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Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study (2022)
Journal Article
Mosanya, A. U., Ukoha-kalu, B. O., Isah, A., Umeh, I., Amorha, K. C., Ayogu, E. E., & Ubaka, C. (2022). Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study. PLoS ONE, 17(9), Article e0274638. https://doi.org/10.1371/journal.pone.0274638

Introduction There is growing scientific evidence of mental and well-being issues that doctoral research students face as a result of not finishing their program on time. This study aims to explore the factors associated with the timely completion o... Read More about Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study.

Rise of the Med-Ed-ists: Achieving a critical mass of non-practicing clinicians within medical education (2022)
Journal Article
Church, H., & Brown, M. E. L. (2022). Rise of the Med-Ed-ists: Achieving a critical mass of non-practicing clinicians within medical education. Medical Education, 56(12), 1160-1162. https://doi.org/10.1111/medu.14940

In the latest "Connections" article, Church and Brown use the concept of 'critical mass' to explain how stigma, lack of career pathways and prioritization of clinical seniority may discourage non-practicing clinicians from becoming educationalists.

A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease (2022)
Journal Article
AL Nasser, M. N., Mellor, I. R., & Carter, W. G. (2022). A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease. Molecules, 27(15), Article 4891. https://doi.org/10.3390/molecules27154891

Alzheimer's disease (AD) is characterised by progressive neuronal atrophy and the loss of neuronal function as a consequence of multiple pathomechanisms. Current AD treatments primarily operate at a symptomatic level to treat a cholinergic deficiency... Read More about A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease.

An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions (2022)
Journal Article
Elmorsy, E., Al-Ghafari, A., Al Doghaither, H., Salama, M., & Carter, W. G. (2022). An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions. Brain Sciences, 12(8), Article 975. https://doi.org/10.3390/brainsci12080975

Acute or chronic exposures to pesticides have been linked to neurotoxicity and the potential development of neurodegenerative diseases (NDDs). This study aimed to consider the neurotoxicity of three widely utilized pesticides: malathion, chlorpyrifos... Read More about An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions.

Applying educational theory to medical education research (2022)
Journal Article
Melvin, A., & Patel, R. S. (2022). Applying educational theory to medical education research. Clinical and Experimental Dermatology, 47(12), 2085-2089. https://doi.org/10.1111/ced.15287

Applying educational theory to medical education research is no different to the way theory drives research and practice in other domains. However, the practical application of theory to research in medical education can often be challenging for many... Read More about Applying educational theory to medical education research.

The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study (2022)
Journal Article
Ali, U. A., Iftikhar, N., Amat-Ur-rasool, H., Ahmed, M., Hafeez, J., & Carter, W. G. (2022). The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study. Healthcare, 10(6), Article 1049. https://doi.org/10.3390/healthcare10061049

The COVID-19 pandemic has had a damaging impact on global health. Post-infection, patients may experience mental health difficulties and therefore require suitable psychological treatment and support. The objective of this study was to identify the p... Read More about The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study.

Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review (2022)
Journal Article
Al-Nasser, M. N., Mellor, I. R., & Carter, W. G. (2022). Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review. Brain Sciences, 12(5), Article 577. https://doi.org/10.3390/brainsci12050577

L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu has been linked to neurotoxicity and neurodegeneration. To investig... Read More about Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review.

Barriers and facilitators for implementation of a national recommended specialty core-curriculum across UK medical schools: a cross-sectional study using an online questionnaire (2022)
Journal Article
Sharma, M., Murphy, R., & Doody, G. A. (2022). Barriers and facilitators for implementation of a national recommended specialty core-curriculum across UK medical schools: a cross-sectional study using an online questionnaire. BMJ Open, 12(3), Article e053565

Objectives The National Health Service (NHS) Long-Term plan published in 2019 set out healthcare reforms to meet the healthcare demands of UK. Undergraduate specialty core-curricula like dermatology aligns well to the training needs of the future wor... Read More about Barriers and facilitators for implementation of a national recommended specialty core-curriculum across UK medical schools: a cross-sectional study using an online questionnaire.

Perceptions of transition into clinical placement (2022)
Journal Article
Scott, N. L., Mahran, S., Patel, R., & Culshaw, M. (2022). Perceptions of transition into clinical placement. Clinical Teacher, 19(2), 129-135. https://doi.org/10.1111/tct.13465

Introduction A major transition for medical students is the change from the pre-clinical to clinical years of their curriculum. Interventions to help students manage this transition effectively, such as preparatory skills courses and peer mentoring,... Read More about Perceptions of transition into clinical placement.

Flexible portfolio training: a novel approach to future physician training (2022)
Journal Article
Saville, R. L., Bowman, R., & Patel, R. (2022). Flexible portfolio training: a novel approach to future physician training. Future Healthcare Journal, 9(1), 13-17. https://doi.org/10.7861/fhj.2021-0143

Flexible portfolio training (FPT) is a novel Royal College of Physicians' training scheme developed in 2019 to tackle issues of burnout, retention and recruitment among medical registrars. Awareness of the FPT scheme may be lacking and this article i... Read More about Flexible portfolio training: a novel approach to future physician training.

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia (2022)
Journal Article
Pardiñas, A. F., Smart, S. E., Willcocks, I. R., Holmans, P. A., Dennison, C. A., Lynham, A. J., …Vázquez-Bourgon, J. (2022). Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia. JAMA Psychiatry, 79(3), 260-269. https://doi.org/10.1001/jamapsychiatry.2021.3799

Importance: About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizoph... Read More about Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia.

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease (2021)
Journal Article
Amat-Ur-rasool, H., Ahmed, M., Hasnain, S., Ahmed, A., & Carter, W. G. (2022). In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease. Current Issues in Molecular Biology, 44(1), 152-175. https://doi.org/10.3390/cimb44010012

The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is... Read More about In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease.

The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies (2021)
Journal Article
Prakash, S., & Carter, W. G. (2021). The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies. Brain Sciences, 11(12), Article 1573. https://doi.org/10.3390/BRAINSCI11121573

Currently, there are no pharmacological treatments able to reverse nigral degeneration in Parkinson’s disease (PD), hence the unmet need for the provision of neuroprotective agents. Cannabis-derived phytocannabinoids (CDCs) and resveratrol (RSV) may... Read More about The Neuroprotective Effects of Cannabis-Derived Phytocannabinoids and Resveratrol in Parkinson’s Disease: A Systematic Literature Review of Pre-Clinical Studies.

Mental health among elite sportspeople: Lessons for medical education (2021)
Journal Article
Walker, I., Brierley, E., Patel, T., Jaffer, R., Rajpara, M., Heslop, C., & Patel, R. (2021). Mental health among elite sportspeople: Lessons for medical education. Medical Teacher, 44(2), 214-216. https://doi.org/10.1080/0142159X.2021.1994134

Leading sportspeople across 2021, such as Simone Biles (US gymnast), Naomi Osaka (Japanese tennis player) and Ben Stokes (English cricketer), have talked openly about the pressure of performing on the highest stage, including the challenge of managin... Read More about Mental health among elite sportspeople: Lessons for medical education.

Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study (2021)
Journal Article
Newman, A., Keeley, V., Pinnington, L., Green, C., Riches, K., Franks, P. J., …Moffatt, C. J. (2021). Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study. Lymphatic Research and Biology, 19(5), 431-441. https://doi.org/10.1089/lrb.2021.0055

Background: Chronic edema (CO) is a complex condition, arising from different factors, including immobility and obesity. Edema and obesity can have a significant impact on quality of life of patients and their families. Understanding how to manage ed... Read More about Prevalence and Impact of Chronic Edema in Bariatric Patients: A LIMPRINT Study.

Applying sport psychology in health professions education: A systematic review of performance mental skills training (2021)
Journal Article
Sandars, J., Jenkins, L., Church, H., Patel, R., Rumbold, J., Maden, M., …Brown, J. (2022). Applying sport psychology in health professions education: A systematic review of performance mental skills training. Medical Teacher, 44(1), 71-78. https://doi.org/10.1080/0142159X.2021.1966403

Introduction Health professionals are expected to consistently perform to a high standard during a variety of challenging clinical situations, which can provoke stress and impair their performance. There is increasing interest in applying sport psyc... Read More about Applying sport psychology in health professions education: A systematic review of performance mental skills training.

Harnessing the medical humanities to consider LGBT+ elder healthcare within the undergraduate curriculum (2021)
Presentation / Conference
Agius, S., & Church, H. (2021, August). Harnessing the medical humanities to consider LGBT+ elder healthcare within the undergraduate curriculum. Poster presented at AMEE 2021, Virtual

Background: Many older LGBT+ adults [elders] in the UK will have endured extraordinary discrimination and homophobia/transphobia during their life course, often intersectional, which may have had an enduring impact upon their physical and mental well... Read More about Harnessing the medical humanities to consider LGBT+ elder healthcare within the undergraduate curriculum.

Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity (2021)
Journal Article
Albogami, S., Todd, I., Negm, O., Fairclough, L. C., & Tighe, P. J. (2021). Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity. Immunology, https://doi.org/10.1111/imm.13400

The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine-rich domains (CRD) in their extracellular regions, and the membrane-distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a p... Read More about Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity.

Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans (2021)
Journal Article
Willis, C. R., Gallagher, I. J., Wilkinson, D. J., Brook, M. S., Bass, J. J., Phillips, B. E., …Atherton, P. J. (2021). Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans. FASEB Journal, 35(9), Article e21830. https://doi.org/10.1096/fj.202100276RR

Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates... Read More about Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.