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Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon (2016)
Journal Article
Alkhader, E., Billa, N., & Roberts, C. J. (2017). Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon. AAPS PharmSciTech, 18(4), 1009-1018. doi:10.1208/s12249-016-0623-y

In the present study, we report the properties of a mucoadhesive chitosan-pectinate nanoparticulate formulation able to retain its integrity in the milieu of the upper gastrointestinal tract and subsequently, mucoadhere and release curcumin in colon... Read More about Mucoadhesive chitosan-pectinate nanoparticles for the delivery of curcumin to the colon.

Distinct microenvironmental cues trigger divergent TLR4-mediated immune signalling in macrophages (2016)
Journal Article
Piccinini, A. M., Zuliani-Alvarez, L., Lim, J. M., & Midwood, K. S. (2016). Distinct microenvironmental cues trigger divergent TLR4-mediated immune signalling in macrophages. Science Signaling, 9(443), doi:10.1126/scisignal.aaf3596

Macrophages exhibit a phenotypic plasticity that enables them to orchestrate specific immune responses to distinct threats. However, the factors that control macrophage behaviour in a context dependent manner are not well understood. Lipopolysacchari... Read More about Distinct microenvironmental cues trigger divergent TLR4-mediated immune signalling in macrophages.

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study (2016)
Journal Article
Jadoon, K. A., Ratcliffe, S. H., Barrett, D. A., Thomas, E. L., Stott, C., Bell, J. D., …Tan, G. D. (2016). Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes Care, 39(10), 1777-1786. https://doi.org/10.2337/dc16-0650

OBJECTIVE Cannabidiol (CBD) and Δ9-tetrahydrocannabivarin (THCV) are nonpsychoactive phytocannabinoids affecting lipid and glucose metabolism in animal models. This study set out to examine the effects of these compounds in patients with type 2 diabe... Read More about Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.

Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers (2016)
Journal Article
Adlington, K., Nguyen, N. T., Eaves, E., Yang, J., Chang, C., Li, J., …Irvine, D. J. (2016). Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules, 17(9), 2830-2838. https://doi.org/10.1021/acs.biomac.6b00615

Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a range of (meth)acrylate copolymer... Read More about Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers.

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation (2016)
Journal Article
Soukarieh, F., Nowicki, M. W., Bastide, A., Poyry, T., Jones, C., Dudek, K., …Fischer, P. M. (2016). Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation. European Journal of Medicinal Chemistry, 124, doi:10.1016/j.ejmech.2016.08.047

Eukaryotic translation initiation factor 4E (eIF4E) is considered as the corner stone in the cap-dependent translation initiation machinery. Its role is to recruit mRNA to the ribosome through recognition of the 50 - terminal mRNA cap structure (m7 G... Read More about Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation.

Linking in vitro lipolysis and microsomal metabolism for the quantitative prediction of oral bioavailability of BCS II drugs administered in lipidic formulations (2016)
Journal Article
Benito-Gallo, P., Marlow, M., Zann, V., Scholes, P., & Gershkovich, P. (in press). Linking in vitro lipolysis and microsomal metabolism for the quantitative prediction of oral bioavailability of BCS II drugs administered in lipidic formulations. Molecular Pharmaceutics, 13(10), doi:10.1021/acs.molpharmaceut.6b00597

Lipidic formulations (LFs) are increasingly utilized for the delivery of drugs that belong to class II of the Biopharmaceutics Classification System (BCS). The current work proposes, for the first time, the combination of in vitro lipolysis and micro... Read More about Linking in vitro lipolysis and microsomal metabolism for the quantitative prediction of oral bioavailability of BCS II drugs administered in lipidic formulations.

Integrating academic, professional and personal learning through multicultural group work (2016)
Conference Proceeding
Bridges, S. (in press). Integrating academic, professional and personal learning through multicultural group work

Multicultural group work is an element of pedagogy which presents rich opportunities for helping students function more effectively within the intercultural contexts of their worlds. Drawing on theories of cosmopolitanism and the ‘capability approac... Read More about Integrating academic, professional and personal learning through multicultural group work.

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors (2016)
Journal Article
Emtage, A. L., Mistry, S. N., Fischer, P. M., Kellam, B., & Laughton, C. A. (2016). GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2016.1226197

G protein-coupled receptors (GPCRs) are proteins of pharmaceutical importance, with over 30% of all drugs in clinical use targeting them. Increasing numbers of X-ray crystal (XRC) structures of GPCRs offer a wealth of data relating to ligand binding.... Read More about GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines (2016)
Journal Article
Zgair, A., Wong, J. C., Lee, J. B., Mistry, J., Sivak, O., Wasan, K. M., …Gershkovich, P. (2016). Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. American Journal of Translational Research, 8(8),

There has been an escalating interest in the medicinal use of Cannabis sativa in recent years. Cannabis is often administered orally with fat-containing foods, or in lipid-based pharmaceutical preparations. However, the impact of lipids on the exposu... Read More about Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines.

PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma (2016)
Journal Article
Luo, T., Loira-Pastoriza, C., Patil, H. P., Ucakar, B., Muccioli, G. G., Bosquillon, C., & Vanbever, R. (in press). PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma. Journal of Controlled Release, 239, doi:10.1016/j.jconrel.2016.08.008

Pulmonary delivery offers an attractive route of administration for chemotherapeutic agents, with the advantages of high drug concentrations locally and low side effects systemically. However, fast clearance mechanisms result in short residence time... Read More about PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma.

Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain (2016)
Journal Article
Burston, J. J., Mapp, P. I., Sarmad, S., Barrett, D. A., Niphakis, M. J., Cravatt, B. F., …Chapman, V. (2016). Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain. British Journal of Pharmacology, 173(21), doi:10.1111/bph.13574

BACKGROUND AND PURPOSE: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate, or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain-rel... Read More about Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain.

Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers (2016)
Journal Article
Kakde, D., Powell, L. G., Bansal, K. K., Howdle, S., Irvine, D., Mantovani, G., …Alexander, C. (2016). Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers. Journal of Controlled Release, 244(B), doi:10.1016/j.jconrel.2016.08.003

Polyesters are extensively used in drug delivery because of their controllable biodegradation properties and perceived favorable cytocompatibility. However, new ester-based materials are continually being sought which can be produced from readily acc... Read More about Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers.

Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion (2016)
Journal Article
Hammad, M., Rao, W., Smith, J. G. W., Anderson, D. G., Langer, R., Young, L. E., …Alexander, M. R. (2016). Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion. Biomaterials Science, 4(9), 1381-1391. https://doi.org/10.1039/c6bm00214e

Improved biomaterials are required for application in regenerative medicine, biosensing, and as medical devices. The response of cells to the chemistry of polymers cultured in media is generally regarded as being dominated by proteins adsorbed to the... Read More about Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion.

Is tapentadol different from classical opioids?: a review of the evidence (2016)
Journal Article
Langford, R. M., Knaggs, R., Farquhar-Smith, P., & Dickenson, A. H. (2016). Is tapentadol different from classical opioids?: a review of the evidence. British Journal of Pain, 10(4), doi:10.1177/2049463716657363

Tapentadol is a single molecule able to deliver analgesia by two distinct mechanisms, a feature which differentiates it from many other analgesics. Pre-clinical data demonstrate two mechanisms of action: mu-opioid receptor agonist activity and noradr... Read More about Is tapentadol different from classical opioids?: a review of the evidence.

New Found Hope for Antibiotic Discovery: Lipid II Inhibitors (2016)
Journal Article
Ng, V., & Chan, W. C. (2016). New Found Hope for Antibiotic Discovery: Lipid II Inhibitors. Chemistry - A European Journal, 22(36), 12606-12616. https://doi.org/10.1002/chem.201601315

Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncoveri... Read More about New Found Hope for Antibiotic Discovery: Lipid II Inhibitors.

Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles (2016)
Journal Article
Taresco, V., Suksiriworapong, J., Creasey, R., Burley, J. C., Mantovani, G., Alexander, C., & Garnett, M. (2016). Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles. Journal of Polymer Science Part A: Polymer Chemistry, 54(20), doi:10.1002/pola.28215

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipa... Read More about Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly (2016)
Journal Article
Adler-Abramovich, L., Marco, P., Arnon, Z. A., Creasey, R. C., Michaels, T. C., Levin, A., …Gazit, E. (2016). Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly. ACS Nano, 10(8), 7436-7442. doi:10.1021/acsnano.6b01587

Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric, and... Read More about Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly.

Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency (2016)
Journal Article
Capel, V., Vllasaliu, D., Watts, P., & Stolnik, S. (2016). Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency. Biochemical and Biophysical Research Communications, 477(2), doi:10.1016/j.bbrc.2016.06.054

Despite research efforts, cell uptake processes determining siRNA silencing efficiency remain unclear. Here, we examine the relationship between in vitro cell culture models, cellular trafficking and siRNA silencing efficiency to provide a mechanisti... Read More about Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency.

Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation (2016)
Journal Article
Roberts, J., Sahoo, J., McNamara, L., Burgess, K., Yang, J., Alakpa, E., …Dalby, M. (2016). Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation. ACS Nano, 10(7), doi:10.1021/acsnano.6b01765

Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Tr... Read More about Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation.