Skip to main content

Research Repository

Advanced Search

All Outputs (1122)

The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm (2019)
Journal Article
Fletcher-Smith, J. C., Pandyan, A. D., Fletcher-Smith, J. C., Walker, D. M., Allatt, K., Sprigg, N., …Pandyan, A. D. (2019). The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm. Clinical Rehabilitation, 33(12), 1919-1930. https://doi.org/10.1177/0269215519868834

© The Author(s) 2019. Objective: To establish feasibility of initiating electrical stimulation treatment of wrist extensors and flexors in patients early after stroke to prevent muscle contractures and pain. Design: Feasibility randomized controlled... Read More about The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm.

Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936 (2019)
Journal Article
Okely, J. A., Akeroyd, M. A., Allerhand, M., Starr, J. M., & Deary, I. J. (2019). Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936. Psychology and Aging, 34(6), 766-779. https://doi.org/10.1037/pag0000385

Hearing impairment is associated with poorer cognitive function in later life. We tested for the potential contribution of childhood cognitive ability to this relationship. Childhood cognitive ability is strongly related to cognitive function in olde... Read More about Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936.

Why Is There No Cure for Tinnitus? (2019)
Journal Article
McFerran, D. J., Stockdale, D., Holme, R., Large, C. H., & Baguley, D. M. (2019). Why Is There No Cure for Tinnitus?. Frontiers in Neuroscience, 13, https://doi.org/10.3389/fnins.2019.00802

Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended... Read More about Why Is There No Cure for Tinnitus?.

High oxygen fraction during airway opening is key to effective airway rescue in obese subjects (2019)
Conference Proceeding
Laviola, M., Christian, N., Alahmadi, H., Das, A., Bates, D. G., & Hardman, J. G. (2019). High oxygen fraction during airway opening is key to effective airway rescue in obese subjects. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2357-2360). https://doi.org/10.1109/EMBC.2019.8857109

Apnea is common after induction of anesthesia and may produce dangerous hypoxemia, particularly in obese subjects. Optimal management of airway emergencies in obese, apneic subjects is complex and controversial, and clinical studies of rescue strateg... Read More about High oxygen fraction during airway opening is key to effective airway rescue in obese subjects.

Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus (2019)
Journal Article
Brennan-Jones, C. G., Thomas, A., Hoare, D. J., & Sereda, M. (2019). Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus. International Journal of Audiology, 59(3), 1-5. https://doi.org/10.1080/14992027.2019.1643503

This Cochrane Corner features “Sound therapy (using amplification devices or sound generators) for tinnitus” published in 2018. Sereda et al. identified eight clinical trials including 590 participants receiving sound therapy for tinnitus. None of th... Read More about Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus.

Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis (2019)
Journal Article
Beukes, E. W., Manchaiah, V., Allen, P. M., Baguley, D. M., & Andersson, G. (2019). Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis. Trends in Hearing, 23, 1-22. https://doi.org/10.1177/2331216519851749

Internet-based interventions have been developed to improve access to audiovestibular health care. This review aimed to identify outcomes of Internet interventions for adults with hearing loss, tinnitus, and vestibular disorders. Electronic databases... Read More about Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis.

Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS (2019)
Journal Article
Mushtaq, F., Wiggins, I. M., Kitterick, P. T., Anderson, C. A., & Hartley, D. E. H. (2019). Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS. PLoS ONE, 14(7), Article e0219927. https://doi.org/10.1371/journal.pone.0219927

Evidence using well-established imaging techniques, such as functional magnetic resonance imaging and electrocorticography, suggest that speech-specific cortical responses can be functionally localised by contrasting speech responses with an auditory... Read More about Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS.

Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality (2019)
Journal Article
Chou, I. J., Kuo, C. F., Tanasescu, R., Tench, C. R., Tiley, C. G., Constantinescu, C. S., & Whitehouse, W. P. (2020). Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality. European Journal of Neurology, 27(1), 105-112. https://doi.org/10.1111/ene.14040

© 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. Background and purpose: We aimed to determine the burden of comorbidities at the time of diagnosis of multiple sclerosi... Read More about Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality.

Joint modelling of diffusion MRI and microscopy (2019)
Journal Article
Howard, A. F., Mollink, J., Kleinnijenhuis, M., Pallebage-Gamarallage, M., Bastiani, M., Cottaar, M., …Jbabdi, S. (2019). Joint modelling of diffusion MRI and microscopy. NeuroImage, 201, Article 116014. https://doi.org/10.1016/j.neuroimage.2019.116014

The combination of diffusion MRI (dMRI) with microscopy provides unique opportunities to study microstructural features of tissue, particularly when acquired in the same sample. Microscopy is frequently used to validate dMRI microstructure models, ad... Read More about Joint modelling of diffusion MRI and microscopy.

Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant (2019)
Journal Article
Thomas, M. G., Maconachie, G. D., Constantinescu, C. S., Chan, W., Barry, B., Hisaund, M., …Thomas, G. (2020). Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant. British Journal of Ophthalmology, 104(4), 547-550. https://doi.org/10.1136/bjophthalmol-2019-314293

Background The genetic basis of monocular elevation deficiency (MED) is unclear. It has previously been considered to arise due to a supranuclear abnormality. Methods Two brothers with MED were referred to Leicester Royal Infirmary, UK from the lo... Read More about Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant.

Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain (2019)
Journal Article
Knight, M. J., Damion, R. A., McGarry, B. L., Bosnell, R., Jokivarsi, K. T., Gröhn, O. H., …Kauppinen, R. A. (2019). Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain. Biomedical Spectroscopy and Imaging, 8(1-2), 11-28. https://doi.org/10.3233/bsi-190185

BACKGROUND AND OBJECTIVE: In hyperacute ischaemic stroke, T2 of cerebral water increases with time. Quantifying this change may be informative of the extent of tissue damage and onset time. Our objective was to develop a user-unbiased method to measu... Read More about Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain.

Preoperative brain imaging using functional near-infrared spectroscopy helps predict cochlear implant outcome in deaf adults (2019)
Journal Article
Anderson, C. A., Wiggins, I. M., Kitterick, P. T., & Hartley, D. E. (2019). Preoperative brain imaging using functional near-infrared spectroscopy helps predict cochlear implant outcome in deaf adults. Journal of the Association for Research in Otolaryngology, 20(5), 511–528. https://doi.org/10.1007/s10162-019-00729-z

Currently it is not possible to accurately predict how well a deaf individual will be able to understand speech when hearing is (re)introduced via a cochlear implant. Differences in brain organisation following deafness are thought to contribute to v... Read More about Preoperative brain imaging using functional near-infrared spectroscopy helps predict cochlear implant outcome in deaf adults.

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial (2019)
Journal Article
Appleton, J., Blair, G. W., Flaherty, K., Law, Z., May, J., Woodhouse, L. J., …Wardlow, J. M. (2019). Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial. Frontiers in Neurology, 10, 1-6. https://doi.org/10.3389/fneur.2019.00723

Background Cilostazol and isosorbide mononitrate (ISMN) are candidate treatments for cerebral small vessel disease and lacunar ischaemic stroke. As both drugs may influence haemoglobin and platelet count, and haemodynamics, we sought to assess their... Read More about Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial.

ICA-based denoising for ASL perfusion imaging (2019)
Journal Article
Carone, D., Harston, G., Garrard, J., De Angeli, F., Griffanti, L., Okell, T., …Kennedy, J. (2019). ICA-based denoising for ASL perfusion imaging. NeuroImage, 200, 363-372. https://doi.org/10.1016/j.neuroimage.2019.07.002

Arterial Spin Labelling (ASL) imaging derives a perfusion image by tracing the accumulation of magnetically labeled blood water in the brain. As the image generated has an intrinsically low signal to noise ratio (SNR), multiple measurements are routi... Read More about ICA-based denoising for ASL perfusion imaging.

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT (2019)
Journal Article
Sprigg, N., Flaherty, K., Appleton, J. P., Al-Shahi Salman, R., Bereczki, D., Beridze, M., …Bath, P. M. (2019). Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT. Health Technology Assessment, 23(35), 1-48. https://doi.org/10.3310/hta23350

BACKGROUND: Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. OBJECTIVE: The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneous... Read More about Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.

Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial (2019)
Journal Article
Sandset, E. C., Appleton, J. P., Berge, E., Christensen, H., Gommans, J., Krishnan, K., …Bath, P. M. (2019). Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial. Journal of Hypertension, 37(10), 2104-2109. https://doi.org/10.1097/HJH.0000000000002154

Objectives: High blood pressure (BP) is associated with a poor outcome after acute stroke. Early reduction in blood pressure (BP) may be associated with fewer early adverse events and deaths, and improved functional outcome. Methods: Analyses used d... Read More about Associations between change in blood pressure and functional outcome, early events and death: results from the Efficacy of Nitric Oxide in Stroke trial.

Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth (2019)
Journal Article
Loczenski-Brown, D. M., Jones, S., Luckett, J., Daniel, Z., Brearley, M. C., Ebling, F. J. P., …Brameld, J. M. (2019). Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth. PLoS ONE, 14(6), 1-12. https://doi.org/10.1371/journal.pone.0218970

We previously identified PEPCK-M (encoded by the Pck2 gene) to be highly up-regulated in skeletal muscle of pigs treated with Ractopamine, an anabolic beta-adrenergic receptor agonist. To determine whether PEPCK-M had a causative role in modulating t... Read More about Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth.

Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages (2019)
Journal Article
Suri, S., Topiwala, A., Chappell, M. A., Okell, T. W., Zsoldos, E., Singh-Manoux, A., …Ebmeier, K. P. (2019). Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages. JAMA Network Open, 2(6), Article e195776. https://doi.org/10.1001/jamanetworkopen.2019.5776

© 2019 AMA. All rights reserved. Importance: Poor cardiovascular health is an established risk factor for dementia, but little is known about its association with brain physiology in older adults. Objective: To examine the association of cardiovascul... Read More about Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages.