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Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction (2015)
Journal Article
Patel, T. R., Nikodemus, D., Besong, T. M., Reuten, R., Meier, M., Harding, S. E., …Stetefeld, J. (2016). Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction. Matrix Biology, 49, doi:10.1016/j.matbio.2015.06.005

Laminins are key basement membrane molecules that influence several biological activities and are linked to a number of diseases. They are secreted as heterotrimeric proteins consisting of one α, one β, and one γ chain, followed by their assembly int... Read More about Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction.

Effect of a single dose of Saccharomyces cerevisiae var. boulardii on the occurrence of porcine neonatal diarrhoea (2015)
Journal Article
Hancox, L., Le Bon, M., Richards, P., Guillou, D., Dodd, C. E., & Mellits, K. (in press). Effect of a single dose of Saccharomyces cerevisiae var. boulardii on the occurrence of porcine neonatal diarrhoea. animal, 9(11), doi:10.1017/S1751731114002687

Piglet neonatal diarrhoea is an important issue in modern pig production and is linked to increased mortality and poor growth rates, affecting long-term pig health, increasing use of medication and cost of production. Saccharomyces cerevisiae var. bo... Read More about Effect of a single dose of Saccharomyces cerevisiae var. boulardii on the occurrence of porcine neonatal diarrhoea.

Assessment of caecal parameters in layer hens fed on diets containing wheat distillers dried grains with solubles (2015)
Journal Article
White, G. A., White, G. A., Richards, P., Wu, S., Mellits, K., & Wiseman, J. (2015). Assessment of caecal parameters in layer hens fed on diets containing wheat distillers dried grains with solubles. British Poultry Science, 56(4), 494-502. https://doi.org/10.1080/00071668.2015.1064859

There is much interest in quantifying the nutritional value of UK wheat distillers dried grains with solubles (W-DDGS) for livestock species. A study was designed to evaluate caecal parameters (pH, short chain fatty acids (SCFAs) and bacterial divers... Read More about Assessment of caecal parameters in layer hens fed on diets containing wheat distillers dried grains with solubles.

Palaeoproxies: botanical monitors and recorders of atmospheric change (2015)
Journal Article
Lomax, B. H., & Fraser, W. T. (2015). Palaeoproxies: botanical monitors and recorders of atmospheric change. Palaeontology, 58(5), (759-768). doi:10.1111/pala.12180. ISSN 0031-0239

The integration of plant and Earth sciences offers the opportunity to develop and test palaeobotanical monitors and recorders (palaeoproxies) of past atmospheric change that are understood from a mechanistic perspective, with the underpinning respons... Read More about Palaeoproxies: botanical monitors and recorders of atmospheric change.

Novel in vitro diagnosis of equine allergies using a protein array and mathematical modelling approach: a proof of concept using insect bite hypersensitivity (2015)
Journal Article
Marti, E., Wang, X., Jambari, N., Rhyner, C., Olzhausen, J., Pérez-Barea, J., …Alcocer, M. J. (2015). Novel in vitro diagnosis of equine allergies using a protein array and mathematical modelling approach: a proof of concept using insect bite hypersensitivity. Veterinary Immunology and Immunopathology, 167(3-4), doi:10.1016/j.vetimm.2015.06.013

Insect bite hypersensitivity (IBH) is a seasonal recurrent skin allergy of horses caused by IgE-mediated reactions to allergens present in the saliva of biting insects of the genus Culicoides, and possibly also Simulium and Stomoxys species. In this... Read More about Novel in vitro diagnosis of equine allergies using a protein array and mathematical modelling approach: a proof of concept using insect bite hypersensitivity.

