., …Rakha, E. (2019). Surgical management of ductal carcinoma in situ of the breast: a large retrospective study from a single institution. Breast Journal, doi:10.1111/tbj.13425

Background: Management of breast ductal carcinoma in situ (DCIS) has various approaches with distinct institutional specific practice. Here, we review DCIS management in a single institution with emphasise on re-operation rates and outcome. Methods:... Read More

Modeling Hypertrophic Cardiomyopathy: mechanistic insights and pharmacological intervention (2019)
Journal Article
Mosqueira, D., Smith, J. G. W., Bhagwan, J. R., & Denning, C. (in press). Modeling Hypertrophic Cardiomyopathy: mechanistic insights and pharmacological intervention. Trends in Molecular Medicine, doi:10.1016/j.molmed.2019.06.005

HCM is a prevalent and complex disease governed by multiple molecular mechanisms, and there is currently no efficient cure. New treatment strategies are under development, and several drugs are reaching the final stages of clinical trials, with parti... Read More

Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells (2019)
Journal Article
De Melo, N., McGinlay, S., Markus, R., Macri-Pellizzeri, L., Symonds, M. E., Ahmed, I., & Sottile, V. (2019). Live Simultaneous Monitoring of Mineral Deposition and Lipid Accumulation in Differentiating Stem Cells. Biomimetics, 4(3), 1-10. doi:10.3390/biomimetics4030048

Mesenchymal stem cells (MSCs) are progenitors for bone-forming osteoblasts and lipid-storing adipocytes, two major lineages co-existing in bone marrow. When isolated in vitro, these stem cells recapitulate osteoblast or adipocyte formation if treated... Read More

Androgen Receptor Status Alone Not a Useful Prognostic Marker in Triple-Negative Breast Cancer (2019)
Journal Article
Bhattarai, S., Klimov, S., Mittal, K., Krishnamurti, U., Li, B., Oprea-Ilies, G., …Aneja, R. (in press). Androgen Receptor Status Alone Not a Useful Prognostic Marker in Triple-Negative Breast Cancer. Cancers,

Background: Androgen Receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR’s prognostic role in TNBC are putting its usefulness in question. Some st... Read More

Cten promotes Epithelial–Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src (2019)
Journal Article
Asiri, A., Toss, M. S., Raposo, T. P., Akhlaq, M., Thorpe, H., Alfahed, A., …Ilyas, M. (2019). Cten promotes Epithelial–Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src. Pathology International, doi:10.1111/pin.12811

Cten is an oncogene promoting EMT in many signaling pathways, namely through Snail. We investigated whether Cten function could be mediated through Src. Cten levels were modulated by forced expression in HCT116 and gene knockdown in SW620 CRC (colore... Read More

Enhanced glutamine uptake influence composition of immune cells infiltrates in breast cancer (2019)
Journal Article
Ansari, R. E., Craze, M. L., Althobiti, M., Alfarsi, L., Ellis, I. O., Rakha, E. A., & Green, A. R. (in press). Enhanced glutamine uptake influence composition of immune cells infiltrates in breast cancer. British Journal of Cancer,

Background: Cancer cells must alter their metabolism to support proliferation. Immune evasion also plays a role in supporting tumour progression. This study aimed to find whether enhanced glutamine uptake in breast cancer (BC) can derive the existenc... Read More

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo (2019)
Journal Article
Velickovic, K., Wayne, D., Lugo Leija, H. A., Bloor, I., Morris, D. E., Law, J., …Sottile, V. (2019). Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Scientific Reports, 9, doi:10.1038/s41598-019-45540-1

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet can modulate UCP1 function but the capacity of individual nut... Read More

De-escalation of tyrosine kinase inhibitor therapy before complete treatment discontinuation in patients with chronic myeloid leukaemia (DESTINY): a non-randomised, phase 2 trial (2019)
Journal Article
Clark, R. E., Polydoros, F., Apperley, J. F., Milojkovic, D., Rothwell, K., Pocock, C., …Copland, M. (2019). De-escalation of tyrosine kinase inhibitor therapy before complete treatment discontinuation in patients with chronic myeloid leukaemia (DESTINY): a non-randomised, phase 2 trial. Lancet Haematology, 6(7), e375-e383 . doi:10.1016/S2352-3026(19)30094-8

Background All studies of treatment-free remission (TFR) in patients with chronic myeloid leukaemia have discontinued tyrosine kinase inhibitor (TKI) treatment abruptly and have focussed on patients with stable MR4 (BCR-ABL to ABL ratio ≤0·01%). We... Read More

Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: An image analysis study (2019)
Journal Article
Toss, M. S., Miligy, I. M., Gorringe, K. L., Alkawaz, A., Mittal, K., Aneja, R., …Rakha, E. A. (2019). Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: An image analysis study. Modern Pathology, doi:10.1038/s41379-019-0296-7

Collagen plays a key role in normal and malignant tissue homeostasis. While the prognostic significance of collagen fibre remodeling in invasive breast cancer has been studied, its role in ductal carcinoma in situ (DCIS) remains poorly defined. Using... Read More

Increased FLYWCH1 Expression is Negatively Correlated with Wnt/β-catenin Target Gene Expression in Acute Myeloid Leukemia Cells (2019)
Journal Article
Almars, A., Chondrou, P. S., Onyido, E. K., Almozyan, S., Seedhouse, C., Babaei-Jadidi, R., & Nateri, A. S. (2019). Increased FLYWCH1 Expression is Negatively Correlated with Wnt/β-catenin Target Gene Expression in Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences, 20(11), doi:10.3390/ijms20112739

Acute myeloid leukaemia (AML) is a heterogeneous clonal malignancy of hematopoietic progenitor cells. The Wnt pathway and its downstream targets are tightly regulated by β-catenin. We recently discovered a new protein, FLYWCH1, which can directly bin... Read More

Meta-Analysis in Metastatic Uveal Melanoma to Determine Progression-Free and Overall Survival Benchmarks: an International Rare Cancers Initiative (IRCI) Ocular Melanoma study (2019)
Journal Article
Khoja, L., Atenafu, E., Suciu, S., Leyvraz, S., Sato, T., Marshall, E., …Joshua, A. (2019). Meta-Analysis in Metastatic Uveal Melanoma to Determine Progression-Free and Overall Survival Benchmarks: an International Rare Cancers Initiative (IRCI) Ocular Melanoma study. Annals of Oncology, 30(8), 1370-1380. doi:10.1093/annonc/mdz176

A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer (2019)
Journal Article
Kurozumi, S., Joseph, C., Alsaeed, S., Kariri, Y., Aljohani, A., Raafat, S., …Rakha, E. A. (2019). A Key Genomic Subtype Associated with Lymphovascular Invasion in Invasive Breast Cancer. British Journal of Cancer, 120, 1129–1136. doi:10.1038/s41416-019-0486-6

Background: Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, usin... Read More

Combining clustering and classification ensembles: A novel pipeline to identify breast cancer profiles (2019)
Journal Article
Agrawal, U., Soria, D., Wagner, C., Garibaldi, J., Ellis, I. O., Bartlett, J. M. S., …Green, A. R. (2019). Combining clustering and classification ensembles: A novel pipeline to identify breast cancer profiles. Artificial Intelligence in Medicine, 97, 27-37. doi:10.1016/j.artmed.2019.05.002

Breast Cancer is one of the most common causes of cancer death in women, representing a very complex disease with varied molecular alterations. To assist breast cancer prognosis, the classification of patients into biological groups is of great signi... Read More

Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma (2019)
Journal Article
Saini, F., Argent, R. H., & Grabowska, A. (2019). Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma. Cells, 8(5), 1-15. doi:10.3390/cells8050424

Pancreatic ductal adenocarcinoma (PDAC) is characterised by desmoplasia, thought to support progression and chemotherapeutic resistance. The Hedgehog pathway is known to play an important role in this cancer. While the upregulation of Sonic hedgehog... Read More