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What influences healthcare professionals' treatment preferences for older women with operable breast cancer?: an application of the discrete choice experiment (2017)
Journal Article
Morgan, J., Walters, S., Collins, K., Robinson, T., Cheung, K., Audisio, R., …Wyld, L. (2017). What influences healthcare professionals' treatment preferences for older women with operable breast cancer?: an application of the discrete choice experiment. EJSO - European Journal of Surgical Oncology, 43(7), https://doi.org/10.1016/j.ejso.2017.01.012

Introduction Primary endocrine therapy (PET) is used variably in the UK as an alternative to surgery for older women with operable breast cancer. Guidelines state that only patients with “significant comorbidity” or “reduced life expectancy” shoul... Read More about What influences healthcare professionals' treatment preferences for older women with operable breast cancer?: an application of the discrete choice experiment.

Investigating the effect of independent blinded digital image assessment on the STOP GAP trial (2017)
Journal Article
Patsko, E., Godolphin, P. J., Thomas, K. S., Hepburn, T., Mitchell, E., Craig, F. E., …Montgomery, A. A. (2017). Investigating the effect of independent blinded digital image assessment on the STOP GAP trial. Trials, 18(1), Article 53. https://doi.org/10.1186/s13063-017-1779-9

Background Blinding is the process of keeping treatment assignment hidden and is used to minimise the possibility of bias. Trials at high risk of bias have been shown to report larger treatment effects than low risk studies. In dermatology, one popu... Read More about Investigating the effect of independent blinded digital image assessment on the STOP GAP trial.

Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study (2017)
Journal Article
Oakley, B., Nightingale, J., Moran, C. G., & Moppett, I. K. (2017). Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study. BMJ Open, 7(2), https://doi.org/10.1136/bmjopen-2016-014190

Objectives: To determine if the introduction of the best practice tariff (BPT) has improved survival of the elderly hip fracture population, or if achieving BPT results in improved survival for an individual. Setting: A single university-affiliated... Read More about Does achieving the best practice tariff improve outcomes in hip fracture patients? An observational cohort study.

Suffering with dementia: the other side of "living well" (2017)
Journal Article
Bartlett, R., Windemuth-Wolfson, L., Oliver, K., & Dening, T. (2017). Suffering with dementia: the other side of "living well". International Psychogeriatrics, 29(2), https://doi.org/10.1017/S104161021600199X

In this editorial, we challenge the current understanding of “Living Well with Dementia.” Such discourse introduces the possibility of not living well with the condition or even of “living badly with dementia.” Numerous words might be relevant here –... Read More about Suffering with dementia: the other side of "living well".

A survey of eMedia-delivered interventions for schizophrenia used in randomized controlled trials (2017)
Journal Article
Naeem, F., Munschi, T., Xiang, S., Yang, M., Shokraneh, F., Syed, Y., …Farooq, S. (2017). A survey of eMedia-delivered interventions for schizophrenia used in randomized controlled trials. Neuropsychiatric Disease and Treatment, 13, 233-243. https://doi.org/10.2147/NDT.S115897

Background: Randomized trials evaluating electronic Media (eMedia) delivery of interventions are increasingly frequent in mental health. Although a number of reviews have reported efficacy of these interventions, none has reviewed the type of eMedia... Read More about A survey of eMedia-delivered interventions for schizophrenia used in randomized controlled trials.

Twittering on about mental health: is it worth the effort? (2017)
Journal Article
Jayaram, M., Moran, L., & Adams, C. (2017). Twittering on about mental health: is it worth the effort?. Evidence-Based Mental Health, 20(1), https://doi.org/10.1136/eb-2016-102580

The medical community disseminates information increasingly using social media. Randomised controlled trials are being conducted in this area to evaluate effectiveness of social media with mixed results so far, but more trials are likely to be publis... Read More about Twittering on about mental health: is it worth the effort?.

Video gaming and gaming addiction in transgender people: an exploratory study (2017)
Journal Article
Arcelus, J., Bouman, W. P., Richards, C., Jimenez-Murcia, S., & Griffiths, M. (in press). Video gaming and gaming addiction in transgender people: an exploratory study. Journal of Behavioral Addictions, https://doi.org/10.1556/2006.6.2017.002

Background: There is anecdotal clinical evidence that transgender people use the online world – such as forums and online video gaming – for the purpose of experiencing their gender identity in a safe, non-threatening, non alienating, nonstigmatizing... Read More about Video gaming and gaming addiction in transgender people: an exploratory study.

Early engagement in physical activity and exercise is key in managing cancer cachexia (2017)
Journal Article
Bayly, J., Wilcock, A., Higginson, I. J., & Maddocks, M. (2017). Early engagement in physical activity and exercise is key in managing cancer cachexia. Oncology, 31(1),

Despite consensus on the diagnosis and staging of cancer anorexia/cachexia syndrome, there is currently no accepted standard of care, and affected patients remain widely undertreated. There is general agreement that, because of the complex pathophysi... Read More about Early engagement in physical activity and exercise is key in managing cancer cachexia.

Fibrin glue for pilonidal sinus disease (2017)
Journal Article
Lund, J. N., Tou, S., Doleman, B., & Williams, J. P. (in press). Fibrin glue for pilonidal sinus disease. Cochrane Database of Systematic Reviews, 2017(1), Article CD011923. https://doi.org/10.1002/14651858.CD011923.pub2

Background Pilonidal sinus disease is a common condition that mainly affects young adults. This condition can cause significant pain and impairment of normal activities. No consensus currently exists on the optimum treatment for pilonidal sinus and... Read More about Fibrin glue for pilonidal sinus disease.

Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA (2017)
Journal Article
Nwosu, L. N., Allen, M., Wyatt, L., Huebner, J., Chapman, V., Walsh, D. A., & Kraus, V. (2017). Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. Osteoarthritis and Cartilage, 25(6), https://doi.org/10.1016/j.joca.2017.01.002

Objectives: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). Methods: Sera and... Read More about Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment (2017)
Journal Article
Boehm-Sturm, P., Füchtemeier, M., Foddis, M., Mueller, S., Trueman, R. C., Zille, M., …Farr, T. D. (in press). Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment. Stroke, 48(1), https://doi.org/10.1161/STROKEAHA.116.014394

Background and Purpose�Chronic hypoperfusion in the mouse brain has been suggested to mimic aspects of vascular cognitive impairment, such as white matter damage. Although this model has attracted attention, our group has struggled to generate a reli... Read More about Neuroimaging biomarkers predict brain structural connectivity change in a mouse model of vascular cognitive impairment.

The competencies of registered nurses working in care homes: a modified Delphi study (2017)
Journal Article
Stanyon, M., Goldberg, S. E., Astle, A., Griffiths, A., & Gordon, A. L. (2017). The competencies of registered nurses working in care homes: a modified Delphi study. Age and Ageing, 46(4), 582–588. https://doi.org/10.1093/ageing/afw244

BACKGROUND: Registered Nurses (RNs) working in UK care homes receive most of their training in acute hospitals. At present the role of care home nursing is underdeveloped and it is seen as a low status career. We describe here research to define cor... Read More about The competencies of registered nurses working in care homes: a modified Delphi study.

Neonatal head and torso vibration exposure during inter-hospital transfer (2017)
Journal Article
Blaxter, L., Yeo, M., McNally, D., Crowe, J., Henry, C., Hill, S., …Sharkey, D. (2017). Neonatal head and torso vibration exposure during inter-hospital transfer. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 231(2), 99-113. https://doi.org/10.1177/0954411916680235

© Institution of Mechanical Engineers. Inter-hospital transport of premature infants is increasingly common, given the centralisation of neonatal intensive care. However, it is known to be associated with anomalously increased morbidity, most notably... Read More about Neonatal head and torso vibration exposure during inter-hospital transfer.

Preferences of informal carers on technology packages to support meal production by people living with dementia, elicited from personalised AT and ICT product brochures (2017)
Journal Article
De Filippis, M. L., Craven, M. P., & Dening, T. (2017). Preferences of informal carers on technology packages to support meal production by people living with dementia, elicited from personalised AT and ICT product brochures. Informatics, 4(1), https://doi.org/10.3390/informatics4010001

Assistive technology (AT) can help support the continued independence of people living with dementia, supported by informal carers. Opinions and preferences of informal carers towards a range of assistive and digital information and communication tec... Read More about Preferences of informal carers on technology packages to support meal production by people living with dementia, elicited from personalised AT and ICT product brochures.

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway (2017)
Journal Article
Ugun-Klusek, A., Tatham, M. H., Elkharaz, J., Constantin-Teodosiu, D., Lawler, K., Mohamed, H., …Bedford, L. (2017). Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death and Disease, 8(1), e2531-e2531. https://doi.org/10.1038/cddis.2016.443

The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS an... Read More about Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.

Pharmacology of modulators of alternative splicing (2017)
Journal Article
Bates, D. O., Morris, J. C., Oltean, S., & Donaldson, L. F. (2017). Pharmacology of modulators of alternative splicing. Pharmacological Reviews, 69(1), https://doi.org/10.1124/pr.115.011239

More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the oppor... Read More about Pharmacology of modulators of alternative splicing.

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease (2016)
Journal Article
Thomas, K. S., Batchelor, J. M., Bath-Hextall, F., Chalmers, J., Clarke, T., Crowe, S., …Williams, H. C. (2016). A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease. Programme Grants for Applied Research, 4(18), https://doi.org/10.3310/pgfar04180

Background Skin diseases are very common and can have a large impact on the quality of life of patients and caregivers. This programme addressed four diseases: (1) eczema, (2) vitiligo, (3) squamous cell skin cancer (SCC) and (4) pyoderma gangreno... Read More about A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease.