All Outputs (1290)

Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip (2021)
Journal Article
Burroughs, L., Amer, M., Vassey, M., Koch, B., Figueredo, G., Mukonoweshuro, B., …Alexander, M. R. (2021). Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip. Biomaterials, 271, Article 120740. https://doi.org/10.1016/j.biomaterials.2021.120740

© 2021 The Authors Human mesenchymal stem cells (hMSCs) are widely represented in regenerative medicine clinical strategies due to their compatibility with autologous implantation. Effective bone regeneration involves crosstalk between macrophages an... Read More about Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip.

Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models (2021)
Journal Article
Simpson, J. D., Monteiro, P. F., Ediriweera, G. R., Sonderegger, S. E., Bell, C. A., Fletcher, N. L., …Thurecht, K. J. (2021). Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models. ACS Applied Bio Materials, 4(3), 2675–2685. https://doi.org/10.1021/acsabm.0c01616

Improving our understanding of how design choices in materials synthesis impact biological outcomes is of critical importance in the development of nanomedicines. Here, we show that fluorophore labeling of polymer nanomedicine candidates significantl... Read More about Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models.

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities (2021)
Journal Article
Zhu, H., Li, W., Shuai, W., Liu, Y., Yang, L., Tan, Y., …Xu, S. (2021). Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. European Journal of Medicinal Chemistry, 216, Article 113316. https://doi.org/10.1016/j.ejmech.2021.113316

A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant antiproliferative activities with IC50 values ranging from 12 to... Read More about Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.

Kerogen nanoscale structure and CO2 adsorption in shale micropores (2021)
Journal Article
Gonciaruk, A., Hall, M. R., Fay, M. W., Parmenter, C. D. J., Vane, C. H., Khlobystov, A. N., & Ripepi, N. (2021). Kerogen nanoscale structure and CO2 adsorption in shale micropores. Scientific Reports, 11, Article 3920. https://doi.org/10.1038/s41598-021-83179-z

Gas storage and recovery processes in shales critically depend on nano-scale porosity and chemical composition, but information about the nanoscale pore geometry and connectivity of kerogen, insoluble organic shale matter, is largely unavailable. Usi... Read More about Kerogen nanoscale structure and CO2 adsorption in shale micropores.

Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation (2021)
Journal Article
Thornley, T., Esquivel, B., Wright, D. J., van den Dop, H., Kirkdale, C. L., & Youssef, E. (2021). Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation. Pharmacy, 9(1), Article 38. https://doi.org/10.3390/pharmacy9010038

Community pharmacy services have evolved to include medical and pharmaceutical interventions alongside dispensing. While established pharmacogenomic (PGx) testing is available throughout the Netherlands, this is primarily based in hospital environmen... Read More about Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation.

PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression (2021)
Working Paper
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Hollis, C., Hippisley-Cox, J., & Coupland, C. PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression

This protocol describes a cohort study comparing the risks of mortality and serious self-harm (suicide or near-fatal deliberate self-harm) between adults with depression prescribed mirtazapine, a selective serotonin reuptake inhibitor (SSRI), amitrip... Read More about PROTOCOL: A cohort study examining the association between mirtazapine and mortality risk in adults with a diagnosis of depression.

An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability (2021)
Journal Article
Wu, Y., Fortunato, G. M., Okesola, B. O., Pellerej Di Brocchetti, F. L., Suntornnond, R., Connelly, J., …Et Al, W. (2021). An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability. Biofabrication, 13(3), Article 035027. https://doi.org/10.1088/1758-5090/abe4c3

Self-assembling bioinks offer the possibility to biofabricate with molecular precision, hierarchical control, and biofunctionality. For this to become a reality with widespread impact, it is essential to engineer these ink systems ensuring reproducib... Read More about An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability.

Immunity in space: prokaryote adaptations and immune response in microgravity (2021)
Journal Article
Green, M. J., Aylott, J. W., Williams, P., Ghaemmaghami, A. M., & Williams, P. M. (2021). Immunity in space: prokaryote adaptations and immune response in microgravity. Life, 11(2), Article 112. https://doi.org/10.3390/life11020112

Immune dysfunction has long been reported by medical professionals regarding astronauts suffering from opportunistic infections both during their time in space and a short period afterwards once back on Earth. Various species of prokaryotes onboard t... Read More about Immunity in space: prokaryote adaptations and immune response in microgravity.

3D printed polymeric drug-eluting implants (2021)
Journal Article
Liaskoni, A., Wildman, R. D., & Roberts, C. J. (2021). 3D printed polymeric drug-eluting implants. International Journal of Pharmaceutics, 597, Article 120330. https://doi.org/10.1016/j.ijpharm.2021.120330

An extrusion-based 3D printer has been used for the manufacturing of sustained drug release poly(ε-caprolactone) (PCL) implants. Such implants can address issues of reduced patient compliance due to the necessary frequent administration of convention... Read More about 3D printed polymeric drug-eluting implants.

Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents (2021)
Journal Article
Shao, H., Foley, D. W., Huang, S., Abbas, A. Y., Lam, F., Gershkovich, P., …Wang, S. (2021). Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents. European Journal of Medicinal Chemistry, 214, Article 113244. https://doi.org/10.1016/j.ejmech.2021.113244

Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the... Read More about Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents.

3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair (2021)
Journal Article
Hamid, O. A., Eltaher, H. M., Sottile, V., & Yang, J. (2021). 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair. Materials Science and Engineering: C, 120, Article 111707. https://doi.org/10.1016/j.msec.2020.111707

© 2020 Elsevier B.V. Development of a biomimetic tubular scaffold capable of recreating developmental neurogenesis using pluripotent stem cells offers a novel strategy for the repair of spinal cord tissues. Recent advances in 3D printing technology h... Read More about 3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair.

Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions (2021)
Journal Article
Tomi-Andrino, C., Norman, R., Millat, T., Soucaille, P., Winzer, K., Barrett, D. A., …Kim, D. (2021). Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions. PLoS Computational Biology, 17(1), Article e1007694. https://doi.org/10.1371/journal.pcbi.1007694

© 2021 Tomi-Andrino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source a... Read More about Physicochemical and metabolic constraints for thermodynamics-based stoichiometric modelling under mesophilic growth conditions.

AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii (2021)
Journal Article
López-Martín, M., Dubern, J., Alexander, M. R., & Williams, P. (2021). AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii. Journal of Bacteriology, 203(8), Article e00635-20. https://doi.org/10.1128/jb.00635-20

Acinetobacter baumannii possesses a single divergent luxR/luxI-type quorum sensing (QS) locus named abaR/abaI. This locus also contains a third gene located between abaR and abaI which we term abaM that codes for an uncharacterized member of the RsaM... Read More about AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii.

Estimating the potential impact of implementing pre-emptive pharmacogenetic testing in primary care across the UK (2021)
Journal Article
Youssef, E., Kirkdale, C. L., Wright, D. J., Guchelaar, H. J., & Thornley, T. (2021). Estimating the potential impact of implementing pre-emptive pharmacogenetic testing in primary care across the UK. British Journal of Clinical Pharmacology, 87(7), 2907-2925. https://doi.org/10.1111/bcp.14704

Aims: Pharmacogenetics (PGx) in the UK is currently implemented in secondary care for a small group of high-risk medicines. However, most prescribing takes place in primary care, with a large group of medicines influenced by commonly occurring geneti... Read More about Estimating the potential impact of implementing pre-emptive pharmacogenetic testing in primary care across the UK.

In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207 (2021)
Journal Article
Vrettos, N., Wang, P., Zhou, Y., Roberts, C. J., Xu, J., Yao, H., & Zhu, Z. (2021). In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207. Pharmaceutical Development and Technology, 26(3), 349-361. https://doi.org/10.1080/10837450.2021.1872087

Hypertension is one of the most common chronic cardiovascular disorders. Sustained-release formulations are developed to maintain drug therapeutic levels throughout the treatment of hypertension, to promote patient compliance and improve patient outc... Read More about In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207.

Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model (2021)
Journal Article
Sennett, M., Friedman, J., Ashley, B., Stoeckl, B., Patel, J., Alini, M., …Dodge, G. (2021). Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model. eCells and Materials Journal, 41, 40-51. https://doi.org/10.22203/ecm.v041a04

The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics. Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis. Current repair technique... Read More about Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.

Strawberry decreases intraluminal and intestinal wall hydrolysis of testosterone undecanoate (2021)
Journal Article
Zgair, A., Dawood, Y., Ibrahem, S. M., Lee, J. B., Feng, W., Fischer, P. M., & Gershkovich, P. (2021). Strawberry decreases intraluminal and intestinal wall hydrolysis of testosterone undecanoate. Molecules, 26(1), Article 233. https://doi.org/10.3390/molecules26010233

Male hypogonadism is often treated by testosterone (T) replacement therapy such as oral administration of the ester prodrug, testosterone undecanoate (TU). However, the systemic exposure to T following oral TU is very low due to esterase-mediated met... Read More about Strawberry decreases intraluminal and intestinal wall hydrolysis of testosterone undecanoate.

A Comparative Exploration of Quality Assurance Results by the Third-Party Pharmaceutical Education Evaluation in Japan (2020)
Journal Article
Takeda, K., & Arakawa, N. (2021). A Comparative Exploration of Quality Assurance Results by the Third-Party Pharmaceutical Education Evaluation in Japan. Pharmacy, 9(1), 9. https://doi.org/10.3390/pharmacy9010006

Background: The Standards for the Establishment of Universities in Japan were revised; subsequently, the number of schools or universities of pharmacy/pharmaceutical sciences increased from 46 in 2002 to 74 in 2016.The pharmacy education programme wa... Read More about A Comparative Exploration of Quality Assurance Results by the Third-Party Pharmaceutical Education Evaluation in Japan.

A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding (2020)
Journal Article
White, C. W., Kilpatrick, L. E., Pfleger, K. D., & Hill, S. J. (2021). A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding. iScience, 24(1), Article 102011. https://doi.org/10.1016/j.isci.2020.102011

© 2020 The Author(s) Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quanti... Read More about A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding.

Modulating the biological function of protein by tailoring the adsorption orientation on nanoparticles (2020)
Journal Article
Jain, A., Trindade, G. F., Hicks, J. M., Potts, J. C., Rahman, R., J. M. Hague, R., …Rawson, F. J. (2021). Modulating the biological function of protein by tailoring the adsorption orientation on nanoparticles. Journal of Colloid and Interface Science, 587, 150-161. https://doi.org/10.1016/j.jcis.2020.12.025

Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein orientation upon adsorpti... Read More about Modulating the biological function of protein by tailoring the adsorption orientation on nanoparticles.