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MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury (2019)
Journal Article
Lawrence, T. P., Steel, A., Ezra, M., Speirs, M., Pretorius, P. M., Douaud, G., …Voets, N. L. (2019). MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury. Brain Injury, 33(7), 854-868. https://doi.org/10.1080/02699052.2019.1584332

The posterior cingulate cortex (PCC) and corpus callosum (CC) are susceptible to trauma, but injury often evades detection. PCC Metabolic disruption may predict CC white matter tract injury and the secondary cascade responsible for progression. While... Read More about MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury.

The genetic vulnerability to cisplatin ototoxicity: a systematic review (2019)
Journal Article
Edvall, N. K., Cederroth, C. R., Tserga, E., Nandwani, T., Edvall, N. K., Bulla, J., …Baguley, D. M. (2019). The genetic vulnerability to cisplatin ototoxicity: a systematic review. Scientific Reports, 9, Article 3455. https://doi.org/10.1038/s41598-019-40138-z

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of g... Read More about The genetic vulnerability to cisplatin ototoxicity: a systematic review.

High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging (2019)
Journal Article
van der Plas, M. C., Teeuwisse, W. M., Schmid, S., Chappell, M., & van Osch, M. J. (2019). High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging. Magnetic Resonance in Medicine, 81(6), 3734-3744. https://doi.org/10.1002/mrm.27692

Purpose The goal of this study was to achieve high temporal resolution, multi?time point pseudo?continuous arterial spin labeling (pCASL) MRI in a time?efficient manner, while maintaining whole?brain coverage. Methods A Hadamard 8?matrix was use... Read More about High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging.

Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ) (2019)
Journal Article
Genitsaridi, E., Partyka, M., Gallus, S., Lopez-Escamez, J. A., Schecklmann, M., Mielczarek, M., …Hall, D. A. (2019). Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ). Hearing Research, 377, 353-359. https://doi.org/10.1016/j.heares.2019.02.017

Background The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced... Read More about Standardised profiling for tinnitus research: the European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement (2019)
Journal Article
Faas, H. M., Krupa, J. L., Taylor, A. J., Zamberlan, F., Philp, C. J., Williams, H. E., …Meersmann, T. (2019). Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement. Contrast Media and Molecular Imaging, 2019, 1-13. https://doi.org/10.1155/2019/4826520

Paramagnetic gadolinium ions (Gd III), complexed within DOTA-based chelates, have become useful tools to increase the magnetic resonance imaging (MRI) contrast in tissues of interest. Recently, " on/off " probes serving as 19 F·MRI biosensor for targ... Read More about Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement.

Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation (2019)
Journal Article
Xing, Y., Tench, C., Wongwandee, M., Schwarz, S., Bajaj, N., & Auer, D. (2020). Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation. Brain Imaging and Behavior, 14(4), 1263–1280. https://doi.org/10.1007/s11682-019-00061-3

Objective To investigate factors affecting the pattern of motor brain activation reported in people with Parkinson’s (PwP), aiming to differentiate disease-specific features from treatment effects. Methods A co-ordinate-based-meta-analysis (CBMA... Read More about Coordinate based meta-analysis of motor functional imaging in Parkinson's: disease-specific patterns and modulation by dopamine replacement and deep brain stimulation.

Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model (2019)
Journal Article
Morales, M. L. O., Marsit, N. M., McIntosh, O. D., Hopkinson, A., & Sidney, L. E. (2019). Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model. World Journal of Stem Cells, 11(2), 84-99. https://doi.org/10.4252/wjsc.v11.i2.84

BACKGROUND An in vitro injury model mimicking a corneal surface injury was optimised using human corneal epithelial cells (hCEC). AIM To investigate whether corneal-stroma derived stem cells (CSSC) seeded on an amniotic membrane (AM) construct m... Read More about Anti-inflammatory potential of human corneal stroma-derived stem cells determined by a novel in vitro corneal epithelial injury model.

Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics (2019)
Journal Article
Demirtas, M., Burt, J. B., Helmer, M., Ji, J. L., Adkinson, B. D., Glasser, M. F., …Murray, J. D. (2019). Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics. Neuron, 101(6), 1181-1194.e13. https://doi.org/10.1016/j.neuron.2019.01.017

The large-scale organization of dynamical neural activity across cortex emerges through long-range interactions among local circuits. We hypothesized that large-scale dynamics are also shaped by heterogeneity of intrinsic local properties across cort... Read More about Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics.

Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international randomised, open-label, blinded-endpoint phase 3 trial (2019)
Journal Article
Anderson, C. S., Huang, Y., Lindley, R. I., Chen, X., Arima, H., Chen, G., …ENCHANTED Investigators and Coordinators. (2019). Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international randomised, open-label, blinded-endpoint phase 3 trial. Lancet, 393(10174), 877-888. https://doi.org/10.1016/S0140-6736%2819%2930038-8

Effective chair training methods for neuroscience research involving rhesus macaques (Macaca mulatta) (2019)
Journal Article
Mason, S., Premereur, E., Pelekanos, V., Emberton, A., Honess, P., & Mitchell, A. S. (2019). Effective chair training methods for neuroscience research involving rhesus macaques (Macaca mulatta). Journal of Neuroscience Methods, 317, 82-93. https://doi.org/10.1016/j.jneumeth.2019.02.001

© 2019 The Authors Background: Neuroscience research using macaques remains fundamental in our endeavours to understand how the human brain functions. Applying the refinement principle of the 3Rs is essential to optimise the monkeys’ welfare and stil... Read More about Effective chair training methods for neuroscience research involving rhesus macaques (Macaca mulatta).

Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice (2019)
Journal Article
Song, D., Ueda, Y., Bhuyan, R., Mohammed, I., Miwa, T., Gullipali, D., …Song, W. (2019). Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice. American Journal of Pathology, 189(4), 826-838. https://doi.org/10.1016/j.ajpath.2019.01.009

© 2019 American Society for Investigative Pathology Single-nucleotide polymorphisms and rare mutations in factor H (FH; official name, CFH) are associated with age-related macular degeneration and atypical hemolytic uremic syndrome, a form of thromb... Read More about Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice.

Discrimination of Gain Increments in Speech (2019)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. M. (2019). Discrimination of Gain Increments in Speech. Trends in Hearing, 23, 233121651988668. https://doi.org/10.1177/2331216519886684

© The Author(s) 2019. During a hearing-aid fitting, the gain applied across frequencies is often adjusted from an initial prescription in order to meet individual needs and preferences. These gain adjustments in one or more frequency bands are common... Read More about Discrimination of Gain Increments in Speech.

Short email with attachment versus long email without attachment when contacting authors to request unpublished data for a systematic review: a nested randomised trial (2019)
Journal Article
Godolphin, P. J., Bath, P. M., & Montgomery, A. A. (2019). Short email with attachment versus long email without attachment when contacting authors to request unpublished data for a systematic review: a nested randomised trial. BMJ Open, 9(1), Article e25273. https://doi.org/10.1136/bmjopen-2018-025273

Objective: Systematic reviews often rely on the acquisition of unpublished analyses or data. We carried out a nested randomised trial comparing two different approaches for contacting authors to request additional data for a systematic review. Part... Read More about Short email with attachment versus long email without attachment when contacting authors to request unpublished data for a systematic review: a nested randomised trial.

Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage (2019)
Journal Article
Pszczolkowski, S., Law, Z. K., Gallagher, R. G., Meng, D., Swienton, D. J., Morgan, P. S., …Dineen, R. A. (2019). Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage. Computers in Biology and Medicine, 106, 126-139. https://doi.org/10.1016/j.compbiomed.2019.01.022

Background Spontaneous intracerebral haemorrhage (SICH) is a common condition with high morbidity and mortality. Segmentation of haematoma and perihaematoma oedema on medical images provides quantitative outcome measures for clinical trials and may... Read More about Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage.

Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging (2019)
Journal Article
Ray, K. J., Simard, M. A., Larkin, J. R., Coates, J., Kinchesh, P., Smart, S. C., …Sibson, N. R. (2019). Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging. Cancer Research, 79(7), 1343-1352. https://doi.org/10.1158/0008-5472.can-18-2168

Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to noninvasively measure tumor pH, yet multiple facto... Read More about Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging.

Observation of angular dependence of T1 in the human white matter at 3T (2019)
Journal Article
Knight, M., Damion, R., & Kauppinen, R. (2019). Observation of angular dependence of T1 in the human white matter at 3T. Biomedical Spectroscopy and Imaging, 7(3-4), 125-133. https://doi.org/10.3233/bsi-180183

Background and Objective: Multiple factors including chemical composition and microstructure influence relaxivity of tissue water in vivo. We have quantified T1 in the human white mater (WM) together with diffusion tensor imaging to study a possible... Read More about Observation of angular dependence of T1 in the human white matter at 3T.

Mobile applications for management of tinnitus: users' survey, quality assessment and content analysis (2019)
Journal Article
Sereda, M., Smith, S., Newton, K., & Stockdale, D. (2019). Mobile applications for management of tinnitus: users' survey, quality assessment and content analysis. Journal of International Medical Research, 7(1), Article e10353. https://doi.org/10.2196/10353

Background: Tinnitus is the perception of a sound without any outside source. It affects 6 million people in the UK. Sound therapy is a core component of many tinnitus management programmes. Potential mechanisms of benefit include making tinnitus le... Read More about Mobile applications for management of tinnitus: users' survey, quality assessment and content analysis.

A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells (2019)
Journal Article
Aladdad, A. M., Amer, M. H., Sidney, L., Hopkinson, A., White, L. J., Alexander, C., & Rose, F. R. (2019). A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells. Acta Biomaterialia, 95, 427-438. https://doi.org/10.1016/j.actbio.2019.01.037

A three-dimensional thermoresponsive fibrous scaffold system for the subsequent extended culture and enzyme-free passaging of a range of mammalian cell types is presented. Poly(PEGMA188) was incorporated with poly(ethylene terephthalate) (PET) via bl... Read More about A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells.