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All Outputs (558)

Opportunistic Non-Governmental Organisation Delivery of a Virtual Stop Smoking Service in England during the COVID-19 Lockdown (2022)
Journal Article
Davies, N. P., Callister, M. E., Copeland, H., Griffiths, S., Holtam, L., Lambert, P., …Murray, R. L. (2022). Opportunistic Non-Governmental Organisation Delivery of a Virtual Stop Smoking Service in England during the COVID-19 Lockdown. International Journal of Environmental Research and Public Health, 19(13), Article 7722. https://doi.org/10.3390/ijerph19137722

Smoking cessation services have rapidly transformed during the COVID-19 pandemic. Changes include pivoting from face-to-face to telephone and video call support, remote provision of stop smoking aids and more flexible appointments. This study reports... Read More about Opportunistic Non-Governmental Organisation Delivery of a Virtual Stop Smoking Service in England during the COVID-19 Lockdown.

Exploring the Psychological Impacts of COVID-19 Social Restrictions on International University Students: A Qualitative Study (2022)
Journal Article
Al-Oraibi, A., Fothergill, L., Yildirim, M., Knight, H., Carlisle, S., O’Connor, M., …Blake, H. (2022). Exploring the Psychological Impacts of COVID-19 Social Restrictions on International University Students: A Qualitative Study. International Journal of Environmental Research and Public Health, 19(13), Article 7631. https://doi.org/10.3390/ijerph19137631

The global COVID-19 pandemic has impacted on the mental well-being of university students, but little attention has been given to international students, who may have a unique experience and perspective. The aim of this study was to explore the views... Read More about Exploring the Psychological Impacts of COVID-19 Social Restrictions on International University Students: A Qualitative Study.

Common protocol for validation of the QCOVID algorithm across the four UK nations (2022)
Journal Article
Kerr, S., Robertson, C., Nafilyan, V., Lyons, R. A., Kee, F., Cardwell, C. R., …Sheikh, A. (2022). Common protocol for validation of the QCOVID algorithm across the four UK nations. BMJ Open, 12(6), Article e050994. https://doi.org/10.1136/bmjopen-2021-050994

Introduction The QCOVID algorithm is a risk prediction tool for infection and subsequent hospitalisation/death due to SARS-CoV-2. At the time of writing, it is being used in important policy-making decisions by the UK and devolved governments for com... Read More about Common protocol for validation of the QCOVID algorithm across the four UK nations.

Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study (2022)
Journal Article
Akyea, R. K., Georgiopoulos, G., Iyen, B., Kai, J., Qureshi, N., & Ntaios, G. (2022). Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study. Thrombosis and Haemostasis, 122(11), 1921-1931. https://doi.org/10.1055/a-1873-9092

Background Patients with ischemic stroke are considered a very high risk population for subsequent cardiovascular events and guidelines recommend intensive preventive strategies. However, there is no clear recommendation that patients with hemorrhagi... Read More about Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study.

Investigating the cost-effectiveness of three cessation interventions on a national scale using the Economics of Smoking in Pregnancy (ESIP) decision analytical model (2022)
Journal Article
Jones, M., Smith, M., Lewis, S., Parrott, S., & Coleman, T. (2022). Investigating the cost-effectiveness of three cessation interventions on a national scale using the Economics of Smoking in Pregnancy (ESIP) decision analytical model. Addiction, https://doi.org/10.1111/add.15968

Aim: To measure the cost-effectiveness of adding text message (TMB), exercise (EB) and abstinent-contingent financial incentive-based (CFIB) stop smoking interventions to standard smoking cessation support for pregnant women in England. Design: Model... Read More about Investigating the cost-effectiveness of three cessation interventions on a national scale using the Economics of Smoking in Pregnancy (ESIP) decision analytical model.

Development and Validation of Population Clusters for Integrating Health and Social Care: Protocol for a Mixed Methods Study in Multiple Long-Term Conditions (Cluster-Artificial Intelligence for Multiple Long-Term Conditions) (2022)
Journal Article
Dambha-Miller, H., Simpson, G., Akyea, R. K., Hounkpatin, H., Morrison, L., Gibson, J., …Farmer, A. (2022). Development and Validation of Population Clusters for Integrating Health and Social Care: Protocol for a Mixed Methods Study in Multiple Long-Term Conditions (Cluster-Artificial Intelligence for Multiple Long-Term Conditions). JMIR Research Protocols, 11(6), Article e34405. https://doi.org/10.2196/34405

Background: Multiple long-term health conditions (multimorbidity) (MLTC-M) are increasingly prevalent and associated with high rates of morbidity, mortality, and health care expenditure. Strategies to address this have primarily focused on the biolog... Read More about Development and Validation of Population Clusters for Integrating Health and Social Care: Protocol for a Mixed Methods Study in Multiple Long-Term Conditions (Cluster-Artificial Intelligence for Multiple Long-Term Conditions).

Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies (2022)
Journal Article
Crabtree, T., Ogendo, J. J., Vinogradova, Y., Gordon, J., & Idris, I. (2022). Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies. Expert Review of Endocrinology and Metabolism, https://doi.org/10.1080/17446651.2022.2079495

Introduction: Guidelines for type 2 diabetes (T2D) recommend individualized HbA1c targets to take into account patient age or frailty. We synthesized evidence from randomized controlled trials and observational studies for intensive glycemic control... Read More about Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies.

Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial (2022)
Journal Article
Hajek, P., Przulj, D., Pesola, F., Griffiths, C., Walton, R., McRobbie, H., …Myers Smith, K. (2022). Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial. Nature Medicine, 28(5), 958-964. https://doi.org/10.1038/s41591-022-01808-0

Nicotine replacement therapy, in the form of nicotine patches, is commonly offered to pregnant women who smoke to help them to stop smoking, but this approach has limited efficacy in this population. Electronic cigarettes (e-cigarettes) are also used... Read More about Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial.

The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout (2022)
Journal Article
Knight, H., Jia, R., Ayling, K., Blake, H., Morling, J. R., Villalon, A. M., …Vedhara, K. (2023). The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout. Perspectives in Public Health, 143(4), 220-224. https://doi.org/10.1177/17579139221094750

Aims: Development and rollout of vaccines offers the best opportunity for population protection against the SARS-CoV-2 (COVID-19) virus. However, hesitancy towards the vaccines might impede successful uptake in the United Kingdom, particularly in you... Read More about The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout.

Characteristics associated with the willingness to receive a COVID-19 vaccine and an exploration of the general public's perceptions: A mixed-methods approach (2022)
Journal Article
Gasteiger, N., Gasteiger, C., Vedhara, K., & Broadbent, E. (2022). Characteristics associated with the willingness to receive a COVID-19 vaccine and an exploration of the general public's perceptions: A mixed-methods approach. Vaccine, 40(25), 3461-3465. https://doi.org/10.1016/j.vaccine.2022.04.092

Demographics and media discourse impact vaccine hesitancy. We explored the New Zealand public's perceptions of COVID-19 vaccines and associated media portrayal, and determined predictive factors associated with willingness to receive vaccines. A comm... Read More about Characteristics associated with the willingness to receive a COVID-19 vaccine and an exploration of the general public's perceptions: A mixed-methods approach.

ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people (2022)
Journal Article
Ong, T., Suazo Di Paola, A., Brookes, C., Drummond, A., Hendrick, P., Leighton, P., …Sahota, O. (2022). ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people. BMJ Open, 12(5), Article e050535. https://doi.org/10.1136/bmjopen-2021-050535

Objective To determine the feasibility of designing and conducting a definitive trial to evaluate the effectiveness of sacral fracture fixation compared with non-surgical management among older people admitted with a lateral compression pelvic fragil... Read More about ASSERT (Acute Sacral inSufficiEncy fractuRe augmenTation): randomised controlled, feasibility trial in older people.

Developing a taxonomy of care coordination for people living with rare conditions: a qualitative study (2022)
Journal Article
Walton, H., Simpson, A., Ramsay, A. I., Hudson, E., Hunter, A., Jones, J., …Fulop, N. J. (2022). Developing a taxonomy of care coordination for people living with rare conditions: a qualitative study. Orphanet Journal of Rare Diseases, 17, Article 171. https://doi.org/10.1186/s13023-022-02321-w

Background: Improving care coordination is particularly important for individuals with rare conditions (who may experience multiple inputs into their care, across different providers and settings). To develop and evaluate strategies to potentially im... Read More about Developing a taxonomy of care coordination for people living with rare conditions: a qualitative study.

Are E-cigarettes associated with postpartum return to smoking? Secondary analyses of a UK pregnancy longitudinal cohort (2022)
Journal Article
Orton, S., Taylor, L., Laing, L., Lewis, S., Ussher, M., Coleman, T., & Cooper, S. (2022). Are E-cigarettes associated with postpartum return to smoking? Secondary analyses of a UK pregnancy longitudinal cohort. BMJ Open, 12(4), Article e061028. https://doi.org/10.1136/bmjopen-2022-061028

Objectives: Postpartum return to smoking (PPRS) is an important public health problem. E-cigarette (EC) use has increased in recent years, and in a contemporary UK pregnancy cohort, we investigated factors, including ECs use, associated with PPRS.... Read More about Are E-cigarettes associated with postpartum return to smoking? Secondary analyses of a UK pregnancy longitudinal cohort.

Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries (2022)
Journal Article
Swain, S., Kamps, A., Runhaar, J., Dell ‘Isola, A., Turkiewicz, A., Robinson, D., …Zhang, W. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries. BMJ Open, 12(4), Article e052816. https://doi.org/10.1136/bmjopen-2021-052816

Introduction: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries.

A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial) (2022)
Journal Article
Patel, S., Boutry, C., Patel, P., Craven, M. P., Guo, B., Zafar, A., …Morriss, R. (2022). A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial). Trials, 23(1), Article 250. https://doi.org/10.1186/s13063-022-06192-1

Background: Major depression is the second leading cause of years lost to disability worldwide and is a leading contributor to suicide. However, first-line antidepressants are only fully effective for 33%, and only 40% of those offered psychological... Read More about A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha-Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial).

Qualitative study exploring factors affecting the implementation of a vocational rehabilitation intervention in the UK major trauma pathway (2022)
Journal Article
Kettlewell, J., Radford, K., Kendrick, D., Patel, P., Bridger, K., Kellezi, B., …Timmons, S. (2022). Qualitative study exploring factors affecting the implementation of a vocational rehabilitation intervention in the UK major trauma pathway. BMJ Open, 12(3), Article e060294. https://doi.org/10.1136/bmjopen-2021-060294

Objectives This study aimed to: (1) understand the context for delivering a trauma vocational rehabilitation (VR) intervention; (2) identify potential barriers and enablers to the implementation of a VR intervention post-trauma. Design Qualitative st... Read More about Qualitative study exploring factors affecting the implementation of a vocational rehabilitation intervention in the UK major trauma pathway.

Co-ordinated care for people affected by rare diseases: the CONCORD mixed-methods study (2022)
Journal Article
Morris, S., Hudson, E., Bloom, L., Chitty, L. S., Fulop, N. J., Hunter, A., …Walton, H. (2022). Co-ordinated care for people affected by rare diseases: the CONCORD mixed-methods study. Health and Social Care Delivery Research, 10(5), 1-220. https://doi.org/10.3310/lnzz5321

This study found evidence of a lack of co-ordinated care for people affected by rare diseases, which could have negative impacts on the physical and mental health of patients and families.

Risk of mortality from suicide in patients with Huntington’s disease is increased compared to the general population in England (2022)
Journal Article
Alothman, D., Marshall, C. R., Tyrrell, E., Lewis, S., Card, T., & Fogarty, A. (2022). Risk of mortality from suicide in patients with Huntington’s disease is increased compared to the general population in England. Journal of Neurology, 269, 4436–4439. https://doi.org/10.1007/s00415-022-11085-z

Objective: To examine the relative risk of suicide mortality in patients with Huntington’s disease (HD). Methods: A case–control study design was used. We used linked electronic records from primary care, secondary care and Office for National Statis... Read More about Risk of mortality from suicide in patients with Huntington’s disease is increased compared to the general population in England.

Introducing genetic testing with case finding for familial hypercholesterolaemia in primary care: qualitative study of patient and health professional experience (2022)
Journal Article
Silva, L., Condon, L., Qureshi, N., Dutton, B., Weng, S., & Kai, J. (2022). Introducing genetic testing with case finding for familial hypercholesterolaemia in primary care: qualitative study of patient and health professional experience. British Journal of General Practice, 72(720), e519-e527. https://doi.org/10.3399/BJGP.2021.0558

Background: Familial hypercholesterolaemia (FH) is a common inherited condition causing elevated cholesterol, premature heart disease and early death. Although FH can be effectively treated, over 80% of people with FH remain undetected. Aim: To e... Read More about Introducing genetic testing with case finding for familial hypercholesterolaemia in primary care: qualitative study of patient and health professional experience.