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Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis (2019)
Journal Article
Grove, J., Aithal, G., Valdes, A., Astbury, S., Atallah, E., & Vijay, A. (2019). Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis. Gut Microbes, https://doi.org/10.1080/19490976.2019.1681861

There is increasing evidence for the role of gut microbial composition in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Non-alcoholic steatohepatitis (NASH) is the most serious form of NAFLD where inflammation causes liver damage tha... Read More

Standards for the development of Enhanced Recovery After Surgery (ERAS) guidelines: Recommendations from the ERAS® Society (2019)
Journal Article
Brindle, M., Nelson, G., Lobo, D., Ljungqvist, O., & Gustafsson, U. O. (in press). Standards for the development of Enhanced Recovery After Surgery (ERAS) guidelines: Recommendations from the ERAS® Society. Annals of Surgery,

Background: ERAS® Society guidelines are holistic, multidisciplinary tools designed to improve outcomes after surgery. The ERAS approach was initially developed for colorectal surgery and has been successfully implemented across a large number of set... Read More

Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers (2019)
Journal Article
Stickel, F., Lutz, P., Buch, S., Nischalke, H. D., Silva, I., Rausch, V., …Morgan, M. Y. (2019). Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers. Hepatology, https://doi.org/10.1002/hep.30996

Background & Aims: Carriage of rs738409:G in patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with an increased risk for developing alcohol-related cirrhosis and hepatocellular carcinoma (HCC). Recently, rs72613567:TA in hydrox... Read More

Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals (2019)
Journal Article
Chowdhury, A. H., Cámara, M., Verma, C., Eremin, O., Kulkarni, A. D., & Lobo, D. N. (2019). Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals. Nutrients, 11(10), https://doi.org/10.3390/nu11102470

The probiotic Bifidus BB536 (BB536), which contains Bifidobacterium longum, has been shown to have enhanced probiotic effects when given together with a standardized extract of cultured Lentinula edodes mycelia (AHCC®, Amino Up Co. Ltd., Sapporo, Jap... Read More

Investigation of colonic motility (2019)
Book Chapter
CORSETTI, M., & GUNN, D. (in press). Investigation of colonic motility. In S. Rao, Y. Lee, & U. Ghosal (Eds.), Clinical and Basic Neurogastroenterology and MotilityElsevier

Investigation of anorectal motility (2019)
Book Chapter
WILKINSON-SMITH, V., Basilisco, G., & CORSETTI, M. (in press). Investigation of anorectal motility. In S. Rao, Y. Lee, & U. Ghoshal (Eds.), Clinical and Basic Neurogastroenterology and MotilityElsevier

Gastrointestinal peptides and small bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease (2019)
Journal Article
Khalaf, A., Hoad, C. L., Menys, A., Nowak, A., Radford, S., Taylor, S. A., …Moran, G. W. (2019). Gastrointestinal peptides and small bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease. American Journal of Clinical Nutrition, https://doi.org/10.1093/ajcn/nqz240

Background Crohn's disease (CD) patients suffer postprandial aversive symptoms, which can lead to anorexia and malnutrition. Changes in the regulation of gut hormones and gut dysmotility are believed to play a role. Objectives This study aimed t... Read More

Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea-are we any closer? Authors' reply (2019)
Journal Article
Gunn, D., Garsed, K., Lam, C., Singh, G., Lingaya, M., Wahl, V., …Spiller, R. (2019). Editorial: understanding differences in patient response to ondansetron in irritable bowel syndrome with diarrhoea-are we any closer? Authors' reply. Alimentary Pharmacology and Therapeutics, 50(7), 826-827. https://doi.org/10.1111/apt.15465

Outcomes following an index emergency admission with cholecystitis: a national cohort study (2019)
Journal Article
Mytton, J., Daliya, P., Singh, P., Parsons, S., Lobo, D., Lilford, R., & Vohra, R. (2019). Outcomes following an index emergency admission with cholecystitis: a national cohort study. Annals of Surgery, https://doi.org/10.1097/SLA.0000000000003599

Objective The objective of this study was to evaluate the differences between patients who undergo cholecystectomy following index admission for cholecystitis, and those that are managed non-operatively. Summary Background Data Index emergency c... Read More

Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P., Adimah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A., Sarmah, P., …Lobo, D. (2019). Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9, https://doi.org/10.1136/bmjopen-2018-028753+

Objectives: To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design: This questionnaire study was designed with the help of patient groups. Dat... Read More

Perioperative probiotics or synbiotics in adults undergoing elective abdominal surgery: A systematic review and meta-analysis of randomized controlled trials (2019)
Journal Article
Chowdhury, A., Adiamah, A., Kushairi, A., Varadhan, K. K., Krznaric, Z., Kulkarni, A. D., …Lobo, D. (2019). Perioperative probiotics or synbiotics in adults undergoing elective abdominal surgery: A systematic review and meta-analysis of randomized controlled trials. Annals of Surgery, doi:10.1097/SLA.0000000000003581

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications foll... Read More

Obesity is the most common risk factor for chronic liver disease: Results from risk stratification pathway using transient elastography (2019)
Journal Article
Harris, R., Card, T. R., Delahooke, T., Aithal, G. P., & Guha, I. N. (2019). Obesity is the most common risk factor for chronic liver disease: Results from risk stratification pathway using transient elastography. American Journal of Gastroenterology, doi:10.14309/ajg.0000000000000357

Introduction Obesity has been associated with liver fibrosis yet guidelines do not emphasise it as an independent risk factor in which to have a high index of suspicion of advanced disease. We aimed to elucidate the effect of a raised body mass inde... Read More

Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia (2019)
Journal Article
Serra-Burriel, M., Graupera, I., Torán, P., Thiele, M., Roulot, D., Wai-Sun Wong, V., …Lammert, F. (2019). Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia. Journal of Hepatology, https://doi.org/10.1016/j.jhep.2019.08.019

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) pose an important challenge to current clinical healthcare pathways due to a large number of at-risk patients. Therefore, we aimed to explore the cost-effec... Read More

Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis (2019)
Journal Article
Sebastian, S., Myers, S., Argyriou, K., Martin, G., Los, L., Fiske, J., …Raine, T. (2019). Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis. Alimentary Pharmacology and Therapeutics, 50(6), 675-683. https://doi.org/10.1111/apt.15456

Background: Accelerated induction regimens of infliximab have been proposed to improve response rates in patients with steroid refractory acute severe colitis. Aims: We aimed to determine differences in outcome for acute severe ulcerative colit... Read More

Practice pattern variability in the management of acute severe colitis: a UK provider survey (2019)
Journal Article
Sebastian, S., Lisle, J., Subramanian, S., Dhar, A., Shenoy, A., Limdi, J., …Kennedy, N. A. (2019). Practice pattern variability in the management of acute severe colitis: a UK provider survey. Frontline Gastroenterology, https://doi.org/10.1136/flgastro-2019-101277

Introduction Lack of comparative trial data on dosing regimens of infliximab in acute severe ulcerative colitis (ASUC) patients failing intravenous (IV) corticosteroids has resulted in variability of rescue regimes in ASUC with potential impact on c... Read More

Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans (2019)
Journal Article
Alyami, J., Whitehouse, E., Yakubov, G. E., Pritchard, S. E., Hoad, C. L., Blackshaw, E., …Marciani, L. (2019). Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans. British Journal of Nutrition, doi:10.1017/S0007114519001880

Whole grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known... Read More