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Four-factor risk score for the prediction of interstitial lung disease in rheumatoid arthritis (2023)
Journal Article
Koduri, G. M., Podlasek, A., Pattapola, S., Zhang, J., Laila, D., Nandagudi, A., …Kelly, C. (2023). Four-factor risk score for the prediction of interstitial lung disease in rheumatoid arthritis. Rheumatology International, 43, 1515–1523. https://doi.org/10.1007/s00296-023-05313-6

Objective: Interstitial lung disease (ILD) is one of the commonest systemic complications in patients with rheumatoid arthritis (RA) and carries a significant morbidity and mortality burden. We aimed to identify key variables to risk-stratify RA pati... Read More about Four-factor risk score for the prediction of interstitial lung disease in rheumatoid arthritis.

World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention (2023)
Journal Article
Grunwald, I. Q., Mathias, K., Bertog, S., Snyder, K. V., Sievert, H., Siddiqui, A., …Hopkins, N. L. (2023). World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention. Advances in Interventional Cardiology / Postępy w Kardiologii Interwencyjnej, 19(1), 6-13. https://doi.org/10.5114/aic.2023.124742

Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most coun... Read More about World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention.

Loss of ancestral function in duckweed roots is accompanied by progressive anatomical reduction and a re-distribution of nutrient transporters (2023)
Journal Article
Ware, A., Jones, D. H., Flis, P., Chrysanthou, E., Smith, K. E., Kümpers, B. M., …Bishopp, A. (2023). Loss of ancestral function in duckweed roots is accompanied by progressive anatomical reduction and a re-distribution of nutrient transporters. Current Biology, 33(9), 1795-1802. https://doi.org/10.1016/j.cub.2023.03.025

Organ loss occurs frequently during plant and animal evolution. Sometimes, non-functional organs are retained through evolution. Vestigial organs are defined as genetically determined structures that have lost their ancestral (or salient) function. D... Read More about Loss of ancestral function in duckweed roots is accompanied by progressive anatomical reduction and a re-distribution of nutrient transporters.

Endoreplication controls cell size via mechanochemical signaling (2023)
Journal Article
Bhosale, R., & Vissenberg, K. (2023). Endoreplication controls cell size via mechanochemical signaling. Trends in Plant Science, 28(6), 611-613. https://doi.org/10.1016/j.tplants.2023.03.016

During hypocotyl development, an asymmetric auxin gradient causes differential cell elongation, leading to tissue bending and apical hook formation. Recently, Ma et al. identified a molecular pathway that links auxin with endoreplication and cell siz... Read More about Endoreplication controls cell size via mechanochemical signaling.

Transcription factor bHLH121 regulates root cortical aerenchyma formation in maize (2023)
Journal Article
Schneider, H. M., Lor, V. S., Zhang, X., Saengwilai, P., Hanlon, M. T., Klein, S. P., …Lynch, J. P. (2023). Transcription factor bHLH121 regulates root cortical aerenchyma formation in maize. Proceedings of the National Academy of Sciences, 120(12), Article e2219668120. https://doi.org/10.1073/pnas.2219668120

Root anatomical phenotypes present a promising yet underexploited avenue to deliver major improvements in yield and climate resilience of crops by improving water and nutrient uptake. For instance, the formation of root cortical aerenchyma (RCA) sign... Read More about Transcription factor bHLH121 regulates root cortical aerenchyma formation in maize.

Chasing the mechanisms of ecologically adaptive salinity tolerance (2023)
Journal Article
Busoms, S., Fischer, S., & Yant, L. (2023). Chasing the mechanisms of ecologically adaptive salinity tolerance. Plant Communications, 4(6), Article 100571. https://doi.org/10.1016/j.xplc.2023.100571

Plants adapted to challenging environments offer fascinating models of evolutionary change. Importantly, they also give information to meet our pressing need to develop resilient, low-input crops. With mounting environmental fluctuation—including tem... Read More about Chasing the mechanisms of ecologically adaptive salinity tolerance.

The influences of stomatal size and density on rice abiotic stress resilience (2023)
Journal Article
Caine, R. S., Harrison, E. L., Sloan, J., Flis, P. M., Fischer, S., Khan, M. S., …Croft, H. (2023). The influences of stomatal size and density on rice abiotic stress resilience. New Phytologist, 237(6), 2180-2195. https://doi.org/10.1111/nph.18704

A warming climate coupled with reductions in water availability and rising salinity are increasingly affecting rice (Oryza sativa) yields. Elevated temperatures combined with vapour pressure deficit (VPD) rises are causing stomatal closure, further r... Read More about The influences of stomatal size and density on rice abiotic stress resilience.

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer (2022)
Journal Article
Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., Metzler, V. M., Persson, J. L., …Mongan, N. P. (2022). The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers, 14(20), Article 5148. https://doi.org/10.3390/cancers14205148

Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing... Read More about The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control (2022)
Journal Article
Baker, M., Williams, A. D., Hooton, S. P., Helliwell, R., King, E., Dodsworth, T., …Stekel, D. J. (2022). Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control. Environment International, 169, Article 107516. https://doi.org/10.1016/j.envint.2022.107516

Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial res... Read More about Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control.

Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat (2022)
Journal Article
Kareem, S. H., Hawkesford, M. J., DeSilva, J., Weerasinghe, M., Wells, D. M., Pound, M. P., …Foulkes, M. J. (2022). Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat. European Journal of Agronomy, 140, Article 126603. https://doi.org/10.1016/j.eja.2022.126603

Root system architecture (RSA) is important in optimizing the use of nitrogen. High-throughput phenotyping techniques may be used to study root system architecture traits under controlled environments. A root phenotyping platform, consisting of germi... Read More about Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat.

Transcriptional network underpinning ploidy-related elevated leaf potassium in neo-tetraploids (2022)
Journal Article
Fischer, S., Flis, P., Zhao, F. J., & Salt, D. E. (2022). Transcriptional network underpinning ploidy-related elevated leaf potassium in neo-tetraploids. Plant Physiology, 190(3), 1715-1730. https://doi.org/10.1093/plphys/kiac360

Whole-genome duplication generates a tetraploid from a diploid. Newly created tetraploids (neo-tetraploids) of Arabidopsis (Arabidopsis thaliana) have elevated leaf potassium (K), compared to their diploid progenitor. Micro-grafting has previously es... Read More about Transcriptional network underpinning ploidy-related elevated leaf potassium in neo-tetraploids.

Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids (2022)
Journal Article
Fischer, S., Flis, P., Zhao, F., & Salt, D. E. (in press). Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids. Plant Physiology, 190(3), 1715-1730. https://doi.org/10.1093/plphys/kiac360

Whole-genome duplication generates a tetraploid from a diploid. Newly created tetraploids (neo-tetraploids) of Arabidopsis (Arabidopsis thaliana) have elevated leaf potassium (K), compared to their diploid progenitor. Micro-grafting has previously es... Read More about Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids.

Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism (2022)
Journal Article
Fusi, R., Rosignoli, S., Lou, H., Sangiorgi, G., Bovina, R., Pattem, J. K., …Salvi, S. (2022). Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism. Proceedings of the National Academy of Sciences,

Root angle in crops represents a key trait for efficient capture of soil resources. Root angle is determined by competing gravitropic versus anti-gravitropic offset (AGO) mechanisms. Here we report a new root angle regulatory gene termed ENHANCED GRA... Read More about Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism.

Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms (2022)
Journal Article
Huang, G., Kilic, A., Karady, M., Zhang, J., Mehra, P., Song, X., …Pandey, B. K. (2022). Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms. Proceedings of the National Academy of Sciences, 119(30), Article e2201072119. https://doi.org/10.1073/pnas.2201072119

Soil compaction represents a major agronomic challenge, inhibiting root elongation and impacting crop yields. Roots use ethylene to sense soil compaction as the restricted air space causes this gaseous signal to accumulate around root tips. Ethylene... Read More about Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms.

