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Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae (2019)
Journal Article
McWilliams, D. F., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae. BMC Rheumatology, 3, 1-9. https://doi.org/10.1186/s41927-019-0100-9

Background RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and pain flares are discrete ent... Read More

Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials (2019)
Journal Article
Davies, G., Rowbotham, N. J., Smith, S., Elliot, Z. C., Gathercole, K., Rayner, O., …Smyth, A. R. (2019). Characterising burden of treatment in cystic fibrosis to identify priority areas for clinical trials. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.10.025

In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the top priority clinical research question was: “What are effective ways of simplifying the treatment burden of people with CF?” We aimed to summarise the lived exp... Read More

What matters to patients? A thematic analysis of patient information and support needs (2019)
Journal Article
Osborn, K., Bradley, J., Knox, E., & Leighton, P. (2019). What matters to patients? A thematic analysis of patient information and support needs. Eye, https://doi.org/10.1038/s41433-019-0644-3

A thematic analysis was done to look at qualitative free text responses to a members survey carried out by the International Glaucoma Association (IGA) in 2017. A further analysis was done on data from calls made to the IGA’s glaucoma helpline during... Read More

Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis (2019)
Journal Article
Grove, J., Aithal, G., Valdes, A., Astbury, S., Atallah, E., & Vijay, A. (2019). Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis. Gut Microbes, https://doi.org/10.1080/19490976.2019.1681861

There is increasing evidence for the role of gut microbial composition in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Non-alcoholic steatohepatitis (NASH) is the most serious form of NAFLD where inflammation causes liver damage tha... Read More

Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane (2019)
Journal Article
Marsit, N. M., Sidney, L. E., Britchford, E. R., McIntosh, O. D., Allen, C. L., Ashraf, W., …Hopkinson, A. (2019). Validation and assessment of an antibiotic-based, aseptic decontamination manufacturing protocol for therapeutic, vacuum-dried human amniotic membrane. Scientific Reports, 9(1), https://doi.org/10.1038/s41598-019-49314-7

Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics (2019)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., & Thomas, K. S. (2019). Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics. BMJ Open, 9(8), e028689

Introduction Diagnosing psoriasis in children can be challenging. Early and accurate diagnosis is important to ensure patients receive psoriasis specific treatment and monitoring. It is recognised that the physical, psychological, quality of life, fi... Read More

Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study: The SOFtened waTER for eczema prevention trial (SOFTER) (2019)
Journal Article
Jabbar-Lopez, Z., Gurung, N., Greenblatt, D., Briley, A., Chalmers, J., Thomas, K., …Flohr, C. (2019). Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study: The SOFtened waTER for eczema prevention trial (SOFTER). BMJ Open, 9(8), doi:10.1136/bmjopen-2018-027168

Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016 (2019)
Journal Article
van Lee, C. B., Kan, W. C., Gran, S., Mooyaart, A., Mureau, M. A., Williams, H., …Hollestein, L. M. (2019). Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016. Acta Dermato-Venereologica, https://doi.org/10.2340/00015555-3287

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (less than 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890... Read More

Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials (2019)
Journal Article
Mousoulis, C., Thomas, K., Leighton, P., Deshmukh, S., Grindlay, D., & Karantana, A. (2019). Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials. Journal of Hand Surgery (European Volume), doi:10.1177/1753193419865897

The aim of this study was to identify and assess all existing randomized studies on treatment interventions for hand fractures and joint injuries, to inform practice and plan future research. PubMed, Cochrane CENTRAL, MEDLINE and Embase were searche... Read More

Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., …Abhishek, A. (2019). Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, 9(8), doi:10.1136/bmjopen-2019-032050

An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study (2019)
Journal Article
Baystson, R., Ashraf, W., Pelegrin, I., Fowkes, K., Bienemann, A. S., Singleton, W. G., & Scott, I. S. (2019). An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study. Journal of Antimicrobial Chemotherapy, doi:10.1093/jac/dkz293

Different strategies for using topical corticosteroids in people with eczema (2019)
Journal Article
Chalmers, J. R., Axon, E., Harvey, J., Santer, M., Ridd, M. J., Lawton, S., …Thomas, K. S. (2019). Different strategies for using topical corticosteroids in people with eczema. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.cd013356

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To establish the effectiveness and safety of different ways of using topical corticosteroids in people with eczema.

Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies (2019)
Journal Article
Swain, S., Sarmanova, A., Coupland, C., Doherty, M., & Zhang, W. (2019). Comorbidities in Osteoarthritis: a systematic review and meta-analysis of observational studies. Arthritis Care and Research, doi:10.1002/acr.24008

Objectives Osteoarthritis (OA) is a common chronic condition in older people but its association with other chronic conditions is largely unknown. This study aimed to systematically review the literature on comorbidities in people with OA compared... Read More

Spatial microsimulation of osteoarthritis prevalence at the small area level in England 1 -Constraint selection for a 2-stage microsimulation process (2019)
Journal Article
Ifesemen, O. S., Bestwick-Stevenson, T., & Edwards, K. L. (in press). Spatial microsimulation of osteoarthritis prevalence at the small area level in England 1 -Constraint selection for a 2-stage microsimulation process. International Journal of Microsimulation,

The presence of identical benchmark/constraint variables in both geographic and survey datasets is a principal requirement for static spatial microsimulation models, particularly in the field of medicine and health sciences. This is also a as key lim... Read More

Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis (2019)
Journal Article
Pearson, R. G., Masud, T., Blackshaw, E., Naylor, A., Hinchcliffe, M., Jeffery, K., …Perkins, A. C. (2019). Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis. Pharmaceutics, 11(6), doi:10.3390/pharmaceutics11060265

Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relati... Read More

Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis (2019)
Journal Article
Goh, S., Persson, M. S., Stocks, J., Hou, Y., Lin, J., Hall, M. C., …Zhang, W. (2019). Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine, 62(5), 356-365. https://doi.org/10.1016/j.rehab.2019.04.006

Background. Exercise is an effective treatment for osteoarthritis. However, the effect may vary from one patient (or study) to another. Objective. To evaluate the efficacy of exercise and its potential determinants for pain, function, performance,... Read More