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Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus (2003)
Journal Article
Dell, G., Wilkinson, K. W., Tranter, R., Parish, J., Brady, R. L., & Gaston, K. (2003). Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. Journal of Molecular Biology, 334(5), 979-991. doi:10.1016/j.jmb.2003.10.009

Human papillomaviruses (HPVs) that infect the genital tract can be divided into two groups: high-risk HPV types, such as HPV 16 and HPV 18, are associated with cancer, low-risk HPV types, such as HPV 6, are associated with benign warts. In both high-... Read More

Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulva intraepithelial neoplasia (2003)
Journal Article
Davidson, E. J., Sehr, P., Faulkner, R. L., Parish, J. L., Gaston, K., Moore, R. A., …Stern, P. L. (2003). Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulva intraepithelial neoplasia. Journal of General Virology, 84(8), 2089-2097. doi:10.1099/vir.0.19095-0

Human papillomavirus type 16 (HPV-16)-associated vulval intraepithelial neoplasia (VIN) is frequently a chronic, multifocal high-grade condition with an appreciable risk of progression to vulval cancer. The requirement to treat women with VIN has... Read More

The transcriptional repressor protein PRH interacts with the proteasome (2003)
Journal Article
Bess, K. L., Swingler, T. E., Rivett, A. J., Gaston, K., & Jayaraman, P. (2003). The transcriptional repressor protein PRH interacts with the proteasome. Biochemical Journal, 374(3), 667-675. doi:10.1042/BJ20030769

PRH (proline-rich homeodomain protein)/Hex is important in the control of cell proliferation and differentiation. We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomai... Read More

Transcriptional repression in eukaryotes: repressors and repression mechanisms (2003)
Journal Article
Gaston, K., & Jayaraman, P. (2003). Transcriptional repression in eukaryotes: repressors and repression mechanisms. Cellular and Molecular Life Sciences, 60(4), 721-741. doi:10.1007/s00018-003-2260-3

For many, if not most genes, the initiation of transcription is the principle point at which their expression is regulated. Transcription factors, some of which bind to specific DNA sequences, generally either activate or repress promoter activity an... Read More