An oxygen-sensing mechanism for angiosperm adaptation to altitude (2022)
Journal Article
Abbas, M., Sharma, G., Dambire, C., Marquez, J., Alonso-Blanco, C., Proaño, K., & Holdsworth, M. J. (2022). An oxygen-sensing mechanism for angiosperm adaptation to altitude. Nature, https://doi.org/10.1038/s41586-022-04740-y

Flowering plants (angiosperms) can grow at extreme altitudes, and have been observed growing as high as 6,400 metres above sea level1,2; however, the molecular mechanisms that enable plant adaptation specifically to altitude are unknown. One distingu... Read More about An oxygen-sensing mechanism for angiosperm adaptation to altitude.

A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment (2022)
Journal Article
Tergemina, E., Elfarargi, A. F., Flis, P., Fulgione, A., Göktay, M., Neto, C., …Hancock, A. M. (2022). A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment. Science Advances, 8(20), Article eabm9385. https://doi.org/10.1126/sciadv.abm9385

Most well-characterized cases of adaptation involve single genetic loci. Theory suggests that multilocus adaptive walks should be common, but these are challenging to identify in natural populations. Here, we combine trait mapping with population gen... Read More about A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment.

Root system size and root hair length are key phenes for nitrate acquisition and biomass production across natural variation in Arabidopsis (2022)
Journal Article
De Pessemier, J., Moturu, T. R., Nacry, P., Ebert, R., De Gernier, H., Tillard, P., …Hermans, C. (2022). Root system size and root hair length are key phenes for nitrate acquisition and biomass production across natural variation in Arabidopsis. Journal of Experimental Botany, 73(11), 3569-3583

The role of root phenes in nitrogen (N) acquisition and biomass production was evaluated in 10 contrasting natural accessions of Arabidopsis thaliana L. Seedlings were grown on vertical agar plates with two different nitrate supplies. The low N treat... Read More about Root system size and root hair length are key phenes for nitrate acquisition and biomass production across natural variation in Arabidopsis.

More sustainable vegetable oil: Balancing productivity with carbon storage opportunities (2022)
Journal Article
Alcock, T. D., Salt, D. E., Wilson, P., & Ramsden, S. J. (2022). More sustainable vegetable oil: Balancing productivity with carbon storage opportunities. Science of the Total Environment, 829, Article 154539. https://doi.org/10.1016/j.scitotenv.2022.154539

Intensive cultivation and post-harvest vegetable oil production stages are major sources of greenhouse gas (GHG) emissions. Variation between production systems and reporting disparity have resulted in discordance in previous emissions estimates. The... Read More about More sustainable vegetable oil: Balancing productivity with carbon storage opportunities.

Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat (2022)
Journal Article
GRIFFITHS, M., ATKINSON, J. A., Gardiner, L. J., SWARUP, R., POUND, M. P., WILSON, M. H., …WELLS, D. M. (2022). Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat. Journal of Integrative Agriculture, 21(4), 917-932. https://doi.org/10.1016/s2095-3119%2821%2963700-0

The root system architecture (RSA) of a crop has a profound effect on the uptake of nutrients and consequently the potential yield. However, little is known about the genetic basis of RSA and resource adaptive responses in wheat (Triticum aestivum L.... Read More about Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat.

First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort (2022)
Journal Article
Rubini, E., Snoek, K. M., Schoenmakers, S., Willemsen, S. P., Sinclair, K. D., Rousian, M., & Steegers-Theunissen, R. P. (2022). First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort. Nutrients, 14(6), Article 1129. https://doi.org/10.3390/nu14061129

Homocysteine is a marker for derangements in one-carbon metabolism. Elevated homocysteine may represent a causal link between poor maternal nutrition and impaired embryonic and fetal development. We sought to investigate associations between referenc... Read More about First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort.