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All Outputs (1130)

Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage (2015)
Journal Article
Abdullah, Z., Rakkar, K., Bath, P. M., & Bayraktutan, U. (2015). Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage. Molecular and Cellular Neuroscience, 69, https://doi.org/10.1016/j.mcn.2015.11.003

Cerebral ischaemia, associated with neuroinflammation and oxidative stress, is known to perturb blood–brain barrier (BBB) integrity and promote brain oedema formation. Using an in vitro model of human BBB composed of brain microvascular endothelial c... Read More about Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage.

Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis (2015)
Journal Article
Rakkar, K., & Bayraktutan, U. (2016). Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis. BBA - Molecular Basis of Disease, 1862(1), https://doi.org/10.1016/j.bbadis.2015.10.016

An increase in intracellular calcium represents one of the early events during an ischaemic stroke. It triggers many downstream processes which promote the formation of brain oedema, the leading cause of death after an ischaemic stroke. As impairment... Read More about Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis.

Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review (2015)
Journal Article
Marufu, T. C., Mannings, A., & Moppett, I. K. (2015). Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review. Injury, 46(12), 2325-2334. https://doi.org/10.1016/j.injury.2015.10.025

Rationale

Accurate peri-operative risk prediction is an essential element of clinical practice. Various risk stratification tools for assessing patients’ risk of mortality or morbidity have been developed and applied in clinical practice over the... Read More about Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review.

Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke (2015)
Journal Article
Woodhouse, L. J., Scutt, P., Krishnan, K., Berge, E., Gommans, J., Ntaios, G., Wardlaw, J. M., Sprigg, N., & Bath, P. M. (2015). Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke. Stroke, 46(11), https://doi.org/10.1161/STROKEAHA.115.009647

Background and Purpose — Nitric oxide donors are candidate treatments for acute stroke, potentially through hemodynamic, reperfusion, and neuroprotectant effects, especially if given early. Although the large Efficacy of Nitric Oxide in Stroke (ENOS)... Read More about Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke.

Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population (2015)
Journal Article
Fackrell, K. L., Hall, D. A., Barry, J. G., & Hoare, D. J. (2016). Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population. Hearing Research, 335, https://doi.org/10.1016/j.heares.2015.09.009

Objectives

Questionnaires are essential for measuring tinnitus severity and intervention-related change but there is no standard instrument used routinely in research settings. Most tinnitus questionnaires are optimised for measuring severity but... Read More about Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population.

Corneal Decellularization: A Method of Recycling Unsuitable Donor Tissue for Clinical Translation? (2015)
Journal Article
Wilson, S. L., Sidney, L. E., Dunphy, S. E., Dua, H. S., & Hopkinson, A. (2016). Corneal Decellularization: A Method of Recycling Unsuitable Donor Tissue for Clinical Translation?. Current Eye Research, 41(6), 769-782. https://doi.org/10.3109/02713683.2015.1062114

Background: There is a clinical need for biomimetic corneas that are as effective, preferably superior, to cadaveric donor tissue. Decellularized tissues are advantageous compared to synthetic or semi-synthetic engineered tissues in that the native m... Read More about Corneal Decellularization: A Method of Recycling Unsuitable Donor Tissue for Clinical Translation?.

Exploring the effects of the narrative embodied in the hearing aid fitting process on treatment outcomes (2015)
Journal Article

Objectives: There is strong evidence from other fields of health, and growing evidence in audiology, that characteristics of the process of intervention as perceived by the client (embodied narratives) can have significant effects on treatment outcom... Read More about Exploring the effects of the narrative embodied in the hearing aid fitting process on treatment outcomes.

Background sounds and hearing aid users: a scoping review (2015)
Journal Article
Gygi, B., & Hall, D. (2016). Background sounds and hearing aid users: a scoping review. International Journal of Audiology, 55(1), 1-10. https://doi.org/10.3109/14992027.2015.1072773

Objectives: A scoping review focused on background sounds and adult hearing-aid users, including aspects of aversiveness and interference. The aim was to establish the current body of knowledge, identify knowledge gaps, and to suggest possible future... Read More about Background sounds and hearing aid users: a scoping review.

Histological validation of high-resolution DTI in human post mortem tissue (2015)
Journal Article
Seehaus, A., Roebroeck, A., Bastiani, M., Fonseca, L., Bratzke, H., Lori, N., …Galuske, R. (2015). Histological validation of high-resolution DTI in human post mortem tissue. Frontiers in Neuroanatomy, 9, Article 98. https://doi.org/10.3389/fnana.2015.00098

Diffusion tensor imaging (DTI) is amongst the simplest mathematical models available for diffusion magnetic resonance imaging, yet still by far the most used one. Despite the success of DTI as an imaging tool for white matter fibers, its anatomical u... Read More about Histological validation of high-resolution DTI in human post mortem tissue.

Consensus on hearing aid candidature and fitting for mild hearing loss, with and without tinnitus: Delphi review (2015)
Journal Article
Sereda, M., Hoare, D. J., Nicholson, R., Smith, S., & Hall, D. A. (2015). Consensus on hearing aid candidature and fitting for mild hearing loss, with and without tinnitus: Delphi review. Ear and Hearing, 36(4), 417-429. https://doi.org/10.1097/AUD.0000000000000140

Objectives:

In many countries including the United Kingdom, hearing aids are a first line of audiologic intervention for many people with tinnitus and aidable hearing loss. Nevertheless, there is a lack of high quality evidence to support that the... Read More about Consensus on hearing aid candidature and fitting for mild hearing loss, with and without tinnitus: Delphi review.

Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer (2015)
Journal Article
Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., …Meersmann, T. (2015). Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16(11), https://doi.org/10.1002/cphc.201500367

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagn... Read More about Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer.

The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests (2015)
Journal Article
Heinrich, A., Henshaw, H., & Ferguson, M. A. (2015). The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests. Frontiers in Psychology, 6, https://doi.org/10.3389/fpsyg.2015.00782

Listeners vary in their ability to understand speech in noisy environments. Hearing sensitivity, as measured by pure-tone audiometry, can only partly explain these results, and cognition has emerged as another key concept. Although cognition relates... Read More about The relationship of speech intelligibility with hearing sensitivity, cognition, and perceived hearing difficulties varies for different speech perception tests.

Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388) (2015)
Journal Article
Beridze, M., Christensen, H., Dineen, R. A., Duley, L., Heptinstall, S., James, M., …Bath, P. M. (2015). Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388). International Journal of Stroke, 10(7), https://doi.org/10.1111/ijs.12538

RATIONALE:

The risk of recurrence following a stroke or transient ischemic attack is high, especially immediately after the event.
HYPOTHESIS:

Because two antiplatelet agents are superior to one in patients with non-cardioembolic events, more... Read More about Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388).

Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI (2015)
Journal Article
Bastiani, M., & Roebroeck, A. (2015). Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI. Frontiers in Neuroanatomy, 9, Article 77. https://doi.org/10.3389/fnana.2015.00077

The structural architecture and the anatomical connectivity of the human brain show different organizational principles at distinct spatial scales. Histological staining and light microscopy techniques have been widely used in classical neuroanatomic... Read More about Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI.

Brightness masking is modulated by disparity structure (2015)
Journal Article
Pelekanos, V., Ban, H., & Welchman, A. E. (2015). Brightness masking is modulated by disparity structure. Vision Research, 110(Part A), 87-92. https://doi.org/10.1016/j.visres.2015.02.010

The luminance contrast at the borders of a surface strongly influences surface’s apparent brightness, as demonstrated by a number of classic visual illusions. Such phenomena are compatible with a propagation mechanism believed to spread contrast info... Read More about Brightness masking is modulated by disparity structure.

Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss (2015)
Journal Article
Ferguson, M. A., & Henshaw, H. (2015). Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss. Frontiers in Psychology, 6, Article 556. https://doi.org/10.3389/FPG.2015.00556

Auditory training (AT) helps compensate for degradation in the auditory signal. A series of three high-quality training studies are discussed, which include, (i) a randomized controlled trial (RCT) of phoneme discrimination in quiet that trained adul... Read More about Auditory training can improve working memory, attention, and communication in adverse conditions for adults with hearing loss.

Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis (2015)
Journal Article
Constantinescu, C. S., Asher, A., Fryze, W., Kozubski, W., Wagner, F., Aram, J., …Radue, E. W. (2015). Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis. Neurology, Neuroimmunology and Neuroinflammation, 2(4), Article e117. https://doi.org/10.1212/nxi.0000000000000117

Objectives: To determine the safety, pharmacokinetics (PK), and immunogenicity of the recombinant human monoclonal antibody MOR103 to granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with multiple sclerosis (MS) with clinical or... Read More about Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis.