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What outcomes should be measured in feline chronic kidney disease treatment trials? Establishing a core outcome set for research (2021)
Journal Article
Doit, H., Dean, R., Duz, M., Finch, N., & Brennan, M. (2021). What outcomes should be measured in feline chronic kidney disease treatment trials? Establishing a core outcome set for research. Preventive Veterinary Medicine, 192, Article 105348. https://doi.org/10.1016/j.prevetmed.2021.105348

Chronic Kidney Disease (CKD) is an important cause of feline morbidity and mortality. There is currently no agreement on which outcomes are most important in CKD treatment trials to assist evidence-based decision making. Core Outcome Sets (COSs) o... Read More about What outcomes should be measured in feline chronic kidney disease treatment trials? Establishing a core outcome set for research.

Storage stability and delivery potential of cytochalasin B induced membrane vesicles (2021)
Journal Article
Kletukhina, S. K., Neustroeva, O. A., Kurbangaleeva, S. V., Salafutdinov, I. I., Rogov, A. M., James, V., …Gomzikova, M. O. (2021). Storage stability and delivery potential of cytochalasin B induced membrane vesicles. Biotechnology Reports, 30, Article e00616. https://doi.org/10.1016/j.btre.2021.e00616

Cell-free therapies based on extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) are considered as a promising tool for stimulating regeneration and immunomodulation. The need to develop a practical approach for large-scale produc... Read More about Storage stability and delivery potential of cytochalasin B induced membrane vesicles.

Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells (2021)
Journal Article
Wang, S. S., Chen, D., He, J. J., Zheng, W. B., Tian, A. L., Zhao, G. H., …Zhu, X. Q. (2021). Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells. Frontiers in Immunology, 12, Article 653755. https://doi.org/10.3389/fimmu.2021.653755

Fasciola gigantica produces excretory-secretory products (ESPs) with immune-modulating effects to promote its own survival. In this study, we performed RNA-seq to gain a comprehensive global understanding of changes in the expression of mRNAs, miRNAs... Read More about Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells.

Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies (2021)
Journal Article
Gomzikova, M., James, V., & Rizvanov, A. (2021). Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies. Frontiers in Cell and Developmental Biology, 9, Article 653322. https://doi.org/10.3389/fcell.2021.653322

The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to injured cells, leading to incre... Read More about Mitochondria donation by mesenchymal stem cells: current understanding and mitochondria transplantation strategies.

Assessing the feasibility of retrospective and prospective clinical audit in farm animal veterinary practice (2021)
Journal Article
Waine, K., White, C., Dean, R. S., Hudson, C., Huxley, J. N., & Brennan, M. L. (2021). Assessing the feasibility of retrospective and prospective clinical audit in farm animal veterinary practice. Veterinary Sciences, 8(4), https://doi.org/10.3390/vetsci8040062

As a quality improvement tool, clinical audit has been extensively described in the medical literature. There is scant literature on the use of clinical audit in the farm animal veterinary setting. This study describes the process and feasibility of... Read More about Assessing the feasibility of retrospective and prospective clinical audit in farm animal veterinary practice.

Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology (2021)
Journal Article
Sumner, R. N., Byers, A., Zhang, Z., Agerholm, J. S., Lindh, L., England, G. C. W., & Lea, R. G. (2021). Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology. Scientific Reports, 11, Article 7361. https://doi.org/10.1038/s41598-021-86805-y

In humans and dogs, a temporal decline in semen quality and increased incidence of testicular cancer is hypothesised to be associated with exposure to anthropogenic chemicals, particularly during fetal development. Human studies suggest that differen... Read More about Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology.

Simulating land use changes, sediment yields, and pesticide use in the Upper Paraguay River Basin: Implications for conservation of the Pantanal wetland (2021)
Journal Article
de Oliveira Roque, F., Guerra, A., Johnson, M., Padovania, C., Corbi, J., Covich, A. P., …Yon, L. (2021). Simulating land use changes, sediment yields, and pesticide use in the Upper Paraguay River Basin: Implications for conservation of the Pantanal wetland. Agriculture, Ecosystems and Environment, 314, 1-11. https://doi.org/10.1016/j.agee.2021.107405

As a consequence of accelerated and excessive use of pesticides in tropical regions, wilderness areas are under threat; this includes the Pantanal wetlands in the Upper Paraguay River Basin (UPRB). Using a Land Cover Land Use Change (LCLUC) modelling... Read More about Simulating land use changes, sediment yields, and pesticide use in the Upper Paraguay River Basin: Implications for conservation of the Pantanal wetland.

Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals (2021)
Journal Article
Occhiuto, F., Mohallal, E., Gilfillan, G. D., Lowe, A., & Reader, T. (2021). Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals. Mammalia, 85(4), 325-335. https://doi.org/10.1515/mammalia-2020-0095

The ecology of the harvest mouse (Micromys minutus) is poorly understood, partly because it is a difficult species to monitor. It is commonly associated with reedbeds, where evidence suggests that it experiences strong seasonal fluctuations in abunda... Read More about Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals.

Prognostic significance of heat shock protein 90AA1 (HSP90?) in invasive breast cancer (2021)
Journal Article
Alsaeed, S. A., Toss, M., Alsaleem, M., Aleskandarany, M., Joseph, C., Kurozumi, S., …Rakha, E. (2022). Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer. Journal of Clinical Pathology, 75(4), 263-269. https://doi.org/10.1136/jclinpath-2020-207106

Aims: The mechanisms that drive breast cancer (BC) progression and poor outcome are not fully understood. The human heat shock protein 90 alpha family class A member 1 (HSP90?) encoded by the HSP90 'A1 gene has a vital role in cellular responses to s... Read More about Prognostic significance of heat shock protein 90AA1 (HSP90?) in invasive breast cancer.

A systematic review of the quality of life assessment tools for cats in the published literature (2021)
Journal Article
Doit, H., Dean, R. S., Duz, M., & Brennan, M. L. (2021). A systematic review of the quality of life assessment tools for cats in the published literature. Veterinary Journal, 272, Article 105658. https://doi.org/10.1016/j.tvjl.2021.105658

Quality of life (QoL) is an important parameter to assess in cats, as it can be pivotal to important decision-making. Research reports that owners of cats with heart disease would trade longevity for QoL, and treatment associated improvement in QoL i... Read More about A systematic review of the quality of life assessment tools for cats in the published literature.

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens (2021)
Journal Article
Cook, R., Hooton, S., Trivedi, U., King, L., Dodd, C. E., Hobman, J. L., …Millard, A. D. (2021). Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens. Microbiome, 9, Article 65. https://doi.org/10.1186/s40168-021-01010-3

Viruses are the most abundant biological entities on Earth, known to be crucial components of microbial ecosystems. However, there is little information on the viral community within agricultural waste. There are currently ~ 2.7 million dairy cattle... Read More about Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens.

Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control (2021)
Journal Article
O’Loughlin, S. M., Forster, A. J., Fuchs, S., Dottorini, T., Nolan, T., Crisanti, A., & Burt, A. (2021). Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control. G3, 11(6), Article jkab086. https://doi.org/10.1093/g3journal/jkab086

DNA sequences that are exactly conserved over long evolutionary time scales have been observed in a variety of taxa. Such sequences are likely under strong functional constraint and they have been useful in the field of comparative genomics for ident... Read More about Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control.

Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis? (2021)
Journal Article
Cooper, E., Cowmeadow, W., & Elsheikha, H. M. (2021). Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?. Parasitologia, 1(1), 12-19. https://doi.org/10.3390/parasitologia1010002

When presented with an animal exhibiting signs of keratitis (inflammation of the cornea), such as impaired vision, mucoid discharges, redness, swelling, and corneal oedema, most veterinarians would think of bacteria, viruses, or fungi as the potentia... Read More about Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?.

Skeleton Growth in Guinea Pigs and Humans (2021)
Journal Article
Skinner, Z., Clark, N., Rutland, S., Dawkins, A., & Rutland, C. S. (2021). Skeleton Growth in Guinea Pigs and Humans. Frontiers for Young Minds, 9,

Every animal has a skeleton made up of many different bones. Bones are vital. Without bones we would not be able to move, protect our internal organs, store important minerals, or even make some cell types! When we are young, in addition to growing,... Read More about Skeleton Growth in Guinea Pigs and Humans.

Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity (2021)
Journal Article
Ogurcov, S., Shulman, I., Garanina, E., Sabirov, D., Baichurina, I., Kuznetcov, M., …Mukhamedshina, Y. (2021). Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity. Brain Sciences, 11(3), Article 322. https://doi.org/10.3390/brainsci11030322

Background: Despite considerable interest in the search for a spinal cord injury (SCI) therapy, there is a critical need to develop a panel of diagnostic biomarkers to determine injury severity. In this regard, there is a requirement for continuing r... Read More about Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity.

Mink is a highly susceptible host species to circulating human and avian influenza viruses (2021)
Journal Article
Sun, H., Li, F., Liu, Q., Du, J., Liu, L., Li, C., …Liu, J. (2021). Mink is a highly susceptible host species to circulating human and avian influenza viruses. Emerging Microbes & Infections, 10(1), 472-480. https://doi.org/10.1080/22221751.2021.1899058

Pandemic influenza, typically caused by reassortment of human and avian influenza viruses, can result in severe or fatal infections in humans. Timely identification of potential pandemic viruses must be a priority in influenza virus surveillance. How... Read More about Mink is a highly susceptible host species to circulating human and avian influenza viruses.

Vector Transmission of Animal Viruses (2021)
Book Chapter
Attoui, H., Jaafar, F. M., Fragkoudis, R., & Mertens, P. P. (2021). Vector Transmission of Animal Viruses. In Encyclopedia of Virology (542-551). (Fourth edition). Elsevier. https://doi.org/10.1016/b978-0-12-814515-9.00135-1

Animal “arboviruses” include viruses that are transmitted between their vertebrate hosts by arthropod vectors. They replicate in both their haematophagous arthropod vectors and vertebrate hosts. Vectors become infected after feeding on infected hosts... Read More about Vector Transmission of Animal Viruses.