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The effects of expressive writing before or after punch biopsy on wound healing (2016)
Journal Article
Robinson, H., Jarrett, P., Vedhara, K., & Broadbent, E. (2017). The effects of expressive writing before or after punch biopsy on wound healing. Brain, Behavior, and Immunity, 61, https://doi.org/10.1016/j.bbi.2016.11.025

Objective: Recent studies have shown that written emotional disclosure (expressive writing) performed in the two weeks prior to wounding improves healing of punch biopsy wounds. In many clinical settings, it would be more practical for patients to pe... Read More about The effects of expressive writing before or after punch biopsy on wound healing.

Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer (2016)
Journal Article
Hunt, K. K., Karakas, C., Ha, M. J., Biernacka, A., Yi, M., Sahin, A., …Keyomarsi, K. (2017). Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer. Clinical Cancer Research, 23(12), 2991-3002. https://doi.org/10.1158/1078-0432.ccr-16-2217

Background: Low-molecular-weight-cyclin E (LMW-E) detected by Western blot, predicts for reduced breast cancer survival, however, it is impractical for clinical use. LMW-E lacks a nuclear localization signal which leads to accumulation in the cytopla... Read More about Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer.

Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews (2016)
Journal Article
Le Cleach, L., Doney, E., Katz, K. A., Williams, H. C., & Trinquart, L. (2016). Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews. Journal of Investigative Dermatology, 136(12), e125-e129. https://doi.org/10.1016/j.jid.2016.09.019

Clinical trials and basic science studies without statistically significant results are less likely to be published than studies with statistically significant results. Systematic reviews and meta-analyses that omit unpublished data are at high risk... Read More about Research techniques made simple: workflow for searching databases to reduce evidence selection bias in systematic reviews.

Bipolar at-risk criteria: an examination of which clinical features have optimal utility for identifying youth at risk of early transition from depression to bipolar disorders (2016)
Journal Article
Scott, J., Marwaha, S., Ratheesh, A., Macmillan, I., Yung, A. R., Morriss, R. K., …Bechdolf, A. (2017). Bipolar at-risk criteria: an examination of which clinical features have optimal utility for identifying youth at risk of early transition from depression to bipolar disorders. Schizophrenia Bulletin, 43(4), 737-744. https://doi.org/10.1093/schbul/sbw154

Background: A clinical and research challenge is to identify which depressed youth are at risk of “early transition to bipolar disorders (ET-BD).” This 2-part study (1) examines the clinical utility of previously reported BD at-risk (BAR) criteria in... Read More about Bipolar at-risk criteria: an examination of which clinical features have optimal utility for identifying youth at risk of early transition from depression to bipolar disorders.

Recovery, responsiveness and interpretability of patient-reported outcome measures after surgery for Dupuytren’s disease (2016)
Journal Article
Rodrigues, J., Zhang, W., Scammell, B. E., Davidson, D., Fullilove, S., Chakrabarti, I., …Davies, T. (2016). Recovery, responsiveness and interpretability of patient-reported outcome measures after surgery for Dupuytren’s disease. Journal of Hand Surgery (European Volume), 42(3), https://doi.org/10.1177/1753193416677712

This prospective cohort study investigated the responsiveness and interpretability of the Disabilities of the Arm, Shoulder and Hand (DASH) and Unité Rhumatologique des Affections de la Main (URAM) outcome measures for assessing recovery after fascie... Read More about Recovery, responsiveness and interpretability of patient-reported outcome measures after surgery for Dupuytren’s disease.

Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement (2016)
Journal Article
Spuls, P., Gerbens, L., Simpson, E., Apfelbacher, C., Chalmers, J., Thomas, K., …Schmitt, J. (2017). Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement. British Journal of Dermatology, 176(4), 979-984. https://doi.org/10.1111/bjd.15179

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, q... Read More about Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement.

