All Outputs (1130)

The effects of verbal and spatial memory load on children's processing speed: Development of WM load effects (2018)
Journal Article
Morey, C. C., Hadley, L. V., Buttelmann, F., Könen, T., Meaney, J.-A., Auyeung, B., …Chevalier, N. (2018). The effects of verbal and spatial memory load on children's processing speed: Development of WM load effects. Annals of the New York Academy of Sciences, 1424(1), 161-174. https://doi.org/10.1111/nyas.13653

Examining the impact of maintenance on processing speed allows us to test whether storage and processing resources are shared. Comparing these relationships in children of different ages allows further insight into whether one or multiple resources f... Read More about The effects of verbal and spatial memory load on children's processing speed: Development of WM load effects.

Lipid-lowering pretreatment and outcome following intravenous thrombolysis for acute ischaemic stroke: a post hoc analysis of the enhanced control of hypertension and thrombolysis stroke study trial (2018)
Journal Article
Minhas, J. S., Wang, X., Arima, H., Bath, P. M., Billot, L., Broderick, J. P., …Robinson, T. G. (in press). Lipid-lowering pretreatment and outcome following intravenous thrombolysis for acute ischaemic stroke: a post hoc analysis of the enhanced control of hypertension and thrombolysis stroke study trial. Cerebrovascular Diseases, 45(5-6), https://doi.org/10.1159/000488911

Background: Debate exists as to whether statin pretreatment confers an increased risk of 90-day mortality and symptomatic intracranial haemorrhage (sICH) in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis. We assessed the... Read More about Lipid-lowering pretreatment and outcome following intravenous thrombolysis for acute ischaemic stroke: a post hoc analysis of the enhanced control of hypertension and thrombolysis stroke study trial.

A MEMS microphone inspired by Ormia for spatial sound detection (2018)
Presentation / Conference Contribution
Zhang, Y., Bauer, R., Whitmer, W. M., Jackson, J. C., Windmill, J. F., & Uttamchandani, D. (2018). A MEMS microphone inspired by Ormia for spatial sound detection. In 2018 IEEE Micro Electro Mechanical Systems (MEMS) (253-256). https://doi.org/10.1109/MEMSYS.2018.8346532

This work introduces a MEMS microphone with two pairs of orthogonal and joined sensor membranes, with independent acoustic directionality responses, leading to a 3D sound localization potential. This single microphone can thus be regarded as two indi... Read More about A MEMS microphone inspired by Ormia for spatial sound detection.

Cueing listeners to attend to a target talker progressively improves word report as the duration of the cue-target interval lengthens to 2000 ms (2018)
Journal Article
Holmes, E., Kitterick, P. T., & Summerfield, A. Q. (2018). Cueing listeners to attend to a target talker progressively improves word report as the duration of the cue-target interval lengthens to 2000 ms. Attention, Perception, and Psychophysics, 80(6), 1520–1538. https://doi.org/10.3758/s13414-018-1531-x

Endogenous attention is typically studied by presenting instructive cues in advance of a target stimulus array. For endogenous visual attention, task performance improves as the duration of the cue-target interval increases up to 800 ms. Less is know... Read More about Cueing listeners to attend to a target talker progressively improves word report as the duration of the cue-target interval lengthens to 2000 ms.

Neurotrophic keratopathy (2018)
Journal Article
Dua, H. S., Said, D. G., Messmer, E. M., Rolando, M., Benitez-del-Castillo, J. M., Hossain, P. N., …Baudouin, C. (2018). Neurotrophic keratopathy. Progress in Retinal and Eye Research, 66, 107-131. https://doi.org/10.1016/j.preteyeres.2018.04.003

Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor... Read More about Neurotrophic keratopathy.

Feasibility of personalised remote long-term follow-up of people with cochlear implants: a randomised controlled trial (2018)
Journal Article
Cullington, H., Kitterick, P. T., Weal, M., & Margol-Gromada, M. (2018). Feasibility of personalised remote long-term follow-up of people with cochlear implants: a randomised controlled trial. BMJ Open, 8(4), Article e019640. https://doi.org/10.1136/bmjopen-2017-019640

Introduction: substantial resources are required to provide lifelong post-operative care to people with cochlear implants. Most patients visit the clinic annually. We introduced a person-centred remote follow-up pathway, giving patients telemedicine... Read More about Feasibility of personalised remote long-term follow-up of people with cochlear implants: a randomised controlled trial.

Haemostatic therapies for acute spontaneous intracerebral haemorrhage (2018)
Journal Article
Al-Shahi Salman, R., Law, Z. K., Bath, P. M., Steiner, T., & Sprigg, N. (2018). Haemostatic therapies for acute spontaneous intracerebral haemorrhage. Cochrane Database of Systematic Reviews, Article CD005951. https://doi.org/10.1002/14651858.CD005951.pub4

Background: Outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH) is influenced by haematoma volume; up to one-third of ICHs enlarge within 24 hours of onset. Early haemostatic therapy might improve outcome by limiting haematoma g... Read More about Haemostatic therapies for acute spontaneous intracerebral haemorrhage.

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel and prasugrel, and bleeding disorders (2018)
Journal Article
Bath, P. M., May, J., & Heptinstall, S. (2018). Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel and prasugrel, and bleeding disorders. Platelets, 29(5), 425-430. https://doi.org/10.1080/09537104.2018.1445839

Vascular diseases such as myocardial infarction and ischaemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel and prasugrel. However, some patients ex... Read More about Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel and prasugrel, and bleeding disorders.

Alterations in the microstructure of white matter in children and adolescents with Tourette syndrome measured using tract-based spatial statistics and probabilistic tractography (2018)
Journal Article
Sigurdsson, H. P., Pépés, S. E., Jackson, G. M., Draper, A., Morgan, P. S., & Jackson, S. R. (2018). Alterations in the microstructure of white matter in children and adolescents with Tourette syndrome measured using tract-based spatial statistics and probabilistic tractography. Cortex, 104, 75-89. https://doi.org/10.1016/j.cortex.2018.04.004

Tourette syndrome (TS) is a neurodevelopmental disorder characterised by repetitive and intermittent motor and vocal tics. TS is thought to reflect fronto-striatal dysfunction and the aetiology of the disorder has been linked to widespread alteration... Read More about Alterations in the microstructure of white matter in children and adolescents with Tourette syndrome measured using tract-based spatial statistics and probabilistic tractography.

A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others (2018)
Journal Article
Hall, D. A., Fackrell, K. L., Li, A. B., Thavayogan, R., Smith, S., Kennedy, V., …Haider, H. (2018). A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others. Health and Quality of Life Outcomes, 16, Article 61. https://doi.org/10.1186/s12955-018-0888-9

Background: There are a large number of assessment tools for tinnitus, with little consensus on what it is important to measure and no preference for a minimum reporting standard. The item content of tinnitus assessment tools should seek to capture r... Read More about A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others.

Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial (2018)
Journal Article
Rowlands, M., Walt, G. V. D., Bradley, J., Mannings, A., Armstrong, S., Bedforth, N. M., …Sahota, O. (2018). Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial. BMJ Open, 8(4), Article e019650. https://doi.org/10.1136/bmjopen-2017-019650

Objective

Fractured neck of femur is a severely painful condition with significant mortality and morbidity. We investigated whether early and continuous use of femoral nerve block can improve pain on movement and mobility after surgery in older p... Read More about Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial.

Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited (2018)
Journal Article
Constantinescu, C. S., & Gershkovich, P. (2018). Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited. European Journal of Neurology, 25(7), 905-906. https://doi.org/10.1111/ene.13658

Cannabinoids are compounds with pleiotropic properties that act on the cannabinoid receptors, CB1 and CB2, and are divided into endocannabinoids, the endogenous ligands of these receptors, synthetic cannabinoids and phytocannabinoids. The latter are... Read More about Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited.

Probing the brain with molecular fMRI (2018)
Journal Article
Ghosh, S., Harvey, P., Simon, J. C., & Jasanoff, A. (2018). Probing the brain with molecular fMRI. Current Opinion in Neurobiology, 50, 201-210. https://doi.org/10.1016/j.conb.2018.03.009

© 2018 Elsevier Ltd One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecul... Read More about Probing the brain with molecular fMRI.

Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different (2018)
Journal Article
Ross, A. R., Said, D. G., El-Amin, A., Altaan, S., Cabrerizo, J., Nubile, M., …Dua, H. S. (2018). Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different. British Journal of Ophthalmology, 102(12), 1646-1652. https://doi.org/10.1136/bjophthalmol-2017-311349

Aims: To investigate and define the nature of big bubbles (BB) formed by injection of viscoelastic in deep anterior lamellar keratoplasty.

Methods: Intrastromal injections of 0.1 and 0.3 mL of sodium hyaluronate 1.2% and 0.6% were made into sclera... Read More about Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different.

Cataract surgery with intraocular lens implantation in 3 brothers with megalocornea: Long-term follow-up (2018)
Journal Article
Messina, M., Ross, A. R., Pocobelli, G., Said, D. G., & Dua, H. S. (2018). Cataract surgery with intraocular lens implantation in 3 brothers with megalocornea: Long-term follow-up. Journal of Cataract and Refractive Surgery, 44(3), 399-402. https://doi.org/10.1016/j.jcrs.2018.01.020

Communication calls produced by electrical stimulation of four structures in the guinea pig brain (2018)
Journal Article
Green, D. B., Shackleton, T. M., Grimsley, J. M., Zobay, O., Wallace, M. N., & Palmer, A. R. (2018). Communication calls produced by electrical stimulation of four structures in the guinea pig brain. PLoS ONE, 13(3), Article e0194091. https://doi.org/10.1371/journal.pone.0194091

One of the main central processes affecting the cortical representation of conspecific vocalizations is the collateral output from the extended motor system for call generation. Before starting to study this interaction we sought to compare the chara... Read More about Communication calls produced by electrical stimulation of four structures in the guinea pig brain.

Development and validation of the Nottingham Auditory Milestones (NAMES) profile for deaf children under 2 years old, using cochlear implants (2018)
Journal Article
Datta, G., Kitterick, P. T., & Ramirez-Inscoe, J. (2018). Development and validation of the Nottingham Auditory Milestones (NAMES) profile for deaf children under 2 years old, using cochlear implants. Cochlear Implants International, 19(4), 181-192. https://doi.org/10.1080/14670100.2018.1452560

Objectives: Clinicians face considerable challenges in setting appropriate auditory goals for babies and young children who receive cochlear implants. This paper describes the rationale, organisation, implementation and validation of the Nottingham... Read More about Development and validation of the Nottingham Auditory Milestones (NAMES) profile for deaf children under 2 years old, using cochlear implants.

Anaesthesia workload measurement devices: qualitative systematic review (2018)
Journal Article
Almghairbi, D. S., Marufu, T. C., & Moppett, I. K. (2018). Anaesthesia workload measurement devices: qualitative systematic review. BMJ Simulation & Technology Enhanced Learning, 4(3), 112-116. https://doi.org/10.1136/bmjstel-2017-000263

Background: Management of mental workload is a key aspect of safety in anaesthesia but there is no gold standard tool to assess mental workload, risking confusion in clinical and research use of such tools.

Objective: This review assessed currentl... Read More about Anaesthesia workload measurement devices: qualitative systematic review.

Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons (2018)
Journal Article
Geiszler, P. C., Ugun-Klusek, A., Lawler, K., Pardon, M.-C., Yuchun, D., Bai, L., …Bedford, L. (in press). Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Scientific Reports, 8, Article 4833. https://doi.org/10.1038/s41598-018-23155-2

Metabolite profiling is an important tool that may better capture the multiple features of neurodegeneration. With the considerable parallels between mouse and human metabolism, the use of metabolomics in mouse models with neurodegenerative pathology... Read More about Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons.

Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis (2018)
Journal Article
Cottam, W. J., Iwabuchi, S. J., Drabek, M. M., Reckziegel, D., & Auer, D. P. (2018). Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. PAIN, 159(5), https://doi.org/10.1097/j.pain.0000000000001209

Resting-state functional connectivity (FC) has proven a powerful approach to understand the neural underpinnings of chronic pain, reporting altered connectivity in three main networks: the default mode (DMN), central executive (CEN), and the salience... Read More about Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis.