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High-throughput spheroid screens using volume, resazurin reduction and acid phosphatase activity (2017)
Book Chapter
Ivanov, D. P., Grabowska, A. M., & Garnett, M. C. (in press). High-throughput spheroid screens using volume, resazurin reduction and acid phosphatase activity. In D. F. Gilbert, & O. Friedrich (Eds.), Cell Viability AssaysHumana Press (Springer). doi:10.1007/978-1-4939-6960-9_4

Mainstream adoption of physiologically-relevant three-dimensional models has been slow in the last 50 years due to long, manual protocols with poor reproducibility, high price and closed commercial platforms. This chapter describes high-throughput, l... Read More

Methods for assessing the regenerative responses of neural tissue (2014)
Book Chapter
Poser, S. W., Rueger, M. A., & Androutsellis-Theotokis, A. (2014). Methods for assessing the regenerative responses of neural tissue. In J. Oerlecke, B. Christ, & P. Stock (Eds.), Animal models for stem cell therapySpringer. doi:10.1007/978-1-4939-1453-1_24

In order to establish novel therapeutic paradigms and advance the field of regenerative medicine, methods for their effective implementation as well as rigorous assessment of outcomes are critical. This is especially evident and challenging in the co... Read More

The regulation of human papillomavirus gene expression by the E2 protein: keeping a finger in every pie (2012)
Book Chapter
Graham, S. V., & Gaston, K. L. (2012). The regulation of human papillomavirus gene expression by the E2 protein: keeping a finger in every pie. In K. Gaston (Ed.), Small DNA tumour viruses, 37--53. Caister Academic Press

The human papillomavirus (HPV) genome is around 8000 base pairs in length and it encodes only eight proteins, a limited number of protein isoforms and no known microRNAs. Despite this relative paucity of genes and gene products these viruses are high... Read More

Measuring the induction or inhibition of apoptosis by HPV proteins (2005)
Book Chapter
Kowalczyk, A. M., Roeder, G. E., Green, K., Stephens, D. J., & Gaston, K. (2005). Measuring the induction or inhibition of apoptosis by HPV proteins. In C. Davy, & J. Doorbar (Eds.), Human Papillomaviruses: methods and protocols, 419 -- 432. Humana Press. doi:10.1385/1-59259-982-6:419

Many viral proteins influence the cellular pathways that control cell proliferation and cell death. Some viral proteins trigger apoptotic cell death, and this may be important in host defense and viral spread. In other cases, viral proteins inhibit a... Read More