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Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging (2018)
Journal Article
Bradley, C. R., Cox, E. F., Scott, R. A., James, M. W., Kaye, P., Aithal, G. P., …Guha, I. N. (2018). Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging. Journal of Hepatology, 69(5), 1015-1024. https://doi.org/10.1016/j.jhep.2018.05.037

© 2018 European Association for the Study of the Liver Background & Aims: Advancing liver disease results in deleterious changes in a number of critical organs. The ability to measure structure, blood flow and tissue perfusion within multiple organs... Read More about Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging.

Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial (2018)
Journal Article
Vleugels, J. L., Rutter, M. D., Ragunath, K., Rees, C. J., Ponsioen, C. Y., Lahiff, C., …Dekker, E. (2018). Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial. The Lancet Gastroenterology & Hepatology, 3(5), 305-316. https://doi.org/10.1016/S2468-1253%2818%2930055-4

Background: Patients with longstanding ulcerative colitis (UC) undergo regular dysplasia surveillance because of increased colorectal cancer risk. Previous studies demonstrated that autofluorescence imaging (AFI) and chromoendoscopy (CE) increased dy... Read More about Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial.

Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study (2018)
Journal Article
Bannister, J., Szatkowski, L., Sharkey, D., Tan, S., Fiaschi, L., & Ban, L. (2018). Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition, 67(5), 580–585. https://doi.org/10.1097/MPG.0000000000002045

Objectives: Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesised link between the gastrointestinal (GI) tract and immune function, this study explores rates of... Read More about Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study.

Post infectious IBS: defining its clinical features and prognosis using an internet-based survey (2018)
Journal Article
Card, T., Enck, P., Barbara, G., Boeckxstaens, G. E., Santos, J., Azpiroz, F., …Spiller, R. C. (2018). Post infectious IBS: defining its clinical features and prognosis using an internet-based survey. United European Gastroenterology Journal, 6(8), 1245-1253. https://doi.org/10.1177/2050640618779923

Background: Gastrointestinal infection is an important risk factor for developing IBS. Our aim was to characterise postinfectious IBS (PI-IBS) compared to other IBS patients. Methods: An internet survey of IBS patients using Rome III diagnostic ques... Read More about Post infectious IBS: defining its clinical features and prognosis using an internet-based survey.

Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications (2018)
Journal Article
Kaliyaperumal, K., Grove, J. I., Delahay, R. M., Griffiths, W. J., Duckworth, A., & Aithal, G. P. (2018). Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications. Journal of Hepatology, 69(4), 948-957. https://doi.org/10.1016/j.jhep.2018.05.013

A number of drug-specific and host-related factors contribute to the development of drug-induced liver injury (DILI). Investigations focused on genetic susceptibility to DILI have advanced our understanding of the pathogenesis of this rare, yet poten... Read More about Pharmacogenomics of drug-induced liver injury (DILI): molecular biology to clinical applications.

Novel oral targeted therapies in inflammatory bowel disease (2018)
Journal Article
White, J. R., Philips, F., Monaghan, T. M., Fateen, W., Samuel, S., Ghosh, S., & Moran, G. W. (2018). Novel oral targeted therapies in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 47(12), 1610-1622. https://doi.org/10.1111/apt.14669

Background: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of me... Read More about Novel oral targeted therapies in inflammatory bowel disease.

The XL probe: a luxury or a necessity? risk stratification in an obese community cohort using transient elastography (2018)
Journal Article
Harris, R., Card, T. R., Delahooke, T., Aithal, G. P., & Guha, I. N. (2018). The XL probe: a luxury or a necessity? risk stratification in an obese community cohort using transient elastography. United European Gastroenterology Journal, 6(9), 1372-1379. https://doi.org/10.1177/2050640618772944

Background: Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination. Objective: The pur... Read More about The XL probe: a luxury or a necessity? risk stratification in an obese community cohort using transient elastography.

Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data (2018)
Journal Article
Otete, H. E., Deleuran, T., Fleming, K. M., Card, T. R., Aithal, G. P., Jepsen, P., & West, J. (2018). Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data. Journal of Hepatology, 69(3), 697-704. https://doi.org/10.1016/j.jhep.2018.04.002

© 2018 European Association for the Study of the Liver Background & Aims: Cirrhosis, the prevalence of which is increasing, is a risk factor for osteoporosis and fractures. However, little is known of the actual risk of hip fractures in patients with... Read More about Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data.

Pretreatment lesions on magnetic resonance imaging in patients with hepatitis C virus infection diagnosed with hepatocellular carcinoma after initiating direct-acting antiviral therapy (2018)
Journal Article
Scott, R. A., Aithal, G. P., Francis, S. T., & Irving, W. L. (2018). Pretreatment lesions on magnetic resonance imaging in patients with hepatitis C virus infection diagnosed with hepatocellular carcinoma after initiating direct-acting antiviral therapy. Gastroenterology, 154(6), https://doi.org/10.1053/j.gastro.2017.12.047

An examination of appetite and disordered eating in active Crohn’s disease (2018)
Journal Article
Wardle, R., Thapaliya, G., Nowak, A., Radford, S., Dalton, M., Finlayson, G., & Moran, G. W. (2018). An examination of appetite and disordered eating in active Crohn’s disease. Journal of Crohn's and Colitis, 12(7), 819-825. https://doi.org/10.1093/ecco-jcc/jjy041

Background: Crohn’s disease (CD) patients suffer from nutritional deficiencies when in active disease. We aim to examine calorific intake, macronutrient choice and disordered eating behaviour in patients with active CD. Methods: CD patients with ma... Read More about An examination of appetite and disordered eating in active Crohn’s disease.

Insights into the different effects of food on intestinal secretion using magnetic resonance imaging (2018)
Journal Article
Wilkinson-Smith, V. C., Major, G., Ashleigh, L., Murray, K., Hoad, C. L., Marciani, L., …Spiller, R. C. (2018). Insights into the different effects of food on intestinal secretion using magnetic resonance imaging. Journal of Parenteral and Enteral Nutrition, 42(8), 1342-1348. https://doi.org/10.1002/jpen.1157

Background: Plant foods may stimulate intestinal secretion through chemicals designed to deter herbivores, including lactucins in lettuce and rhein in rhubarb. This may increase ileostomy output and induce diarrhoea in people with intact bowels. Obj... Read More about Insights into the different effects of food on intestinal secretion using magnetic resonance imaging.

Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease (2018)
Journal Article
Grove, J. I., Thiagarajan, P., Astbury, S., Harris, R., Delahooke, T., Guha, I. N., & Aithal, G. P. (2018). Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease. Liver International, 38(10), 1832-1838. https://doi.org/10.1111/liv.13733

Background & Aims Chronic liver disease presents a major global public health challenge. Stratification of asymptomatic, at-risk patients in primary care using non-invasive methods has the potential to address this by identifying those likely to pr... Read More about Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non-alcoholic fatty liver disease.

Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease (2018)
Journal Article
Kendall, T., Dolman, G., Duff, C., Paish, E. C., Zaitoun, A., Irving, W. L., …Guha, I. N. (2018). Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease. Histopathology, 73(1), 90-100. https://doi.org/10.1111/his.13499

Aims. Needle biopsy remains essential for diagnosis in assessment of liver disease, although there remains associated risk. Examination is largely limited to subjective evaluation and biopsies are not exploited to provide personalised prognostic info... Read More about Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease.

Orbital inflammatory complications of Crohn’s disease: a rare case series (2018)
Journal Article
Monaghan, T. M., Albanese, G., Kaye, P., Thomas, J. D., Abercrombie, L., & Moran, G. W. (in press). Orbital inflammatory complications of Crohn’s disease: a rare case series. Clinical Medicine Insights: Gastroenterology, 11, https://doi.org/10.1177/1179552218757512

Orbital inflammatory disease is a rare ophthalmic manifestation of Crohn’s disease. Inflammation is characteristically non-specific, involving one or multiple structures of the orbit. Mechanisms of disease and optimal methods of treatment are poorly... Read More about Orbital inflammatory complications of Crohn’s disease: a rare case series.

MDM2 expression in the progression of Barrett’s oesophagus (2018)
Journal Article
Robinson, L., Ilyas, M., Ragunath, K., Card, T. R., Abradu-Berchie, B., & Kaye, P. (2018). MDM2 expression in the progression of Barrett’s oesophagus. Histopathology, 72(7), 1230-1233. https://doi.org/10.1111/his.13480

Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amoun... Read More about MDM2 expression in the progression of Barrett’s oesophagus.

PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer (2018)
Journal Article
Ghaneh, P., Hanson, R., Titman, A., Lancaster, G., Plumpton, C., Lloyd-Williams, H., …Neoptolemos, J. P. (2018). PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer. Health Technology Assessment, 22(7), 1-114. https://doi.org/10.3310/hta22070

Background: Pancreatic cancer diagnosis and staging can be difficult in 10–20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of PET/CT may add further value t... Read More about PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer.

Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour cell death induced by NAC (2018)
Journal Article
Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G. P., Ilyas, M., & Eremin, O. (2018). Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour cell death induced by NAC. BMC Cancer, 18, Article 123. https://doi.org/10.1186/s12885-018-4044-z

Background The tumour microenvironment consists of malignant cells, stroma and immune cells. In women with large and locally advanced breast cancers (LLABCs) undergoing neoadjuvant chemotherapy (NAC), tumour-infiltrating lymphocytes (TILs), variou... Read More about Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour cell death induced by NAC.