Working hours and common mental disorders in English police officers (2016)
Journal Article
Houdmont, J., & Randall, R. (2016). Working hours and common mental disorders in English police officers. Occupational Medicine, 66(9), https://doi.org/10.1093/occmed/kqw166

Background: There is a paucity of evidence on working hours and their psychological correlates in police officers of the federated ranks in England. Aims: An exploratory study to establish the extent to which a sample of English police officers work... Read More about Working hours and common mental disorders in English police officers.

Exploring the acceptability of innovative technology: a pilot study using LENA with parents of young deaf children in the UK (2016)
Journal Article
Allen, S., Crawford, P., & Mulla, I. (2017). Exploring the acceptability of innovative technology: a pilot study using LENA with parents of young deaf children in the UK. Child Language Teaching and Therapy, 33(2), https://doi.org/10.1177/0265659016671168

Early intervention is widely recommended for children at risk of difficulties with speech, language and communication. Evidence for effective practice remains limited due in part to inherent difficulties in defining complex interventions and measurin... Read More about Exploring the acceptability of innovative technology: a pilot study using LENA with parents of young deaf children in the UK.

The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A Record Linkage Study (2016)
Journal Article
Chu, T. P., Moran, G. W., & Card, T. R. (2016). The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A Record Linkage Study. Journal of Crohn's and Colitis, 11(5), 578-585. https://doi.org/10.1093/ecco-jcc/jjw192

Background and Aims: Numerous studies have established that mortality risk in IBD patients is higher than the general population, but the causes of death have seldom been examined. We aimed to describe causes of death in IBD. Methods: A matched co... Read More about The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A Record Linkage Study.

HCA care certificate use to be assessed in national study (2016)
Journal Article
Merrifield, N. (2016). HCA care certificate use to be assessed in national study. Nursing Times,

Elaine Argyle and Louise Thomson interviewed about the care certificate evaluation being carried out at the University of Nottingham.

In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies (2016)
Journal Article
Schwarz, S. T., Xing, Y., Tomar, P., Bajaj, N., & Auer, D. P. (2017). In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies. Radiology, 283(3), 789-798. https://doi.org/10.1148/radiol.2016160662

Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nigra pars compacta (SNpc), locus coeruleus, and ventral tegmental area in Parkinson disease (PD); the specific aims were (a) to study regional magnetic... Read More about In Vivo Assessment of Brainstem Depigmentation in Parkinson Disease: Potential as a Severity Marker for Multicenter Studies.

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans (2016)
Journal Article
Brook, M. S., Wilkinson, D. J., Mitchell, W. K., Lund, J. N., Phillips, B. E., Szewczyk, N. J., …Atherton, P. J. (2016). Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. Journal of Physiology, 594(24), 7399-7417. https://doi.org/10.1113/JP272857

Ageing is associated with impaired hypertrophic responses to resistance exercise training (RET). Here we investigated the aetiology of ‘anabolic resistance’ in older humans. Twenty healthy male individuals, 10 younger (Y; 23 ± 1 years) and 10 older (... Read More about Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.

Promoting help-seeking in response to symptoms amongst primary care patients at high risk of lung cancer: a mixed method study (2016)
Journal Article
Wagland, R., Brindle, L., Ewings, S., James, E., Moore, M., Rivas, C., …Corner, J. (2016). Promoting help-seeking in response to symptoms amongst primary care patients at high risk of lung cancer: a mixed method study. PLoS ONE, 11(11), 1-20. https://doi.org/10.1371/journal.pone.0165677

Background: Lung cancer symptoms are vague and difficult to detect. Interventions are needed to promote early diagnosis, however health services are already pressurised. This study explored symptomology and help-seeking behaviours of primary care pat... Read More about Promoting help-seeking in response to symptoms amongst primary care patients at high risk of lung cancer: a mixed method study.

Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis (2016)
Journal Article
Toot, S., Swinson, T., Devine, M., Challis, D., & Orrell, M. (in press). Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis. International Psychogeriatrics, 29(2), https://doi.org/10.1017/S1041610216001654

Background: Up to half of people with dementia in high income countries live in nursing homes and more than two-thirds of care home residents have dementia. Fewer than half of these residents report good quality of life and most older people are anxi... Read More about Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis.

Effects of noise exposure on young adults with normal audiograms I: Electrophysiology (2016)
Journal Article
Prendergast, G., Guest, H., Munro, K. J., Kluk, K., Léger, A., Hall, D. A., …Plack, C. J. (2017). Effects of noise exposure on young adults with normal audiograms I: Electrophysiology. Hearing Research, 344, 68-81. https://doi.org/10.1016/j.heares.2016.10.028

Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas... Read More about Effects of noise exposure on young adults with normal audiograms I: Electrophysiology.

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival (2016)
Journal Article
Xuan, P., Storr, S. J., Zhang, Y., Rakha, E., Green, A. R., Ellis, I. O., & Martin, S. G. (in press). Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival. Apoptosis, https://doi.org/10.1007/s10495-016-1323-5

Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis. The current study sought... Read More about Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival.

Investigating splicing variants uncovered by next-generation sequencing the Alzheimer’s disease candidate genes, CLU, PICALM, CR1, ABCA7, BIN1, the MS4A locus, CD2AP, EPHA1 and CD33 (2016)
Journal Article
Clement, N., Braae, A., Turton, J., Lord, J., Guetta-Baranes, T., Medway, C., …Morgan, K. (in press). Investigating splicing variants uncovered by next-generation sequencing the Alzheimer’s disease candidate genes, CLU, PICALM, CR1, ABCA7, BIN1, the MS4A locus, CD2AP, EPHA1 and CD33. Journal of Alzheimer's Disease and Parkinsonism, 6(6), https://doi.org/10.4172/2161-0460.1000276

Late onset Alzheimer’s disease (LOAD), the most common cause of late onset dementia, has a strong genetic component. To date, 21 disease-risk loci have been identified through genome wide association studies (GWAS). However, the causative functional... Read More about Investigating splicing variants uncovered by next-generation sequencing the Alzheimer’s disease candidate genes, CLU, PICALM, CR1, ABCA7, BIN1, the MS4A locus, CD2AP, EPHA1 and CD33.

Shared decision-making and patient decision aids in dermatology (2016)
Journal Article
Tan, J., Linos, E., Sendelweck, M. A., van Zuuren, E. J., Ersser, S., Dellavalle, R. P., & Williams, H. C. (in press). Shared decision-making and patient decision aids in dermatology. British Journal of Dermatology, 175(5), https://doi.org/10.1111/bjd.14803

Shared decision making combines individual patient interests and values with clinical best evidence under the guiding principle of patient autonomy. Patient decision aids can support shared decision making and facilitate decisions that have multiple... Read More about Shared decision-making and patient decision aids in dermatology.

Psychometric properties of a generic, patient-centred palliative care outcome measure of symptom burden for people with progressive long term neurological conditions (2016)
Journal Article
Gao, W., Crosby, V., Wilcock, A., Burman, R., Silber, E., Hepgul, N., …Higginson, I. J. (2016). Psychometric properties of a generic, patient-centred palliative care outcome measure of symptom burden for people with progressive long term neurological conditions. PLoS ONE, 11(10), 1-15. https://doi.org/10.1371/journal.pone.0165379

Background There is no standard palliative care outcome measure for people with progressive long term neurological conditions (LTNC). This study aims to determine the psychometric properties of a new 8-item palliative care outcome scale of symptom b... Read More about Psychometric properties of a generic, patient-centred palliative care outcome measure of symptom burden for people with progressive long term neurological conditions.

The future of multiple sclerosis treatments (2016)
Journal Article
Coclitu, C., Constantinescu, C. S., & Tanasescu, R. (in press). The future of multiple sclerosis treatments. Expert Review of Neurotherapeutics, 16(12), https://doi.org/10.1080/14737175.2016.1243056

Introduction. There are not many conditions in which the last few decades have brought such a major change in the landscape of treatments as is the case of multiple sclerosis (MS). A number of disease modifying treatments (DMTs) are presently availab... Read More about The future of multiple sclerosis treatments.