Selection of yeast strains for bioethanol production from UK seaweeds (2015)
Journal Article
Kostas, E. T., White, D. A., Du, C., & Cook, D. J. (2016). Selection of yeast strains for bioethanol production from UK seaweeds. Journal of Applied Phycology, 28(2), 1427-1441. https://doi.org/10.1007/s10811-015-0633-2

Macroalgae (seaweeds) are a promising feedstock for the production of third generation bioethanol, since they have high carbohydrate contents, contain little or no lignin and are available in abundance. However, seaweeds typically contain a more dive... Read More about Selection of yeast strains for bioethanol production from UK seaweeds.

Salinity is an agent of divergent selection driving local adaptation of arabidopsis to coastal habitats (2015)
Journal Article
Busoms, S., Teres, J., Huang, X. Y., Bomblies, K., Danku, J., Douglas, A., …Salt, D. E. (2015). Salinity is an agent of divergent selection driving local adaptation of arabidopsis to coastal habitats. Plant Physiology, 168(3), 915-929. https://doi.org/10.1104/pp.15.00427

© 2015 American Society of Plant Biologists. All rights reserved. Understanding the molecular mechanism of adaptive evolution in plants provides insights into the selective forces driving adaptation and the genetic basis of adaptive traits with agric... Read More about Salinity is an agent of divergent selection driving local adaptation of arabidopsis to coastal habitats.

A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation (2015)
Journal Article
Langowski, J., Zhao, H., Ghirlando, R., Alfonso, C., Arisaka, F., Attali, I., …Schuck, P. (2015). A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation. PLoS ONE, 10(5), https://doi.org/10.1371/journal.pone.0126420

Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose o... Read More about A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation.

Matrix-free hydrodynamic study on the size distribution and conformation of three technical lignins from wood and non-wood (2015)
Journal Article
Alzahrani, Q. E., Adams, G. G., Gillis, R. B., Besong, T. M., Kök, M. S., Fong, E., …Harding, S. E. (2016). Matrix-free hydrodynamic study on the size distribution and conformation of three technical lignins from wood and non-wood. Holzforschung, 70(2), doi:10.1515/hf-2014-0318

Molecular weight (MW) and related conformational data of three commercially available technical lignins (Alcell L, kraft L, and soda L) have been studied by means of analytical ultracentrifugation, taking advantage of some recent developments in both... Read More about Matrix-free hydrodynamic study on the size distribution and conformation of three technical lignins from wood and non-wood.

Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes (2015)
Journal Article
German, S. D., Lee, J., Campbell, K. H., Sweetman, D., & Alberio, R. (in press). Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes. Biology of Reproduction, 92(4), doi:10.1095/biolreprod.114.122341

Oocytes treated with the protein synthesis inhibitor cycloheximide (CHX) arrest at the germinal vesicle (GV) stage and undergo accelerated GV breakdown (GVBD) after CHX is removed. However, little is known about the underlying mechanism of accelerate... Read More about Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes.

Impacts of zero tillage on soil enzyme activities, microbial characteristics and organic matter functional chemistry in temperate soils (2015)
Journal Article
Mangalassery, S., Mooney, S. J., Sparkes, D., Fraser, W., & Sjögersten, S. (2015). Impacts of zero tillage on soil enzyme activities, microbial characteristics and organic matter functional chemistry in temperate soils. European Journal of Soil Biology, 68, doi:10.1016/j.ejsobi.2015.03.001

Zero tillage management of agricultural soils has potential for enhancing soil carbon (C) storage and reducing greenhouse gas emissions. However, the mechanisms which control carbon (C) sequestration in soil in response to zero tillage are not well u... Read More about Impacts of zero tillage on soil enzyme activities, microbial characteristics and organic matter functional chemistry in temperate soils.

Recent advances in the analysis of macromolecular interactions using the matrix-free method of sedimentation in the analytical ultracentrifuge (2015)
Journal Article
Harding, S., Gillis, R., Almutairi, F., Erten, T., Kök, M., & Adams, G. (2015). Recent advances in the analysis of macromolecular interactions using the matrix-free method of sedimentation in the analytical ultracentrifuge. Biology, 4(1), doi:10.3390/biology4010237

Sedimentation in the analytical ultracentrifuge is a matrix free solution technique with no immobilisation, columns, or membranes required and can be used to study self-association and complex or “hetero”-interactions, stoichiometry, reversibility an... Read More about Recent advances in the analysis of macromolecular interactions using the matrix-free method of sedimentation in the analytical ultracentrifuge.

