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Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection (2022)
Journal Article
Dhillon, P. S., Butt, W., Podlasek, A., McConachie, N., Lenthall, R., Nair, S., …England, T. J. (2023). Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection. Journal of NeuroInterventional Surgery, 15(4), 336-342. https://doi.org/10.1136/neurintsurg-2021-018564

Background: The effectiveness and safety of endovascular thrombectomy (EVT) in the late window (6-24 hours) for acute ischemic stroke (AIS) patients selected without advanced imaging is undetermined. We aimed to assess clinical outcomes and the relat... Read More about Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection.

Ageing and exercise-induced motor unit remodelling (2022)
Journal Article
Jones, E. J., Chiou, S. Y., Atherton, P. J., Phillips, B. E., & Piasecki, M. (2022). Ageing and exercise-induced motor unit remodelling. Journal of Physiology, 600(8), 1839-1849. https://doi.org/10.1113/JP281726

A motor unit (MU) comprises the neuron cell body, its corresponding axon and each of the muscle fibres it innervates. Many studies highlight age-related reductions in the number of MUs, yet the ability of a MU to undergo remodelling and to expand to... Read More about Ageing and exercise-induced motor unit remodelling.

Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer (2022)
Journal Article
Wang, Y., Gavan, S. P., Steinke, D., Cheung, K. L., & Chen, L. C. (2022). Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer. Cost Effectiveness and Resource Allocation, 20(1), Article 9. https://doi.org/10.1186/s12962-022-00342-7

Objective: To appraise the sources of evidence and methods to estimate input parameter values in decision-analytic model-based cost-effectiveness analyses of treatments for primary breast cancer (PBC) in older patients (≥70years old). Methods: Two el... Read More about Systematic review of the evidence sources applied to cost-effectiveness analyses for older women with primary breast cancer.

'Don't let the trial kill the intervention': how can researchers and care home teams implement complex intervention trials in care homes? (2022)
Journal Article
Shenkin, S. D., Gordon, A. L., Johnston, L., Henderson, C., & Achterberg, W. P. (2022). 'Don't let the trial kill the intervention': how can researchers and care home teams implement complex intervention trials in care homes?. Age and Ageing, 51(3), Article afac068. https://doi.org/10.1093/ageing/afac068

The profile of care homes has never been higher, and not necessarily for the best reasons[1]. The COVID-19 pandemic has had, and continues to have, a massive impact on care home residents[2] , their families, the staff and organisations who care for... Read More about 'Don't let the trial kill the intervention': how can researchers and care home teams implement complex intervention trials in care homes?.

Developing a minimum data set for older adult care homes in the UK: exploring the concept and defining early core principles (2022)
Journal Article
Burton, J. K., Wolters, A. T., Towers, A. M., Jones, L., Meyer, J., Gordon, A. L., …Goodman, C. (2022). Developing a minimum data set for older adult care homes in the UK: exploring the concept and defining early core principles. Lancet Healthy Longevity, 3(3), e186-e193. https://doi.org/10.1016/S2666-7568%2822%2900010-1

Reforms to social care in response to the COVID-19 pandemic, in the UK and internationally, place data at the heart of proposed innovations and solutions. The principles are not well established of what constitutes core, or minimum, data to support c... Read More about Developing a minimum data set for older adult care homes in the UK: exploring the concept and defining early core principles.

Contextual factors influencing complex intervention research processes in care homes: A systematic review and framework synthesis (2022)
Journal Article
Peryer, G., Kelly, S., Blake, J., Burton, J. K., Irvine, L., Cowan, A., …Goodman, C. (2022). Contextual factors influencing complex intervention research processes in care homes: A systematic review and framework synthesis. Age and Ageing, 51(3), Article afac014. https://doi.org/10.1093/ageing/afac014

Background: Care homes are complex settings to undertake intervention research. Barriers to research implementation processes can threaten studies' validity, reducing the value to residents, staff, researchers and funders. We aimed to (i) identify an... Read More about Contextual factors influencing complex intervention research processes in care homes: A systematic review and framework synthesis.

Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans (2022)
Journal Article
Gharahdaghi, N., Rudrappa, S., Brook, M. S., Farrash, W., Idris, I., Aziz, M. H. A., …Atherton, P. J. (2022). Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans. Journal of Cachexia, Sarcopenia and Muscle, 13(2), 1134-1150. https://doi.org/10.1002/jcsm.12843

Background: The relative role of skeletal muscle mechano-transduction in comparison with systemic hormones, such as testosterone (T), in regulating hypertrophic responses to exercise is contentious. We investigated the mechanistic effects of chemical... Read More about Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans.

The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure (2022)
Journal Article
Gordon, A. L., Rick, C., Juszczak, E., Montgomery, A., Howard, R., Guthrie, B., …Tate, V. (2022). The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure. Age and Ageing, 51(3), Article afac052. https://doi.org/10.1093/ageing/afac052

The COVID-19 pandemic resulted in catastrophic levels of morbidity and mortality for care home residents. Despite this, research platforms for COVID-19 in care homes arrived late in the pandemic compared with other care settings. The Prophylactic The... Read More about The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure.

The Childhood Cancer Diagnosis (CCD) Study: a UK observational study to describe referral pathways and quantify diagnostic intervals in children and young people with cancer (2022)
Journal Article
Shanmugavadivel, D., Liu, J., Ball-Gamble, A., Polanco, A., Vedhara, K., Walker, D., & Ojha, S. (2022). The Childhood Cancer Diagnosis (CCD) Study: a UK observational study to describe referral pathways and quantify diagnostic intervals in children and young people with cancer. BMJ Open, 12(2), Article e058744. https://doi.org/10.1136/bmjopen-2021-058744

Introduction: Childhood cancer is diagnosed in 400 000 children and young people (CYP) aged 0–19 years worldwide annually. In the UK, a child’s cumulative cancer risk increases from 1 in 4690 from birth to aged 1, to 1 in 470 by age 15. Once diagnose... Read More about The Childhood Cancer Diagnosis (CCD) Study: a UK observational study to describe referral pathways and quantify diagnostic intervals in children and young people with cancer.

Childhood Cancer Diagnosis (CCD) Study: a UK observational study to describe referral pathways and quantify diagnostic intervals in children and young people with cancer (2022)
Journal Article
Shanmugavadivel, D., Liu, J., Gamble, A., Polanco, A., Vedhara, K., Walker, D., & Ojha, S. (2022). Childhood Cancer Diagnosis (CCD) Study: a UK observational study to describe referral pathways and quantify diagnostic intervals in children and young people with cancer. BMJ Open, 12(2), Article e058744. https://doi.org/10.1136/bmjopen-2021-058744

Introduction: Childhood cancer is diagnosed in 400,000 children and young people (CYP) aged 0-19 years worldwide annually. In the UK, a child’s cumulative cancer risk increases from 1 in 4690 from birth to aged 1, to 1 in 470 by age 15. Once diagnose... Read More about Childhood Cancer Diagnosis (CCD) Study: a UK observational study to describe referral pathways and quantify diagnostic intervals in children and young people with cancer.

Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial (2022)
Journal Article
The LACE study group, Achison, M., Adamson, S., Akpan, A., Aspray, T., Avenell, A., …Witham, M. D. (2022). Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial. Journal of Cachexia, Sarcopenia and Muscle, 13(2), 858-871. https://doi.org/10.1002/jcsm.12934

BACKGROUND: This trial aimed to determine the efficacy of leucine and/or perindopril in improving physical function in older people with sarcopenia. METHODS: Placebo-controlled, parallel group, double-blind, randomized two-by-two factorial trial. We... Read More about Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial.

Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: A propensity score matched cohort study (2022)
Journal Article
Singh Dhillon, P., Butt, W., Podlasek, A., Barrett, E., McConachie, N., Lenthall, R., …England, T. J. (2023). Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: A propensity score matched cohort study. Journal of NeuroInterventional Surgery, 15(3), 233-237. https://doi.org/10.1136/neurintsurg-2021-018591

Background: The safety and functional outcome of endovascular thrombectomy (EVT) in the very late (VL; >24 hours) time window from ischemic stroke onset remains undetermined. Methods: Using data from a national stroke registry, we used propensity sco... Read More about Endovascular thrombectomy beyond 24 hours from ischemic stroke onset: A propensity score matched cohort study.

Differences in progression by surgical specialty: A national cohort study (2022)
Journal Article
Hope, C., Lund, J., Griffiths, G., & Humes, D. (2022). Differences in progression by surgical specialty: A national cohort study. BMJ Open, 12(2), Article e053391. https://doi.org/10.1136/bmjopen-2021-053391

The aim of surgical training across the 10 surgical specialties is to produce competent day 1 consultants. Progression through training in the UK is assessed by the Annual Review of Competency Progression (ARCP). Objective This study aimed to examine... Read More about Differences in progression by surgical specialty: A national cohort study.

The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism (2022)
Journal Article
Jaconelli, M., Greenhaff, P. L., Atherton, P. J., Lobo, D. N., & Brook, M. S. (2022). The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism. Clinical Nutrition, 41(3), 709-722. https://doi.org/10.1016/j.clnu.2022.01.023

Background & aims Elective surgery induces skeletal muscle wasting driven by an imbalance between muscle protein synthesis and breakdown. From examination of diverse stable isotope tracer techniques, the dynamic processes driving this imbalance ar... Read More about The effects of elective abdominal surgery on protein turnover: A meta-analysis of stable isotope techniques to investigate postoperative catabolism.

Challenges in Geriatric Oncology—A Surgeon’s Perspective (2022)
Journal Article
Parks, R., & Cheung, K. L. (2022). Challenges in Geriatric Oncology—A Surgeon’s Perspective. Current Oncology, 29(2), 659-674. https://doi.org/10.3390/curroncol29020058

As our global population ages, we will see more cancer diagnoses in older adults. Surgery is an important treatment modality for solid tumours, forming the majority of all cancers. However, the management of older adults with cancer can be more compl... Read More about Challenges in Geriatric Oncology—A Surgeon’s Perspective.

Daily Bread: Women’s Self-Help Microfinance and the Social Meanings of Money (2022)
Journal Article
Bott, E., Ojha, S., Mini, S., Smyth, A. R., Kamal Kumar, R., Choudhary, S., & Yaron, G. (2023). Daily Bread: Women’s Self-Help Microfinance and the Social Meanings of Money. Sociological Research Online, 28(2), 442-461. https://doi.org/10.1177/13607804211058745

In this article, we explore the impacts and implications of ‘Rojiroti’, a women’s self-help group (SHG) microfinance scheme operating in poor communities in Bihar, India. We focus particularly on how improvements found in women’s circumstances and in... Read More about Daily Bread: Women’s Self-Help Microfinance and the Social Meanings of Money.

Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes (2022)
Journal Article
Patel, R., Crabtree, T. S., Taylor, N., Langeland, L., Gazis, A. (., Mendis, B., …Idris, I. (2022). Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes. Diabetic Medicine, 39(5), Article e14793. https://doi.org/10.1111/dme.14793

Aims: The use of do-it-yourself artificial pancreas systems (DIYAPS) among people with type 1 diabetes is increasing. At present, it is unclear how DIYAPS compares with other technologies such as FreeStyle Libre (FSL) and continuous subcutaneous insu... Read More about Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with free style libre in people with type 1 diabetes.

Drug utilisation in neonatal units in England and Wales: a national cohort study (2022)
Journal Article
Al-Turkait, A., Szatkowski, L., Choonara, I., & Ojha, S. (2022). Drug utilisation in neonatal units in England and Wales: a national cohort study. European Journal of Clinical Pharmacology, 78(4), 669-677. https://doi.org/10.1007/s00228-021-03267-x

Purpose: To describe drug utilisation patterns in neonatal units. Methods: Retrospective observational cohort study using data held in the National Neonatal Research Database (NNRD) for neonatal units in England and Wales including infants born at 23... Read More about Drug utilisation in neonatal units in England and Wales: a national cohort study.