Skip to main content

Research Repository

Advanced Search

All Outputs (558)

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study (2016)
Journal Article
Mackenzie, I. S., Ford, I., Walker, A., Hawkey, C., Begg, A., Avery, A., …MacDonald, T. M. (2016). Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study. BMJ Open, 6(9), Article e013774. https://doi.org/10.1136/bmjopen-2016-013774

Introduction Ischaemic heart disease (IHD) is one of the most common causes of death in the UK and treatment of patients with IHD costs the National Health System (NHS) billions of pounds each year. Allopurinol is a xanthine oxidase inhibitor use... Read More about Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study.

Characterising the nature of primary care patient safety incident reports in the England and Wales National Reporting and Learning System: a mixed-methods agenda-setting study for general practice (2016)
Journal Article
Carson-Stevens, A., Hibbert, P., Williams, H., Prosser Evans, H., Cooper, A., Rees, P., …Edwards, A. (2016). Characterising the nature of primary care patient safety incident reports in the England and Wales National Reporting and Learning System: a mixed-methods agenda-setting study for general practice. Health Services and Delivery Research, 4(27), 1-76. https://doi.org/10.3310/hsdr04270

Background There is an emerging interest in the inadvertent harm caused to patients by the provision of primary health-care services. To date (up to 2015), there has been limited research interest and few policy directives focused on patient saf... Read More about Characterising the nature of primary care patient safety incident reports in the England and Wales National Reporting and Learning System: a mixed-methods agenda-setting study for general practice.

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF (2016)
Journal Article
Massey, A., Campbell, B. K., Raine-Fenning, N., Pincott-Allen, C., Perry, J., & Vedhara, K. (2016). Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF. Psychoneuroendocrinology, 74, https://doi.org/10.1016/j.psyneuen.2016.08.027

Evidence for an association between cortisol and clinical pregnancy in women undergoing In Vitro Fertilisation (IVF) is mixed with previous studies relying exclusively on short term measures of cortisol in blood, saliva, urine, and/or follicular flui... Read More about Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF.

Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study (2016)
Journal Article
Stewart, J., Benford, P., Wynn, P., Watson, M. C., Coupland, C., Deave, T., …Kendrick, D. (2016). Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study. Burns, 42(8), 1831-1843. https://doi.org/10.1016/j.burns.2016.06.027

Objective: To determine the relationship between a range of modifiable risk factors and medically attended scalds in children under the age of 5 years. Methods: Multicentre matched case-control study in acute hospitals, minor injury units and GP pr... Read More about Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study.

Real-world uptake of a tailored, text message pregnancy smoking cessation programme (MiQuit) when offered online (2016)
Conference Proceeding
Emery, J., Coleman, T., Sutton, S., Cooper, S., Leonardi-Bee, J., Jones, M., & Naughton, F. (2016). Real-world uptake of a tailored, text message pregnancy smoking cessation programme (MiQuit) when offered online.

Background: Prenatal smoking is a major public health concern and uptake of NHS cessation support is low in this group. Text message-based self-help is a promising intervention for this population but little is known about its likely real-world uptak... Read More about Real-world uptake of a tailored, text message pregnancy smoking cessation programme (MiQuit) when offered online.

Multicentre, randomised controlled trial of a low-cost smoking cessation text message intervention for pregnant smokers (MiQuit) (2016)
Conference Proceeding
Naughton, F., Foster, K., Emery, J., Cooper, S., Sutton, S., Leonardi-Bee, J., …Coleman, T. (2016). Multicentre, randomised controlled trial of a low-cost smoking cessation text message intervention for pregnant smokers (MiQuit).

Background: Text message cessation programmes have potential to change smoking behaviour during pregnancy but their effectiveness is unknown. This study aimed to estimate key parameters, including effectiveness and cost-effectiveness, for delivering... Read More about Multicentre, randomised controlled trial of a low-cost smoking cessation text message intervention for pregnant smokers (MiQuit).

Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study (2016)
Journal Article
Tyrrell, E. G., Orton, E., Sayal, K., Baker, R., & Kendrick, D. (2017). Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study. Journal of Public Health, 39(2), Article e1-e9. https://doi.org/10.1093/pubmed/fdw075

Background Accurate and up to date data on changes in poisoning incidence among young people are lacking. Recent linkage of UK primary care, hospital and mortality data allows these to be quantified to inform service delivery. Methods An open coh... Read More about Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study.

A decision analytic model to investigate the cost-effectiveness of poisoning prevention practices in households with young children (2016)
Journal Article
Achana, F., Sutton, A. J., Kendrick, D., Hayes, M., Jones, D. R., Hubbard, S. J., & Cooper, N. J. (2016). A decision analytic model to investigate the cost-effectiveness of poisoning prevention practices in households with young children. BMC Public Health, 16, Article 705. https://doi.org/10.1186/s12889-016-3334-0

Background: Systematic reviews and a network meta-analysis show home safety education with or without the provision of safety equipment is effective in promoting poison prevention behaviours in households with children. This paper compares the cost-e... Read More about A decision analytic model to investigate the cost-effectiveness of poisoning prevention practices in households with young children.

Anxiety associated with diagnostic uncertainties in early pregnancy. (2016)
Journal Article
Richardson, A., Raine-Fenning, N., Deb, S., Campbell, B., & Vedhara, K. (in press). Anxiety associated with diagnostic uncertainties in early pregnancy. Ultrasound in Obstetrics and Gynaecology, https://doi.org/10.1002/uog.17214

Objectives: To determine anxiety levels of women presenting to Early Pregnancy Assessment Units (EPAU) with abdominal pain and/or vaginal bleeding and assess how these change over time and according to ultrasonographic diagnosis. Methods: We under... Read More about Anxiety associated with diagnostic uncertainties in early pregnancy..

Smoking in pregnancy: who makes quit attempts whilst pregnant and what types of cessation support do they prefer? (2016)
Conference Proceeding
Brotherton, E., Orton, S., & Coleman, T. (2016). Smoking in pregnancy: who makes quit attempts whilst pregnant and what types of cessation support do they prefer?.

Background Smoking in pregnancy is strongly associated with adverse pregnancy and birth outcomes. In England, 26% of women smoke at some point during pregnancy, and 12% smoke throughout. Reducing smoking during pregnancy is therefore an NHS priority... Read More about Smoking in pregnancy: who makes quit attempts whilst pregnant and what types of cessation support do they prefer?.

Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care (2016)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2016). Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care. BMJ, 354(i3477), https://doi.org/10.1136/bmj.i3477

Objective: To assess associations between risks of cardiovascular disease, heart failure, and all cause mortality and different diabetes drugs in people with type 2 diabetes, particularly newer agents, including gliptins and thiazolidinediones (glita... Read More about Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care.

Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses (2016)
Journal Article
Davies, E. A., Coupland, V. H., Dixon, S., Mokbel, K., & Jack, R. H. (2016). Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses. BMC Cancer, 16(1), https://doi.org/10.1186/s12885-016-2439-2

© 2016 The Author(s). Background: Data from providers of private cancer care are not yet formally included in English cancer registration data. This study aimed to test the exchange of breast cancer data from one Hospital Corporation of America Inter... Read More about Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses.

The association between treatment adherence to nicotine patches and smoking cessation in pregnancy (2016)
Conference Proceeding
Vaz, L. R., Aveyard, P., Cooper, S., Leonardi-Bee, J., & Coleman, T. (2016). The association between treatment adherence to nicotine patches and smoking cessation in pregnancy.

Background: In non-pregnant “quitters,” adherence to nicotine replacement therapy (NRT) increases smoking cessation. We investigated relationships between adherence to placebo or NRT patches and cessation in pregnancy, including an assessment of reve... Read More about The association between treatment adherence to nicotine patches and smoking cessation in pregnancy.

Reducing falls among older people in general practice: the ProAct65+ exercise intervention trial (2016)
Journal Article
Gawler, S., Skelton, D. A., Dinan-Young, S., Masud, T., Morris, R. W., Griffin, M., …Iliffe, S. (2016). Reducing falls among older people in general practice: the ProAct65+ exercise intervention trial. Archives of Gerontology and Geriatrics, 67, https://doi.org/10.1016/j.archger.2016.06.019

Background: Falls are common in the older UK population and associated costs to the NHS are high. Systematic reviews suggest that home exercise and group-based exercise interventions, which focus on progressively challenging balance and increasing st... Read More about Reducing falls among older people in general practice: the ProAct65+ exercise intervention trial.

Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database (2016)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (in press). Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. BMJ, 353, Article i3305. https://doi.org/10.1136/bmj.i3305

Objectives: To estimate rates of discontinuation and restarting of statins, and to identify patient characteristics associated with either discontinuation or restarting. Design: Prospective open cohort study. Setting: 664 general practices con... Read More about Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database.

“I was a full time proper smoker”: A qualitative exploration of smoking in the home after childbirth among women who relapse postpartum (2016)
Journal Article
Orton, S., Coleman, T., Lewis, S., Cooper, S., & Jones, L. L. (2016). “I was a full time proper smoker”: A qualitative exploration of smoking in the home after childbirth among women who relapse postpartum. PLoS ONE, 11(6), e0157525. https://doi.org/10.1371/journal.pone.0157525

Background: Many women stop smoking during pregnancy but relapse shortly afterwards, potentially putting their infants at risk of secondhand smoke (SHS) exposure. Women who were able to stop during pregnancy may be a motivated group, receptive to m... Read More about “I was a full time proper smoker”: A qualitative exploration of smoking in the home after childbirth among women who relapse postpartum.

Building a patient safety toolkit for use in general practice (2016)
Journal Article
Bell, B., Spencer, R., Marsden, K., Perryman, K., Cambeth, S., & Avery, A. (in press). Building a patient safety toolkit for use in general practice. InnovAiT, https://doi.org/10.1177/1755738016650468

Despite 340?000?000 primary care consultations annually in the UK, most of the literature on patient safety has focused on hospital-based services. To improve safety in primary care settings, we must know what methods, tools and indicators are availa... Read More about Building a patient safety toolkit for use in general practice.

Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England (2016)
Journal Article
Baker, R., Tata, L. J., Kendrick, D., Burch, T., Kennedy, M., & Orton, E. (2016). Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England. Burns, 42(7), 1609-1616. https://doi.org/10.1016/j.burns.2016.05.007

Objective: To describe patterns in thermal injury incidence and hospitalisations by age, sex, calendar year and socioeconomic status among 0-4 year olds in England for the period 1998-2013. Participants: 708,050 children with linked primary care a... Read More about Differing patterns in thermal injury incidence and hospitalisations among 0–4 year old children from England.

Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data (2016)
Journal Article
Baker, R., Orton, E., Tata, L. J., & Kendrick, D. (2016). Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data. European Journal of Public Health, 26(6), 940-946. https://doi.org/10.1093/eurpub/ckw064

Background: Understanding patterns of injury in England is challenging due to a lack of national injury surveillance data. Through recent linkage of a large primary care research database to hospitalization and mortality data, we describe the epide... Read More about Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data.