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All Outputs (3)

Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo (2021)
Journal Article
James, V., Nizamudeen, Z. A., Lea, D., Dottorini, T., Holmes, T. L., Johnson, B. B., …Smith, J. G. (2021). Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo. Stem Cells and Development, 30(24), 1215-1227. https://doi.org/10.1089/scd.2021.0202

Hypertrophic cardiomyopathy (HCM) is characterised by increased left ventricular wall thickness that can lead to devastating conditions such as heart failure and sudden cardiac death. Despite extensive study, the mechanisms mediating many of the asso... Read More about Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo.

Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties (2021)
Journal Article
Nizamudeen, Z. A., Xerri, R., Parmenter, C., Suain, K., Markus, R., Chakrabarti, L., & Sottile, V. (2021). Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties. Cells, 10(9), Article 2413. https://doi.org/10.3390/cells10092413

Low-power sonication is widely used to disaggregate extracellular vesicles (EVs) after isolation, however, the effects of sonication on EV samples beyond dispersion are unclear. The present study analysed the characteristics of EVs collected from mes... Read More about Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties.

Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro (2018)
Journal Article
Nizamudeen, Z. A., Chakrabarti, L., & Sottile, V. (2018). Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro. Stem Cell Research, 28, 75-86. https://doi.org/10.1016/j.scr.2018.02.001

Fasudil is a clinically approved Rho-associated protein kinase (ROCK) inhibitor that has been used widely to treat cerebral consequences of subarachnoid haemorrhage. It is known to have a positive effect on animal models of neurological disorders inc... Read More about Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro.