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Service dogs (2019)
Book Chapter
Harvey, N. (2019). Service dogs. In J. Vonk, & T. K. Shackelford (Eds.), Encyclopedia of Animal Cognition and Behavior

Production and Application of Multicistronic Constructs for Various Human Disease Therapies (2019)
Journal Article
Shaimardanova, A. A., Kitaeva, K. V., Abdrakhmanova, I. I., Chernov, V. M., Rutland, C. S., Rizvanov, A. A., …Solovyeva, V. V. (2019). Production and Application of Multicistronic Constructs for Various Human Disease Therapies. Pharmaceutics, 11, 580. https://doi.org/10.3390/pharmaceutics11110580

The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the exampl... Read More

Label-Free Quantitative Acetylome Analysis Reveals Toxoplasma gondii Genotype-Specific Acetylomic Signatures (2019)
Journal Article
Wang, Z., Hu, R., Zhou, C., He, J., M. Elsheikha, H., & Zhu, X. (2019). Label-Free Quantitative Acetylome Analysis Reveals Toxoplasma gondii Genotype-Specific Acetylomic Signatures. Microorganisms, 7(11), 1-19. https://doi.org/10.3390/microorganisms7110510

Distinct genotypic and pathogenic differences exist between Toxoplasma gondii genotypes. For example, genotype I is highly virulent, whereas genotype II and genotype III are less virulent. Moreover, Chinese 1 genotype (ToxoDB#9) is also virulent. Her... Read More

Animals, Veterinarians, and the Sociology of Diagnosis (2019)
Journal Article
Hobson-West, P., & Jutel, A. (2019). Animals, Veterinarians, and the Sociology of Diagnosis. Sociology of Health and Illness, https://doi.org/10.1111/1467-9566.13017

While sociologists of medicine have focused their efforts on understanding human health, illness, and medicine, veterinary medical practice has not yet caught their attention in any sustained way. In this critical review paper, we use insights from t... Read More

Potential therapeutic application of mesenchymal stem cells in ophthalmology (2019)
Journal Article
Zakirova, E. Y., Valeeva, A., Aimaletdinov, A., Nefedovskaya, L., Akhmetshin, R., Rutland, C., & Rizvanov, A. (2019). Potential therapeutic application of mesenchymal stem cells in ophthalmology. Experimental Eye Research, https://doi.org/10.1016/j.exer.2019.107863

At present a wide variety of methods have been proposed to treat eye disorders, drug therapies are most commonly used. It should be noted that effective treatment modalities especially for degeneration of the retina and optic nerve are lacking. In th... Read More

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells (2019)
Journal Article
Brearley, M. C., Li, C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2019). Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells. Biochemistry and Biophysics Reports, 20, https://doi.org/10.1016/j.bbrep.2019.100694

Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is... Read More

Antigen array for serological diagnosis and novel allergen identification in severe equine asthma (2019)
Journal Article
White, S. J., Moore-Colyer, M., Marti, E., Hannant, D., Gerber, V., Coüetil, L., …Alcocer, M. (2019). Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-51820-7

Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immun... Read More

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases (2019)
Journal Article
Shaimardanova, A. A., Solovyeva, V. V., Chulpanova, D. S., James, V., Kitaeva, K. V., & Rizvanov, A. A. (2020). Extracellular vesicles in the diagnosis and treatment of central nervous system diseases. Neural Regeneration Research, 15(4), 586=596. https://doi.org/10.4103/1673-5374.266908

Extracellular vesicles, exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system (CNS) with all body system... Read More

Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus (2019)
Journal Article
Harvey, N. D., Craigon, P. J., Shaw, S. C., Blott, S. C., & England, G. C. (2019). Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus. Animals, 9(10), https://doi.org/10.3390/ani9100813

Canine atopic dermatitis (cAD) is a common allergic skin condition in dogs that causes chronic pruritus. The overall quality of life in dogs with cAD is known to be reduced, and human patients with pruritic conditions report significant psychological... Read More

Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHΔgM) confers partial protection against infection (2019)
Journal Article
Kydd, J. H., Hannant, D., Robinson, R. S., Bryant, N., & Osterrieder, N. (2019). Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHΔgM) confers partial protection against infection. Vaccine, https://doi.org/10.1016/j.vaccine.2019.09.106

Equid herpesvirus-1 (EHV-1) causes respiratory and neurological disease and late gestation abortion in pregnant mares. Current vaccines contain either inactivated or live EHV-1, but fail to provide complete clinical or virological protection, namely... Read More

Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHΔgM) confers partial protection against infection (2019)
Journal Article
Kydd, J. H., & Hannant, D. (2019). Vaccination of foals with a modified live, equid herpesvirus-1 gM deletion mutant (RacHΔgM) confers partial protection against infection. Vaccine, https://doi.org/10.1016/j.vaccine.2019.09.106