Leaf energy balance modelling as a tool to infer habitat preference in the early angiosperms (2015)
Journal Article
Lee, A. P., Upchurch, G., Murchie, E. H., & Lomax, B. H. (2015). Leaf energy balance modelling as a tool to infer habitat preference in the early angiosperms. Proceedings of the Royal Society B: Biological Sciences, 282(1803), doi:10.1098/rspb.2014.3052

Despite more than a century of research, some key aspects of habitat preference and ecology of the earliest angiosperms remain poorly constrained. Proposed growth ecology has varied from opportunistic weedy species growing in full sun to slow-growing... Read More about Leaf energy balance modelling as a tool to infer habitat preference in the early angiosperms.

A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology (2015)
Journal Article
Gillis, R. B., Rowe, A. J., Adams, G. G., & Harding, S. E. (2015). A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology. Biotechnology and Genetic Engineering Reviews, 30(2), doi:10.1080/02648725.2014.994870

This short review considers the range of modern techniques for the hydrodynamic characterisation of macromolecules – particularly large glycosylated systems used in the food, biopharma and healthcare industries. The range or polydispersity of molecul... Read More about A review of modern approaches to the hydrodynamic characterisation of polydisperse macromolecular systems in biotechnology.

Plant embryogenesis requires AUX/LAX-mediated auxin influx (2015)
Journal Article
Robert, H. S., Grunewald, W., Sauer, M., Cannoot, B., Soriano, M., Swarup, R., …Friml, J. (2015). Plant embryogenesis requires AUX/LAX-mediated auxin influx. Development, 142(4), doi:10.1242/dev.115832

The plant hormone auxin and its directional transport are known to play a crucial role in defining the embryonic axis and subsequent development of the body plan. Although the role of PIN auxin efflux transporters has been clearly assigned during emb... Read More about Plant embryogenesis requires AUX/LAX-mediated auxin influx.

Entometabolomics: applications of modern analytical techniques to insect studies (2015)
Journal Article
Snart, C. J., Hardy, I. C., & Barrett, D. A. (2015). Entometabolomics: applications of modern analytical techniques to insect studies. Entomologia Experimentalis et Applicata, 155(1), 1-17. https://doi.org/10.1111/eea.12281

Metabolomic analyses can reveal associations between an organism's metabolome and further aspects of its phenotypic state, an attractive prospect for many life-sciences researchers. The metabolomic approach has been employed in some, but not many, in... Read More about Entometabolomics: applications of modern analytical techniques to insect studies.

Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding (2015)
Journal Article
Ware, S., Voigt, J., & Langley-Evans, S. C. (2015). Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding. Journal of Nutritional Science, 4(e3), doi:10.1017/jns.2014.64

Fetal exposure to maternal undernutrition has lifelong consequences for physiological and metabolic function. Maternal low-protein diet is associated with an age-related phenotype in rats, characterised by a period of resistance to development of obe... Read More about Body composition and behaviour in adult rats are influenced by maternal diet, maternal age and high-fat feeding.

Multi-trait mimicry of ants by a parasitoid wasp (2015)
Journal Article
Malcicka, M., Bezemer, T. M., Visser, B., Bloemberg, M., Snart, C. J., Hardy, I. C., & Harvey, J. A. (in press). Multi-trait mimicry of ants by a parasitoid wasp. Scientific Reports, 5, doi:10.1038/srep08043

Many animals avoid attack from predators through toxicity or the emission of repellent chemicals. Defensive mimicry has evolved in many species to deceive shared predators, for instance through colouration and other morphological adaptations, but mim... Read More about Multi-trait mimicry of ants by a parasitoid wasp.