Equid herpesvirus-1 (EHV-1) causes respiratory and neurological disease and late gestation abortion in pregnant mares. Current vaccines contain either inactivated or live EHV-1, but fail to provide complete clinical or virological protection, namely... Read More

Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts (2019)
Journal Article
Zhang, X., Cwiklinski, K., Hu, R., Zheng, W., Sheng, Z., Zhang, F., …Zhu, X. (2019). Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts. BMC Genomics, 20, 1-18. https://doi.org/10.1186/s12864-019-6103-5

Background The tropical liver fluke, Fasciola gigantica causes fasciolosis, an important disease of humans and livestock. We characterized dynamic transcriptional changes associated with the development of the parasite in its two hosts, the snail in... Read More

The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer (2019)
Journal Article
Aljohani, A. I., Toss, M. S., Kurozumi, S., Joseph, C., Aleskandarany, M. A., Miligy, I. M., …Rakha, E. (2019). The prognostic significance of wild type isocitrate dehydrogenase 2 (IDH2) in breast cancer. Breast Cancer Research and Treatment, https://doi.org/10.1007/s10549-019-05459-7

Background: Lymphovascular invasion (LVI) is a prerequisite step in breast cancer (BC) metastasis. We have previously identified wild type isocitrate dehydrogenase 2 (IDH2) as a key putative driver of LVI. Thus, we explored the prognostic significanc... Read More

Reducing antimicrobial use on dairy farms using a herd health approach (2019)
Journal Article
Hyde, R., Tisdall, D., Gordon, P., & Remnant, J. (2019). Reducing antimicrobial use on dairy farms using a herd health approach. In Practice, 41(8), 368-382. https://doi.org/10.1136/inp.l5518

Background: There has been much scrutiny of antimicrobial use in the livestock sector, since the O’Neill report, a 2015 government -commissioned review of antimicrobial resistance, called for the agriculture industry to reduce its use of antimicrobia... Read More

What Makes a Rabbit Cute? Preference for Rabbit Faces Differs according to Skull Morphology and Demographic Factors (2019)
Journal Article
Harvey, N. D., Oxley, J. A., Miguel-Pacheco, G., Gosling, E. M., & Farnworth, M. (2019). What Makes a Rabbit Cute? Preference for Rabbit Faces Differs according to Skull Morphology and Demographic Factors. Animals, 9(10), https://doi.org/10.3390/ani9100728

Domesticated rabbits typically exhibit shorter, flatter skulls than their wild counterparts (brachycephalism). However, brachycephaly is associated with considerable health problems, including problems with dentition. The aim of this study was to est... Read More

Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis (2019)
Journal Article
Zou, Y., Zheng, W., Elsheikha, H. M., Liu, G., Hu, M., Wang, S., & Zhu, X. (2019). Serum metabolomic alterations in Beagle dogs experimentally infected with Toxocara canis. Parasites and Vectors, 12(1), 1-10. https://doi.org/10.1186/s13071-019-3703-5

Background Toxocara canis, a globally distributed roundworm, can cause debilitating disease in dogs and humans; however, little is known about the metabolomic response of the hosts to T. canis infection. There is an increasing need to understand the... Read More

Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity (2019)
Journal Article
Colom, J., Batista, D., Baig, A., Tang, Y., Liu, S., Yuan, F., …Barrow, P. (2019). Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity. Scientific Reports, 9, 1-11. doi:10.1038/s41598-019-48483-9

Antimicrobial resistance (AMR) is now a major global problem largely resulting from the overuse of antibiotics in humans and livestock. In some AMR bacteria, resistance is encoded by conjugative plasmids expressing sex-pili that can readily spread re... Read More

Advances in the Production and Batch Reformatting of Phage Antibody Libraries (2019)
Journal Article
Reader, R. H., Workman, R. G., Maddison, B. C., & Gough, K. C. (2019). Advances in the Production and Batch Reformatting of Phage Antibody Libraries. Molecular Biotechnology, doi:10.1007/s12033-019-00207-0

Phage display antibody libraries have proven an invaluable resource for the isolation of diagnostic and potentially therapeutic antibodies, the latter usually being antibody fragments converted into IgG formats. Recent advances in the production of h... Read More

iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes (2019)
Journal Article
Wang, Z., Zhou, C., Calderón-Mantilla, G., Petsalaki, E., He, J., Song, H., …Zhu, X. (2019). iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes. Frontiers in Cellular and Infection Microbiology, 9, 1-19. doi:10.3389/fcimb.2019.00307

To gain insights into differences in the virulence among T. gondii strains at the post-translational level, we conducted a quantitative analysis of the phosphoproteome profile of T. gondii strains belonging to three different genotypes. Phosphopeptid... Read More